Aliases for ANGPT2 Gene
External Ids for ANGPT2 Gene
Previous GeneCards Identifiers for ANGPT2 Gene
This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
GeneCards Summary for ANGPT2 Gene
ANGPT2 (Angiopoietin 2) is a Protein Coding gene. Diseases associated with ANGPT2 include Microcephaly 1, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are ERK Signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is ANGPT1.
UniProtKB/Swiss-Prot Summary for ANGPT2 Gene
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.