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Aliases for ANGPTL7 Gene

Aliases for ANGPTL7 Gene

  • Angiopoietin Like 7 2 3 5
  • Cornea-Derived Transcript 6 Protein 3 4
  • Angiopoietin-Like Protein 7 3 4
  • CDT6 3 4
  • Angiopoietin-Like Factor (CDT6) 3
  • Angiopoietin-Related Protein 7 3
  • Angiopoietin-Like Factor 4
  • Angiopoietin-Like 7 2
  • DJ647M16.1 3
  • AngX 3

External Ids for ANGPTL7 Gene

Previous GeneCards Identifiers for ANGPTL7 Gene

  • GC01P011184
  • GC01P011249
  • GC01P010400

Summaries for ANGPTL7 Gene

GeneCards Summary for ANGPTL7 Gene

ANGPTL7 (Angiopoietin Like 7) is a Protein Coding gene. An important paralog of this gene is ANGPT4.

Gene Wiki entry for ANGPTL7 Gene

Additional gene information for ANGPTL7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL7 Gene

Genomics for ANGPTL7 Gene

GeneHancer (GH) Regulatory Elements for ANGPTL7 Gene

Promoters and enhancers for ANGPTL7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J011189 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +0.0 47 0.1 ANGPTL7 GC01P011226 MTOR GC01M011183
GH01J010790 Promoter/Enhancer 3.3 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.9 -395.5 -395476 6.4 PKNOX1 ARID4B NEUROD1 SIN3A ZNF2 YY1 ZNF213 ZNF548 KLF13 SP3 CASZ1 TARDBP ANGPTL7 ENSG00000226849 CLSTN1 UBIAD1 FBXO44 EXOSC10 GC01P010673
GH01J010753 Enhancer 0.8 FANTOM5 dbSUPER 25.1 -435.8 -435771 0.4 CTCF GLIS2 ZNF341 ZIC2 MAFK ANGPTL7 CASZ1 GC01P010673
GH01J011175 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 14 -11.8 -11785 3.6 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF121 ZNF766 ZNF213 KLF7 YY2 ENSG00000226849 CLCN6 LOC102724659 RNU5E-1 RNU5E-4P ANGPTL7 MTOR TARDBP FBXO44 EXOSC10
GH01J010789 Enhancer 0.8 FANTOM5 dbSUPER 16.7 -399.4 -399372 0.3 ZNF223 ZIC2 PRDM6 GLIS2 ZNF366 PATZ1 GLIS1 ZNF423 ANGPTL7 CASZ1 GC01P010673
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANGPTL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGPTL7 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • CHOP-10
  • C/EBPalpha
  • Olf-1
  • MyoD
  • FOXJ2
  • FOXJ2 (long isoform)
  • c-Myc
  • Max

Genomic Locations for ANGPTL7 Gene

Genomic Locations for ANGPTL7 Gene
6,693 bases
Plus strand
6,641 bases
Plus strand

Genomic View for ANGPTL7 Gene

Genes around ANGPTL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL7 Gene

Proteins for ANGPTL7 Gene

  • Protein details for ANGPTL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Angiopoietin-related protein 7
    Protein Accession:
    Secondary Accessions:
    • B2R9B2
    • F1T0A6
    • Q4ZGK4

    Protein attributes for ANGPTL7 Gene

    346 amino acids
    Molecular mass:
    40018 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL7 Gene

Post-translational modifications for ANGPTL7 Gene

  • Glycosylation at posLast=267267, Asn253, and Asn58
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANGPTL7 Gene

Domains & Families for ANGPTL7 Gene

Gene Families for ANGPTL7 Gene

Protein Domains for ANGPTL7 Gene

Suggested Antigen Peptide Sequences for ANGPTL7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANGPTL7: view

No data available for UniProtKB/Swiss-Prot for ANGPTL7 Gene

Function for ANGPTL7 Gene

Phenotypes From GWAS Catalog for ANGPTL7 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25910212
genes like me logo Genes that share ontologies with ANGPTL7: view
genes like me logo Genes that share phenotypes with ANGPTL7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL7

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGPTL7 Gene

Localization for ANGPTL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL7 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ANGPTL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ANGPTL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPTL7 Gene

Pathways & Interactions for ANGPTL7 Gene

SuperPathways for ANGPTL7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGPTL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress TAS 8026862
genes like me logo Genes that share ontologies with ANGPTL7: view

No data available for Pathways by source and SIGNOR curated interactions for ANGPTL7 Gene

Drugs & Compounds for ANGPTL7 Gene

No Compound Related Data Available

Transcripts for ANGPTL7 Gene

mRNA/cDNA for ANGPTL7 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANGPTL7 Gene

Angiopoietin-like 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP2: -

Relevant External Links for ANGPTL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPTL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPTL7 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL7 Gene

This gene is overexpressed in Nerve - Tibial (x38.3).

Protein differential expression in normal tissues from HIPED for ANGPTL7 Gene

This gene is overexpressed in Vitreous humor (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL7 Gene

Protein tissue co-expression partners for ANGPTL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL7 Gene:


SOURCE GeneReport for Unigene cluster for ANGPTL7 Gene:


mRNA Expression by UniProt/SwissProt for ANGPTL7 Gene:

Tissue specificity: Highly and specifically expressed in the cornea where is confined to the stromal layer.

Evidence on tissue expression from TISSUES for ANGPTL7 Gene

  • Eye(4.8)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ANGPTL7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL7 Gene

Orthologs for ANGPTL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGPTL7 34 33
  • 99.42 (n)
(Bos Taurus)
Mammalia ANGPTL7 34 33
  • 90.7 (n)
(Canis familiaris)
Mammalia ANGPTL7 34 33
  • 90.31 (n)
(Mus musculus)
Mammalia Angptl7 16 34 33
  • 88.39 (n)
(Rattus norvegicus)
Mammalia LOC102552055 33
  • 87.92 (n)
(Ornithorhynchus anatinus)
Mammalia ANGPTL7 34
  • 80 (a)
(Monodelphis domestica)
Mammalia ANGPTL7 34
  • 78 (a)
(Gallus gallus)
Aves ANGPTL7 34 33
  • 75.24 (n)
(Anolis carolinensis)
Reptilia ANGPTL7 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl7 33
  • 71.74 (n)
(Danio rerio)
Actinopterygii angptl7 34 33
  • 68.84 (n)
Species where no ortholog for ANGPTL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL7 Gene

Gene Tree for ANGPTL7 (if available)
Gene Tree for ANGPTL7 (if available)
Evolutionary constrained regions (ECRs) for ANGPTL7: view image

Paralogs for ANGPTL7 Gene

(25) SIMAP similar genes for ANGPTL7 Gene using alignment to 2 proteins:

  • F1T0A6_HUMAN
genes like me logo Genes that share paralogs with ANGPTL7: view

Variants for ANGPTL7 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000483893 -- 11,187,785(+) G/A upstream_transcript_variant
rs1000537759 -- 11,187,559(+) A/C upstream_transcript_variant
rs1000689007 -- 11,193,375(+) T/C intron_variant
rs1000759509 -- 11,191,992(+) A/T intron_variant
rs1001588851 -- 11,191,099(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL7 Gene

Variant ID Type Subtype PubMed ID
nsv545407 CNV gain 21841781

Variation tolerance for ANGPTL7 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL7 Gene

Disorders for ANGPTL7 Gene

Additional Disease Information for ANGPTL7

No disorders were found for ANGPTL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL7 Gene

Publications for ANGPTL7 Gene

  1. Molecular cloning of a new angiopoietinlike factor from the human cornea. (PMID: 9727400) Peek R … Kijlstra A (Investigative ophthalmology & visual science 1998) 2 3 4 22 58
  2. The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea. (PMID: 11682471) Peek R … Westphal JR (The Journal of biological chemistry 2002) 2 3 22 58
  3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 4 58
  4. Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. (PMID: 18421092) Kuchtey J … Kuchtey RW (Investigative ophthalmology & visual science 2008) 3 22 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for ANGPTL7 Gene

Sources for ANGPTL7 Gene

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