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ANGPTL6 (Angiopoietin Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include Familial Cerebral Saccular Aneurysm and Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. An important paralog of this gene is ANGPTL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0030141 | secretory granule | IEA | -- |
GO:0062023 | collagen-containing extracellular matrix | HDA,IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||
SP2: | |||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ANGPTL6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ANGPTL6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ANGPTL6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Angptl6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Angptl6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ANGPTL6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | ANGPTL6 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12563 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.13338 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | angptl6 31 |
|
OneToOne | |
Dr.24020 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
736966 | Likely Benign: not provided | 10,096,549(-) | C/T | NONSENSE | |
738121 | Likely Benign: not provided | 10,096,138(-) | G/A | SYNONYMOUS_VARIANT | |
757118 | Likely Benign: not provided | 10,096,195(-) | G/C | SYNONYMOUS_VARIANT | |
778156 | Benign: not provided | 10,093,467(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6266n54 | CNV | loss | 21841781 |
esv2675304 | CNV | deletion | 23128226 |
esv29826 | CNV | loss | 19812545 |
esv3556016 | CNV | deletion | 23714750 |
esv3643648 | CNV | loss | 21293372 |
nsv2414 | CNV | insertion | 18451855 |
nsv458355 | CNV | loss | 19166990 |
nsv578606 | CNV | loss | 21841781 |
nsv578610 | CNV | loss | 21841781 |
nsv833743 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial cerebral saccular aneurysm |
|
|
myasthenic syndrome, congenital, 6, presynaptic |
|
|
gnathomiasis |
|
|
enterobiasis |
|
|
neuromuscular junction disease |
|
|