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Aliases for ANGPTL1 Gene

Aliases for ANGPTL1 Gene

  • Angiopoietin Like 1 2 3 5
  • Angiopoietin-Like Protein 1 3 4
  • Angioarrestin 2 3
  • ANGPT3 3 4
  • ANG-3 3 4
  • ANG3 3 4
  • ARP1 3 4
  • Angiopoietin-Related Protein 1 3
  • DJ595C2.2 (Angiopoietin Y1) 3
  • Angiopoietin-Like 1 2
  • Angiopoietin Y1 3
  • Angiopoietin 3 3
  • Angiopoietin-3 4
  • DJ595C2.2 3
  • UNQ162 3
  • AngY 3

External Ids for ANGPTL1 Gene

Previous HGNC Symbols for ANGPTL1 Gene

  • ANGPT3

Previous GeneCards Identifiers for ANGPTL1 Gene

  • GC01M176344
  • GC01M174248
  • GC01M175400
  • GC01M176059
  • GC01M176060
  • GC01M175551
  • GC01M177085
  • GC01M150047

Summaries for ANGPTL1 Gene

Entrez Gene Summary for ANGPTL1 Gene

  • Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPTL1 Gene

ANGPTL1 (Angiopoietin Like 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is ANGPTL2.

Gene Wiki entry for ANGPTL1 Gene

Additional gene information for ANGPTL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL1 Gene

Genomics for ANGPTL1 Gene

GeneHancer (GH) Regulatory Elements for ANGPTL1 Gene

Promoters and enhancers for ANGPTL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J178870 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 71 2.2 ELF3 FOXA2 RARA MIXL1 EGR2 RXRA SP5 PPARG NFIL3 SP1 ANGPTL1 GC01M178803 RALGPS2
GH01J178931 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -61.7 -61698 3.7 PKNOX1 L3MBTL2 HLF CEBPB MAX JUNB BATF NR2F2 SP1 DIDO1 ANGPTL1 RALGPS2 LOC102724754
GH01J178844 Enhancer 0.6 ENCODE dbSUPER 19.5 +25.7 25664 3 ZNF316 ZNF792 ANGPTL1 ENSG00000273062 GC01M178803 RALGPS2
GH01J178766 Enhancer 0.7 dbSUPER 16.6 +101.5 101487 7.7 CTCF FOXA2 CEBPG ZNF2 RAD21 TEAD3 FOXK2 ARID2 ZNF143 SMC3 ANGPTL1 C1orf220 CRYZL2P RALGPS2 ENSG00000201791 GC01M178756 GC01M178803
GH01J178790 Enhancer 0.6 dbSUPER 18.9 +73.8 73797 13.8 MAFG CEBPB CEBPG ATF4 MAFF ZNF316 POLR2A SCRT2 ATF7 MAFK ANGPTL1 FAM20B C1orf220 CLEC20A CRYZL2P RALGPS2 GC01M178803 GC01M178756 ENSG00000201791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANGPTL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGPTL1 gene promoter:
  • FOXL1
  • MEF-2A
  • aMEF-2
  • STAT3
  • HNF-3beta
  • GR-alpha
  • GR
  • Nkx6-1
  • FOXI1
  • HFH-3

Genomic Locations for ANGPTL1 Gene

Genomic Locations for ANGPTL1 Gene
21,819 bases
Minus strand
21,546 bases
Minus strand

Genomic View for ANGPTL1 Gene

Genes around ANGPTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL1 Gene

Proteins for ANGPTL1 Gene

  • Protein details for ANGPTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Angiopoietin-related protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5T5Z5

    Protein attributes for ANGPTL1 Gene

    491 amino acids
    Molecular mass:
    56720 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL1 Gene

Post-translational modifications for ANGPTL1 Gene

  • Glycosylation at posLast=188188 and posLast=160160
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL1 Gene

No data available for DME Specific Peptides for ANGPTL1 Gene

Domains & Families for ANGPTL1 Gene

Gene Families for ANGPTL1 Gene

Suggested Antigen Peptide Sequences for ANGPTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANGPTL1: view

No data available for UniProtKB/Swiss-Prot for ANGPTL1 Gene

Function for ANGPTL1 Gene

Phenotypes From GWAS Catalog for ANGPTL1 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
genes like me logo Genes that share ontologies with ANGPTL1: view
genes like me logo Genes that share phenotypes with ANGPTL1: view

Animal Models for ANGPTL1 Gene

MGI Knock Outs for ANGPTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL1

miRNA for ANGPTL1 Gene

miRTarBase miRNAs that target ANGPTL1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL1 Gene

Localization for ANGPTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 10025962
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with ANGPTL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPTL1 Gene

Pathways & Interactions for ANGPTL1 Gene

genes like me logo Genes that share pathways with ANGPTL1: view

Pathways by source for ANGPTL1 Gene

SIGNOR curated interactions for ANGPTL1 Gene


Gene Ontology (GO) - Biological Process for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
genes like me logo Genes that share ontologies with ANGPTL1: view

Drugs & Compounds for ANGPTL1 Gene

(1) Drugs for ANGPTL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ANGPTL1: view

Transcripts for ANGPTL1 Gene

mRNA/cDNA for ANGPTL1 Gene

Unigene Clusters for ANGPTL1 Gene

Angiopoietin-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP4: - -

Relevant External Links for ANGPTL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPTL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANGPTL1 Gene

This gene is overexpressed in Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for ANGPTL1 Gene

This gene is overexpressed in Vitreous humor (51.6) and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL1 Gene:


SOURCE GeneReport for Unigene cluster for ANGPTL1 Gene:


mRNA Expression by UniProt/SwissProt for ANGPTL1 Gene:

Tissue specificity: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.

Evidence on tissue expression from TISSUES for ANGPTL1 Gene

  • Heart(4.4)
genes like me logo Genes that share expression patterns with ANGPTL1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL1 Gene

Orthologs for ANGPTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGPTL1 34 33
  • 99.39 (n)
(Canis familiaris)
Mammalia ANGPTL1 34 33
  • 93.28 (n)
(Monodelphis domestica)
Mammalia ANGPTL1 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia ANGPTL1 34
  • 92 (a)
(Bos Taurus)
Mammalia ANGPTL1 34 33
  • 91.85 (n)
(Mus musculus)
Mammalia Angptl1 16 34 33
  • 88.71 (n)
(Gallus gallus)
Aves ANGPTL1 34 33
  • 79.21 (n)
(Anolis carolinensis)
Reptilia ANGPTL1 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl1 33
  • 71.75 (n)
(Danio rerio)
Actinopterygii angptl1 34 33
  • 63.37 (n)
ANGPTL1 (1 of 2) 34
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00929.7 35
  • 44 (a)
CG10359 35
  • 41 (a)
CG8642 35
  • 41 (a)
CG30281 35
  • 40 (a)
CG1791 35
  • 40 (a)
CG30280 35
  • 40 (a)
CG9500 35
  • 37 (a)
CG1889 35
  • 36 (a)
CG5550 35
  • 36 (a)
sca 35
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for ANGPTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL1 Gene

Gene Tree for ANGPTL1 (if available)
Gene Tree for ANGPTL1 (if available)
Evolutionary constrained regions (ECRs) for ANGPTL1: view image

Paralogs for ANGPTL1 Gene

(9) SIMAP similar genes for ANGPTL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANGPTL1: view

Variants for ANGPTL1 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000090913 -- 178,851,841(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000332602 -- 178,872,136(-) G/C upstream_transcript_variant
rs1000450296 -- 178,871,955(-) A/G upstream_transcript_variant
rs1000469920 -- 178,872,435(-) C/A upstream_transcript_variant
rs1000561357 -- 178,853,761(-) T/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL1 Gene

Variant ID Type Subtype PubMed ID
nsv947455 CNV duplication 23825009
nsv548265 CNV gain 21841781
nsv525444 CNV loss 19592680
nsv470748 CNV gain 18288195
nsv466206 CNV gain 19166990
nsv3710 CNV insertion 18451855
nsv1005359 CNV loss 25217958

Variation tolerance for ANGPTL1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL1 Gene

Disorders for ANGPTL1 Gene

Additional Disease Information for ANGPTL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANGPTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL1 Gene

Publications for ANGPTL1 Gene

  1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PMID: 10025962) Kim I … Koh GY (FEBS letters 1999) 2 3 4 22 58
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. (PMID: 15940350) Smagur A … Szala S (Acta biochimica Polonica 2005) 3 22 58
  5. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PMID: 15950186) Dhanabal M … Lichenstein HS (Biochemical and biophysical research communications 2005) 3 22 58

Products for ANGPTL1 Gene

Sources for ANGPTL1 Gene

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