Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells throug... See more...

Aliases for ANGPTL2 Gene

Aliases for ANGPTL2 Gene

  • Angiopoietin Like 2 2 3 5
  • ARP2 2 3 4
  • Angiopoietin-Related Protein 2 3 4
  • Angiopoietin-Like Protein 2 3 4
  • HARP 2 3
  • Angiopoietin-Like 2 2
  • ANGPTL2 5

External Ids for ANGPTL2 Gene

Previous GeneCards Identifiers for ANGPTL2 Gene

  • GC09M120965
  • GC09M121496
  • GC09M123303
  • GC09M125226
  • GC09M125225
  • GC09M126929
  • GC09M128889
  • GC09M129849
  • GC09M099465

Summaries for ANGPTL2 Gene

Entrez Gene Summary for ANGPTL2 Gene

  • Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPTL2 Gene

ANGPTL2 (Angiopoietin Like 2) is a Protein Coding gene. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is ANGPTL1.

UniProtKB/Swiss-Prot Summary for ANGPTL2 Gene

  • Induces sprouting in endothelial cells through an autocrine and paracrine action.

Gene Wiki entry for ANGPTL2 Gene

Additional gene information for ANGPTL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGPTL2 Gene

Genomics for ANGPTL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANGPTL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGPTL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANGPTL2

Top Transcription factor binding sites by QIAGEN in the ANGPTL2 gene promoter:
  • AML1a
  • ARP-1
  • Bach2
  • HEN1
  • Lmo2
  • POU2F1
  • POU2F1a
  • PPAR-alpha

Genomic Locations for ANGPTL2 Gene

Genomic Locations for ANGPTL2 Gene
chr9:127,087,348-127,122,684
(GRCh38/hg38)
Size:
35,337 bases
Orientation:
Minus strand
chr9:129,849,611-129,885,162
(GRCh37/hg19)
Size:
35,552 bases
Orientation:
Minus strand

Genomic View for ANGPTL2 Gene

Genes around ANGPTL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL2 Gene

Proteins for ANGPTL2 Gene

  • Protein details for ANGPTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKU9-ANGL2_HUMAN
    Recommended name:
    Angiopoietin-related protein 2
    Protein Accession:
    Q9UKU9
    Secondary Accessions:
    • Q5JT58
    • Q8NCH7

    Protein attributes for ANGPTL2 Gene

    Size:
    493 amino acids
    Molecular mass:
    57104 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANGPTL2 Gene

    Alternative splice isoforms for ANGPTL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANGPTL2 Gene

Post-translational modifications for ANGPTL2 Gene

  • N-glycosylated.
  • Glycosylation at Asn164, Asn192, and Thr229
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ANGL2_HUMAN (1009)

Other Protein References for ANGPTL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ANGPTL2
  • Boster Bio Antibodies for ANGPTL2
  • Santa Cruz Biotechnology (SCBT) Antibodies for ANGPTL2

No data available for DME Specific Peptides for ANGPTL2 Gene

Domains & Families for ANGPTL2 Gene

Gene Families for ANGPTL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ANGPTL2 Gene

InterPro:
Blocks:
  • Fibrinogen, beta/gamma chain, C-terminal globular
ProtoNet:

Suggested Antigen Peptide Sequences for ANGPTL2 Gene

GenScript: Design optimal peptide antigens:
  • Angiopoietin-like protein 2 (ANGL2_HUMAN)
  • cDNA FLJ90245 fis, clone NT2RM2001792, highly similar to Homo sapiens angiopoietin-related protein-2 mRNA (Q8NCH7_HUMAN)
genes like me logo Genes that share domains with ANGPTL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANGPTL2 Gene

Function for ANGPTL2 Gene

Molecular function for ANGPTL2 Gene

UniProtKB/Swiss-Prot Function:
Induces sprouting in endothelial cells through an autocrine and paracrine action.

Phenotypes From GWAS Catalog for ANGPTL2 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 22660330
genes like me logo Genes that share ontologies with ANGPTL2: view
genes like me logo Genes that share phenotypes with ANGPTL2: view

Animal Models for ANGPTL2 Gene

MGI Knock Outs for ANGPTL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL2 Gene

Localization for ANGPTL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
peroxisome 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANGPTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0062023 collagen-containing extracellular matrix HDA,IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ANGPTL2: view

Pathways & Interactions for ANGPTL2 Gene

PathCards logo

SuperPathways for ANGPTL2 Gene

genes like me logo Genes that share pathways with ANGPTL2: view

Pathways by source for ANGPTL2 Gene

1 R&D Systems pathway for ANGPTL2 Gene

Gene Ontology (GO) - Biological Process for ANGPTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA 21873635
GO:0007275 multicellular organism development TAS 10473614
genes like me logo Genes that share ontologies with ANGPTL2: view

No data available for SIGNOR curated interactions for ANGPTL2 Gene

Drugs & Compounds for ANGPTL2 Gene

No Compound Related Data Available

Transcripts for ANGPTL2 Gene

mRNA/cDNA for ANGPTL2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL2

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL2 Gene

No ASD Table

Relevant External Links for ANGPTL2 Gene

GeneLoc Exon Structure for
ANGPTL2

Expression for ANGPTL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGPTL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANGPTL2 Gene

This gene is overexpressed in Urine (31.2), Gallbladder (13.2), Urinary Bladder (6.8), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL2 Gene



Protein tissue co-expression partners for ANGPTL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANGPTL2

SOURCE GeneReport for Unigene cluster for ANGPTL2 Gene:

Hs.653262

mRNA Expression by UniProt/SwissProt for ANGPTL2 Gene:

Q9UKU9-ANGL2_HUMAN
Tissue specificity: Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.

Evidence on tissue expression from TISSUES for ANGPTL2 Gene

  • Heart(4.6)
  • Nervous system(3.6)
  • Muscle(3.2)
  • Intestine(2.5)
  • Liver(2.5)
  • Blood(2.4)
  • Spleen(2.3)
  • Kidney(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with ANGPTL2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL2 Gene

Orthologs for ANGPTL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANGPTL2 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANGPTL2 30 31
  • 92.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANGPTL2 30 31
  • 91.95 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANGPTL2 31
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Angptl2 30 17 31
  • 89.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Angptl2 30
  • 89.11 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL2 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ANGPTL2 30 31
  • 73.24 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANGPTL2 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia angptl2 30
  • 79.39 (n)
Zebrafish
(Danio rerio)
Actinopterygii angptl2b 30 31
  • 74.57 (n)
OneToMany
angptl2a 31
  • 71 (a)
OneToMany
ANGPTL2 (3 of 3) 31
  • 61 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG30280 32
  • 46 (a)
CG30281 32
  • 46 (a)
BG:DS00929.7 32
  • 45 (a)
CG8642 32
  • 44 (a)
CG1791 32
  • 43 (a)
CG1889 32
  • 38 (a)
CG9500 32
  • 37 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToMany
Species where no ortholog for ANGPTL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANGPTL2 Gene

ENSEMBL:
Gene Tree for ANGPTL2 (if available)
TreeFam:
Gene Tree for ANGPTL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGPTL2: view image

Paralogs for ANGPTL2 Gene

(23) SIMAP similar genes for ANGPTL2 Gene using alignment to 2 proteins:

  • ANGL2_HUMAN
  • Q8NCH7_HUMAN
genes like me logo Genes that share paralogs with ANGPTL2: view

Variants for ANGPTL2 Gene

Additional dbSNP identifiers (rs#s) for ANGPTL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL2 Gene

Variant ID Type Subtype PubMed ID
nsv615342 CNV loss 21841781

Variation tolerance for ANGPTL2 Gene

Residual Variation Intolerance Score: 8.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL2 Gene

Human Gene Mutation Database (HGMD)
ANGPTL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANGPTL2 Gene

Disorders for ANGPTL2 Gene

No disorders were found for ANGPTL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL2 Gene

Publications for ANGPTL2 Gene

  1. Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. (PMID: 10473614) Kim I … Koh GY (The Journal of biological chemistry 1999) 2 3 4 23
  2. Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis. (PMID: 20304962) Okada T … Oike Y (The American journal of pathology 2010) 3 23
  3. Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. (PMID: 17347581) Sun H … Li LS (Nephron. Experimental nephrology 2007) 3 23
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ANGPTL2 Gene

Sources for ANGPTL2 Gene