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Aliases for ANKDD1B Gene

Aliases for ANKDD1B Gene

  • Ankyrin Repeat And Death Domain Containing 1B 2 3 5
  • Ankyrin Repeat And Death Domain-Containing Protein ENSP00000345065 3
  • Ankyrin Repeat And Death Domain-Containing Protein 1B 3

External Ids for ANKDD1B Gene

Previous GeneCards Identifiers for ANKDD1B Gene

  • GC00U921788
  • GC05U900758
  • GC05P074935
  • GC05P070112
  • GC05P074907

Summaries for ANKDD1B Gene

GeneCards Summary for ANKDD1B Gene

ANKDD1B (Ankyrin Repeat And Death Domain Containing 1B) is a Protein Coding gene. An important paralog of this gene is ANKDD1A.

Additional gene information for ANKDD1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKDD1B Gene

Genomics for ANKDD1B Gene

GeneHancer (GH) Regulatory Elements for ANKDD1B Gene

Promoters and enhancers for ANKDD1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J075610 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.6 +3.3 3309 8.5 ARID4B FEZF1 ZNF48 TCF12 KLF7 FOS ZNF202 NCOA1 GLIS1 MXD3 ANKDD1B POC5 RPS26P26 GCNT4 COL4A3BP RNU6-680P
GH05J075335 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.4 -272.3 -272278 7.8 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC HMGCR POC5 RAP1BL RPS26P26 ANKDD1B GCNT4 POLK GC05P075337 ENSG00000247372 ENSG00000271815
GH05J075668 Enhancer 1.2 Ensembl ENCODE 13.1 +58.1 58100 1.5 ATF1 SMAD1 ARNT ARID4B DMAP1 IRF4 YY1 TCF12 ZNF143 ATF7 POC5 ANKDD1B RNU6-680P
GH05J075715 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7 +105.7 105732 2.3 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B POC5 LOC441087 RPS26P26 NSA2 F2R ANKDD1B RNU6-680P
GH05J075677 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.7 +66.9 66863 1.6 NFIL3 HLF ZMYM3 RARA NR2F2 POC5 ANKDD1B POLK COL4A3BP ANKRD31 RNU6-680P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANKDD1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANKDD1B gene promoter:
  • Zic1
  • FOXO1a
  • FOXO1
  • HNF-3beta
  • AP-2rep
  • MZF-1
  • Ik-1
  • POU6F1 (c2)
  • Nkx6-1
  • C/EBPalpha

Genomic Locations for ANKDD1B Gene

Genomic Locations for ANKDD1B Gene
chr5:75,611,218-75,671,846
(GRCh38/hg38)
Size:
60,629 bases
Orientation:
Plus strand
chr5:74,907,284-74,967,671
(GRCh37/hg19)
Size:
60,388 bases
Orientation:
Plus strand

Genomic View for ANKDD1B Gene

Genes around ANKDD1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKDD1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKDD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKDD1B Gene

Proteins for ANKDD1B Gene

  • Protein details for ANKDD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHY2-AKD1B_HUMAN
    Recommended name:
    Ankyrin repeat and death domain-containing protein 1B
    Protein Accession:
    A6NHY2

    Protein attributes for ANKDD1B Gene

    Size:
    528 amino acids
    Molecular mass:
    59088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKDD1B Gene

Post-translational modifications for ANKDD1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKDD1B Gene

No data available for DME Specific Peptides for ANKDD1B Gene

Domains & Families for ANKDD1B Gene

Gene Families for ANKDD1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ANKDD1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKDD1B: view

No data available for UniProtKB/Swiss-Prot for ANKDD1B Gene

Function for ANKDD1B Gene

Phenotypes From GWAS Catalog for ANKDD1B Gene

Phenotypes for ANKDD1B Gene

genes like me logo Genes that share phenotypes with ANKDD1B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKDD1B Gene

Localization for ANKDD1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKDD1B gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKDD1B Gene

Pathways & Interactions for ANKDD1B Gene

SuperPathways for ANKDD1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKDD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ANKDD1B: view

No data available for Pathways by source and SIGNOR curated interactions for ANKDD1B Gene

Drugs & Compounds for ANKDD1B Gene

No Compound Related Data Available

Transcripts for ANKDD1B Gene

mRNA/cDNA for ANKDD1B Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKDD1B Gene

Ankyrin repeat and death domain containing 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKDD1B Gene

No ASD Table

Relevant External Links for ANKDD1B Gene

GeneLoc Exon Structure for
ANKDD1B
ECgene alternative splicing isoforms for
ANKDD1B

Expression for ANKDD1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKDD1B Gene

mRNA differential expression in normal tissues according to GTEx for ANKDD1B Gene

This gene is overexpressed in Colon - Transverse (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKDD1B Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKDD1B Gene:

ANKDD1B

SOURCE GeneReport for Unigene cluster for ANKDD1B Gene:

Hs.370455
genes like me logo Genes that share expression patterns with ANKDD1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKDD1B Gene

Orthologs for ANKDD1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKDD1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKDD1B 34 33
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANKDD1B 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankdd1b 16 34 33
  • 82.67 (n)
cow
(Bos Taurus)
Mammalia ANKDD1B 34 33
  • 79.89 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKDD1B 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 8 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANKDD1B 34 33
  • 68.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKDD1B 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankdd1b 33
  • 53.84 (n)
zebrafish
(Danio rerio)
Actinopterygii ankdd1b 34 33
  • 54.43 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mib-1 34
  • 14 (a)
ManyToMany
ikb-1 34
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for ANKDD1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKDD1B Gene

ENSEMBL:
Gene Tree for ANKDD1B (if available)
TreeFam:
Gene Tree for ANKDD1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANKDD1B: view image

Paralogs for ANKDD1B Gene

Paralogs for ANKDD1B Gene

(12) SIMAP similar genes for ANKDD1B Gene using alignment to 1 proteins:

  • AKD1B_HUMAN
genes like me logo Genes that share paralogs with ANKDD1B: view

Variants for ANKDD1B Gene

Sequence variations from dbSNP and Humsavar for ANKDD1B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000034158 -- 75,647,788(+) A/G intron_variant
rs1000046954 -- 75,623,794(+) T/C intron_variant
rs1000109648 -- 75,630,809(+) A/G intron_variant
rs1000110971 -- 75,652,048(+) C/T intron_variant
rs1000245784 -- 75,637,200(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANKDD1B Gene

Variant ID Type Subtype PubMed ID
nsv830353 CNV gain 17160897
nsv522003 CNV loss 19592680
nsv518475 CNV gain 19592680
nsv478221 CNV novel sequence insertion 20440878
nsv1150512 CNV duplication 26484159
nsv1140549 CNV deletion 24896259

Variation tolerance for ANKDD1B Gene

Gene Damage Index Score: 14.92; 96.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANKDD1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKDD1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKDD1B Gene

Disorders for ANKDD1B Gene

Additional Disease Information for ANKDD1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANKDD1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKDD1B Gene

Publications for ANKDD1B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for ANKDD1B Gene

Sources for ANKDD1B Gene

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