Aliases for ANGEL1 Gene

Aliases for ANGEL1 Gene

  • Angel Homolog 1 2 3 5
  • Protein Angel Homolog 1 3 4
  • KIAA0759 3 4
  • Ccr4e 2 3
  • Angel Homolog 1 (Drosophila) 2
  • ANGEL1 5

External Ids for ANGEL1 Gene

Previous HGNC Symbols for ANGEL1 Gene

  • KIAA0759

Previous GeneCards Identifiers for ANGEL1 Gene

  • GC14M076324
  • GC14M077255
  • GC14M057422

Summaries for ANGEL1 Gene

GeneCards Summary for ANGEL1 Gene

ANGEL1 (Angel Homolog 1) is a Protein Coding gene. Diseases associated with ANGEL1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 9. An important paralog of this gene is ANGEL2.

Additional gene information for ANGEL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANGEL1 Gene

Genomics for ANGEL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANGEL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J076810 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 614.6 +14.2 14180 3.7 SP1 CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 REST TFE3 RFX1 ANGEL1 VIPAS39 GPATCH2L SNW1 IRF2BPL ALKBH1 RPL22P2 ZMYND19P1 ENSG00000259081 VASH1-AS1
GH14J076863 Promoter/Enhancer 1 EPDnew ENCODE 600.3 -37.9 -37882 1.8 ZIC2 IKZF2 EED DPF2 RUNX3 TCF12 NR2F2 IKZF1 NR2F1 SPI1 ANGEL1 VASH1 AB372638 LRRC74A LOC107984638
GH14J076826 Promoter 0.4 EPDnew 600.7 -0.2 -171 0.1 KLF1 ANGEL1 LRRC74A AB372638 LOC107984638
GH14J076827 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 17.9 -3.1 -3134 3.4 SOX13 RXRB CEBPA ZBTB25 FOXP1 SAP130 POLR2A ZGPAT CEBPB SMAD4 ANGEL1 ENSG00000259081 LRRC74A AB372638 LOC107984638
GH14J077074 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -250.4 -250419 4 REST GABPA SP1 FOXA2 NR3C1 CEBPB CHD2 ATF3 RCOR1 YY1 LINC02289 TMEM63C CIPC ANGEL1 LRRC74A LINC02288 ENSG00000258473 ENSG00000287004 LOC105370579
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGEL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANGEL1

Top Transcription factor binding sites by QIAGEN in the ANGEL1 gene promoter:
  • aMEF-2
  • c-Myb
  • COUP
  • COUP-TF1
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • Olf-1
  • YY1

Genomic Locations for ANGEL1 Gene

Genomic Locations for ANGEL1 Gene
40,238 bases
Minus strand
39,004 bases
Minus strand

Genomic View for ANGEL1 Gene

Genes around ANGEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL1 Gene

Proteins for ANGEL1 Gene

  • Protein details for ANGEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DWL7
    • O94859
    • Q8NCS9

    Protein attributes for ANGEL1 Gene

    670 amino acids
    Molecular mass:
    75276 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANGEL1 Gene

Post-translational modifications for ANGEL1 Gene

  • Ubiquitination at Lys29, Lys416, Lys460, and Lys475
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGEL1 Gene

No data available for DME Specific Peptides for ANGEL1 Gene

Domains & Families for ANGEL1 Gene

Gene Families for ANGEL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANGEL1 Gene

Suggested Antigen Peptide Sequences for ANGEL1 Gene

GenScript: Design optimal peptide antigens:
  • Protein angel homolog 1 (ANGE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL1: view

Function for ANGEL1 Gene

Phenotypes From GWAS Catalog for ANGEL1 Gene

Gene Ontology (GO) - Molecular Function for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IBA 21873635
GO:0008190 eukaryotic initiation factor 4E binding IDA 23814182
GO:0019904 protein domain specific binding IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view
genes like me logo Genes that share phenotypes with ANGEL1: view

Animal Models for ANGEL1 Gene

MGI Knock Outs for ANGEL1:
  • Angel1 Angel1<tm1(NCOM)Cmhd>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGEL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGEL1 Gene

Localization for ANGEL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGEL1 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 4
golgi apparatus 4
extracellular 2
plasma membrane 0
mitochondrion 0
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23814182
GO:0005783 endoplasmic reticulum IDA 23814182
GO:0005801 cis-Golgi network IDA 23814182
GO:0005829 cytosol IDA 23814182
GO:0048471 perinuclear region of cytoplasm IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL1 Gene

Pathways & Interactions for ANGEL1 Gene

PathCards logo

SuperPathways for ANGEL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Pathways by source and SIGNOR curated interactions for ANGEL1 Gene

Drugs & Compounds for ANGEL1 Gene

No Compound Related Data Available

Transcripts for ANGEL1 Gene

mRNA/cDNA for ANGEL1 Gene

8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANGEL1

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP3: - - - - - - -

Relevant External Links for ANGEL1 Gene

GeneLoc Exon Structure for

Expression for ANGEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGEL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for ANGEL1 Gene

This gene is overexpressed in Lung (40.7) and Testis (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANGEL1 Gene

Protein tissue co-expression partners for ANGEL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANGEL1

SOURCE GeneReport for Unigene cluster for ANGEL1 Gene:


Evidence on tissue expression from TISSUES for ANGEL1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ANGEL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGEL1 Gene

Orthologs for ANGEL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGEL1 30 31
  • 99.45 (n)
(Canis familiaris)
Mammalia ANGEL1 30 31
  • 91.02 (n)
(Bos Taurus)
Mammalia ANGEL1 30 31
  • 89.81 (n)
(Mus musculus)
Mammalia Angel1 30 17 31
  • 89.46 (n)
(Rattus norvegicus)
Mammalia Angel1 30
  • 89.46 (n)
(Monodelphis domestica)
Mammalia ANGEL1 31
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANGEL1 31
  • 67 (a)
(Gallus gallus)
Aves ANGEL1 30 31
  • 66.1 (n)
(Anolis carolinensis)
Reptilia ANGEL1 31
  • 59 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia angel1 30
  • 56.74 (n)
(Danio rerio)
Actinopterygii ANGEL1 (2 of 2) 31
  • 49 (a)
angel1 31
  • 37 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta angel 30 31
  • 50.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011401 30
  • 48.39 (n)
(Caenorhabditis elegans)
Secernentea angl-1 31
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 31
  • 15 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5917 31
  • 21 (a)
Species where no ortholog for ANGEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ANGEL1 Gene

Gene Tree for ANGEL1 (if available)
Gene Tree for ANGEL1 (if available)
Evolutionary constrained regions (ECRs) for ANGEL1: view image

Paralogs for ANGEL1 Gene

Paralogs for ANGEL1 Gene

(1) SIMAP similar genes for ANGEL1 Gene using alignment to 5 proteins:

  • G3V414_HUMAN
  • G3V437_HUMAN
  • G3V5C4_HUMAN
  • L8E9T2_HUMAN
genes like me logo Genes that share paralogs with ANGEL1: view

Variants for ANGEL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANGEL1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs2075773 - p.Phe515Cys
rs34270005 - p.Gly141Trp
rs45499197 - p.Val383Leu

Additional dbSNP identifiers (rs#s) for ANGEL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANGEL1 Gene

Variant ID Type Subtype PubMed ID
esv3551798 CNV deletion 23714750
nsv952869 CNV deletion 24416366

Variation tolerance for ANGEL1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGEL1 Gene

Disorders for ANGEL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANGEL1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANGEL1

genes like me logo Genes that share disorders with ANGEL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGEL1 Gene

Publications for ANGEL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L … Quigley JG (Gene 2002) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3

Products for ANGEL1 Gene

Sources for ANGEL1 Gene