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Aliases for ANKRD16 Gene

Aliases for ANKRD16 Gene

  • Ankyrin Repeat Domain 16 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 16 3

External Ids for ANKRD16 Gene

Previous GeneCards Identifiers for ANKRD16 Gene

  • GC10M005907
  • GC10M005942
  • GC10M005905
  • GC10M005906
  • GC10M005830
  • GC10M005909
  • GC10M005911
  • GC10M005912
  • GC10M005914
  • GC10M005916
  • GC10M005918
  • GC10M005920

Summaries for ANKRD16 Gene

GeneCards Summary for ANKRD16 Gene

ANKRD16 (Ankyrin Repeat Domain 16) is a Protein Coding gene. An important paralog of this gene is ESPN.

Additional gene information for ANKRD16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD16 Gene

Genomics for ANKRD16 Gene

GeneHancer (GH) Regulatory Elements for ANKRD16 Gene

Promoters and enhancers for ANKRD16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J005887 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 664.9 -0.5 -452 5.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 FBH1 ANKRD16 FAM208B LOC105376384 ENSG00000226647 IL15RA NRBF2P5 RBM17 GDI2 ASB13
GH10J005808 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.2 +77.6 77597 6.9 CLOCK MLX YBX1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 GDI2 ENSG00000272764 ANKRD16 FAM208B RBM17 FBH1 ASB13 GC10P005778
GH10J005843 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 28.4 +44.7 44656 4.2 PKNOX1 FOXA2 ZFP64 BATF ZNF335 ATF7 FOS IKZF2 RUNX3 KLF13 ANKRD16 FAM208B LOC105376384 NRBF2P5 FBH1 ASB13 GDI2 PFKFB3 IL15RA GC10M005854
GH10J006736 Enhancer 1.2 Ensembl ENCODE dbSUPER 28.5 -849.5 -849537 6.1 PKNOX1 FOXA2 ZSCAN4 ZFP64 KLF17 SIN3A RARA RFX5 ZNF213 SCRT2 NRBF2P5 LOC105376384 FBH1 ENSG00000226647 ANKRD16 RBM17 LINP1 LINC00706 GC10P006679
GH10J005852 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +36.9 36874 1.9 PKNOX1 ARID4B SIN3A ZNF2 IRF4 ZNF213 ZNF143 KLF13 SP3 MXD4 GC10M005854 TRV-TAC3-1 FAM208B FBH1 LOC105376384 ENSG00000226647 ANKRD16 GDI2 RBM17 NRBF2P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD16 gene promoter:
  • YY1
  • LCR-F1
  • SRY
  • ITF-2
  • Tal-1beta
  • CUTL1
  • c-Myb
  • SEF-1 (1)
  • Sox9
  • Brachyury

Genomic Locations for ANKRD16 Gene

Genomic Locations for ANKRD16 Gene
chr10:5,861,617-5,889,906
(GRCh38/hg38)
Size:
28,290 bases
Orientation:
Minus strand
chr10:5,903,580-5,931,869
(GRCh37/hg19)
Size:
28,290 bases
Orientation:
Minus strand

Genomic View for ANKRD16 Gene

Genes around ANKRD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD16 Gene

Proteins for ANKRD16 Gene

  • Protein details for ANKRD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P6B7-ANR16_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 16
    Protein Accession:
    Q6P6B7
    Secondary Accessions:
    • A6NEF0
    • F8WEI4
    • Q9NT01

    Protein attributes for ANKRD16 Gene

    Size:
    361 amino acids
    Molecular mass:
    39284 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD16 Gene

Post-translational modifications for ANKRD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD16 Gene

No data available for DME Specific Peptides for ANKRD16 Gene

Domains & Families for ANKRD16 Gene

Gene Families for ANKRD16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD16 Gene

Suggested Antigen Peptide Sequences for ANKRD16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD16: view

No data available for UniProtKB/Swiss-Prot for ANKRD16 Gene

Function for ANKRD16 Gene

Phenotypes From GWAS Catalog for ANKRD16 Gene

genes like me logo Genes that share phenotypes with ANKRD16: view

Animal Model Products

CRISPR Products

miRNA for ANKRD16 Gene

miRTarBase miRNAs that target ANKRD16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD16 Gene

Localization for ANKRD16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD16 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD16 Gene

Pathways & Interactions for ANKRD16 Gene

SuperPathways for ANKRD16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD16 Gene

Drugs & Compounds for ANKRD16 Gene

No Compound Related Data Available

Transcripts for ANKRD16 Gene

mRNA/cDNA for ANKRD16 Gene

Unigene Clusters for ANKRD16 Gene

Ankyrin repeat domain 16:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD16 Gene

No ASD Table

Relevant External Links for ANKRD16 Gene

GeneLoc Exon Structure for
ANKRD16
ECgene alternative splicing isoforms for
ANKRD16

Expression for ANKRD16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD16 Gene

This gene is overexpressed in Platelet (42.4) and Bone (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD16 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKRD16 Gene:

ANKRD16

SOURCE GeneReport for Unigene cluster for ANKRD16 Gene:

Hs.289828
genes like me logo Genes that share expression patterns with ANKRD16: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD16 Gene

Orthologs for ANKRD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD16 34 33
  • 99.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD16 34 33
  • 82.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd16 16 34 33
  • 82.54 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd16 33
  • 82.44 (n)
dog
(Canis familiaris)
Mammalia ANKRD16 34 33
  • 78.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD16 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD16 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD16 34 33
  • 69.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD16 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd16 33
  • 64.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14968 33
zebrafish
(Danio rerio)
Actinopterygii ankrd16 34 33
  • 62.36 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pain 34
  • 7 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for ANKRD16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD16 Gene

ENSEMBL:
Gene Tree for ANKRD16 (if available)
TreeFam:
Gene Tree for ANKRD16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD16: view image

Paralogs for ANKRD16 Gene

Paralogs for ANKRD16 Gene

(4) SIMAP similar genes for ANKRD16 Gene using alignment to 1 proteins:

  • ANR16_HUMAN
genes like me logo Genes that share paralogs with ANKRD16: view

Variants for ANKRD16 Gene

Sequence variations from dbSNP and Humsavar for ANKRD16 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000007378 -- 5,881,978(-) C/T intron_variant
rs1000020695 -- 5,862,257(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000030463 -- 5,862,546(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000152350 -- 5,871,959(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000169381 -- 5,876,093(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD16 Gene

Variant ID Type Subtype PubMed ID
nsv831775 CNV loss 17160897
nsv825229 CNV gain 20364138
nsv5654 CNV deletion 18451855
nsv549906 CNV loss 21841781
nsv549905 CNV loss 21841781
nsv549904 CNV loss 21841781
nsv520941 CNV loss 19592680
nsv519773 CNV loss 19592680
nsv437655 CNV loss 16327808
nsv1118070 CNV deletion 24896259
esv3622239 CNV loss 21293372
esv3622238 CNV loss 21293372
esv3545829 CNV deletion 23714750
esv2676037 CNV deletion 23128226
esv2668731 CNV deletion 23128226
dgv1e49 CNV loss 18971310

Variation tolerance for ANKRD16 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD16 Gene

Human Gene Mutation Database (HGMD)
ANKRD16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD16 Gene

Disorders for ANKRD16 Gene

Additional Disease Information for ANKRD16

No disorders were found for ANKRD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD16 Gene

Publications for ANKRD16 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. Genome-wide association study identifies five new breast cancer susceptibility loci. (PMID: 20453838) Turnbull C … Easton DF (Nature genetics 2010) 3 58

Products for ANKRD16 Gene

Sources for ANKRD16 Gene

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