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Aliases for ANGEL1 Gene

Aliases for ANGEL1 Gene

  • Angel Homolog 1 2 3 5
  • KIAA0759 3 4
  • Angel Homolog 1 (Drosophila) 2
  • Protein Angel Homolog 1 3
  • Ccr4e 3

External Ids for ANGEL1 Gene

Previous HGNC Symbols for ANGEL1 Gene

  • KIAA0759

Previous GeneCards Identifiers for ANGEL1 Gene

  • GC14M076324
  • GC14M077255
  • GC14M057422

Summaries for ANGEL1 Gene

GeneCards Summary for ANGEL1 Gene

ANGEL1 (Angel Homolog 1) is a Protein Coding gene. Diseases associated with ANGEL1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 1. An important paralog of this gene is ANGEL2.

Additional gene information for ANGEL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL1 Gene

Genomics for ANGEL1 Gene

GeneHancer (GH) Regulatory Elements for ANGEL1 Gene

Promoters and enhancers for ANGEL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J076810 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 664.6 +16.2 16228 3.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 CBX5 ANGEL1 ALKBH1 SNW1 RPL22P2 ZMYND19P1 RPL21P10 GPATCH2L ENSG00000259081 VASH1-AS1 LRRC74A
GH14J076863 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.3 -35.6 -35640 1.8 ZNF687 RXRA NR2F1 MAX DPF2 ZIC2 NR2F2 GABPA IKZF1 EED GC14M076862 ANGEL1 VASH1 GC14P076854 RPL22P2 LRRC74A
GH14J076827 Enhancer 0.9 Ensembl ENCODE 668 -1.0 -995 3.3 ELF3 SOX13 TFAP4 SAP130 ZFP64 ARID4B CEBPG ZNF644 THRB POLR2A ANGEL1 ENSG00000259081 LRRC74A GC14P076854
GH14J076715 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11 +112.6 112569 1.8 NFATC3 TEAD4 TAL1 FOSL1 TCF12 POLR2A NCOR1 EGR1 VEZF1 CBFA2T2 VASH1 ANGEL1 LRRC74A ENSG00000259124 LOC105370577 LOC100130048 ENSG00000258569
GH14J077074 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.5 -248.2 -248192 4 CTCF FOXA2 TAF1 MAX RAD21 YY1 POLR2A EGR1 HNF4G RCOR1 LINC02289 TMEM63C CIPC LRRC74A ANGEL1 LINC02288 ENSG00000258473 GC14P077053
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGEL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGEL1 gene promoter:
  • Olf-1
  • c-Myb
  • YY1
  • CUTL1
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • aMEF-2

Genomic Locations for ANGEL1 Gene

Genomic Locations for ANGEL1 Gene
42,296 bases
Minus strand
39,004 bases
Minus strand

Genomic View for ANGEL1 Gene

Genes around ANGEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL1 Gene

Proteins for ANGEL1 Gene

  • Protein details for ANGEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DWL7
    • O94859
    • Q8NCS9

    Protein attributes for ANGEL1 Gene

    670 amino acids
    Molecular mass:
    75276 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANGEL1 Gene

Post-translational modifications for ANGEL1 Gene

  • Ubiquitination at Lys475, Lys460, posLast=416416, and posLast=2929
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGEL1 Gene

Antibody Products

  • Boster Bio Antibodies for ANGEL1

No data available for DME Specific Peptides for ANGEL1 Gene

Domains & Families for ANGEL1 Gene

Gene Families for ANGEL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ANGEL1 Gene

Suggested Antigen Peptide Sequences for ANGEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL1: view

Function for ANGEL1 Gene

Phenotypes From GWAS Catalog for ANGEL1 Gene

Gene Ontology (GO) - Molecular Function for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008190 eukaryotic initiation factor 4E binding IDA 23814182
GO:0019904 protein domain specific binding IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view
genes like me logo Genes that share phenotypes with ANGEL1: view

Animal Models for ANGEL1 Gene

MGI Knock Outs for ANGEL1:
  • Angel1 Angel1<tm1(NCOM)Cmhd>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGEL1 Gene

Localization for ANGEL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGEL1 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23814182
GO:0005783 endoplasmic reticulum IDA 23814182
GO:0005801 cis-Golgi network IDA 23814182
GO:0005829 cytosol IDA 23814182
GO:0048471 perinuclear region of cytoplasm IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL1 Gene

Pathways & Interactions for ANGEL1 Gene

SuperPathways for ANGEL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGEL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANGEL1 Gene

Drugs & Compounds for ANGEL1 Gene

No Compound Related Data Available

Transcripts for ANGEL1 Gene

mRNA/cDNA for ANGEL1 Gene

Unigene Clusters for ANGEL1 Gene

Angel homolog 1 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP3: - - - - - - -

Relevant External Links for ANGEL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGEL1 Gene

Protein differential expression in normal tissues from HIPED for ANGEL1 Gene

This gene is overexpressed in Lung (40.7) and Testis (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANGEL1 Gene

Protein tissue co-expression partners for ANGEL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGEL1 Gene:


SOURCE GeneReport for Unigene cluster for ANGEL1 Gene:


Evidence on tissue expression from TISSUES for ANGEL1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ANGEL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGEL1 Gene

Orthologs for ANGEL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGEL1 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia ANGEL1 34 33
  • 91.02 (n)
(Bos Taurus)
Mammalia ANGEL1 34 33
  • 89.81 (n)
(Mus musculus)
Mammalia Angel1 16 34 33
  • 89.46 (n)
(Rattus norvegicus)
Mammalia Angel1 33
  • 89.46 (n)
(Monodelphis domestica)
Mammalia ANGEL1 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANGEL1 34
  • 67 (a)
(Gallus gallus)
Aves ANGEL1 34 33
  • 66.1 (n)
(Anolis carolinensis)
Reptilia ANGEL1 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angel1 33
  • 56.74 (n)
(Danio rerio)
Actinopterygii ANGEL1 (2 of 2) 34
  • 49 (a)
angel1 34
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta angel 34 33
  • 50.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011401 33
  • 48.39 (n)
(Caenorhabditis elegans)
Secernentea angl-1 34
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 34
  • 21 (a)
Species where no ortholog for ANGEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL1 Gene

Gene Tree for ANGEL1 (if available)
Gene Tree for ANGEL1 (if available)
Evolutionary constrained regions (ECRs) for ANGEL1: view image

Paralogs for ANGEL1 Gene

Paralogs for ANGEL1 Gene

(1) SIMAP similar genes for ANGEL1 Gene using alignment to 5 proteins:

  • G3V414_HUMAN
  • G3V437_HUMAN
  • G3V5C4_HUMAN
  • L8E9T2_HUMAN
genes like me logo Genes that share paralogs with ANGEL1: view

Variants for ANGEL1 Gene

Sequence variations from dbSNP and Humsavar for ANGEL1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000207153 -- 76,789,928(-) G/A intron_variant
rs1000348240 -- 76,813,946(-) C/T upstream_transcript_variant
rs1000466767 -- 76,796,050(-) A/T intron_variant
rs1000690432 -- 76,802,379(-) T/C intron_variant
rs1000997428 -- 76,802,638(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGEL1 Gene

Variant ID Type Subtype PubMed ID
esv3551798 CNV deletion 23714750
nsv952869 CNV deletion 24416366

Variation tolerance for ANGEL1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGEL1 Gene

Disorders for ANGEL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANGEL1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANGEL1

genes like me logo Genes that share disorders with ANGEL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGEL1 Gene

Publications for ANGEL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L … Quigley JG (Gene 2002) 2 3 58
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ANGEL1 Gene

Sources for ANGEL1 Gene

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