Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA ... See more...

Aliases for ANGPTL1 Gene

Aliases for ANGPTL1 Gene

  • Angiopoietin Like 1 2 3 5
  • ANG3 2 3 4
  • ARP1 2 3 4
  • Angiopoietin-Related Protein 1 3 4
  • Angiopoietin-Like Protein 1 3 4
  • Angioarrestin 2 3
  • ANGPT3 3 4
  • ANG-3 3 4
  • AngY 2 3
  • DJ595C2.2 (Angiopoietin Y1) 3
  • Angiopoietin-Like 1 2
  • Angiopoietin Y1 3
  • Angiopoietin 3 3
  • Angiopoietin-3 4
  • DJ595C2.2 3
  • ANGPTL1 5
  • UNQ162 3

External Ids for ANGPTL1 Gene

Previous HGNC Symbols for ANGPTL1 Gene

  • ANGPT3

Previous GeneCards Identifiers for ANGPTL1 Gene

  • GC01M176344
  • GC01M174248
  • GC01M175400
  • GC01M176059
  • GC01M176060
  • GC01M175551
  • GC01M177085
  • GC01M150047

Summaries for ANGPTL1 Gene

Entrez Gene Summary for ANGPTL1 Gene

  • Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPTL1 Gene

ANGPTL1 (Angiopoietin Like 1) is a Protein Coding gene. Diseases associated with ANGPTL1 include Hyperlipoproteinemia, Type I. Among its related pathways are Immune response IL-23 signaling pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is ANGPTL2.

Gene Wiki entry for ANGPTL1 Gene

Additional gene information for ANGPTL1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGPTL1 Gene

Genomics for ANGPTL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANGPTL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGPTL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANGPTL1

Top Transcription factor binding sites by QIAGEN in the ANGPTL1 gene promoter:
  • aMEF-2
  • FOXI1
  • FOXL1
  • GR
  • GR-alpha
  • HFH-3
  • HNF-3beta
  • MEF-2A
  • Nkx6-1
  • STAT3

Genomic Locations for ANGPTL1 Gene

Genomic Locations for ANGPTL1 Gene
chr1:178,849,535-178,871,077
(GRCh38/hg38)
Size:
21,543 bases
Orientation:
Minus strand
chr1:178,818,670-178,840,215
(GRCh37/hg19)
Size:
21,546 bases
Orientation:
Minus strand

Genomic View for ANGPTL1 Gene

Genes around ANGPTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL1 Gene

Proteins for ANGPTL1 Gene

  • Protein details for ANGPTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95841-ANGL1_HUMAN
    Recommended name:
    Angiopoietin-related protein 1
    Protein Accession:
    O95841
    Secondary Accessions:
    • Q5T5Z5

    Protein attributes for ANGPTL1 Gene

    Size:
    491 amino acids
    Molecular mass:
    56720 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL1 Gene

Post-translational modifications for ANGPTL1 Gene

  • Glycosylation at Asn160 and Asn188
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL1 Gene

No data available for DME Specific Peptides for ANGPTL1 Gene

Domains & Families for ANGPTL1 Gene

Gene Families for ANGPTL1 Gene

Protein Domains for ANGPTL1 Gene

InterPro:
Blocks:
  • Fibrinogen, beta/gamma chain, C-terminal globular
ProtoNet:

Suggested Antigen Peptide Sequences for ANGPTL1 Gene

GenScript: Design optimal peptide antigens:
  • Angiopoietin-like protein 1 (ANGL1_HUMAN)
genes like me logo Genes that share domains with ANGPTL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ANGPTL1 Gene

Function for ANGPTL1 Gene

Phenotypes From GWAS Catalog for ANGPTL1 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS,IBA 21873635
genes like me logo Genes that share ontologies with ANGPTL1: view
genes like me logo Genes that share phenotypes with ANGPTL1: view

Animal Models for ANGPTL1 Gene

MGI Knock Outs for ANGPTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL1

CRISPR Products

miRNA for ANGPTL1 Gene

miRTarBase miRNAs that target ANGPTL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL1 Gene

Localization for ANGPTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
peroxisome 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 10025962
GO:0062023 collagen-containing extracellular matrix IBA 21873635
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with ANGPTL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPTL1 Gene

Pathways & Interactions for ANGPTL1 Gene

PathCards logo

SuperPathways for ANGPTL1 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.41
3 Akt Signaling
.60
.60
.55
4 Immune response IL-23 signaling pathway
.38
.36
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with ANGPTL1: view

Pathways by source for ANGPTL1 Gene

1 BioSystems pathway for ANGPTL1 Gene
1 GeneGo (Thomson Reuters) pathway for ANGPTL1 Gene
  • Development Angiopoietin - Tie2 signaling
26 Qiagen pathways for ANGPTL1 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Angiopoietin-TIE2 Signaling
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway

SIGNOR curated interactions for ANGPTL1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA 21873635
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA,IBA 21873635
genes like me logo Genes that share ontologies with ANGPTL1: view

Drugs & Compounds for ANGPTL1 Gene

(1) Drugs for ANGPTL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ANGPTL1: view

Transcripts for ANGPTL1 Gene

mRNA/cDNA for ANGPTL1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPTL1

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for ANGPTL1 Gene

GeneLoc Exon Structure for
ANGPTL1

Expression for ANGPTL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGPTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANGPTL1 Gene

This gene is overexpressed in Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for ANGPTL1 Gene

This gene is overexpressed in Vitreous humor (51.6) and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANGPTL1

SOURCE GeneReport for Unigene cluster for ANGPTL1 Gene:

Hs.591474

mRNA Expression by UniProt/SwissProt for ANGPTL1 Gene:

O95841-ANGL1_HUMAN
Tissue specificity: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.

Evidence on tissue expression from TISSUES for ANGPTL1 Gene

  • Heart(4.6)
  • Liver(2.6)
  • Muscle(2.6)
  • Intestine(2.3)
  • Kidney(2.2)
  • Thyroid gland(2.2)
  • Nervous system(2.1)
  • Pancreas(2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ANGPTL1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL1 Gene

Orthologs for ANGPTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANGPTL1 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANGPTL1 30 31
  • 93.28 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANGPTL1 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL1 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ANGPTL1 30 31
  • 91.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Angptl1 30 17 31
  • 88.71 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ANGPTL1 30 31
  • 79.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANGPTL1 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia angptl1 30
  • 71.75 (n)
Zebrafish
(Danio rerio)
Actinopterygii angptl1 30 31
  • 63.37 (n)
OneToMany
ANGPTL1 (1 of 2) 31
  • 52 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta BG:DS00929.7 32
  • 44 (a)
CG10359 32
  • 41 (a)
CG8642 32
  • 41 (a)
CG1791 32
  • 40 (a)
CG30280 32
  • 40 (a)
CG30281 32
  • 40 (a)
CG9500 32
  • 37 (a)
CG1889 32
  • 36 (a)
CG5550 32
  • 36 (a)
sca 32
  • 27 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToMany
Species where no ortholog for ANGPTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANGPTL1 Gene

ENSEMBL:
Gene Tree for ANGPTL1 (if available)
TreeFam:
Gene Tree for ANGPTL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGPTL1: view image

Paralogs for ANGPTL1 Gene

(9) SIMAP similar genes for ANGPTL1 Gene using alignment to 1 proteins:

  • ANGL1_HUMAN
genes like me logo Genes that share paralogs with ANGPTL1: view

Variants for ANGPTL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANGPTL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
784965 Benign: not provided 178,852,705(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ANGPTL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL1 Gene

Variant ID Type Subtype PubMed ID
nsv1005359 CNV loss 25217958
nsv3710 CNV insertion 18451855
nsv466206 CNV gain 19166990
nsv470748 CNV gain 18288195
nsv525444 CNV loss 19592680
nsv548265 CNV gain 21841781
nsv947455 CNV duplication 23825009

Variation tolerance for ANGPTL1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPTL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL1 Gene

Disorders for ANGPTL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANGPTL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hyperlipoproteinemia, type i
  • lipoprotein lipase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANGPTL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANGPTL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL1 Gene

Publications for ANGPTL1 Gene

  1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PMID: 10025962) Kim I … Koh GY (FEBS letters 1999) 2 3 4 23
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  5. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PMID: 15950186) Dhanabal M … Lichenstein HS (Biochemical and biophysical research communications 2005) 3 23

Products for ANGPTL1 Gene

  • Biorbyt antibodies for ANGPTL1

Sources for ANGPTL1 Gene