Aliases for ANGPT4 Gene
External Ids for ANGPT4 Gene
Previous GeneCards Identifiers for ANGPT4 Gene
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANGPT4 Gene
ANGPT4 (Angiopoietin 4) is a Protein Coding gene. Diseases associated with ANGPT4 include Gastrointestinal Stromal Tumor and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Immune response IL-23 signaling pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include receptor tyrosine kinase binding and transmembrane receptor protein tyrosine kinase activator activity. An important paralog of this gene is ANGPT1.
UniProtKB/Swiss-Prot Summary for ANGPT4 Gene
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.