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Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
ANGPTL2 (Angiopoietin Like 2) is a Protein Coding gene. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is ANGPTL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 22660330 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | TAS,IBA | 21873635 |
GO:0062023 | collagen-containing extracellular matrix | IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IBA | 21873635 |
GO:0007275 | multicellular organism development | TAS | 10473614 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ANGPTL2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ANGPTL2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ANGPTL2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ANGPTL2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Angptl2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Angptl2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ANGPTL2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ANGPTL2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ANGPTL2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | angptl2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | angptl2b 30 31 |
|
OneToMany | |
angptl2a 31 |
|
OneToMany | |||
ANGPTL2 (3 of 3) 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG30280 32 |
|
|
|
CG30281 32 |
|
|
|||
BG:DS00929.7 32 |
|
|
|||
CG8642 32 |
|
|
|||
CG1791 32 |
|
|
|||
CG1889 32 |
|
|
|||
CG9500 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
No disorders were found for ANGPTL2 Gene.