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Aliases for ANKRD13C Gene

Aliases for ANKRD13C Gene

  • Ankyrin Repeat Domain 13C 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 13C 3
  • DJ677H15.3 3

External Ids for ANKRD13C Gene

Previous GeneCards Identifiers for ANKRD13C Gene

  • GC01M070439
  • GC01M070500
  • GC01M070724
  • GC01M068835

Summaries for ANKRD13C Gene

GeneCards Summary for ANKRD13C Gene

ANKRD13C (Ankyrin Repeat Domain 13C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is ANKRD13D.

UniProtKB/Swiss-Prot for ANKRD13C Gene

  • Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.

Gene Wiki entry for ANKRD13C Gene

Additional gene information for ANKRD13C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD13C Gene

Genomics for ANKRD13C Gene

GeneHancer (GH) Regulatory Elements for ANKRD13C Gene

Promoters and enhancers for ANKRD13C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I070352 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.4 +0.6 599 3.6 CLOCK MLX YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 HHLA3 ANKRD13C LRRC40 LOC102724548 GC01M070275
GH01I070409 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 17.4 -56.4 -56444 3.5 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 CTH SRSF11 HHLA3 ZRANB2 ANKRD13C ENSG00000278636
GH01I070504 Enhancer 1.1 Ensembl ENCODE 11 -150.0 -149995 0.6 ATF1 PKNOX1 FOXA2 SMAD1 FEZF1 IRF4 ATF7 RUNX3 JUNB TSHZ1 LRRC40 ANKRD13C GC01M070501 GC01M070486
GH01I070226 Enhancer 0.6 FANTOM5 dbSUPER 4 +128.4 128370 0.4 POLR2A LRRC40 SRSF11 ANKRD13C GC01P070230 ENSG00000228988
GH01I070281 Enhancer 0.6 FANTOM5 1.3 +73.5 73538 0.2 MITF SMARCE1 HDAC1 STAT1 SOX6 ZNF366 ZEB2 SRSF11 ANKRD13C GC01M070275 GC01P070230
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKRD13C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD13C gene promoter:

Genomic Locations for ANKRD13C Gene

Genomic Locations for ANKRD13C Gene
chr1:70,259,002-70,354,788
(GRCh38/hg38)
Size:
95,787 bases
Orientation:
Minus strand
chr1:70,724,685-70,820,417
(GRCh37/hg19)

Genomic View for ANKRD13C Gene

Genes around ANKRD13C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD13C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD13C Gene

Proteins for ANKRD13C Gene

  • Protein details for ANKRD13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6S4-AN13C_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 13C
    Protein Accession:
    Q8N6S4
    Secondary Accessions:
    • B3KQ97
    • Q5VYH4
    • Q5VYH5
    • Q6PJE4
    • Q9H0N9

    Protein attributes for ANKRD13C Gene

    Size:
    541 amino acids
    Molecular mass:
    60818 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG51959.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD13C Gene

Post-translational modifications for ANKRD13C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD13C Gene

Domains & Families for ANKRD13C Gene

Gene Families for ANKRD13C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD13C Gene

Suggested Antigen Peptide Sequences for ANKRD13C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD13C: view

No data available for UniProtKB/Swiss-Prot for ANKRD13C Gene

Function for ANKRD13C Gene

Molecular function for ANKRD13C Gene

UniProtKB/Swiss-Prot Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.

Phenotypes From GWAS Catalog for ANKRD13C Gene

Gene Ontology (GO) - Molecular Function for ANKRD13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20959461
genes like me logo Genes that share ontologies with ANKRD13C: view
genes like me logo Genes that share phenotypes with ANKRD13C: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD13C Gene

Localization for ANKRD13C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD13C Gene

Endoplasmic reticulum membrane. Note=Associated with the cytosolic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD13C gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ANKRD13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 colocalizes_with endoplasmic reticulum IDA 20959461
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 20959461
genes like me logo Genes that share ontologies with ANKRD13C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANKRD13C Gene

Pathways & Interactions for ANKRD13C Gene

SuperPathways for ANKRD13C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006621 protein retention in ER lumen IMP 20959461
GO:0010869 regulation of receptor biosynthetic process IDA 20959461
GO:2000209 regulation of anoikis IDA 20959461
genes like me logo Genes that share ontologies with ANKRD13C: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD13C Gene

Drugs & Compounds for ANKRD13C Gene

No Compound Related Data Available

Transcripts for ANKRD13C Gene

Unigene Clusters for ANKRD13C Gene

Ankyrin repeat domain 13C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13C Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:
SP2: - - - - - - -
SP3: -
SP4: - -

Relevant External Links for ANKRD13C Gene

GeneLoc Exon Structure for
ANKRD13C
ECgene alternative splicing isoforms for
ANKRD13C

Expression for ANKRD13C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD13C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD13C Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD13C Gene



Protein tissue co-expression partners for ANKRD13C Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD13C Gene:

ANKRD13C

SOURCE GeneReport for Unigene cluster for ANKRD13C Gene:

Hs.744989

Evidence on tissue expression from TISSUES for ANKRD13C Gene

  • Intestine(4.2)
  • Kidney(4.2)
  • Eye(4.1)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ANKRD13C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD13C Gene

Orthologs for ANKRD13C Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD13C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD13C 33 34
  • 99.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD13C 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD13C 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD13C 33 34
  • 95.37 (n)
rat
(Rattus norvegicus)
Mammalia Ankrd13c 33
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Ankrd13c 33 16 34
  • 88.74 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRD13C 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD13C 33 34
  • 89.55 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRD13C 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd13c 33
  • 79.09 (n)
Str.8944 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53218 33
zebrafish
(Danio rerio)
Actinopterygii ankrd13c 33 34
  • 74.25 (n)
wufc57c01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10323 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009954 33
  • 58.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5742 33 34
  • 55.43 (n)
worm
(Caenorhabditis elegans)
Secernentea C01F1.6 33 34
  • 56.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6516 34
  • 46 (a)
OneToOne
Species where no ortholog for ANKRD13C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD13C Gene

ENSEMBL:
Gene Tree for ANKRD13C (if available)
TreeFam:
Gene Tree for ANKRD13C (if available)

Paralogs for ANKRD13C Gene

Paralogs for ANKRD13C Gene

(4) SIMAP similar genes for ANKRD13C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD13C: view

Variants for ANKRD13C Gene

Sequence variations from dbSNP and Humsavar for ANKRD13C Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000006114 -- 70,321,041(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000017914 -- 70,268,178(-) C/T intron_variant
rs1000046756 -- 70,287,894(-) C/T intron_variant
rs1000060852 -- 70,280,998(-) A/G intron_variant
rs1000068370 -- 70,350,731(-) TACTTAC/TAC genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD13C Gene

Variant ID Type Subtype PubMed ID
esv1997734 CNV deletion 18987734
esv2555384 CNV deletion 19546169
esv2657438 CNV deletion 23128226
esv2749597 CNV deletion 23290073
esv3563704 CNV deletion 23714750
esv3586352 CNV loss 21293372
esv3586353 CNV loss 21293372
esv4055 CNV loss 18987735
nsv1012563 CNV gain 25217958
nsv1014292 CNV gain 25217958
nsv473705 CNV novel sequence insertion 20440878
nsv830137 CNV loss 17160897

Variation tolerance for ANKRD13C Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD13C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD13C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD13C Gene

Disorders for ANKRD13C Gene

Additional Disease Information for ANKRD13C

No disorders were found for ANKRD13C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD13C Gene

Publications for ANKRD13C Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. ANKRD13C acts as a molecular chaperone for G protein-coupled receptors. (PMID: 20959461) Parent A … Parent JL (The Journal of biological chemistry 2010) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ANKRD13C Gene

Sources for ANKRD13C Gene

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