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ANGPTL8 (Angiopoietin Like 8) is a Protein Coding gene. Diseases associated with ANGPTL8 include Hypobetalipoproteinemia, Familial, 2 and Diabetes Mellitus. Among its related pathways are Lipoprotein metabolism and Metabolism.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
GO:0005515 | protein binding | IPI | 21988832 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA,TAS | -- |
SuperPathway | Contained pathways | ||
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1 | Lipoprotein metabolism | ||
2 | Metabolism |
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3 | Statin Pathway | ||
4 | Angiopoietin Like Protein 8 Regulatory Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0010954 | positive regulation of protein processing | IDA | 23150577 |
GO:0019216 | regulation of lipid metabolic process | IBA,IDA | 25417115 |
GO:0044255 | cellular lipid metabolic process | IEA,ISS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | C19H19orf80 30 |
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C19orf80 31 |
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OneToOne | |||
Dog (Canis familiaris) |
Mammalia | C20H19orf80 30 |
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C19orf80 31 |
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OneToOne | |||
Cow (Bos Taurus) |
Mammalia | C7H19orf80 30 |
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C19orf80 31 |
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OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Gm6484 30 31 |
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OneToOne | |
Angptl8 17 |
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Rat (Rattus norvegicus) |
Mammalia | LOC100361444 30 |
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Oppossum (Monodelphis domestica) |
Mammalia | C19orf80 31 |
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OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | C19orf80 31 |
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OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2278426 | - | p.Arg59Trp | |||
rs34056604 | - | p.Arg147Gln |
Disorder | Aliases | PubMed IDs |
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hypobetalipoproteinemia, familial, 2 |
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diabetes mellitus |
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hepatocellular carcinoma |
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prader-willi syndrome |
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diabetes mellitus, noninsulin-dependent |
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