Aliases for ANKRD12 Gene
Aliases for ANKRD12 Gene
External Ids for ANKRD12 Gene
- HGNC: 29135
- Entrez Gene: 23253
- Ensembl: ENSG00000101745
- OMIM: 610616
- UniProtKB: Q6UB98
Previous GeneCards Identifiers for ANKRD12 Gene
- GC18P009172
- GC18P009126
Summaries for ANKRD12 Gene
-
This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for ANKRD12 Gene
ANKRD12 (Ankyrin Repeat Domain 12) is a Protein Coding gene. An important paralog of this gene is ANKRD11.
UniProtKB/Swiss-Prot for ANKRD12 Gene
-
May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
Additional gene information for ANKRD12 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD12 Gene
Genomics for ANKRD12 Gene
GeneHancer (GH) Regulatory Elements for ANKRD12 Gene
Promoters and enhancers for ANKRD12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ANKRD12 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ANKRD12 gene promoter:
-
- AML1a
- N-Myc
- Pbx1a
- XBP-1
- IRF-2
- HEN1
- Roaz
- COMP1
- c-Myb
- Oct-B1
Regulatory Element Products
Genomic Locations for ANKRD12 Gene
Genomic Locations for ANKRD12 Gene
- chr18:9,136,228-9,285,985
- (GRCh38/hg38)
- Size:
- 149,758 bases
- Orientation:
- Plus strand
- chr18:9,136,226-9,285,983
- (GRCh37/hg19)
- Size:
- 149,758 bases
- Orientation:
- Plus strand
Genomic View for ANKRD12 Gene
Genes around ANKRD12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.22 by Entrez Gene
- 18p11.22 by HGNC
- 18p11.22 by Ensembl
ANKRD12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD12 Gene
Proteins for ANKRD12 Gene
-
Protein details for ANKRD12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UB98-ANR12_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 12
- Protein Accession:
- Q6UB98
- O94951
- Q658K1
- Q6QMF7
- Q9H231
- Q9H784
Protein attributes for ANKRD12 Gene
- Size:
- 2062 amino acids
- Molecular mass:
- 235652 Da
- Quaternary structure:
-
- Interacts with the PAS region of the p160 coactivators.
- SequenceCaution:
-
- Sequence=BAB15014.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ANKRD12 Gene
Post-translational modifications for ANKRD12 Gene
Other Protein References for ANKRD12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011523941.1
- XP_016881151.1
- XP_016881156.1
- XP_005258152.1
- NP_001077094.1
- XP_011523940.1
- XP_016881159.1
- NP_056023.3
- XP_005258153.1
- XP_016881153.1
- XP_016881150.1
- XP_024306877.1
- XP_016881155.1
- XP_005258150.1
- XP_005258149.1
- XP_016881158.1
- XP_016881152.1
- XP_024306875.1
- XP_016881157.1
- XP_016881154.1
- NP_001190985.1
Antibody Products
- Novus Biologicals Antibodies for ANKRD12
-
Abcam antibodies for ANKRD12
- Invitrogen Antibodies for ANKRD12
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-
Boster Bio Antibodies for ANKRD12
Protein Products
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Assay Products
- Novus Biologicals ELISA Kits for ANKRD12
- antibodies-online: Search results for 1 available ANKRD12 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for ANKRD12 Gene
Domains & Families for ANKRD12 Gene
Gene Families for ANKRD12 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for ANKRD12 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD12 Gene
Function for ANKRD12 Gene
Molecular function for ANKRD12 Gene
- UniProtKB/Swiss-Prot Function:
- May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
Phenotypes From GWAS Catalog for ANKRD12 Gene
Phenotypes for ANKRD12 Gene
- GenomeRNAi human phenotypes for ANKRD12:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD12
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- Overview of 85 available ANKRD12 gene related products
- Applied Biological Materials CRISPR for ANKRD12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD12
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miRNA for ANKRD12 Gene
- miRTarBase miRNAs that target ANKRD12
-
- hsa-mir-342-5p (MIRT038230)
- hsa-mir-365a-3p (MIRT044032)
- hsa-mir-17-5p (MIRT148865)
- hsa-mir-19a-3p (MIRT148866)
- hsa-mir-19b-3p (MIRT148867)
- hsa-mir-20a-5p (MIRT148868)
- hsa-mir-93-5p (MIRT148869)
- hsa-mir-106b-5p (MIRT148874)
- hsa-mir-20b-5p (MIRT148878)
- hsa-mir-519d-3p (MIRT148882)
- hsa-mir-374a-5p (MIRT148913)
- hsa-mir-155-5p (MIRT376128)
- hsa-mir-1273e (MIRT376130)
- hsa-mir-3692-3p (MIRT449018)
- hsa-mir-140-3p (MIRT449019)
- hsa-mir-144-3p (MIRT449020)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKRD12
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Clone Products
- Sino Biological Human cDNA Clone for ANKRD12
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKRD12
- Applied Biological Materials Clones for ANKRD12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANKRD12
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD12 Gene
Localization for ANKRD12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Nucleoplasm (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ANKRD12 Gene
No Data Available
Interacting Proteins for ANKRD12 Gene
GPS-Prot Interaction Network for ANKRD12
No data available for Pathways by source and SIGNOR curated interactions for ANKRD12 Gene
Transcripts for ANKRD12 Gene
mRNA/cDNA for ANKRD12 Gene
- (21) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (244) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000585234 313 bps (uc060nfo.1)
- ENST00000262126 11288 bps (uc002knv.4)
- ENST00000577992 390 bps (uc060nfp.1)
- ENST00000540578 1338 bps (uc060nfq.1)
- ENST00000581635 631 bps (uc060nfr.1)
Unigene Clusters for ANKRD12 Gene
- Ankyrin repeat domain 12:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKRD12
- genomics-online: gRNA clones - Search results for 85 available ANKRD12 gene related products
- Overview of 85 available ANKRD12 gene related products
- Applied Biological Materials CRISPR for ANKRD12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD12
- GenScript: Design CRISPR guide RNA sequences for ANKRD12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKRD12
- Browse OriGene Inhibitory RNA Products For ANKRD12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD12
- genomics-online: shRNA clones - Search results for 85 available ANKRD12 gene related products
- Overview of 85 available ANKRD12 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANKRD12
- VectorBuilder custom plasmid, inducible vectors for ANKRD12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKRD12
- Applied Biological Materials Clones for ANKRD12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: |
Expression for ANKRD12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Eye (Sensory Organs)
This gene is overexpressed in Liver (28.8), Fetal Brain (9.4), and Platelet (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD12 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD12 Gene:
ANKRD12SOURCE GeneReport for Unigene cluster for ANKRD12 Gene:
Hs.464585Evidence on tissue expression from TISSUES for ANKRD12 Gene
- Nervous system(4.5)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for ANKRD12
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD12 Gene
Orthologs for ANKRD12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD12 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANKRD12 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ANKRD12 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ankrd12 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd12 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD12 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD12 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD12 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANKRD12 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ankrd12 34 |
|
OneToOne | |
| wufi16c02 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10984 34 |
|
OneToMany |
- Species where no ortholog for ANKRD12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ANKRD12 Gene
- ENSEMBL:
- Gene Tree for ANKRD12 (if available)
- TreeFam:
- Gene Tree for ANKRD12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANKRD12: view image
Paralogs for ANKRD12 Gene
(23) SIMAP similar genes for ANKRD12 Gene using alignment to 8 proteins:
- ANR12_HUMAN
- B5MEA4_HUMAN
- F5GYX2_HUMAN
- J3KS53_HUMAN
- J3KSU9_HUMAN
- J3QRX3_HUMAN
- Q6NSE1_HUMAN
- Q6PG48_HUMAN
Variants for ANKRD12 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs864622035 | uncertain-significance, Malignant tumor of prostate | 9,255,860(+) | G/T | coding_sequence_variant, missense_variant | |
| rs1000015089 | -- | 9,165,823(+) | C/G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000026401 | -- | 9,251,185(+) | C/T | intron_variant | |
| rs1000046153 | -- | 9,168,018(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000047148 | -- | 9,173,094(+) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
2.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.50;
85.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANKRD12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD12 Gene
Disorders for ANKRD12 Gene
Additional Disease Information for ANKRD12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ANKRD12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD12 Gene
Publications for ANKRD12 Gene
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PMID: 18377363) Li CW … Chen JD (The Biochemical journal 2008) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. (PMID: 15184363) Zhang A … Chen JD (The Journal of biological chemistry 2004) 3 4 58
Products for ANKRD12 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 21 available ANKRD12 Antibodies ranked by validation data
- Compare Top ANKRD12 Antibodies
- Quality Products:
- antibodies-online: Search results for 1 available ANKRD12 Elisa Kits ranked by validation data
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- Horizon Cell Lines for ANKRD12
- genomics-online: cdna clones - Search results for 85 available ANKRD12 gene related products
- Overview of 85 available ANKRD12 gene related products
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- Overview of 85 available ANKRD12 gene related products
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- Boster Bio Antibodies for ANKRD12
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Sources for ANKRD12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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