Aliases for ANGPTL5 Gene

Aliases for ANGPTL5 Gene

  • Angiopoietin Like 5 2 3 5
  • Angiopoietin-Related Protein 5 3 4
  • Angiopoietin-Like Protein 5 3 4
  • Angiopoietin-Like 5 2

External Ids for ANGPTL5 Gene

Previous GeneCards Identifiers for ANGPTL5 Gene

  • GC00U902896
  • GC11M101795
  • GC11M101299
  • GC11M101266
  • GC11M097686

Summaries for ANGPTL5 Gene

GeneCards Summary for ANGPTL5 Gene

ANGPTL5 (Angiopoietin Like 5) is a Protein Coding gene. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is TNC.

Additional gene information for ANGPTL5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGPTL5 Gene

Genomics for ANGPTL5 Gene

GeneHancer (GH) Regulatory Elements for ANGPTL5 Gene

Promoters and enhancers for ANGPTL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J101916 Promoter/Enhancer 0.5 Ensembl dbSUPER 750.6 -0.2 -185 0.2 CEP126 ANGPTL5 piR-33730-020
GH11J101907 Promoter 0.3 EPDnew 760.1 +8.7 8728 0.1 ANGPTL5 piR-57134-034 TRPC6 lnc-TRPC6-1
GH11J101911 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 +2.5 2461 5 SP1 ZBTB40 CTCF POLR2A USF2 CREB1 HCFC1 MIXL1 NFYC HLF CEP126 TRPC6 ANGPTL5 piR-57134-034
GH11J102010 Enhancer 1.1 FANTOM5 Ensembl ENCODE 5.2 -94.9 -94886 3.6 SIN3A FOSL2 SMARCC1 BRCA1 CTBP1 CEBPB POLR2A CHD2 JUN RCOR1 piR-57133-089 TRPC6 CEP126 ANGPTL5 piR-52475-003
GH11J102551 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.9 -636.0 -635985 3.8 ZNF24 SP1 ETV6 RELA ELF3 MAFK MLLT1 POLR2A ELF1 ZNF687 HSALNG0086792 MMP7 ENSG00000256916 MMP20 ANGPTL5 lnc-MMP7-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGPTL5 gene promoter:
  • AP-4
  • CREB
  • deltaCREB
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • S8
  • Sox5
  • TGIF

Genomic Locations for ANGPTL5 Gene

Genomic Locations for ANGPTL5 Gene
chr11:101,890,674-101,916,715
(GRCh38/hg38)
Size:
26,042 bases
Orientation:
Minus strand
chr11:101,761,405-101,787,253
(GRCh37/hg19)
Size:
25,849 bases
Orientation:
Minus strand

Genomic View for ANGPTL5 Gene

Genes around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL5 Gene

Proteins for ANGPTL5 Gene

  • Protein details for ANGPTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XS5-ANGL5_HUMAN
    Recommended name:
    Angiopoietin-related protein 5
    Protein Accession:
    Q86XS5
    Secondary Accessions:
    • A8K658
    • Q86VR9

    Protein attributes for ANGPTL5 Gene

    Size:
    388 amino acids
    Molecular mass:
    44144 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL5 Gene

Post-translational modifications for ANGPTL5 Gene

  • Glycosylation at Asn53, Asn238, and Asn329
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL5 Gene

No data available for DME Specific Peptides for ANGPTL5 Gene

Domains & Families for ANGPTL5 Gene

Gene Families for ANGPTL5 Gene

Suggested Antigen Peptide Sequences for ANGPTL5 Gene

GenScript: Design optimal peptide antigens:
  • Angiopoietin-like protein 5 (ANGL5_HUMAN)
genes like me logo Genes that share domains with ANGPTL5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANGPTL5 Gene

Function for ANGPTL5 Gene

Phenotypes From GWAS Catalog for ANGPTL5 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22660330
genes like me logo Genes that share ontologies with ANGPTL5: view
genes like me logo Genes that share phenotypes with ANGPTL5: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL5 Gene

Localization for ANGPTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL5 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for ANGPTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ANGPTL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPTL5 Gene

Pathways & Interactions for ANGPTL5 Gene

genes like me logo Genes that share pathways with ANGPTL5: view

Pathways by source for ANGPTL5 Gene

Gene Ontology (GO) - Biological Process for ANGPTL5 Gene

None

No data available for SIGNOR curated interactions for ANGPTL5 Gene

Drugs & Compounds for ANGPTL5 Gene

No Compound Related Data Available

Transcripts for ANGPTL5 Gene

mRNA/cDNA for ANGPTL5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -

Relevant External Links for ANGPTL5 Gene

GeneLoc Exon Structure for
ANGPTL5
ECgene alternative splicing isoforms for
ANGPTL5

Expression for ANGPTL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPTL5 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL5 Gene

This gene is overexpressed in Ovary (x12.4) and Adipose - Subcutaneous (x5.9).

Protein differential expression in normal tissues from HIPED for ANGPTL5 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL5 Gene



Protein tissue co-expression partners for ANGPTL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL5 Gene:

ANGPTL5

SOURCE GeneReport for Unigene cluster for ANGPTL5 Gene:

Hs.318370

mRNA Expression by UniProt/SwissProt for ANGPTL5 Gene:

Q86XS5-ANGL5_HUMAN
Tissue specificity: Mainly expressed in adult heart.

Evidence on tissue expression from TISSUES for ANGPTL5 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ANGPTL5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL5 Gene

Orthologs for ANGPTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL5 33 32
  • 99.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANGPTL5 33 32
  • 90.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL5 33 32
  • 88.14 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANGPTL5 33
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL5 33
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPTL5 33 32
  • 72.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGPTL5 33
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl5 32
  • 65.57 (n)
zebrafish
(Danio rerio)
Actinopterygii angptl5 33 32
  • 59.12 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7668 33
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 33
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
OneToOne
Species where no ortholog for ANGPTL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGPTL5 Gene

ENSEMBL:
Gene Tree for ANGPTL5 (if available)
TreeFam:
Gene Tree for ANGPTL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGPTL5: view image

Paralogs for ANGPTL5 Gene

(5) SIMAP similar genes for ANGPTL5 Gene using alignment to 2 proteins:

  • ANGL5_HUMAN
  • E9PKF7_HUMAN
genes like me logo Genes that share paralogs with ANGPTL5: view

Variants for ANGPTL5 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000039510 -- 101,893,580(-) G/A/C/T intron_variant
rs1000225044 -- 101,908,457(-) A/T intron_variant
rs1000327131 -- 101,904,668(-) C/T intron_variant
rs1000414477 -- 101,910,528(-) G/A/C intron_variant
rs1000719122 -- 101,916,836(-) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL5 Gene

Variant ID Type Subtype PubMed ID
nsv1052159 CNV gain 25217958
nsv832250 CNV gain 17160897

Variation tolerance for ANGPTL5 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL5 Gene

Human Gene Mutation Database (HGMD)
ANGPTL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL5 Gene

Disorders for ANGPTL5 Gene

Additional Disease Information for ANGPTL5

No disorders were found for ANGPTL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL5 Gene

Publications for ANGPTL5 Gene

  1. Identification of a novel human angiopoietin-like gene expressed mainly in heart. (PMID: 12624729) Zeng L … Mao Y (Journal of human genetics 2003) 2 3 4 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  4. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J … Thomson W (The pharmacogenomics journal 2014) 3 56
  5. A motif in LILRB2 critical for Angptl2 binding and activation. (PMID: 24899623) Deng M … Zhang CC (Blood 2014) 3 56

Products for ANGPTL5 Gene

Sources for ANGPTL5 Gene