Aliases for ANGPTL6 Gene

Aliases for ANGPTL6 Gene

  • Angiopoietin Like 6 2 3 5
  • Angiopoietin-Related Protein 5 2 3 4
  • Angiopoietin-Related Growth Factor 3 4
  • Angiopoietin-Related Protein 6 3 4
  • Angiopoietin-Like Protein 6 3 4
  • ARP5 3 4
  • AGF 3 4
  • Angiopoietin-Like 6 2

External Ids for ANGPTL6 Gene

Previous GeneCards Identifiers for ANGPTL6 Gene

  • GC19M010048
  • GC19M010064
  • GC19M010203
  • GC19M009783

Summaries for ANGPTL6 Gene

GeneCards Summary for ANGPTL6 Gene

ANGPTL6 (Angiopoietin Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include Familial Cerebral Saccular Aneurysm and Enterobiasis. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. An important paralog of this gene is ANGPTL2.

UniProtKB/Swiss-Prot Summary for ANGPTL6 Gene

  • May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

Additional gene information for ANGPTL6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGPTL6 Gene

Genomics for ANGPTL6 Gene

GeneHancer (GH) Regulatory Elements for ANGPTL6 Gene

Promoters and enhancers for ANGPTL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 752.7 +1.8 1822 8.3 GTF3C2 ZNF24 SP1 ZBTB40 SIX5 ZBTB6 MLX RBPJ POLR2A ATF1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 EIF3G ZNF266 FBXL12 KRI1 ILF3 ZNF317
GH19J010192 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.7 -88.1 -88100 3.4 E2F8 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 FOXA1 POLR2A TCF7L2 DNMT1 ILF3 PPAN ZNF699 ZNF266 ENSG00000270614 KRI1 ENSG00000267510 ZNF559 ZNF561
GH19J010198 Promoter/Enhancer 1 Ensembl ENCODE 17.1 -93.9 -93908 3.4 ZBTB40 ZNF362 HLF ZNF384 IKZF1 ZNF316 NR2C1 EGR1 RUNX3 GATAD2A SHFL ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 PPAN PPAN-P2RY11 SNORD105
GH19J010141 Promoter/Enhancer 0.6 Ensembl ENCODE 17 -36.9 -36899 2.2 POLR2A lnc-EIF3G-2 SHFL ANGPTL6 EIF3G P2RY11 SNORD105B PPAN PPAN-P2RY11 SNORD105 RDH8
GH19J010191 Enhancer 0.7 ENCODE 11.7 -85.3 -85265 0.9 RAD21 ZNF121 ZNF652 SP1 CEBPG ZNF384 ZNF644 CEBPA RXRA ZBTB8A ANGPTL6 PPAN PPAN-P2RY11 SHFL lnc-S1PR2-3 FJ601684-215 DNMT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGPTL6 gene promoter:
  • AREB6
  • c-Myc
  • FOXO1
  • FOXO1a
  • GATA-2
  • LyF-1
  • Max
  • Pax-6
  • Zic3

Genomic Locations for ANGPTL6 Gene

Genomic Locations for ANGPTL6 Gene
chr19:10,092,337-10,106,209
(GRCh38/hg38)
Size:
13,873 bases
Orientation:
Minus strand
chr19:10,203,013-10,213,472
(GRCh37/hg19)
Size:
10,460 bases
Orientation:
Minus strand

Genomic View for ANGPTL6 Gene

Genes around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL6 Gene

Proteins for ANGPTL6 Gene

  • Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI99-ANGL6_HUMAN
    Recommended name:
    Angiopoietin-related protein 6
    Protein Accession:
    Q8NI99
    Secondary Accessions:
    • A5PKV7
    • Q9BZZ0

    Protein attributes for ANGPTL6 Gene

    Size:
    470 amino acids
    Molecular mass:
    51694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL6 Gene

Post-translational modifications for ANGPTL6 Gene

  • Glycosylation at Asn58 and Asn145
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ANGL6_HUMAN (1919)

No data available for DME Specific Peptides for ANGPTL6 Gene

Domains & Families for ANGPTL6 Gene

Gene Families for ANGPTL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ANGPTL6 Gene

GenScript: Design optimal peptide antigens:
  • Angiopoietin-related protein 5 (ANGL6_HUMAN)
genes like me logo Genes that share domains with ANGPTL6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANGPTL6 Gene

Function for ANGPTL6 Gene

Molecular function for ANGPTL6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

Phenotypes From GWAS Catalog for ANGPTL6 Gene

genes like me logo Genes that share phenotypes with ANGPTL6: view

Human Phenotype Ontology for ANGPTL6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ANGPTL6 Gene

MGI Knock Outs for ANGPTL6:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL6 Gene

Localization for ANGPTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL6 gene
Compartment Confidence
extracellular 3
mitochondrion 2
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IEA --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPTL6 Gene

Pathways & Interactions for ANGPTL6 Gene

PathCards logo

SuperPathways for ANGPTL6 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with ANGPTL6: view

Pathways by source for ANGPTL6 Gene

54 Qiagen pathways for ANGPTL6 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for SIGNOR curated interactions for ANGPTL6 Gene

Drugs & Compounds for ANGPTL6 Gene

(2) Additional Compounds for ANGPTL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPTL6: view

Transcripts for ANGPTL6 Gene

mRNA/cDNA for ANGPTL6 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for ANGPTL6 Gene

GeneLoc Exon Structure for
ANGPTL6
ECgene alternative splicing isoforms for
ANGPTL6

Expression for ANGPTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPTL6 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene

This gene is overexpressed in Liver (x15.6).

Protein differential expression in normal tissues from HIPED for ANGPTL6 Gene

This gene is overexpressed in Plasma (48.6) and Liver (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL6 Gene



Protein tissue co-expression partners for ANGPTL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL6 Gene:

ANGPTL6

SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene:

Hs.712850

Evidence on tissue expression from TISSUES for ANGPTL6 Gene

  • Liver(4.4)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ANGPTL6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL6 Gene

Orthologs for ANGPTL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL6 33 32
  • 98.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANGPTL6 33 32
  • 87.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL6 33 32
  • 87.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Angptl6 17 33 32
  • 76.85 (n)
rat
(Rattus norvegicus)
Mammalia Angptl6 32
  • 76.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ANGPTL6 33
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANGPTL6 33
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12563 32
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13338 32
zebrafish
(Danio rerio)
Actinopterygii angptl6 33
  • 43 (a)
OneToOne
Dr.24020 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 34 (a)
OneToMany
Species where no ortholog for ANGPTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL6 Gene

ENSEMBL:
Gene Tree for ANGPTL6 (if available)
TreeFam:
Gene Tree for ANGPTL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGPTL6: view image

Paralogs for ANGPTL6 Gene

(10) SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:

  • ANGL6_HUMAN
  • K7EKF6_HUMAN
genes like me logo Genes that share paralogs with ANGPTL6: view

Variants for ANGPTL6 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1551570 association, Cataplexy and narcolepsy 10,107,354(-) C/T upstream_transcript_variant
rs1000134422 -- 10,094,621(-) G/A intron_variant
rs1000143334 -- 10,100,444(-) C/T intron_variant
rs1000270421 -- 10,094,442(-) G/A intron_variant
rs1000522015 -- 10,095,972(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL6 Gene

Variant ID Type Subtype PubMed ID
dgv6266n54 CNV loss 21841781
esv2675304 CNV deletion 23128226
esv29826 CNV loss 19812545
esv3556016 CNV deletion 23714750
esv3643648 CNV loss 21293372
nsv2414 CNV insertion 18451855
nsv458355 CNV loss 19166990
nsv578606 CNV loss 21841781
nsv578610 CNV loss 21841781
nsv833743 CNV loss 17160897

Variation tolerance for ANGPTL6 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL6 Gene

Human Gene Mutation Database (HGMD)
ANGPTL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Disorders for ANGPTL6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ANGPTL6 Gene - From: HGMD, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
familial cerebral saccular aneurysm
  • familial berry aneurysm
enterobiasis
  • enterobius vermicularis infection
myasthenic syndrome, congenital, 6, presynaptic
  • cms6
gnathomiasis
  • gnathostomiasis
dentin caries
  • compound dental caries
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANGPTL6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL6 Gene

Publications for ANGPTL6 Gene

  1. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PMID: 12871997) Oike Y … Suda T (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 56
  2. Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. (PMID: 19447061) Legry V … Meirhaeghe A (Diabetes & metabolism 2009) 3 43 56
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 43 56
  4. Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PMID: 16806062) Zhang Y … Gong Y (Biochemical and biophysical research communications 2006) 3 23 56
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 56

Products for ANGPTL6 Gene

Sources for ANGPTL6 Gene