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Aliases for ANGEL2 Gene

Aliases for ANGEL2 Gene

  • Angel Homolog 2 2 3 5
  • KIAA0759L 3 4
  • Angel Homolog 2 (Drosophila) 2
  • Protein Angel Homolog 2 3
  • Ccr4d 3

External Ids for ANGEL2 Gene

Previous GeneCards Identifiers for ANGEL2 Gene

  • GC01M209555
  • GC01M211232
  • GC01M213165
  • GC01M183840

Summaries for ANGEL2 Gene

GeneCards Summary for ANGEL2 Gene

ANGEL2 (Angel Homolog 2) is a Protein Coding gene. An important paralog of this gene is ANGEL1.

Additional gene information for ANGEL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL2 Gene

Genomics for ANGEL2 Gene

GeneHancer (GH) Regulatory Elements for ANGEL2 Gene

Promoters and enhancers for ANGEL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J213014 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 657 -0.1 -92 3.6 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 CBX5 ANGEL2 VASH2 GC01M213006
GH01J212605 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29 +408.1 408081 5.2 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 ATF3 ANGEL2 FLVCR1 BATF3 GC01M212615
GH01J212789 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 30 +224.3 224278 4.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TATDN3 BATF3 NSL1 FLVCR1 FLVCR1-DT ANGEL2 RPL21P28 LOC105372907 ENSG00000225233 LOC105372912
GH01J212283 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +729.9 729939 4.4 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D LOC101929541 PPP2R5A TMEM206 ANGEL2 INTS7 ENSG00000230063
GH01J213050 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 -35.8 -35847 3.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 POLR2B ZNF766 CBX5 RPS6KC1 ANGEL2 PPP2R5A GC01P213058
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGEL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGEL2 gene promoter:
  • AREB6
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • AML1a
  • NCX
  • POU6F1 (c2)
  • ATF6

Genomic Locations for ANGEL2 Gene

Genomic Locations for ANGEL2 Gene
23,694 bases
Minus strand
23,645 bases
Minus strand

Genomic View for ANGEL2 Gene

Genes around ANGEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL2 Gene

Proteins for ANGEL2 Gene

  • Protein details for ANGEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7Z2U4
    • D3DTA3
    • Q86X13
    • Q8NHH3

    Protein attributes for ANGEL2 Gene

    544 amino acids
    Molecular mass:
    62339 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47469.1; Type=Erroneous termination; Positions=456; Note=Translated as Ser.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANGEL2 Gene


neXtProt entry for ANGEL2 Gene

Post-translational modifications for ANGEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANGEL2 Gene

Domains & Families for ANGEL2 Gene

Gene Families for ANGEL2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ANGEL2 Gene

Suggested Antigen Peptide Sequences for ANGEL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL2: view

Function for ANGEL2 Gene

Phenotypes From GWAS Catalog for ANGEL2 Gene

Gene Ontology (GO) - Molecular Function for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 22547059
genes like me logo Genes that share ontologies with ANGEL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGEL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGEL2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGEL2 Gene

Localization for ANGEL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGEL2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17178830
GO:0015030 Cajal body IDA 17178830
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL2 Gene

Pathways & Interactions for ANGEL2 Gene

SuperPathways for ANGEL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045930 negative regulation of mitotic cell cycle IMP 22547059
GO:0070935 3-UTR-mediated mRNA stabilization IMP 22547059
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Pathways by source and SIGNOR curated interactions for ANGEL2 Gene

Drugs & Compounds for ANGEL2 Gene

No Compound Related Data Available

Transcripts for ANGEL2 Gene

Unigene Clusters for ANGEL2 Gene

Angel homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGEL2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - - - - -
SP4: - -
SP7: - - -

Relevant External Links for ANGEL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGEL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANGEL2 Gene

This gene is overexpressed in CD8 Tcells (17.6), Fetal heart (12.4), Peripheral blood mononuclear cells (12.4), and CD4 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANGEL2 Gene

Protein tissue co-expression partners for ANGEL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGEL2 Gene:


SOURCE GeneReport for Unigene cluster for ANGEL2 Gene:


Evidence on tissue expression from TISSUES for ANGEL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ANGEL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGEL2 Gene

Orthologs for ANGEL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGEL2 34 33
  • 99.88 (n)
(Canis familiaris)
Mammalia ANGEL2 34 33
  • 93.5 (n)
(Bos Taurus)
Mammalia ANGEL2 34 33
  • 92.46 (n)
(Rattus norvegicus)
Mammalia Angel2 33
  • 84.93 (n)
(Mus musculus)
Mammalia Angel2 16 34 33
  • 84.5 (n)
(Ornithorhynchus anatinus)
Mammalia ANGEL2 34
  • 77 (a)
(Monodelphis domestica)
Mammalia ANGEL2 34
  • 77 (a)
(Gallus gallus)
Aves ANGEL2 34 33
  • 70.48 (n)
(Anolis carolinensis)
Reptilia ANGEL2 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angel2 33
  • 63.26 (n)
Str.11476 33
(Danio rerio)
Actinopterygii angel2 34 33
  • 58.83 (n)
wufl78e02 33
fruit fly
(Drosophila melanogaster)
Insecta angel 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea W02G9.5 33
  • 48 (n)
angl-1 34
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 34
  • 23 (a)
Species where no ortholog for ANGEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL2 Gene

Gene Tree for ANGEL2 (if available)
Gene Tree for ANGEL2 (if available)
Evolutionary constrained regions (ECRs) for ANGEL2: view image

Paralogs for ANGEL2 Gene

Paralogs for ANGEL2 Gene

(1) SIMAP similar genes for ANGEL2 Gene using alignment to 4 proteins:

  • B7Z5T0_HUMAN
  • F5H476_HUMAN
  • Q96AL9_HUMAN
genes like me logo Genes that share paralogs with ANGEL2: view

Variants for ANGEL2 Gene

Sequence variations from dbSNP and Humsavar for ANGEL2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000050349 -- 213,006,966(-) C/T intron_variant
rs1000051498 -- 213,003,780(-) A/G intron_variant
rs1000106157 -- 212,994,079(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000168899 -- 212,998,998(-) G/A intron_variant
rs1000313010 -- 213,004,088(-) C/T intron_variant

Variation tolerance for ANGEL2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGEL2 Gene

Disorders for ANGEL2 Gene

Additional Disease Information for ANGEL2

No disorders were found for ANGEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL2 Gene

Publications for ANGEL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L … Quigley JG (Gene 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ANGEL2 Gene

Sources for ANGEL2 Gene

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