Aliases for ANGPT1 Gene
Aliases for ANGPT1 Gene
External Ids for ANGPT1 Gene
- HGNC: 484
- Entrez Gene: 284
- Ensembl: ENSG00000154188
- OMIM: 601667
- UniProtKB: Q15389
Previous GeneCards Identifiers for ANGPT1 Gene
- GC08M108328
- GC08M107930
- GC08M108218
- GC08M108330
- GC08M103581
Summaries for ANGPT1 Gene
-
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
GeneCards Summary for ANGPT1 Gene
ANGPT1 (Angiopoietin 1) is a Protein Coding gene. Diseases associated with ANGPT1 include Pyogenic Granuloma and Macrophage Activation Syndrome. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is ANGPT2.
UniProtKB/Swiss-Prot for ANGPT1 Gene
-
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Additional gene information for ANGPT1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT1 Gene
Genomics for ANGPT1 Gene
GeneHancer (GH) Regulatory Elements for ANGPT1 Gene
Promoters and enhancers for ANGPT1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J107494 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 658.7 | +1.6 | 1631 | 4.4 | ATF1 BATF RAD21 YY1 ZNF143 SMARCA5 ZNF654 REST PRDM6 GLIS1 | ANGPT1 GC08M107369 | |
| GH08J107499 | Enhancer | 0.8 | Ensembl ENCODE | 650.7 | -1.5 | -1502 | 0.5 | SMARCA5 BCOR CTCF ZMYM3 HDAC2 ZNF143 ZNF580 KDM1A | ANGPT1 PGAM1P13 | |
| GH08J107321 | Promoter | 0.5 | EPDnew | 650.1 | +176.0 | 176042 | 0.1 | ANGPT1 GC08M107314 GC08M107369 | ||
| GH08J107331 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 10.4 | +165.9 | 165850 | 1.3 | GTF2E2 ZNF316 FOXK2 MAFK ZNF639 ZNF197 AFF1 E2F5 MAFG ELF1 | ANGPT1 GC08M107314 GC08M107369 | |
| GH08J107334 | Enhancer | 0.8 | dbSUPER | 10.4 | +162.3 | 162300 | 3.3 | HDAC1 ATF1 TAF9B ARNT NFRKB CHAMP1 POLR2B ATF7 CEBPB NCOA1 | ANGPT1 GC08M107314 GC08M107369 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ANGPT1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ANGPT1 Gene
Genomic Locations for ANGPT1 Gene
- chr8:107,249,482-107,498,055
- (GRCh38/hg38)
- Size:
- 248,574 bases
- Orientation:
- Minus strand
- chr8:108,261,710-108,510,283
- (GRCh37/hg19)
Genomic View for ANGPT1 Gene
Genes around ANGPT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q23.1 by Entrez Gene
- 8q23.1 by HGNC
- 8q23.1 by Ensembl
ANGPT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPT1 Gene
Proteins for ANGPT1 Gene
-
Protein details for ANGPT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15389-ANGP1_HUMAN
- Recommended name:
- Angiopoietin-1
- Protein Accession:
- Q15389
- Q5HYA0
Protein attributes for ANGPT1 Gene
- Size:
- 498 amino acids
- Molecular mass:
- 57513 Da
- Quaternary structure:
-
- Homooligomer. Interacts with TEK/TIE2.
- Miscellaneous:
-
- It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.
- SequenceCaution:
-
- Sequence=BAA02793.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ANGPT1 Gene
Post-translational modifications for ANGPT1 Gene
- Glycosylated.
- Glycosylation at Asn295, posLast=243243, posLast=154154, Asn122, and Asn92
- Modification sites at PhosphoSitePlus
Other Protein References for ANGPT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANGPT1 (Angiopoietin-1)
-
Custom Antibody ServicesOriGene Antibodies for ANGPT1
- Novus Biologicals Antibodies for ANGPT1
- Invitrogen Antibodies for ANGPT1
- antibodies-online: Search results for 206 available Angiopoietin 1 Antibodies ranked by validation data
- Compare Top Angiopoietin 1 Antibodies
-
Recommended
- 133 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 57 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- GeneTex Angpt1 Antibody for ANGPT1
Protein Products
- R&D Systems Proteins and Enzymes for ANGPT1 (Angiopoietin-1)
-
OriGene Purified Proteins for ANGPT1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANGPT1
- Origene Custom Protein Services for ANGPT1
- Sino Biological Cell Lysates for ANGPT1
- Sino Biological Recombinant Proteins for ANGPT1
- ProSpec Recombinant Proteins for ANGPT1
- GeneTex Proteins for ANGPT1
-
ProSci Proteins for ANGPT1
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for ANGPT1 (Angiopoietin-1)
- Novus Biologicals ELISA Kits for ANGPT1
- antibodies-online: Search results for 103 available Angiopoietin 1 Elisa Kits ranked by validation data
- Compare Top Angiopoietin 1 Elisa Kits
-
Recommended
- 3 Chicken ELISA Kits
- 9 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 31 Human ELISA Kits
- 2 Monkey ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 13 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 18 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 1 Wild boar (Sus scrofa) ELISA Kit
No data available for DME Specific Peptides for ANGPT1 Gene
Domains & Families for ANGPT1 Gene
Gene Families for ANGPT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for ANGPT1 Gene
Suggested Antigen Peptide Sequences for ANGPT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANGPT1 Gene
Function for ANGPT1 Gene
Molecular function for ANGPT1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
- GENATLAS Biochemistry:
- angiopoietin 1,75kDa,secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,widely expressed,involved in late stages of angiogenesis,promoting angiogenic remodeling as well as vessel maturation and stabilization
LifeMap Function Summary for ANGPT1 Gene
During embryonic development, ANGPT1 as signaling molecule is secreted from the following cells
- Lateral Plate Mesoderm
- Lung
- Head Mesenchyme
It affects the following cells:
- Lateral Plate Mesoderm
- Lung
- Blood
Phenotypes From GWAS Catalog for ANGPT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0030971 | receptor tyrosine kinase binding | IPI,IEA | 8980223 |
Phenotypes for ANGPT1 Gene
- MGI mutant phenotypes for ANGPT1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for ANGPT1:
-
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Decreased IL-8 secretion
- Increased viability
Animal Models for ANGPT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPT1
-
CRISPR Products
-
OriGene CRISPR knockouts for ANGPT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANGPT1
- Applied Biological Materials CRISPR for ANGPT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPT1
- GenScript: Design CRISPR guide RNA sequences for ANGPT1
miRNA for ANGPT1 Gene
- miRTarBase miRNAs that target ANGPT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANGPT1
- Browse OriGene Inhibitory RNA Products For ANGPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPT1
- genomics-online: shRNA clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANGPT1
- VectorBuilder custom plasmid, inducible vectors for ANGPT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANGPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANGPT1
- genomics-online: cdna clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- orf clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- Applied Biological Materials Clones for ANGPT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANGPT1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPT1 Gene
Localization for ANGPT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPT1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 8980223 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | IDA | 19424712 |
| GO:0005902 | microvillus | IDA | 19424712 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPT1 Gene
Pathways & Interactions for ANGPT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | PEDF Induced Signaling |
.61
|
.47
|
| 3 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 4 | Immune response IL-23 signaling pathway | ||
| 5 | Akt Signaling |
.60
.60
|
|
Pathways by source for ANGPT1 Gene
4 BioSystems pathways for ANGPT1 Gene
49 Reactome pathways for ANGPT1 Gene
6 KEGG pathways for ANGPT1 Gene
2 GeneGo (Thomson Reuters) pathways for ANGPT1 Gene
26 Qiagen pathways for ANGPT1 Gene
Interacting Proteins for ANGPT1 Gene
Selected Interacting proteins:
Q15389-ANGP1_HUMAN
ENSP00000428340
for ANGPT1 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for ANGPT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0001936 | NOT regulation of endothelial cell proliferation | IDA | 8980223 |
Transcripts for ANGPT1 Gene
mRNA/cDNA for ANGPT1 Gene
- (75) Selected AceView cDNA sequences:
- (11) Additional mRNA sequences :
- (4) REFSEQ mRNAs :
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000297450 4353 bps (uc003ymo.4)
- ENST00000517746 4322 bps (uc003ymn.4)
- ENST00000518386 813 bps (uc064plz.1)
- ENST00000520033 548 bps (uc064pmc.1)
- ENST00000520052 1523 bps (uc064ply.1)
CRISPR Products
-
OriGene CRISPR knockouts for ANGPT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANGPT1
- Applied Biological Materials CRISPR for ANGPT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPT1
- GenScript: Design CRISPR guide RNA sequences for ANGPT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ANGPT1
- Browse OriGene Inhibitory RNA Products For ANGPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGPT1
- genomics-online: shRNA clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ANGPT1
- VectorBuilder custom plasmid, inducible vectors for ANGPT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANGPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ANGPT1
- genomics-online: cdna clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- orf clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- Applied Biological Materials Clones for ANGPT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for ANGPT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Angioblasts Perineural Capillary Plexus
- Pericytes Blood Brain Barrier
- Neural stem cell line (CTX0E03)
-
Endothelium (Cardiovascular System)
- Angioblasts Perineural Capillary Plexus
- MultiGeneAngio, transduced vein-derived endothelial cells
- Blood (Hematopoietic System)
-
Neural Tube (Nervous System)
- Angioblasts Perineural Capillary Plexus
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
mRNA differential expression in normal tissues according to GTEx for ANGPT1 Gene
This gene is overexpressed in Artery - Tibial (x5.9).
This gene is overexpressed in Peripheral blood mononuclear cells (25.5), Serum (20.2), CD8 Tcells (16.7), and Platelet (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANGPT1 Gene:
ANGPT1SOURCE GeneReport for Unigene cluster for ANGPT1 Gene:
Hs.369675Evidence on tissue expression from TISSUES for ANGPT1 Gene
- Lung(4.5)
- Bone marrow(4.4)
- Liver(4.3)
- Intestine(4.2)
- Heart(3.2)
- Blood(2.7)
- Muscle(2.7)
- Kidney(2.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANGPT1
-
OriGene qPCR primer pairs for ANGPT1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPT1 Gene
Orthologs for ANGPT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANGPT1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANGPT1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ANGPT1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Angpt1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANGPT1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Angpt1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANGPT1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANG-1 34 |
|
OneToOne | |
| ANGPT1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | ANGPT1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | angpt1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | angpt1 34 33 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG10359 35 |
|
|
- Species where no ortholog for ANGPT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ANGPT1 Gene
- ENSEMBL:
- Gene Tree for ANGPT1 (if available)
- TreeFam:
- Gene Tree for ANGPT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ANGPT1: view image
Paralogs for ANGPT1 Gene
Paralogs for ANGPT1 Gene
(19) SIMAP similar genes for ANGPT1 Gene using alignment to 4 proteins:
- ANGP1_HUMAN
- B4DTQ9_HUMAN
- E5RFF4_HUMAN
- E7ERK4_HUMAN
Variants for ANGPT1 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008147 | -- | 107,438,640(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000024132 | -- | 107,384,238(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000038760 | -- | 107,431,995(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000079926 | -- | 107,333,486(-) | T/C | intron_variant | |
| rs1000092211 | -- | 107,312,955(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.72;
32.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANGPT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPT1 Gene
Disorders for ANGPT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pyogenic granuloma |
|
|
| macrophage activation syndrome |
|
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| twin-to-twin transfusion syndrome |
|
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| funisitis |
|
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| epileptic encephalopathy, childhood-onset |
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|
Search ANGPT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ANGPT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPT1 Gene
Publications for ANGPT1 Gene
- A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. (PMID: 20378606) Chen J … Hui R (Human molecular genetics 2010) 3 22 44 58
- Biological characterization of angiopoietin-3 and angiopoietin-4. (PMID: 15284220) Lee HJ … Koh GY (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004) 3 4 22 58
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. (PMID: 8980223) Davis S … Yancopoulos GD (Cell 1996) 3 4 22 58
- Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts KE … Pulmonary Vascular Complications of Liver Disease Study Group (Gastroenterology 2010) 3 44 58
- Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
Products for ANGPT1 Gene
- R&D Systems Antibodies for ANGPT1 (Angiopoietin-1)
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- ProSpec Recombinant Proteins for ANGPT1
- VectorBuilder custom plasmid, inducible vectors for ANGPT1
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANGPT1
- antibodies-online: Search results for 206 available Angiopoietin 1 Antibodies ranked by validation data
- Compare Top Angiopoietin 1 Antibodies
- Recommended
- 133 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 57 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 103 available Angiopoietin 1 Elisa Kits ranked by validation data
- Compare Top Angiopoietin 1 Elisa Kits
- Recommended
- 3 Chicken ELISA Kits
- 9 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 31 Human ELISA Kits
- 2 Monkey ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 13 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 18 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 1 Wild boar (Sus scrofa) ELISA Kit
- antibodies-online: Search results for 37 available Angiopoietin 1 Proteins ranked by validation data
- Compare Top Angiopoietin 1 Proteins
- GeneTex Angpt1 Antibody for ANGPT1
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- Horizon Cell Lines for ANGPT1
- genomics-online: cdna clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- orf clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- genomics-online: gRNA clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- genomics-online: primer clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- genomics-online: shRNA clones - Search results for 138 available Angiopoietin 1 gene related products
- Overview of 138 available Angiopoietin 1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ANGPT1
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- GeneCopoeia miRNA 3'UTR Target clone products for ANGPT1
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Sources for ANGPT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
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- (68) Cloud-Clone Corp.
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