Aliases for ANGPT2 Gene
External Ids for ANGPT2 Gene
Previous GeneCards Identifiers for ANGPT2 Gene
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANGPT2 Gene
ANGPT2 (Angiopoietin 2) is a Protein Coding gene. Diseases associated with ANGPT2 include Placenta Accreta and Placental Insufficiency. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is ANGPT1.
UniProtKB/Swiss-Prot for ANGPT2 Gene
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.