Aliases for ANKRD13C Gene

Aliases for ANKRD13C Gene

  • Ankyrin Repeat Domain 13C 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 13C 3 4
  • DJ677H15.3 2 3
  • DKFZP566D1346 2
  • ANKRD13C 5

External Ids for ANKRD13C Gene

Previous GeneCards Identifiers for ANKRD13C Gene

  • GC01M070439
  • GC01M070500
  • GC01M070724
  • GC01M068835

Summaries for ANKRD13C Gene

GeneCards Summary for ANKRD13C Gene

ANKRD13C (Ankyrin Repeat Domain 13C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is ANKRD13B.

UniProtKB/Swiss-Prot Summary for ANKRD13C Gene

  • Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.

Gene Wiki entry for ANKRD13C Gene

Additional gene information for ANKRD13C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD13C Gene

Genomics for ANKRD13C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKRD13C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J070352 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 611.3 +1.0 976 4.8 BRCA1 ARHGAP35 CREB1 GATAD2A HNRNPL ATF7 TEAD4 PRDM10 REST ZNF629 HHLA3 ANKRD13C ZRANB2 MIR186 LRRC40 HHLA3-AS1 lnc-LRRC40-5 SRSF11
GH01J070360 Promoter 0.8 EPDnew 600.4 -5.5 -5480 0.1 IKZF1 ZNF692 PKNOX1 HDAC1 EP300 MGA SP2 HDAC2 MNT MYC HHLA3-AS1 ANKRD13C HHLA3 CTH
GH01J070409 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 17.4 -57.0 -56972 4.9 SP1 HNRNPL CREB1 ATF7 TEAD4 PRDM10 REST ZNF629 TFE3 IKZF1 CTH lnc-ANKRD13C-4 HHLA3 ZRANB2 ANKRD13C SRSF11 ENSG00000278636 PTGER3
GH01J069993 Enhancer 0.7 Ensembl 10.2 +360.7 360677 1 CREB1 ATF7 ZNF629 ZNF37A SMARCC1 ZNF10 OSR2 ZNF580 ATF2 JUND LRRC7-AS1 SRSF11 ANKRD13C lnc-SRSF11-4 piR-58308-011 LRRC40 LRRC7
GH01J070226 Enhancer 0.5 FANTOM5 dbSUPER 4 +128.6 128559 0.4 POLR2A LRRC40 SRSF11 ANKRD13C NONHSAG001792.2-001 lnc-LRRC7-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD13C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKRD13C

Top Transcription factor binding sites by QIAGEN in the ANKRD13C gene promoter:
  • AML1a
  • COUP
  • COUP-TF
  • COUP-TF1
  • GATA-1
  • GATA-2
  • GATA-3
  • HEN1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for ANKRD13C Gene

Genomic Locations for ANKRD13C Gene
chr1:70,258,999-70,354,977
(GRCh38/hg38)
Size:
95,979 bases
Orientation:
Minus strand
chr1:70,724,685-70,820,417
(GRCh37/hg19)
Size:
95,733 bases
Orientation:
Minus strand

Genomic View for ANKRD13C Gene

Genes around ANKRD13C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD13C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD13C Gene

Proteins for ANKRD13C Gene

  • Protein details for ANKRD13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6S4-AN13C_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 13C
    Protein Accession:
    Q8N6S4
    Secondary Accessions:
    • B3KQ97
    • Q5VYH4
    • Q5VYH5
    • Q6PJE4
    • Q9H0N9

    Protein attributes for ANKRD13C Gene

    Size:
    541 amino acids
    Molecular mass:
    60818 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG51959.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD13C Gene

Post-translational modifications for ANKRD13C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD13C Gene

Domains & Families for ANKRD13C Gene

Gene Families for ANKRD13C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD13C Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for ANKRD13C Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 13C (AN13C_HUMAN)
genes like me logo Genes that share domains with ANKRD13C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD13C Gene

Function for ANKRD13C Gene

Molecular function for ANKRD13C Gene

UniProtKB/Swiss-Prot Function:
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.

Phenotypes From GWAS Catalog for ANKRD13C Gene

Gene Ontology (GO) - Molecular Function for ANKRD13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 20959461
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKRD13C: view
genes like me logo Genes that share phenotypes with ANKRD13C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD13C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD13C Gene

Localization for ANKRD13C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD13C Gene

Endoplasmic reticulum membrane. Note=Associated with the cytosolic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD13C gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 2
cytosol 2
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANKRD13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 colocalizes_with endoplasmic reticulum IDA 20959461
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 20959461
genes like me logo Genes that share ontologies with ANKRD13C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANKRD13C Gene

Pathways & Interactions for ANKRD13C Gene

PathCards logo

SuperPathways for ANKRD13C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006621 protein retention in ER lumen IMP 20959461
GO:0010869 regulation of receptor biosynthetic process IBA,IDA 20959461
GO:2000209 regulation of anoikis IDA 20959461
genes like me logo Genes that share ontologies with ANKRD13C: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD13C Gene

Drugs & Compounds for ANKRD13C Gene

No Compound Related Data Available

Transcripts for ANKRD13C Gene

mRNA/cDNA for ANKRD13C Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD13C

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13C Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:
SP2: - - - - - - -
SP3: -
SP4: - -

Relevant External Links for ANKRD13C Gene

GeneLoc Exon Structure for
ANKRD13C

Expression for ANKRD13C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKRD13C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD13C Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD13C Gene



Protein tissue co-expression partners for ANKRD13C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKRD13C

SOURCE GeneReport for Unigene cluster for ANKRD13C Gene:

Hs.744989

Evidence on tissue expression from TISSUES for ANKRD13C Gene

  • Intestine(4.3)
  • Kidney(4.2)
  • Eye(4.1)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with ANKRD13C: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD13C Gene

Orthologs for ANKRD13C Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD13C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKRD13C 30 31
  • 99.75 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD13C 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKRD13C 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKRD13C 30 31
  • 95.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ankrd13c 30
  • 88.97 (n)
Mouse
(Mus musculus)
Mammalia Ankrd13c 30 17 31
  • 88.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANKRD13C 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANKRD13C 30 31
  • 89.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKRD13C 31
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankrd13c 30
  • 79.09 (n)
Str.8944 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53218 30
Zebrafish
(Danio rerio)
Actinopterygii ankrd13c 30 31
  • 74.25 (n)
OneToOne
wufc57c01 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10323 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009954 30
  • 58.95 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5742 30 31
  • 55.43 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C01F1.6 30 31
  • 56.07 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6516 31
  • 46 (a)
OneToOne
Species where no ortholog for ANKRD13C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANKRD13C Gene

ENSEMBL:
Gene Tree for ANKRD13C (if available)
TreeFam:
Gene Tree for ANKRD13C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD13C: view image

Paralogs for ANKRD13C Gene

Paralogs for ANKRD13C Gene

(4) SIMAP similar genes for ANKRD13C Gene using alignment to 1 proteins:

  • AN13C_HUMAN
genes like me logo Genes that share paralogs with ANKRD13C: view

Variants for ANKRD13C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKRD13C Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17852616 - p.Thr413Ser

Additional dbSNP identifiers (rs#s) for ANKRD13C Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKRD13C Gene

Variant ID Type Subtype PubMed ID
esv1997734 CNV deletion 18987734
esv2555384 CNV deletion 19546169
esv2657438 CNV deletion 23128226
esv2749597 CNV deletion 23290073
esv3563704 CNV deletion 23714750
esv3586352 CNV loss 21293372
esv3586353 CNV loss 21293372
esv4055 CNV loss 18987735
nsv1012563 CNV gain 25217958
nsv1014292 CNV gain 25217958
nsv473705 CNV novel sequence insertion 20440878
nsv830137 CNV loss 17160897

Variation tolerance for ANKRD13C Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD13C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD13C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD13C Gene

Disorders for ANKRD13C Gene

No disorders were found for ANKRD13C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD13C Gene

Publications for ANKRD13C Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. ANKRD13C acts as a molecular chaperone for G protein-coupled receptors. (PMID: 20959461) Parent A … Parent JL (The Journal of biological chemistry 2010) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ANKRD13C Gene

Sources for ANKRD13C Gene