Aliases for ANGEL2 Gene

Aliases for ANGEL2 Gene

  • Angel Homolog 2 2 3 5
  • Protein Angel Homolog 2 3 4
  • KIAA0759L 3 4
  • Angel Homolog 2 (Drosophila) 2
  • Ccr4d 3

External Ids for ANGEL2 Gene

Previous GeneCards Identifiers for ANGEL2 Gene

  • GC01M209555
  • GC01M211232
  • GC01M213165
  • GC01M183840

Summaries for ANGEL2 Gene

GeneCards Summary for ANGEL2 Gene

ANGEL2 (Angel Homolog 2) is a Protein Coding gene. An important paralog of this gene is ANGEL1.

Additional gene information for ANGEL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGEL2 Gene

Genomics for ANGEL2 Gene

GeneHancer (GH) Regulatory Elements for ANGEL2 Gene

Promoters and enhancers for ANGEL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGEL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGEL2 gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • NCX
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU6F1 (c2)

Genomic Locations for ANGEL2 Gene

Genomic Locations for ANGEL2 Gene
23,694 bases
Minus strand
23,645 bases
Minus strand

Genomic View for ANGEL2 Gene

Genes around ANGEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL2 Gene

Proteins for ANGEL2 Gene

  • Protein details for ANGEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7Z2U4
    • D3DTA3
    • Q86X13
    • Q8NHH3

    Protein attributes for ANGEL2 Gene

    544 amino acids
    Molecular mass:
    62339 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47469.1; Type=Erroneous termination; Positions=456; Note=Translated as Ser.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANGEL2 Gene


neXtProt entry for ANGEL2 Gene

Post-translational modifications for ANGEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANGEL2 Gene

Domains & Families for ANGEL2 Gene

Gene Families for ANGEL2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ANGEL2 Gene

Suggested Antigen Peptide Sequences for ANGEL2 Gene

GenScript: Design optimal peptide antigens:
  • Protein angel homolog 2 (ANGE2_HUMAN)
  • cDNA FLJ50631, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA (B7Z5T0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL2: view

Function for ANGEL2 Gene

Phenotypes From GWAS Catalog for ANGEL2 Gene

Gene Ontology (GO) - Molecular Function for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IBA 21873635
GO:0003730 mRNA 3'-UTR binding IDA 22547059
genes like me logo Genes that share ontologies with ANGEL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGEL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGEL2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGEL2 Gene

Localization for ANGEL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGEL2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17178830
GO:0015030 Cajal body IDA 17178830
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL2 Gene

Pathways & Interactions for ANGEL2 Gene

PathCards logo

SuperPathways for ANGEL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045930 negative regulation of mitotic cell cycle IMP 22547059
GO:0070935 3'-UTR-mediated mRNA stabilization IMP 22547059
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Pathways by source and SIGNOR curated interactions for ANGEL2 Gene

Drugs & Compounds for ANGEL2 Gene

No Compound Related Data Available

Transcripts for ANGEL2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGEL2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - - - - -
SP4: - -
SP7: - - -

Relevant External Links for ANGEL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGEL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANGEL2 Gene

This gene is overexpressed in CD8 Tcells (17.6), Fetal heart (12.4), Peripheral blood mononuclear cells (12.4), and CD4 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANGEL2 Gene

Protein tissue co-expression partners for ANGEL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGEL2 Gene:


SOURCE GeneReport for Unigene cluster for ANGEL2 Gene:


Evidence on tissue expression from TISSUES for ANGEL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ANGEL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGEL2 Gene

Orthologs for ANGEL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGEL2 33 32
  • 99.88 (n)
(Canis familiaris)
Mammalia ANGEL2 33 32
  • 93.5 (n)
(Bos Taurus)
Mammalia ANGEL2 33 32
  • 92.46 (n)
(Rattus norvegicus)
Mammalia Angel2 32
  • 84.93 (n)
(Mus musculus)
Mammalia Angel2 17 33 32
  • 84.5 (n)
(Monodelphis domestica)
Mammalia ANGEL2 33
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANGEL2 33
  • 77 (a)
(Gallus gallus)
Aves ANGEL2 33 32
  • 70.48 (n)
(Anolis carolinensis)
Reptilia ANGEL2 33
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angel2 32
  • 63.26 (n)
Str.11476 32
(Danio rerio)
Actinopterygii angel2 33 32
  • 58.83 (n)
wufl78e02 32
fruit fly
(Drosophila melanogaster)
Insecta angel 33
  • 31 (a)
(Caenorhabditis elegans)
Secernentea W02G9.5 32
  • 48 (n)
angl-1 33
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 33
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 33
  • 23 (a)
Species where no ortholog for ANGEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL2 Gene

Gene Tree for ANGEL2 (if available)
Gene Tree for ANGEL2 (if available)
Evolutionary constrained regions (ECRs) for ANGEL2: view image

Paralogs for ANGEL2 Gene

Paralogs for ANGEL2 Gene

(1) SIMAP similar genes for ANGEL2 Gene using alignment to 4 proteins:

  • B7Z5T0_HUMAN
  • F5H476_HUMAN
  • Q96AL9_HUMAN
genes like me logo Genes that share paralogs with ANGEL2: view

Variants for ANGEL2 Gene

Sequence variations from dbSNP and Humsavar for ANGEL2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000050349 -- 213,006,966(-) C/T intron_variant
rs1000051498 -- 213,003,780(-) A/G intron_variant
rs1000106157 -- 212,994,079(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000168899 -- 212,998,998(-) G/A intron_variant
rs1000313010 -- 213,004,088(-) C/T intron_variant

Variation tolerance for ANGEL2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGEL2 Gene

Disorders for ANGEL2 Gene

Additional Disease Information for ANGEL2

No disorders were found for ANGEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL2 Gene

Publications for ANGEL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L … Quigley JG (Gene 2002) 2 3 56
  3. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56

Products for ANGEL2 Gene

Sources for ANGEL2 Gene