Aliases for ANKFN1 Gene

Aliases for ANKFN1 Gene

  • Ankyrin Repeat And Fibronectin Type III Domain Containing 1 2 3 5
  • Ankyrin Repeat And Fibronectin Type-III Domain-Containing Protein 1 3 4
  • FLJ38335 2
  • ANKFN1 5

External Ids for ANKFN1 Gene

Previous GeneCards Identifiers for ANKFN1 Gene

  • GC17P051586
  • GC17P054230
  • GC17P049590
  • GC17P056110
  • GC17P055965

Summaries for ANKFN1 Gene

GeneCards Summary for ANKFN1 Gene

ANKFN1 (Ankyrin Repeat And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. Diseases associated with ANKFN1 include Cannabis Dependence and Proximal Symphalangism.

Additional gene information for ANKFN1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKFN1 Gene

Genomics for ANKFN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKFN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J056440 Enhancer 0.7 Ensembl ENCODE 12 +558.8 558789 1.8 CEBPB FOS JUN KLF4 PKNOX1 JUND EP300 RFX5 STAT1 TBP ANKFN1 ENSG00000279606 piR-49322-274 NOG
GH17J056171 Enhancer 0.7 Ensembl ENCODE 11.7 +292.0 292007 6.6 FOXA1 ESR1 GATA3 RAD21 CTCF STAT1 RFX5 ZNF24 SMARCA4 EGR2 ANKFN1 RF00994-409 HSALNG0117558 NOG
GH17J056129 Enhancer 0.5 VISTA UCNEbase 11.7 +247.9 247911 1.7 ANKFN1 HSALNG0117558 RF00994-409 NOG
GH17J056320 Enhancer 0.5 ENCODE dbSUPER 10.8 +438.4 438384 1.2 GABPA CTCF ANKFN1 piR-40110-282 HSALNG0117560 NOG
GH17J056126 Enhancer 0.5 Ensembl 11.2 +244.2 244200 1 CTCF FOXA1 RAD21 SMC3 ARID3A TRIM22 ANKFN1 HSALNG0117558 RF00994-409 NOG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKFN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKFN1

Top Transcription factor binding sites by QIAGEN in the ANKFN1 gene promoter:
  • AML1a
  • CUTL1
  • Egr-2
  • Egr-4
  • En-1
  • FOXO1
  • FOXO1a
  • FOXO4
  • RSRFC4

Genomic Locations for ANKFN1 Gene

Genomic Locations for ANKFN1 Gene
634,716 bases
Plus strand
400,702 bases
Plus strand

Genomic View for ANKFN1 Gene

Genes around ANKFN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKFN1 Gene

Proteins for ANKFN1 Gene

  • Protein details for ANKFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and fibronectin type-III domain-containing protein 1
    Protein Accession:

    Protein attributes for ANKFN1 Gene

    763 amino acids
    Molecular mass:
    87604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKFN1 Gene

Post-translational modifications for ANKFN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKFN1 Gene

Domains & Families for ANKFN1 Gene

Gene Families for ANKFN1 Gene

Protein Domains for ANKFN1 Gene

  • Ankyrin repeat signature

Suggested Antigen Peptide Sequences for ANKFN1 Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat and fibronectin type-III domain-containing protein 1 (ANKF1_HUMAN)
genes like me logo Genes that share domains with ANKFN1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKFN1 Gene

Function for ANKFN1 Gene

Phenotypes From GWAS Catalog for ANKFN1 Gene

Gene Ontology (GO) - Molecular Function for ANKFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKFN1: view
genes like me logo Genes that share phenotypes with ANKFN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKFN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKFN1 Gene

Localization for ANKFN1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKFN1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKFN1 Gene

Pathways & Interactions for ANKFN1 Gene

PathCards logo

SuperPathways for ANKFN1 Gene

No Data Available

Interacting Proteins for ANKFN1 Gene

Gene Ontology (GO) - Biological Process for ANKFN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKFN1 Gene

Drugs & Compounds for ANKFN1 Gene

(1) Drugs for ANKFN1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibitor, Inhibition 453
genes like me logo Genes that share compounds with ANKFN1: view

Transcripts for ANKFN1 Gene

mRNA/cDNA for ANKFN1 Gene

1 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKFN1

Alternative Splicing Database (ASD) splice patterns (SP) for ANKFN1 Gene

No ASD Table

Relevant External Links for ANKFN1 Gene

GeneLoc Exon Structure for

Expression for ANKFN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKFN1 Gene

mRNA differential expression in normal tissues according to GTEx for ANKFN1 Gene

This gene is overexpressed in Cervix - Endocervix (x5.0) and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for ANKFN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKFN1 Gene

Protein tissue co-expression partners for ANKFN1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKFN1

SOURCE GeneReport for Unigene cluster for ANKFN1 Gene:

genes like me logo Genes that share expression patterns with ANKFN1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKFN1 Gene

Orthologs for ANKFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKFN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKFN1 30 31
  • 99.48 (n)
(Canis familiaris)
Mammalia ANKFN1 30 31
  • 93.36 (n)
(Bos Taurus)
Mammalia ANKFN1 30 31
  • 93.08 (n)
(Mus musculus)
Mammalia Ankfn1 30 17 31
  • 89.44 (n)
(Monodelphis domestica)
Mammalia ANKFN1 31
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ANKFN1 31
  • 75 (a)
(Gallus gallus)
Aves ANKFN1 30 31
  • 80.03 (n)
(Anolis carolinensis)
Reptilia ANKFN1 31
  • 84 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490095 30
  • 75.97 (n)
(Danio rerio)
Actinopterygii LOC557615 30
  • 69.61 (n)
ANKFN1 (1 of 3) 31
  • 47 (a)
AL935268.1 31
  • 39 (a)
ANKFN1 (3 of 3) 31
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001726 30
  • 49.25 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6954 30 31
  • 47.38 (n)
(Caenorhabditis elegans)
Secernentea R07E4.1 31
  • 16 (a)
Species where no ortholog for ANKFN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANKFN1 Gene

Gene Tree for ANKFN1 (if available)
Gene Tree for ANKFN1 (if available)
Evolutionary constrained regions (ECRs) for ANKFN1: view image

Paralogs for ANKFN1 Gene

No data available for Paralogs for ANKFN1 Gene

Variants for ANKFN1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKFN1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs10852985 - p.Val445Ile

Additional dbSNP identifiers (rs#s) for ANKFN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKFN1 Gene

Variant ID Type Subtype PubMed ID
esv2406695 CNV deletion 18987734
esv2716060 CNV deletion 23290073
esv2716061 CNV deletion 23290073
esv2716063 CNV deletion 23290073
esv2716064 CNV deletion 23290073
esv2716065 CNV deletion 23290073
esv3377290 CNV insertion 20981092
esv3554576 CNV deletion 23714750
esv3582828 CNV loss 25503493
esv3640848 CNV loss 21293372
nsv1152564 CNV duplication 26484159
nsv2100 CNV deletion 18451855
nsv2102 CNV insertion 18451855
nsv2103 CNV insertion 18451855
nsv575691 CNV gain 21841781
nsv575714 CNV gain 21841781
nsv833493 CNV loss 17160897
nsv833494 CNV gain 17160897
nsv960507 CNV duplication 23825009

Variation tolerance for ANKFN1 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKFN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKFN1 Gene

Disorders for ANKFN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANKFN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cannabis dependence
  • marijuana abuse
proximal symphalangism
  • symphalangism, proximal, 1a
hallucinogen dependence
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANKFN1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANKFN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKFN1 Gene

Publications for ANKFN1 Gene

  1. A genome-wide association study of DSM-IV cannabis dependence. (PMID: 21668797) Agrawal A … Bierut LJ (Addiction biology 2011) 3 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G … Hirschhorn JN (Nature genetics 2008) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3

Products for ANKFN1 Gene

Sources for ANKFN1 Gene