Aliases for ANGEL1 Gene

Aliases for ANGEL1 Gene

  • Angel Homolog 1 2 3 5
  • Protein Angel Homolog 1 3 4
  • KIAA0759 3 4
  • Angel Homolog 1 (Drosophila) 2
  • Ccr4e 3

External Ids for ANGEL1 Gene

Previous HGNC Symbols for ANGEL1 Gene

  • KIAA0759

Previous GeneCards Identifiers for ANGEL1 Gene

  • GC14M076324
  • GC14M077255
  • GC14M057422

Summaries for ANGEL1 Gene

GeneCards Summary for ANGEL1 Gene

ANGEL1 (Angel Homolog 1) is a Protein Coding gene. An important paralog of this gene is ANGEL2.

Additional gene information for ANGEL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGEL1 Gene

Genomics for ANGEL1 Gene

GeneHancer (GH) Regulatory Elements for ANGEL1 Gene

Promoters and enhancers for ANGEL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J076810 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 764.6 +16.4 16407 3.7 ZNF24 SP1 ZBTB40 CTCF SREBF1 MLX RBPJ POLR2A USF2 CREB1 ANGEL1 GPATCH2L ALKBH1 ENSG00000259081 VASH1-AS1 VIPAS39 SNW1 RPL22P2 ZMYND19P1 RPL21P10
GH14J076827 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 767.9 -0.9 -907 3.4 NR2F6 CEBPG ZNF644 CEBPA SOX13 RXRB SAP130 POLR2A ZBTB25 FOXP1 ANGEL1 ENSG00000259081 LRRC74A AB372638
GH14J076863 Promoter/Enhancer 0.9 EPDnew ENCODE 750.3 -35.7 -35655 1.8 MYC MAX ZNF687 IKZF1 ZIC2 RXRA IKZF2 DPF2 EED RUNX3 ANGEL1 VASH1 AB372638 LRRC74A
GH14J077074 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -248.2 -248192 4 FOXA1 RAD21 SP1 ZNF148 RXRA FOXA2 CEBPB CHD2 RCOR1 JUND LINC02289 TMEM63C CIPC LRRC74A ANGEL1 LINC02288 ENSG00000258473 ENSG00000287004
GH14J076760 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.3 +65.4 65372 5.8 L3MBTL2 MNT POLR2A IKZF1 GLIS2 ZIC2 ZBTB8A BACH1 NRF1 LEF1 VASH1 ENSG00000258569 ANGEL1 ENSG00000258610
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGEL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGEL1 gene promoter:
  • aMEF-2
  • c-Myb
  • COUP
  • COUP-TF
  • COUP-TF1
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • Olf-1
  • YY1

Genomic Locations for ANGEL1 Gene

Genomic Locations for ANGEL1 Gene
chr14:76,786,178-76,828,473
(GRCh38/hg38)
Size:
42,296 bases
Orientation:
Minus strand
chr14:77,253,586-77,292,589
(GRCh37/hg19)
Size:
39,004 bases
Orientation:
Minus strand

Genomic View for ANGEL1 Gene

Genes around ANGEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL1 Gene

Proteins for ANGEL1 Gene

  • Protein details for ANGEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNK9-ANGE1_HUMAN
    Recommended name:
    Protein angel homolog 1
    Protein Accession:
    Q9UNK9
    Secondary Accessions:
    • B4DWL7
    • O94859
    • Q8NCS9

    Protein attributes for ANGEL1 Gene

    Size:
    670 amino acids
    Molecular mass:
    75276 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANGEL1 Gene

Post-translational modifications for ANGEL1 Gene

  • Ubiquitination at Lys29, Lys416, Lys460, and Lys475
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGEL1 Gene

No data available for DME Specific Peptides for ANGEL1 Gene

Domains & Families for ANGEL1 Gene

Gene Families for ANGEL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ANGEL1 Gene

Suggested Antigen Peptide Sequences for ANGEL1 Gene

GenScript: Design optimal peptide antigens:
  • Protein angel homolog 1 (ANGE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UNK9

UniProtKB/Swiss-Prot:

ANGE1_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL1: view

Function for ANGEL1 Gene

Phenotypes From GWAS Catalog for ANGEL1 Gene

Gene Ontology (GO) - Molecular Function for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IBA 21873635
GO:0008190 eukaryotic initiation factor 4E binding IDA 23814182
GO:0019904 protein domain specific binding IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view
genes like me logo Genes that share phenotypes with ANGEL1: view

Animal Models for ANGEL1 Gene

MGI Knock Outs for ANGEL1:
  • Angel1 Angel1<tm1(NCOM)Cmhd>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGEL1 Gene

Localization for ANGEL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGEL1 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 4
golgi apparatus 4
extracellular 2
plasma membrane 0
mitochondrion 0
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23814182
GO:0005783 endoplasmic reticulum IDA 23814182
GO:0005801 cis-Golgi network IDA 23814182
GO:0005829 cytosol IDA 23814182
GO:0048471 perinuclear region of cytoplasm IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL1 Gene

Pathways & Interactions for ANGEL1 Gene

PathCards logo

SuperPathways for ANGEL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Pathways by source and SIGNOR curated interactions for ANGEL1 Gene

Drugs & Compounds for ANGEL1 Gene

No Compound Related Data Available

Transcripts for ANGEL1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2:
SP3: - - - - - - -
SP4:

Relevant External Links for ANGEL1 Gene

GeneLoc Exon Structure for
ANGEL1
ECgene alternative splicing isoforms for
ANGEL1

Expression for ANGEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGEL1 Gene

Protein differential expression in normal tissues from HIPED for ANGEL1 Gene

This gene is overexpressed in Lung (40.7) and Testis (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANGEL1 Gene



Protein tissue co-expression partners for ANGEL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGEL1 Gene:

ANGEL1

SOURCE GeneReport for Unigene cluster for ANGEL1 Gene:

Hs.497448

Evidence on tissue expression from TISSUES for ANGEL1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ANGEL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGEL1 Gene

Orthologs for ANGEL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGEL1 33 32
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANGEL1 33 32
  • 91.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANGEL1 33 32
  • 89.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Angel1 17 33 32
  • 89.46 (n)
rat
(Rattus norvegicus)
Mammalia Angel1 32
  • 89.46 (n)
oppossum
(Monodelphis domestica)
Mammalia ANGEL1 33
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGEL1 33
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGEL1 33 32
  • 66.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGEL1 33
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angel1 32
  • 56.74 (n)
zebrafish
(Danio rerio)
Actinopterygii ANGEL1 (2 of 2) 33
  • 49 (a)
OneToMany
angel1 33
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta angel 33 32
  • 50.42 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011401 32
  • 48.39 (n)
worm
(Caenorhabditis elegans)
Secernentea angl-1 33
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 33
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 33
  • 21 (a)
OneToMany
Species where no ortholog for ANGEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL1 Gene

ENSEMBL:
Gene Tree for ANGEL1 (if available)
TreeFam:
Gene Tree for ANGEL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANGEL1: view image

Paralogs for ANGEL1 Gene

Paralogs for ANGEL1 Gene

(1) SIMAP similar genes for ANGEL1 Gene using alignment to 5 proteins:

  • ANGE1_HUMAN
  • G3V414_HUMAN
  • G3V437_HUMAN
  • G3V5C4_HUMAN
  • L8E9T2_HUMAN
genes like me logo Genes that share paralogs with ANGEL1: view

Variants for ANGEL1 Gene

Sequence variations from dbSNP and Humsavar for ANGEL1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000207153 -- 76,789,928(-) G/A intron_variant
rs1000348240 -- 76,813,946(-) C/T upstream_transcript_variant
rs1000466767 -- 76,796,050(-) A/G/T intron_variant
rs1000690432 -- 76,802,379(-) T/C intron_variant
rs1000997428 -- 76,802,638(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGEL1 Gene

Variant ID Type Subtype PubMed ID
esv3551798 CNV deletion 23714750
nsv952869 CNV deletion 24416366

Variation tolerance for ANGEL1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGEL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGEL1 Gene

Disorders for ANGEL1 Gene

Additional Disease Information for ANGEL1

No disorders were found for ANGEL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL1 Gene

Publications for ANGEL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 56
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L … Quigley JG (Gene 2002) 2 3 56
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 56

Products for ANGEL1 Gene

Sources for ANGEL1 Gene