Aliases for ANKRD10 Gene

Aliases for ANKRD10 Gene

  • Ankyrin Repeat Domain 10 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 10 3 4

External Ids for ANKRD10 Gene

Previous GeneCards Identifiers for ANKRD10 Gene

  • GC13M105918
  • GC13M110367
  • GC13M109228
  • GC13M110328
  • GC13M111530
  • GC13M092129

Summaries for ANKRD10 Gene

GeneCards Summary for ANKRD10 Gene

ANKRD10 (Ankyrin Repeat Domain 10) is a Protein Coding gene. An important paralog of this gene is ANKRD6.

Additional gene information for ANKRD10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKRD10 Gene

Genomics for ANKRD10 Gene

GeneHancer (GH) Regulatory Elements for ANKRD10 Gene

Promoters and enhancers for ANKRD10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKRD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKRD10 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • JunB
  • JunD
  • Nkx2-5
  • Olf-1
  • RORalpha2

Genomic Locations for ANKRD10 Gene

Genomic Locations for ANKRD10 Gene
chr13:110,878,540-110,915,107
(GRCh38/hg38)
Size:
36,568 bases
Orientation:
Minus strand
chr13:111,530,887-111,567,416
(GRCh37/hg19)
Size:
36,530 bases
Orientation:
Minus strand

Genomic View for ANKRD10 Gene

Genes around ANKRD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD10 Gene

Proteins for ANKRD10 Gene

  • Protein details for ANKRD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR5-ANR10_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 10
    Protein Accession:
    Q9NXR5
    Secondary Accessions:
    • Q5VW12
    • Q9BV12

    Protein attributes for ANKRD10 Gene

    Size:
    420 amino acids
    Molecular mass:
    44768 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD10 Gene

Post-translational modifications for ANKRD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD10 Gene

Domains & Families for ANKRD10 Gene

Gene Families for ANKRD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANKRD10 Gene

Suggested Antigen Peptide Sequences for ANKRD10 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 10 (ANR10_HUMAN)
genes like me logo Genes that share domains with ANKRD10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKRD10 Gene

Function for ANKRD10 Gene

Phenotypes From GWAS Catalog for ANKRD10 Gene

Gene Ontology (GO) - Molecular Function for ANKRD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ANKRD10: view
genes like me logo Genes that share phenotypes with ANKRD10: view

Animal Models for ANKRD10 Gene

MGI Knock Outs for ANKRD10:
  • Ankrd10 Ankrd10<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ANKRD10 Gene

miRTarBase miRNAs that target ANKRD10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD10 Gene

Localization for ANKRD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD10 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD10 Gene

Pathways & Interactions for ANKRD10 Gene

PathCards logo

SuperPathways for ANKRD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD10 Gene

Drugs & Compounds for ANKRD10 Gene

No Compound Related Data Available

Transcripts for ANKRD10 Gene

mRNA/cDNA for ANKRD10 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKRD10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - -
SP9: - - - - - - -
SP10: - - - - -
SP11: -
SP12: - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - -
SP15:
SP16: -
SP17:

ExUns: 10e · 10f · 10g · 10h · 10i ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - - -
SP12:
SP13:
SP14:
SP15: - - - -
SP16:
SP17:

Relevant External Links for ANKRD10 Gene

GeneLoc Exon Structure for
ANKRD10
ECgene alternative splicing isoforms for
ANKRD10

Expression for ANKRD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD10 Gene

This gene is overexpressed in Bone (54.8) and CD8 Tcells (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD10 Gene



Protein tissue co-expression partners for ANKRD10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD10 Gene:

ANKRD10

SOURCE GeneReport for Unigene cluster for ANKRD10 Gene:

Hs.525163

Evidence on tissue expression from TISSUES for ANKRD10 Gene

  • Eye(4.4)
  • Intestine(4.4)
  • Nervous system(4.3)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with ANKRD10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD10 Gene

Orthologs for ANKRD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD10 33 32
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD10 33 32
  • 84.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd10 32
  • 84.12 (n)
mouse
(Mus musculus)
Mammalia Ankrd10 17 33 32
  • 83.29 (n)
cow
(Bos Taurus)
Mammalia ANKRD10 33 32
  • 78.65 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD10 33
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD10 33
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD10 33 32
  • 77.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD10 33
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd10 32
  • 66.67 (n)
Str.12012 32
zebrafish
(Danio rerio)
Actinopterygii ankrd10b 33 32
  • 63.4 (n)
OneToMany
ankrd10a 33
  • 49 (a)
OneToMany
zgc55353 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11213 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 50 (a)
OneToMany
Species where no ortholog for ANKRD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD10 Gene

ENSEMBL:
Gene Tree for ANKRD10 (if available)
TreeFam:
Gene Tree for ANKRD10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKRD10: view image

Paralogs for ANKRD10 Gene

Paralogs for ANKRD10 Gene

(14) SIMAP similar genes for ANKRD10 Gene using alignment to 4 proteins:

  • ANR10_HUMAN
  • L8EAX8_HUMAN
  • Q8IUW1_HUMAN
  • S4R3R2_HUMAN
genes like me logo Genes that share paralogs with ANKRD10: view

Variants for ANKRD10 Gene

Sequence variations from dbSNP and Humsavar for ANKRD10 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000007324 -- 110,903,531(-) A/G coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000160980 -- 110,892,018(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000165963 -- 110,883,041(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000197587 -- 110,894,889(-) C/A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000278966 -- 110,898,051(-) A/G 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD10 Gene

Variant ID Type Subtype PubMed ID
dgv1039n106 CNV deletion 24896259
dgv3402n54 CNV gain 21841781
dgv3403n54 CNV loss 21841781
dgv3404n54 CNV gain+loss 21841781
esv1002915 CNV deletion 20482838
esv1666847 CNV deletion 17803354
esv2018264 CNV deletion 18987734
esv2504656 CNV deletion 19546169
esv2583876 CNV deletion 19546169
esv2748046 CNV deletion 23290073
esv29570 CNV loss 19812545
esv3077 CNV loss 18987735
esv3551085 CNV deletion 23714750
esv6134 CNV loss 19470904
nsv1044340 CNV gain 25217958
nsv1070616 CNV deletion 25765185
nsv1120429 CNV deletion 24896259
nsv1134352 CNV deletion 24896259
nsv1149745 CNV deletion 26484159
nsv563148 CNV loss 21841781
nsv563149 CNV loss 21841781
nsv563150 CNV loss 21841781
nsv563158 CNV gain 21841781
nsv563159 CNV loss 21841781
nsv563160 CNV gain 21841781
nsv563161 CNV gain+loss 21841781
nsv958124 CNV deletion 24416366

Variation tolerance for ANKRD10 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKRD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD10 Gene

Disorders for ANKRD10 Gene

Additional Disease Information for ANKRD10

No disorders were found for ANKRD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD10 Gene

Publications for ANKRD10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 56
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 56

Products for ANKRD10 Gene

Sources for ANKRD10 Gene