Aliases for ANKDD1B Gene

Aliases for ANKDD1B Gene

  • Ankyrin Repeat And Death Domain Containing 1B 2 3 5
  • Ankyrin Repeat And Death Domain-Containing Protein 1B 3 4
  • Ankyrin Repeat And Death Domain-Containing Protein ENSP00000345065 3
  • ANKDD1B 5

External Ids for ANKDD1B Gene

Previous GeneCards Identifiers for ANKDD1B Gene

  • GC00U921788
  • GC05U900758
  • GC05P074935
  • GC05P070112
  • GC05P074907

Summaries for ANKDD1B Gene

GeneCards Summary for ANKDD1B Gene

ANKDD1B (Ankyrin Repeat And Death Domain Containing 1B) is a Protein Coding gene. An important paralog of this gene is ANKDD1A.

Additional gene information for ANKDD1B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANKDD1B Gene

Genomics for ANKDD1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANKDD1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANKDD1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANKDD1B

Top Transcription factor binding sites by QIAGEN in the ANKDD1B gene promoter:
  • AP-2rep
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • HNF-3beta
  • Ik-1
  • MZF-1
  • Nkx6-1
  • POU6F1 (c2)
  • Zic1

Genomic Locations for ANKDD1B Gene

Genomic Locations for ANKDD1B Gene
chr5:75,611,182-75,681,773
(GRCh38/hg38)
Size:
70,592 bases
Orientation:
Plus strand
chr5:74,907,284-74,967,671
(GRCh37/hg19)
Size:
60,388 bases
Orientation:
Plus strand

Genomic View for ANKDD1B Gene

Genes around ANKDD1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKDD1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKDD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKDD1B Gene

Proteins for ANKDD1B Gene

  • Protein details for ANKDD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHY2-AKD1B_HUMAN
    Recommended name:
    Ankyrin repeat and death domain-containing protein 1B
    Protein Accession:
    A6NHY2

    Protein attributes for ANKDD1B Gene

    Size:
    528 amino acids
    Molecular mass:
    59088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKDD1B Gene

Post-translational modifications for ANKDD1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKDD1B Gene

Domains & Families for ANKDD1B Gene

Gene Families for ANKDD1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ANKDD1B Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat and death domain-containing protein 1B (AKD1B_HUMAN)
genes like me logo Genes that share domains with ANKDD1B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANKDD1B Gene

Function for ANKDD1B Gene

Phenotypes From GWAS Catalog for ANKDD1B Gene

Gene Ontology (GO) - Molecular Function for ANKDD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANKDD1B: view

Phenotypes for ANKDD1B Gene

genes like me logo Genes that share phenotypes with ANKDD1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKDD1B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKDD1B Gene

Localization for ANKDD1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKDD1B gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKDD1B Gene

Pathways & Interactions for ANKDD1B Gene

PathCards logo

SuperPathways for ANKDD1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKDD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ANKDD1B: view

No data available for Pathways by source and SIGNOR curated interactions for ANKDD1B Gene

Drugs & Compounds for ANKDD1B Gene

No Compound Related Data Available

Transcripts for ANKDD1B Gene

mRNA/cDNA for ANKDD1B Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANKDD1B

Alternative Splicing Database (ASD) splice patterns (SP) for ANKDD1B Gene

No ASD Table

Relevant External Links for ANKDD1B Gene

GeneLoc Exon Structure for
ANKDD1B

Expression for ANKDD1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKDD1B Gene

mRNA differential expression in normal tissues according to GTEx for ANKDD1B Gene

This gene is overexpressed in Colon - Transverse (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKDD1B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANKDD1B

SOURCE GeneReport for Unigene cluster for ANKDD1B Gene:

Hs.370455
genes like me logo Genes that share expression patterns with ANKDD1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKDD1B Gene

Orthologs for ANKDD1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKDD1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANKDD1B 30 31
  • 99.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANKDD1B 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ankdd1b 30 17 31
  • 82.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANKDD1B 30 31
  • 79.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANKDD1B 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 8 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ANKDD1B 30 31
  • 68.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANKDD1B 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ankdd1b 30
  • 53.84 (n)
Zebrafish
(Danio rerio)
Actinopterygii ankdd1b 30 31
  • 54.43 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea mib-1 31
  • 14 (a)
ManyToMany
ikb-1 31
  • 11 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for ANKDD1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANKDD1B Gene

ENSEMBL:
Gene Tree for ANKDD1B (if available)
TreeFam:
Gene Tree for ANKDD1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKDD1B: view image

Paralogs for ANKDD1B Gene

Paralogs for ANKDD1B Gene

(12) SIMAP similar genes for ANKDD1B Gene using alignment to 1 proteins:

  • AKD1B_HUMAN
genes like me logo Genes that share paralogs with ANKDD1B: view

Variants for ANKDD1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANKDD1B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
715602 Likely Benign: not provided 75,625,897(+) G/A MISSENSE_VARIANT
718612 Benign: not provided 75,666,988(+) G/A NONSENSE
718613 Benign: not provided 75,669,341(+) C/G MISSENSE_VARIANT
719096 Benign: not provided 75,669,267(+) G/A MISSENSE_VARIANT
734732 Likely Benign: not provided 75,666,984(+) C/T NONSENSE

Additional dbSNP identifiers (rs#s) for ANKDD1B Gene

Structural Variations from Database of Genomic Variants (DGV) for ANKDD1B Gene

Variant ID Type Subtype PubMed ID
nsv1140549 CNV deletion 24896259
nsv1150512 CNV duplication 26484159
nsv478221 CNV novel sequence insertion 20440878
nsv518475 CNV gain 19592680
nsv522003 CNV loss 19592680
nsv830353 CNV gain 17160897

Variation tolerance for ANKDD1B Gene

Gene Damage Index Score: 14.92; 96.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKDD1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKDD1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKDD1B Gene

Disorders for ANKDD1B Gene

Additional Disease Information for ANKDD1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ANKDD1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKDD1B Gene

Publications for ANKDD1B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4

Products for ANKDD1B Gene

Sources for ANKDD1B Gene