This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitinat... See more...

Aliases for ANAPC7 Gene

Aliases for ANAPC7 Gene

  • Anaphase Promoting Complex Subunit 7 2 3 5
  • APC7 2 3 4
  • Anaphase-Promoting Complex Subunit 7 3 4
  • Cyclosome Subunit 7 3 4
  • ANAPC7 5

External Ids for ANAPC7 Gene

Previous GeneCards Identifiers for ANAPC7 Gene

  • GC12M9C0183
  • GC12P9H0002
  • GC12U900269
  • GC12M109274
  • GC12M109295
  • GC12M110810
  • GC12M107829

Summaries for ANAPC7 Gene

Entrez Gene Summary for ANAPC7 Gene

  • This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC7 Gene

ANAPC7 (Anaphase Promoting Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding. An important paralog of this gene is CDC27.

UniProtKB/Swiss-Prot Summary for ANAPC7 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for ANAPC7 Gene

Additional gene information for ANAPC7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANAPC7 Gene

Genomics for ANAPC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANAPC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANAPC7

Top Transcription factor binding sites by QIAGEN in the ANAPC7 gene promoter:
  • Bach1
  • GATA-1
  • GATA-6
  • Lmo2
  • LyF-1
  • RORalpha1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT1beta

Genomic Locations for ANAPC7 Gene

Genomic Locations for ANAPC7 Gene
chr12:110,372,900-110,403,730
(GRCh38/hg38)
Size:
30,831 bases
Orientation:
Minus strand
chr12:110,810,705-110,841,535
(GRCh37/hg19)
Size:
30,831 bases
Orientation:
Minus strand

Genomic View for ANAPC7 Gene

Genes around ANAPC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC7 Gene

Proteins for ANAPC7 Gene

  • Protein details for ANAPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX3-APC7_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 7
    Protein Accession:
    Q9UJX3
    Secondary Accessions:
    • Q96AC4
    • Q96GF4
    • Q9BU24
    • Q9NT16

    Protein attributes for ANAPC7 Gene

    Size:
    599 amino acids
    Molecular mass:
    66855 Da
    Quaternary structure:
    • V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:25043029, PubMed:26083744).
    SequenceCaution:
    • Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC7 Gene

    Alternative splice isoforms for ANAPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC7 Gene

Post-translational modifications for ANAPC7 Gene

  • Ubiquitination at Lys99, Lys115, Lys139, Lys193, Lys293, Lys306, Lys353, Lys364, Lys379, Lys467, Lys477, Lys482, and Lys491
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ANAPC7
  • Boster Bio Antibodies for ANAPC7
  • Santa Cruz Biotechnology (SCBT) Antibodies for ANAPC7

No data available for DME Specific Peptides for ANAPC7 Gene

Domains & Families for ANAPC7 Gene

Gene Families for ANAPC7 Gene

Protein Domains for ANAPC7 Gene

Suggested Antigen Peptide Sequences for ANAPC7 Gene

GenScript: Design optimal peptide antigens:
  • Anaphase promoting complex subunit 7 (A5D8X2_HUMAN)
  • ANAPC7 protein (A8KAQ7_HUMAN)
  • Cyclosome subunit 7 (APC7_HUMAN)
  • ANAPC7 protein (Q2M2R1_HUMAN)
  • ANAPC7 protein (Q4KMX6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJX3

UniProtKB/Swiss-Prot:

APC7_HUMAN :
  • Belongs to the APC7 family.
Family:
  • Belongs to the APC7 family.
genes like me logo Genes that share domains with ANAPC7: view

Function for ANAPC7 Gene

Molecular function for ANAPC7 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC7 Gene

Gene Ontology (GO) - Molecular Function for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019903 protein phosphatase binding IPI 21241890
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ANAPC7: view
genes like me logo Genes that share phenotypes with ANAPC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC7 Gene

Localization for ANAPC7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC7 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IBA,IDA 16364912
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC7 Gene

Pathways & Interactions for ANAPC7 Gene

PathCards logo

SuperPathways for ANAPC7 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC7: view

Pathways by source for ANAPC7 Gene

7 GeneGo (Thomson Reuters) pathways for ANAPC7 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for ANAPC7 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases

UniProtKB/Swiss-Prot Q9UJX3-APC7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0031145 anaphase-promoting complex-dependent catabolic process IBA,TAS --
genes like me logo Genes that share ontologies with ANAPC7: view

Drugs & Compounds for ANAPC7 Gene

(1) Drugs for ANAPC7 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC7 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC7: view

Drug Products

Transcripts for ANAPC7 Gene

mRNA/cDNA for ANAPC7 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC7

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - -

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ANAPC7 Gene

GeneLoc Exon Structure for
ANAPC7

Expression for ANAPC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANAPC7 Gene

Protein differential expression in normal tissues from HIPED for ANAPC7 Gene

This gene is overexpressed in Breast (23.5), Bone (22.4), and Lung (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC7 Gene



Protein tissue co-expression partners for ANAPC7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANAPC7

SOURCE GeneReport for Unigene cluster for ANAPC7 Gene:

Hs.719935

Evidence on tissue expression from TISSUES for ANAPC7 Gene

  • Skin(4.4)
  • Nervous system(3.5)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with ANAPC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC7 Gene

Orthologs for ANAPC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANAPC7 30 31
  • 99.78 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANAPC7 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC7 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANAPC7 30 31
  • 95.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANAPC7 30 31
  • 94.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Anapc7 30 17 31
  • 88.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Anapc7 30
  • 88.5 (n)
Chicken
(Gallus gallus)
Aves ANAPC7 30 31
  • 82.06 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANAPC7 31
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anapc7 30
  • 78.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii anapc7 30 31
  • 75.58 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003902 30
  • 45.4 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Apc7 30 31
  • 40.64 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G39090 30
  • 44.67 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0149900 30
  • 41.51 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToOne
Species where no ortholog for ANAPC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANAPC7 Gene

ENSEMBL:
Gene Tree for ANAPC7 (if available)
TreeFam:
Gene Tree for ANAPC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC7: view image

Paralogs for ANAPC7 Gene

Paralogs for ANAPC7 Gene

(1) SIMAP similar genes for ANAPC7 Gene using alignment to 7 proteins:

  • APC7_HUMAN
  • A5D8X2_HUMAN
  • A8KAQ7_HUMAN
  • H0YIW2_HUMAN
  • H0YIX7_HUMAN
  • Q2M2R1_HUMAN
  • Q4KMX6_HUMAN
genes like me logo Genes that share paralogs with ANAPC7: view

Variants for ANAPC7 Gene

Additional dbSNP identifiers (rs#s) for ANAPC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANAPC7 Gene

Variant ID Type Subtype PubMed ID
esv1001296 CNV deletion 20482838
nsv1044428 CNV gain 25217958
nsv1115970 CNV insertion 24896259

Variation tolerance for ANAPC7 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC7 Gene

Human Gene Mutation Database (HGMD)
ANAPC7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANAPC7 Gene

Disorders for ANAPC7 Gene

No disorders were found for ANAPC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC7 Gene

Publications for ANAPC7 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H … Kirschner MW (Science (New York, N.Y.) 1998) 3 4 23
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  4. Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. (PMID: 19091741) Han D … Kim Y (The Journal of biological chemistry 2009) 3 4
  5. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4

Products for ANAPC7 Gene

Sources for ANAPC7 Gene