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Aliases for ANGPTL4 Gene

Aliases for ANGPTL4 Gene

  • Angiopoietin Like 4 2 3 5
  • Hepatic Fibrinogen/Angiopoietin-Related Protein 2 3 4
  • Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced Angiopoietin-Related Protein 2 3
  • Hepatic Angiopoietin-Related Protein 2 3
  • PPARG Angiopoietin Related Protein 2 3
  • Angiopoietin-Related Protein 4 2 3
  • Fasting-Induced Adipose Factor 2 3
  • HFARP 3 4
  • ARP4 3 4
  • PGAR 3 4
  • Angiopoietin-Like Protein 4 4
  • Angiopoietin-Like 4 2
  • UNQ171 3
  • Pp1158 3
  • TGQTL 3
  • FIAF 3
  • HARP 3
  • NL2 3

External Ids for ANGPTL4 Gene

Previous GeneCards Identifiers for ANGPTL4 Gene

  • GC19P008372
  • GC19P008643
  • GC19P008324
  • GC19P008335
  • GC19P008429
  • GC19P008082

Summaries for ANGPTL4 Gene

Entrez Gene Summary for ANGPTL4 Gene

  • This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

GeneCards Summary for ANGPTL4 Gene

ANGPTL4 (Angiopoietin Like 4) is a Protein Coding gene. Diseases associated with ANGPTL4 include Plasma Triglyceride Level Quantitative Trait Locus and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is ANGPTL3.

UniProtKB/Swiss-Prot for ANGPTL4 Gene

  • Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

Gene Wiki entry for ANGPTL4 Gene

Additional gene information for ANGPTL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL4 Gene

Genomics for ANGPTL4 Gene

GeneHancer (GH) Regulatory Elements for ANGPTL4 Gene

Promoters and enhancers for ANGPTL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008361 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.8 +0.1 120 3.6 FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 FOS DEK ZC3H11A ANGPTL4 HNRNPM ZNF317 XAB2 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF559 ZNF414
GH19J008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 8.9 +29.6 29555 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 MAP2K7 ZNF559 ENSG00000269300
GH19J008365 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.8 +3.9 3863 3.1 SIN3A YY1 ZNF121 GLIS2 ZFP91 FOS SP3 RXRA REST PPARG RAB11B ENSG00000267510 ANGPTL4 MARCH2 MYO1F MIR4999
GH19J008373 Enhancer 1.1 ENCODE dbSUPER 9.4 +11.0 11002 1.5 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 ZNF121 RAB11B-AS1 MARCH2 ANGPTL4 MIR4999
GH19J008387 Enhancer 0.8 ENCODE dbSUPER 8.5 +24.1 24099 0.5 ZNF639 ZNF740 SMAD5 CAVIN1 TEAD2 BACH1 GTF2A2 ZNF354B ZNF592 MEF2D MIR4999 ZNF558 ZNF699 HNRNPM ELAVL1 ZNF559 ZNF317 XAB2 ENSG00000269300 ANGPTL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANGPTL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGPTL4 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for ANGPTL4 Gene

Genomic Locations for ANGPTL4 Gene
chr19:8,363,289-8,374,375
(GRCh38/hg38)
Size:
11,087 bases
Orientation:
Plus strand
chr19:8,428,173-8,439,257
(GRCh37/hg19)
Size:
11,085 bases
Orientation:
Plus strand

Genomic View for ANGPTL4 Gene

Genes around ANGPTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL4 Gene

Proteins for ANGPTL4 Gene

  • Protein details for ANGPTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY76-ANGL4_HUMAN
    Recommended name:
    Angiopoietin-related protein 4
    Protein Accession:
    Q9BY76
    Secondary Accessions:
    • A8MY84
    • B4E089
    • D6W670
    • F5H0I2
    • Q53HQ6
    • Q53HU1
    • Q6UXN0
    • Q9HBV4
    • Q9NZU4
    • Q9Y5B3

    Protein attributes for ANGPTL4 Gene

    Size:
    406 amino acids
    Molecular mass:
    45214 Da
    Quaternary structure:
    • Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).
    SequenceCaution:
    • Sequence=AAQ88642.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANGPTL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANGPTL4 Gene

Post-translational modifications for ANGPTL4 Gene

No data available for DME Specific Peptides for ANGPTL4 Gene

Domains & Families for ANGPTL4 Gene

Gene Families for ANGPTL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ANGPTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANGPTL4: view

No data available for UniProtKB/Swiss-Prot for ANGPTL4 Gene

Function for ANGPTL4 Gene

Molecular function for ANGPTL4 Gene

UniProtKB/Swiss-Prot Function:
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

Phenotypes From GWAS Catalog for ANGPTL4 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS --
GO:0005515 protein binding IPI 21397862
GO:0042802 identical protein binding IPI 19028676
genes like me logo Genes that share ontologies with ANGPTL4: view
genes like me logo Genes that share phenotypes with ANGPTL4: view

Human Phenotype Ontology for ANGPTL4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ANGPTL4 Gene

MGI Knock Outs for ANGPTL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL4

miRNA for ANGPTL4 Gene

Clone Products

  • R&D Systems cDNA Clones for ANGPTL4 (Angiopoietin-like Protein 4/ANGPTL4)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ANGPTL4 Gene

Localization for ANGPTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL4 Gene

Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL4 gene
Compartment Confidence
extracellular 5
peroxisome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANGPTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 10698685
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with ANGPTL4: view

Pathways & Interactions for ANGPTL4 Gene

genes like me logo Genes that share pathways with ANGPTL4: view

Gene Ontology (GO) - Biological Process for ANGPTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia NAS 12707035
GO:0007275 multicellular organism development IEA --
GO:0019216 regulation of lipid metabolic process TAS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL4: view

No data available for SIGNOR curated interactions for ANGPTL4 Gene

Drugs & Compounds for ANGPTL4 Gene

(8) Drugs for ANGPTL4 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Inulin Approved, Investigational Nutra 119
Acidophilus Nutra 616
Bifidobacterium Nutra 285

(4) Additional Compounds for ANGPTL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPTL4: view

Transcripts for ANGPTL4 Gene

Unigene Clusters for ANGPTL4 Gene

Angiopoietin-like 4:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for ANGPTL4 (Angiopoietin-like Protein 4/ANGPTL4)

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for ANGPTL4 Gene

GeneLoc Exon Structure for
ANGPTL4
ECgene alternative splicing isoforms for
ANGPTL4

Expression for ANGPTL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPTL4 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.1), Liver (x4.8), and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for ANGPTL4 Gene

This gene is overexpressed in Islet of Langerhans (20.9), Milk (18.4), and Bone marrow mesenchymal stem cell (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANGPTL4 Gene:

ANGPTL4

SOURCE GeneReport for Unigene cluster for ANGPTL4 Gene:

Hs.9613

mRNA Expression by UniProt/SwissProt for ANGPTL4 Gene:

Q9BY76-ANGL4_HUMAN
Tissue specificity: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.

Evidence on tissue expression from TISSUES for ANGPTL4 Gene

  • Pancreas(4.4)
  • Skin(4.4)
  • Nervous system(3.1)
  • Liver(2.8)
  • Heart(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with ANGPTL4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL4 Gene

Orthologs for ANGPTL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL4 34 33
  • 99.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANGPTL4 34 33
  • 83.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL4 34 33
  • 82.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Angptl4 16 34 33
  • 77.7 (n)
rat
(Rattus norvegicus)
Mammalia Angptl4 33
  • 77.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL4 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPTL4 34 33
  • 58.66 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl4 33
  • 51.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10669 33
zebrafish
(Danio rerio)
Actinopterygii angptl4 34 33
  • 55.06 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sca 35
  • 31 (a)
CG7668 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for ANGPTL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGPTL4 Gene

ENSEMBL:
Gene Tree for ANGPTL4 (if available)
TreeFam:
Gene Tree for ANGPTL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGPTL4: view image

Paralogs for ANGPTL4 Gene

Paralogs for ANGPTL4 Gene

(13) SIMAP similar genes for ANGPTL4 Gene using alignment to 7 proteins:

  • ANGL4_HUMAN
  • F5H0I2_HUMAN
  • M0QZ51_HUMAN
  • M0R0N8_HUMAN
  • M0R2X8_HUMAN
  • M0R369_HUMAN
  • M0R3A2_HUMAN
genes like me logo Genes that share paralogs with ANGPTL4: view

Variants for ANGPTL4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL4 Gene

ANGL4_HUMAN-Q9BY76
Genetic variations in ANGPTL4 are associated with low plasma triglyceride levels and define the plasma triglyceride level quantitative trait locus (TGQTL) [MIM:615881].

Sequence variations from dbSNP and Humsavar for ANGPTL4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs116843064 association, Plasma triglyceride level quantitative trait locus 8,364,439(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs587777517 association, Plasma triglyceride level quantitative trait locus 8,369,320(+) A/T coding_sequence_variant, intron_variant, stop_gained
rs1000182337 -- 8,372,823(+) G/A intron_variant
rs1000235949 -- 8,372,621(+) T/G intron_variant
rs1000584534 -- 8,362,163(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL4 Gene

Variant ID Type Subtype PubMed ID
esv3643616 CNV gain 21293372
esv3643614 CNV gain 21293372

Variation tolerance for ANGPTL4 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.86; 79.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL4 Gene

Human Gene Mutation Database (HGMD)
ANGPTL4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL4

Disorders for ANGPTL4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ANGPTL4 Gene - From: HGMD, OMIM, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANGPTL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ANGPTL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL4 Gene

Publications for ANGPTL4 Gene

  1. Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (PMID: 10698685) Kim I … Koh GY (The Biochemical journal 2000) 2 3 4 22 58
  2. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (PMID: 10866690) Yoon JC … Spiegelman BM (Molecular and cellular biology 2000) 2 3 4 22 58
  3. [Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis]. (PMID: 11953136) Zhu H … Gu J (Zhonghua yi xue za zhi 2002) 3 4 22 58
  4. Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation. (PMID: 23960078) Lafferty MJ … Neher SB (The Journal of biological chemistry 2013) 2 3 58
  5. Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways. (PMID: 20025870) Stapleton CM … Jetten AM (Experimental cell research 2010) 3 22 58

Products for ANGPTL4 Gene

Sources for ANGPTL4 Gene

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