ANKK1 Gene (Protein Coding)

Ankyrin Repeat And Kinase Domain Containing 1

GCID:: GC11P113387

GIFtS:: 38

Genes Participants

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined t... See more...

Aliases for ANKK1 Gene

Ankyrin Repeat And Kinase Domain Containing 1 ² ³ ⁵
Ankyrin Repeat And Protein Kinase Domain-Containing Protein 1 ³ ⁴
Protein Kinase PKK2 ³ ⁴
Sugen Kinase 288 ³ ⁴
EC 2.7.11.1 ⁴ ⁵²

X-Kinase ³ ⁴
SgK288 ³ ⁴
PKK2 ³ ⁴
EC 2.7.11 ⁵²
SGK288 ⁴

External Ids for ANKK1 Gene

HGNC: 21027
Entrez Gene: 255239
Ensembl: ENSG00000170209
OMIM: 608774
UniProtKB: Q8NFD2

Previous GeneCards Identifiers for ANKK1 Gene

GC11P113292
GC11P112796
GC11P112763
GC11P109186
GC11P113258

Search aliases for ANKK1 gene in PubMed and other databases

Summaries for ANKK1 Gene

Entrez Gene Summary for ANKK1 Gene

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]

GeneCards Summary for ANKK1 Gene

ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1) is a Protein Coding gene. Diseases associated with ANKK1 include Impulse Control Disorder and Alexithymia. Among its related pathways are Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RIPK4.

Gene Wiki entry for ANKK1 Gene

Additional gene information for ANKK1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKK1 Gene

Genomics for ANKK1 Gene

GeneHancer (GH) Regulatory Elements for ANKK1 Gene

Promoters and enhancers for ANKK1 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH11J113387	Promoter/Enhancer	1.3	EPDnew Ensembl ENCODE	500.7	+1.9	1926	1.1	CTCF HDAC2 EZH2 POLR2A YY1 NANOG PHF8 TCF12 RAD21 JUND	ANKK1 DRD2 ENSG00000256757
GH11J113383	Enhancer	0.8	Ensembl ENCODE	500.7	-1.1	-1137	3	ZNF217 JUND FOS CTBP1 OSR2 GATA3 STAT3 ZNF189 ESR1 GATA2	ANKK1 TTC12 lnc-DRD2-5
GH11J113312	Promoter/Enhancer	2	EPDnew Ensembl ENCODE CraniofacialAtlas	10.5	-71.6	-71615	3.6	EP300 SIN3A NRF1 POLR2G SP1 NCOR1 PHF8 ZFX ZBTB10 POLR2A	TTC12 ENSG00000255129 DRD2 ENSG00000256757 ANKK1 NCAM1-AS1
GH11J113278	Enhancer	0.4	dbSUPER	5.2	-106.6	-106642	1.7	SMC3 CTCF RAD21 POLR2A	TTC12 ANKK1 NCAM1-AS1 ENSG00000255129
GH11J113370	Enhancer	0.2	Ensembl	6.4	-15.6	-15637	0.4		ENSG00000270179 ANKK1 lnc-DRD2-5 TTC12

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKK1

Top Transcription factor binding sites by QIAGEN in the ANKK1 gene promoter:

AREB6
C/EBPbeta
FOXI1
FOXJ2
FOXJ2 (long isoform)
HFH-3
p53
POU2F1
POU2F1a
POU2F1b

Genomic Locations for ANKK1 Gene

chr11:113,386,038-113,400,418: (GRCh38/hg38)

Size:: 14,381 bases
Orientation:: Plus strand

chr11:113,258,513-113,271,140: (GRCh37/hg19)

Size:: 12,628 bases
Orientation:: Plus strand

Genomic View for ANKK1 Gene

Genes around ANKK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

11q23.2 by HGNC
11q23.2 by Entrez Gene
11q23.2 by Ensembl

ANKK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for ANKK1 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ANKK1 Gene

NC_000011.10

Proteins for ANKK1 Gene

Protein details for ANKK1 Gene (UniProtKB/Swiss-Prot)

Protein Symbol:

Q8NFD2-ANKK1_HUMAN

Recommended name:

Ankyrin repeat and protein kinase domain-containing protein 1

Protein Accession:

Q8NFD2

Protein attributes for ANKK1 Gene

Size:

765 amino acids

Molecular mass:

84632 Da

Quaternary structure:

No Data Available

neXtProt entry for ANKK1 Gene

Protein Expression for ANKK1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ANKK1 Gene

Q8NFD2:

KPGNILL
LHLDLKP

Post-translational modifications for ANKK1 Gene

Modification sites at PhosphoSitePlus
- Q8NFD2
Modification sites at neXtProt
- NX_Q8NFD2

Other Protein References for ANKK1 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

G Biosciences Immunotag™ ANKK1 Antibody

Creative Diagnostics Anti-ANKK1 (internal region) polyclonal antibody

OriGene Antibodies for ANKK1
- TA305881
- TA312554
Custom Antibody Services

Novus Biologicals Antibodies for ANKK1

Abcam antibodies for ANKK1
- ANKK1

Invitrogen Antibodies for ANKK1 (AFLGC-ANKK1)

antibodies-online: Show 4 available ANKK1 Antibodies ranked by validation data

Biorbyt antibodies for ANKK1
- orb155663
- orb225758

Browse Boster Bio Antibodies

Browse Santa Cruz Biotechnology (SCBT) Antibodies

Browse Sino Biological Antibodies

Protein Products

OriGene Purified Proteins for ANKK1
- NM_178510
- NM_178510
Search Origene for MassSpec and Protein Over-expression Lysates for ANKK1
Origene Custom Protein Services for ANKK1

Novus Biologicals proteins and lysates for ANKK1

Browse ProSpec Recombinant Proteins

antibodies-online: Search results for available ANKK1 related products ranked by validation data

Search for ANKK1 Proteins at ProSci

Abcam proteins for ANKK1
- ANKK1

Assay Products

antibodies-online: Search results for available ANKK1 related products ranked by validation data

Boster Bio ELISA Kits for ANKK1
- EKC1875

Browse Sino Biological Assays

Domains & Families for ANKK1 Gene

Gene Families for ANKK1 Gene

HGNC:

Ankyrin repeat domain containing

IUPHAR :

Receptor interacting protein kinase (RIPK) family

Human Protein Atlas (HPA):

Enzymes
Predicted intracellular proteins

Protein Domains for ANKK1 Gene

InterPro:

ProtoNet:

Q8NFD2

Suggested Antigen Peptide Sequences for ANKK1 Gene

GenScript: Design optimal peptide antigens:

X-kinase (ANKK1_HUMAN)
Ankyrin repeat and protein kinase domain-containing protein 1 (B0YIV3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NFD2

UniProtKB/Swiss-Prot:

ANKK1_HUMAN :

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Family:

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Function for ANKK1 Gene

Molecular function for ANKK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.

ANKK1_HUMAN,Q8NFD2

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

ANKK1_HUMAN,Q8NFD2

Enzyme Numbers (IUBMB) for ANKK1 Gene

EC 2.7.11.1 ⁵² ⁴
EC 2.7.11 ⁵²

Phenotypes From GWAS Catalog for ANKK1 Gene

Gene Ontology (GO) - Molecular Function for ANKK1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	IEA	--

Phenotypes for ANKK1 Gene

GenomeRNAi human phenotypes for ANKK1:

Animal Model Products

Taconic Biosciences Mouse Models for ANKK1
- Ankk1

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for ANKK1 - Select products 50% OFF >
* ANKK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* ANKK1 CRISPR applications: KO, Activation, Repression, and more - Browse All

OriGene CRISPR knockouts for ANKK1
- KN416746
- KN501256
- GA116815
- GA215228

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKK1

genomics-online: gRNA clones - Search for available ANKK1 gRNA products
Overview of 69 available ANKK1 gene related products
Recommended

Santa Cruz Biotechnology (SCBT) CRISPR for ANKK1

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for ANKK1

Browse OriGene miRNA Products For ANKK1

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKK1
Browse OriGene Inhibitory RNA Products For ANKK1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKK1

genomics-online: shRNA clones - Search for available ANKK1 shRNA products
Overview of 69 available ANKK1 gene related products
Recommended

Search Santa Cruz Biotechnology (SCBT) for ANKK1 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for ANKK1 - Select products 50% OFF >
* ANKK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* ANKK1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

OriGene clones in human,mouse,rat for ANKK1
OriGene ORF clones in human,mouse for ANKK1
- RC216746
- RG216746
- MR222918
- MG222918
- RC216746L1
- RC216746L1V
- RC216746L2
- RC216746L2V
- RC216746L3
- RC216746L3V
- RC216746L4
- RC216746L4V
- MR222918L3
- MR222918L3V
- MR222918L4
- MR222918L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for ANKK1

Search Addgene for plasmids for ANKK1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKK1

genomics-online: cdna clones - Search for available ANKK1 CDNA products
Overview of 69 available ANKK1 gene related products
Recommended
orf clones - Search for available ANKK1 ORF products
Overview of 69 available ANKK1 gene related products
Recommended

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for ANKK1

Browse GeneCopoeia Cell Lines

Horizon Cell Lines for ANKK1
- ANKK1 knockout cell line

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKK1 Gene

Localization for ANKK1 Gene

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	3
plasma membrane	1
extracellular	1
cytoskeleton	1
mitochondrion	1
endoplasmic reticulum	1

Gene Ontology (GO) - Cellular Components for ANKK1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA,IDA	27166167
GO:0005737	cytoplasm	IEA	--
GO:0042995	cell projection	IEA	--

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ANKK1 Gene

Pathways & Interactions for ANKK1 Gene

SuperPathways for ANKK1 Gene

	SuperPathway	Contained pathways
1	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics -

Pathways by source for ANKK1 Gene

1 PharmGKB pathway for ANKK1 Gene

Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics

Interacting Proteins for ANKK1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: ENSP00000306678 Q8NFD2-ANKK1_HUMAN for ANKK1 Gene via STRING IID

Symbol	External ID(s)	Details
DRD2	ENSP00000354859 ²¹ P14416 ¹²⁷	STRING: ENSP00000354859 IID: # pred=1
ENSG00000272822	ENSP00000443189 ²¹ ENSP00000438507 ²¹	STRING: ENSP00000443189 STRING: ENSP00000438507
NCAM1	ENSP00000480132 ²¹ P13591 ¹²⁷	STRING: ENSP00000480132 IID: # pred=1
PAK6	ENSP00000453858 ²¹ ENSP00000406873 ²¹	STRING: ENSP00000453858 STRING: ENSP00000406873
SGK3	ENSP00000429022 ²¹ ENSP00000379842 ²¹	STRING: ENSP00000429022 STRING: ENSP00000379842

GPS-Prot Interaction Network for ANKK1

;

Gene Ontology (GO) - Biological Process for ANKK1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IEA	--
GO:0010564	regulation of cell cycle process	IDA	27166167
GO:0016310	phosphorylation	IEA	--

No data available for SIGNOR curated interactions for ANKK1 Gene

Drugs & Compounds for ANKK1 Gene

(16) Drugs for ANKK1 Gene - From: DrugBank and PharmGKB

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
fostamatinib	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, inhibitor	Kinase Inhibitors	0
Aripiprazole	Approved, Investigational	MalaCards Medline Plus	Pharma	Antagonist, Full agonist, Agonist	Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist	395
Bupropion	Approved	MalaCards Medline Plus	Pharma			373
Clozapine	Approved	MalaCards Medline Plus	Pharma	Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist	Antipsychotic medication	134
Disulfiram	Approved	MalaCards Medline Plus	Pharma		Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities	46

Drug Products

Browse Tocris compounds for ANKK1

Browse compounds at ApexBio

Transcripts for ANKK1 Gene

mRNA/cDNA for ANKK1 Gene

1 REFSEQ mRNAs :

NM_178510.2

2 NCBI additional mRNA sequence :

2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000303941 2553 bps (ENST00000303941.4)
ENST00000542948 508 bps (ENST00000542948.1)

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for ANKK1 - Select products 50% OFF >
* ANKK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* ANKK1 CRISPR applications: KO, Activation, Repression, and more - Browse All

OriGene CRISPR knockouts for ANKK1
- KN416746
- KN501256
- GA116815
- GA215228

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANKK1

genomics-online: gRNA clones - Search for available ANKK1 gRNA products
Overview of 69 available ANKK1 gene related products
Recommended

Santa Cruz Biotechnology (SCBT) CRISPR for ANKK1

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for ANKK1

Browse OriGene miRNA Products For ANKK1

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for ANKK1
Browse OriGene Inhibitory RNA Products For ANKK1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKK1

genomics-online: shRNA clones - Search for available ANKK1 shRNA products
Overview of 69 available ANKK1 gene related products
Recommended

Search Santa Cruz Biotechnology (SCBT) for ANKK1 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for ANKK1 - Select products 50% OFF >
* ANKK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* ANKK1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

OriGene clones in human,mouse,rat for ANKK1
OriGene ORF clones in human,mouse for ANKK1
- RC216746
- RG216746
- MR222918
- MG222918
- RC216746L1
- RC216746L1V
- RC216746L2
- RC216746L2V
- RC216746L3
- RC216746L3V
- RC216746L4
- RC216746L4V
- MR222918L3
- MR222918L3V
- MR222918L4
- MR222918L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for ANKK1

Search Addgene for plasmids for ANKK1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANKK1

genomics-online: cdna clones - Search for available ANKK1 CDNA products
Overview of 69 available ANKK1 gene related products
Recommended
orf clones - Search for available ANKK1 ORF products
Overview of 69 available ANKK1 gene related products
Recommended

Alternative Splicing Database (ASD) splice patterns (SP) for ANKK1 Gene

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8
SP1:							-
SP2:

Relevant External Links for ANKK1 Gene

GeneLoc Exon Structure for: ANKK1

Expression for ANKK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKK1 Gene

mRNA expression in normal human tissues for ANKK1 Gene

mRNA expression by BioGPS for ANKK1 Gene

mRNA differential expression in normal tissues according to GTEx for ANKK1 Gene

This gene is overexpressed in Pituitary (x5.5) and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for ANKK1 Gene

This gene is overexpressed in Lung (56.5) and Heart (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ANKK1 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for ANKK1 Gene

Protein tissue co-expression partners for ANKK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKK1

SOURCE GeneReport for Unigene cluster for ANKK1 Gene:

Hs.448473

mRNA Expression by UniProt/SwissProt for ANKK1 Gene:

Q8NFD2-ANKK1_HUMAN

Tissue specificity: Highly expressed in brain and weakly expressed in placenta and spinal cord.

Evidence on tissue expression from TISSUES for ANKK1 Gene

Nervous system(2.3)

Primer Products

OriGene qPCR primer pairs for ANKK1
- HP218840
- MP200698

genomics-online: primer clones - Search for available ANKK1 Primer products
Overview of 69 available ANKK1 gene related products
Recommended

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for ANKK1

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKK1 Gene

Orthologs for ANKK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKK1 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	ANKK1 ³¹ ³⁰	98.65 (n)	OneToOne	11:111295647-111307229 466783 XM_003952042.1 XP_003952091.1
dog (Canis familiaris)	Mammalia	ANKK1 ³¹ ³⁰	85.86 (n)	OneToOne	5:19802078-19814562 489403 XM_546521.3 XP_546521.2
mouse (Mus musculus)	Mammalia	Ankk1 ¹⁷ ³¹ ³⁰	81.67 (n)		49415194 9:49415222-49427021 244859 NM_172922.3 NP_766510.1
rat (Rattus norvegicus)	Mammalia	Ankk1 ³⁰	80.79 (n)		367080 XM_006243023.1 XP_006243085.1
cow (Bos Taurus)	Mammalia	ANKK1 ³¹ ³⁰	73.08 (n)	OneToOne	15:24284192-24291480 785303 XM_003586937.1 XP_003586985.1
oppossum (Monodelphis domestica)	Mammalia	ANKK1 ³¹	73 (a)	OneToOne	4:239025661-239043525
chicken (Gallus gallus)	Aves	ANKK1 ³¹ ³⁰	67.7 (n)	OneToOne	24:5769724-5780497 100859406 XM_003642615.2 XP_003642663.2
lizard (Anolis carolinensis)	Reptilia	-- ³¹	20 (a)	ManyToMany	LGc:6849338-6872565
tropical clawed frog (Silurana tropicalis)	Amphibia	ankk1 ³⁰	57.9 (n)		100493231 XM_002937826.2 XP_002937872.1
zebrafish (Danio rerio)	Actinopterygii	ankk1 ³¹ ³⁰	53.03 (n)	OneToOne	15:20975671-20986596 100170831 NM_001130665.1 NP_001124137.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	AVO2 ³³
thale cress (Arabidopsis thaliana)	eudicotyledons	KEG ³⁰	41.44 (n)		831197 NM_121356.2 NP_196857.2
sea squirt (Ciona savignyi)	Ascidiacea	-- ³¹	31 (a)	ManyToMany	reftig_0:2356071-2361769
		-- ³¹	28 (a)	ManyToMany	reftig_41:1246818-1251179
		-- ³¹	27 (a)	ManyToMany	reftig_156:1178360-1179522

Species where no ortholog for ANKK1 was found in the sources mined by GeneCards:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
platypus (Ornithorhynchus anatinus)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)

Evolution for ANKK1 Gene

ENSEMBL:: Gene Tree for ANKK1 (if available)
TreeFam:: Gene Tree for ANKK1 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for ANKK1: view image

Paralogs for ANKK1 Gene

RIPK4 ⁵

(13) SIMAP similar genes for ANKK1 Gene using alignment to 3 proteins:

ANKK1_HUMAN
B0YIV3_HUMAN
H0YH32_HUMAN

Variants for ANKK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKK1 Gene

SNP ID	Clinical significance and condition	Chr 11 pos	Variation	Type
638474	Uncertain Significance: not specified	113,396,150(+)	G/A	MISSENSE_VARIANT
rs1800497	Drug Response: Dopamine receptor d2, reduced brain density of; not specified; antipsychotics response - Toxicity/ADR; bupropion response - Efficacy; clozapine response - Toxicity/ADR; ethanol response - Toxicity/ADR; olanzapine response - Toxicity/ADR; risperidone response - Toxicity/ADR. -	113,400,106(+)	G/Ap.Glu713Lys	MISSENSE_VARIANT
VAR_040362	A breast infiltrating ductal carcinoma sample		p.Lys347Thr
VAR_040372	A lung large cell carcinoma sample		p.Gln717Leu
VAR_040373	A lung squamous cell carcinoma sample		p.Arg736Leu

Additional dbSNP identifiers (rs#s) for ANKK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKK1 Gene

Variant ID	Type	Subtype	PubMed ID
nsv1040152	CNV	loss	25217958
nsv483080	CNV	loss	15286789
nsv515795	CNV	loss	19592680
nsv556444	CNV	gain	21841781
nsv556445	CNV	loss	21841781

Variation tolerance for ANKK1 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 9.49; 88.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKK1 Gene

Human Gene Mutation Database (HGMD): ANKK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for: ANKK1

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for ANKK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKK1 Gene

Disorders for ANKK1 Gene

(22) MalaCards diseases for ANKK1 Gene - From: DISEASES and GeneCards

Disorder	Aliases	PubMed IDs
impulse control disorder	disruptive, impulse control, and conduct disorders
alexithymia
antisocial personality disorder	asocial personality
heroin dependence
drug dependence

- elite association - COSMIC cancer census association via MalaCards

Search ANKK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANKK1

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for ANKK1 gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKK1 Gene

Publications for ANKK1 Gene

Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (PMID: 15146457) Neville MJ … Walton RT (Human mutation 2004) ² ³ ⁴ ²³ ⁵⁴
Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. (PMID: 19512960) Doehring A … Lötsch J (Psychiatric genetics 2009) ³ ²³ ⁴¹ ⁵⁴
Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (PMID: 18698520) McAllister TW … Tsongalis GJ (Brain injury 2008) ³ ²³ ⁴¹ ⁵⁴
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (PMID: 17850642) Dick DM … Goate A (Alcoholism, clinical and experimental research 2007) ³ ²³ ⁴¹ ⁵⁴
The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. (PMID: 14741327) Dubertret C … Gorwood P (Schizophrenia research 2004) ³ ⁴ ²³ ⁵⁴