Aliases for ANGPTL6 Gene

Aliases for ANGPTL6 Gene

  • Angiopoietin Like 6 2 3 5
  • Angiopoietin-Related Protein 5 2 3 4
  • ARP5 2 3 4
  • AGF 2 3 4
  • Angiopoietin-Related Growth Factor 3 4
  • Angiopoietin-Related Protein 6 3 4
  • Angiopoietin-Like Protein 6 3 4
  • Angiopoietin-Like 6 2
  • ANGPTL6 5

External Ids for ANGPTL6 Gene

Previous GeneCards Identifiers for ANGPTL6 Gene

  • GC19M010048
  • GC19M010064
  • GC19M010203
  • GC19M009783

Summaries for ANGPTL6 Gene

GeneCards Summary for ANGPTL6 Gene

ANGPTL6 (Angiopoietin Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include Familial Cerebral Saccular Aneurysm and Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. An important paralog of this gene is ANGPTL2.

UniProtKB/Swiss-Prot Summary for ANGPTL6 Gene

  • May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

Additional gene information for ANGPTL6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGPTL6 Gene

Genomics for ANGPTL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANGPTL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 602.7 +2.0 2020 8.3 SP1 CREB1 GATAD2A HNRNPL ZNF629 TFE3 ZNF512 RFX1 SIX5 NFKBIZ PPAN ANGPTL6 PPAN-P2RY11 ILF3 ZNF699 LOC100419831 ZNF317 KRI1 FBXL12 ZNF559
GH19J010192 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.7 -87.9 -87902 3.4 BRCA1 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 SIX5 IKZF1 DNMT1 PPAN ILF3 ENSG00000270614 ENSG00000267510 ZNF559 ANGPTL6 PPAN-P2RY11 ZNF699 KRI1
GH19J010198 Promoter/Enhancer 1 Ensembl ENCODE 17.1 -93.7 -93710 3.4 NR2C1 EGR1 RUNX3 GATAD2A ZNF316 NR2C2 CEBPG NR2F1 CEBPB PRDM10 SHFL ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 PPAN PPAN-P2RY11 SNORD105
GH19J010141 Promoter/Enhancer 0.7 Ensembl ENCODE 17.1 -36.7 -36701 2.2 POLR2A CTCF lnc-EIF3G-2 SHFL ANGPTL6 EIF3G SNORD105B P2RY11 SNORD105 PPAN PPAN-P2RY11 RDH8
GH19J010191 Enhancer 0.7 ENCODE 11.7 -85.1 -85067 0.9 SP1 GABPA CEBPA CEBPB FOXA2 ATF3 FOS YY1 TEAD1 JUND ANGPTL6 PPAN PPAN-P2RY11 SHFL lnc-S1PR2-3 FJ601684-215 DNMT1 EIF3G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGPTL6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANGPTL6

Top Transcription factor binding sites by QIAGEN in the ANGPTL6 gene promoter:
  • AREB6
  • c-Myc
  • FOXO1
  • FOXO1a
  • GATA-2
  • LyF-1
  • Max
  • Pax-6
  • Zic3

Genomic Locations for ANGPTL6 Gene

Genomic Locations for ANGPTL6 Gene
chr19:10,092,337-10,106,407
(GRCh38/hg38)
Size:
14,071 bases
Orientation:
Minus strand
chr19:10,203,013-10,213,472
(GRCh37/hg19)
Size:
10,460 bases
Orientation:
Minus strand

Genomic View for ANGPTL6 Gene

Genes around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL6 Gene

Proteins for ANGPTL6 Gene

  • Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI99-ANGL6_HUMAN
    Recommended name:
    Angiopoietin-related protein 6
    Protein Accession:
    Q8NI99
    Secondary Accessions:
    • A5PKV7
    • Q9BZZ0

    Protein attributes for ANGPTL6 Gene

    Size:
    470 amino acids
    Molecular mass:
    51694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANGPTL6 Gene

neXtProt entry for ANGPTL6 Gene

Post-translational modifications for ANGPTL6 Gene

  • Glycosylation at Asn58 and Asn145
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ANGL6_HUMAN (1919)

No data available for DME Specific Peptides for ANGPTL6 Gene

Domains & Families for ANGPTL6 Gene

Gene Families for ANGPTL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for ANGPTL6 Gene

InterPro:
Blocks:
  • Fibrinogen, beta/gamma chain, C-terminal globular
ProtoNet:

Suggested Antigen Peptide Sequences for ANGPTL6 Gene

GenScript: Design optimal peptide antigens:
  • Angiopoietin-related protein 5 (ANGL6_HUMAN)
genes like me logo Genes that share domains with ANGPTL6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANGPTL6 Gene

Function for ANGPTL6 Gene

Molecular function for ANGPTL6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

Phenotypes From GWAS Catalog for ANGPTL6 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA 21873635
genes like me logo Genes that share ontologies with ANGPTL6: view
genes like me logo Genes that share phenotypes with ANGPTL6: view

Human Phenotype Ontology for ANGPTL6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ANGPTL6 Gene

MGI Knock Outs for ANGPTL6:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL6

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL6 Gene

Localization for ANGPTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL6 gene
Compartment Confidence
extracellular 5
mitochondrion 3
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0030141 secretory granule IEA --
GO:0062023 collagen-containing extracellular matrix HDA,IBA 21873635
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPTL6 Gene

Pathways & Interactions for ANGPTL6 Gene

PathCards logo

SuperPathways for ANGPTL6 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.62
.62
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with ANGPTL6: view

Pathways by source for ANGPTL6 Gene

54 Qiagen pathways for ANGPTL6 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for SIGNOR curated interactions for ANGPTL6 Gene

Drugs & Compounds for ANGPTL6 Gene

(2) Additional Compounds for ANGPTL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPTL6: view

Transcripts for ANGPTL6 Gene

mRNA/cDNA for ANGPTL6 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL6

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for ANGPTL6 Gene

GeneLoc Exon Structure for
ANGPTL6

Expression for ANGPTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGPTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene

This gene is overexpressed in Liver (x15.6).

Protein differential expression in normal tissues from HIPED for ANGPTL6 Gene

This gene is overexpressed in Plasma (48.6) and Liver (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL6 Gene



Protein tissue co-expression partners for ANGPTL6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANGPTL6

SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene:

Hs.712850

Evidence on tissue expression from TISSUES for ANGPTL6 Gene

  • Liver(4.5)
  • Bone marrow(4.3)
  • Skin(2.5)
  • Heart(2.2)
  • Kidney(2.2)
  • Muscle(2.1)
  • Blood(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ANGPTL6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL6 Gene

Orthologs for ANGPTL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANGPTL6 30 31
  • 98.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANGPTL6 30 31
  • 87.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANGPTL6 30 31
  • 87.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Angptl6 30 17 31
  • 76.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Angptl6 30
  • 76.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia ANGPTL6 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 36 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ANGPTL6 31
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12563 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.13338 30
Zebrafish
(Danio rerio)
Actinopterygii angptl6 31
  • 43 (a)
OneToOne
Dr.24020 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for ANGPTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANGPTL6 Gene

ENSEMBL:
Gene Tree for ANGPTL6 (if available)
TreeFam:
Gene Tree for ANGPTL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGPTL6: view image

Paralogs for ANGPTL6 Gene

(10) SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:

  • ANGL6_HUMAN
  • K7EKF6_HUMAN
genes like me logo Genes that share paralogs with ANGPTL6: view

Variants for ANGPTL6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANGPTL6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
736966 Likely Benign: not provided 10,096,549(-) C/T NONSENSE
738121 Likely Benign: not provided 10,096,138(-) G/A SYNONYMOUS_VARIANT
757118 Likely Benign: not provided 10,096,195(-) G/C SYNONYMOUS_VARIANT
778156 Benign: not provided 10,093,467(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ANGPTL6 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL6 Gene

Variant ID Type Subtype PubMed ID
dgv6266n54 CNV loss 21841781
esv2675304 CNV deletion 23128226
esv29826 CNV loss 19812545
esv3556016 CNV deletion 23714750
esv3643648 CNV loss 21293372
nsv2414 CNV insertion 18451855
nsv458355 CNV loss 19166990
nsv578606 CNV loss 21841781
nsv578610 CNV loss 21841781
nsv833743 CNV loss 17160897

Variation tolerance for ANGPTL6 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL6 Gene

Human Gene Mutation Database (HGMD)
ANGPTL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Disorders for ANGPTL6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ANGPTL6 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
familial cerebral saccular aneurysm
  • familial berry aneurysm
myasthenic syndrome, congenital, 6, presynaptic
  • cms6
gnathomiasis
  • gnathostomiasis
enterobiasis
  • enterobius vermicularis infection
neuromuscular junction disease
  • neuromuscular junction diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANGPTL6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL6 Gene

Publications for ANGPTL6 Gene

  1. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PMID: 12871997) Oike Y … Suda T (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4
  2. Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. (PMID: 19447061) Legry V … Meirhaeghe A (Diabetes & metabolism 2009) 3 41
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 41
  4. Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PMID: 16806062) Zhang Y … Gong Y (Biochemical and biophysical research communications 2006) 3 23
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4

Products for ANGPTL6 Gene

Sources for ANGPTL6 Gene