Aliases for ANGPT2 Gene
External Ids for ANGPT2 Gene
Previous GeneCards Identifiers for ANGPT2 Gene
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANGPT2 Gene
ANGPT2 (Angiopoietin 2) is a Protein Coding gene. Diseases associated with ANGPT2 include Placenta Accreta and Placental Insufficiency. Among its related pathways are Immune response IL-23 signaling pathway and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is ANGPT1.
UniProtKB/Swiss-Prot Summary for ANGPT2 Gene
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.