ANAPC5 Gene (Protein Coding)

Anaphase Promoting Complex Subunit 5

GC12M121308
GIFtS:
38
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination ... See more...

Aliases for ANAPC5 Gene

Aliases for ANAPC5 Gene

  • Anaphase Promoting Complex Subunit 5 2 3 5
  • Anaphase-Promoting Complex Subunit 5 3 4
  • Cyclosome Subunit 5 3 4
  • APC5 3 4

External Ids for ANAPC5 Gene

Previous GeneCards Identifiers for ANAPC5 Gene

  • GC12M120611
  • GC12M121326
  • GC12M121529
  • GC12M120158
  • GC12M120208
  • GC12M121746
  • GC12M118756

Summaries for ANAPC5 Gene

Entrez Gene Summary for ANAPC5 Gene

  • This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC5 Gene

ANAPC5 (Anaphase Promoting Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot Summary for ANAPC5 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for ANAPC5 Gene

Additional gene information for ANAPC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANAPC5 Gene

Genomics for ANAPC5 Gene

GeneHancer (GH) Regulatory Elements for ANAPC5 Gene

Promoters and enhancers for ANAPC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANAPC5 gene promoter:
  • HOXA9
  • MIF-1
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ANAPC5 Gene

Genomic Locations for ANAPC5 Gene
chr12:121,308,245-121,399,896
(GRCh38/hg38)
Size:
91,652 bases
Orientation:
Minus strand
chr12:121,746,048-121,837,699
(GRCh37/hg19)
Size:
91,652 bases
Orientation:
Minus strand

Genomic View for ANAPC5 Gene

Genes around ANAPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ANAPC5 Gene

Proteins for ANAPC5 Gene

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  • Protein details for ANAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX4-APC5_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 5
    Protein Accession:
    Q9UJX4
    Secondary Accessions:
    • E9PFB2
    • Q8N4H7
    • Q9BQD4

    Protein attributes for ANAPC5 Gene

    Size:
    755 amino acids
    Molecular mass:
    85077 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

    Three dimensional structures from OCA and Proteopedia for ANAPC5 Gene

    Alternative splice isoforms for ANAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC5 Gene

Protein Expression for ANAPC5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ANAPC5 Gene

  • Ubiquitination at Lys224, Lys229, Lys238, Lys289, Lys403, and Lys669
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC5 Gene

Domains & Families for ANAPC5 Gene

Gene Families for ANAPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC5 Gene

GenScript: Design optimal peptide antigens:
  • Cyclosome subunit 5 (APC5_HUMAN)
  • cDNA FLJ55537, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5) (B4DFK4_HUMAN)
  • cDNA FLJ30217 fis, clone BRACE2001709, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5) (Q49A41_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJX4

UniProtKB/Swiss-Prot:

APC5_HUMAN :
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
  • Belongs to the APC5 family.
Domain:
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
Family:
  • Belongs to the APC5 family.
genes like me logo Genes that share domains with ANAPC5: view

Function for ANAPC5 Gene

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Molecular function for ANAPC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC5 Gene

Gene Ontology (GO) - Molecular Function for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IPI 21241890
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with ANAPC5: view
genes like me logo Genes that share phenotypes with ANAPC5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC5 Gene

Localization for ANAPC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC5 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 0
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IEA,IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC5 Gene

Pathways & Interactions for ANAPC5 Gene

PathCards logo

SuperPathways for ANAPC5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Canonical Wnt Pathway
.32
Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase
.01
Phosphorylation of the APC/C
.01
2 APC-Cdc20 mediated degradation of Nek2A
APC-Cdc20 mediated degradation of Nek2A
.80
Inactivation of APC/C via direct inhibition of the APC/C complex
.80
APC/C-Cdc20 mediated degradation of Cyclin B
.78
Mitotic Spindle Checkpoint
.77
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
.01
3 Class I MHC mediated antigen processing and presentation
Antigen processing- Ubiquitination and Proteasome degradation
.83
Class I MHC mediated antigen processing and presentation
.83
Adaptive Immune System
.45
4 Cell Cycle, Mitotic
Cell Cycle
.83
Cell Cycle, Mitotic
.83
M Phase
.60
5 Cellular Senescence (REACTOME)
Cellular Senescence
.64
Senescence-Associated Secretory Phenotype (SASP)
.56
Cellular responses to stress
.44
genes like me logo Genes that share pathways with ANAPC5: view

UniProtKB/Swiss-Prot Q9UJX4-APC5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS,IBA --
GO:0045842 positive regulation of mitotic metaphase/anaphase transition IBA 21873635
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for SIGNOR curated interactions for ANAPC5 Gene

Drugs & Compounds for ANAPC5 Gene

Products:

  1. Drug

(1) Drugs for ANAPC5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC5 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC5: view

Transcripts for ANAPC5 Gene

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mRNA/cDNA for ANAPC5 Gene

(3) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(744) Selected AceView cDNA sequences:
(22) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC5

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Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13: - - - - - - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ANAPC5 Gene

GeneLoc Exon Structure for
ANAPC5
ECgene alternative splicing isoforms for
ANAPC5

Expression for ANAPC5 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC5 Gene

mRNA expression in normal human tissues for ANAPC5 Gene
mRNA expression by BioGPS for ANAPC5 GenemRNA expression by GTEx for ANAPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC5 Gene

This gene is overexpressed in Breast (17.2), Plasma (14.0), Bone (8.3), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC5 Gene



Protein tissue co-expression partners for ANAPC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC5 Gene:

ANAPC5

SOURCE GeneReport for Unigene cluster for ANAPC5 Gene:

Hs.7101

Evidence on tissue expression from TISSUES for ANAPC5 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Eye(3)
  • Intestine(3)
  • Skin(2.9)
genes like me logo Genes that share expression patterns with ANAPC5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC5 Gene

Orthologs for ANAPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ANAPC5 33 32
  • 99.78 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ANAPC5 33 32
  • 92.89 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ANAPC5 33 32
  • 92.05 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 91 (a)
 OneToMany
-- 33
  • 82 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Anapc5 17 33 32
  • 90.05 (n)
oppossum
(Monodelphis domestica)
 Mammalia ANAPC5 33
  • 90 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Anapc5 32
  • 89.04 (n)
chicken
(Gallus gallus)
 Aves ANAPC5 33 32
  • 78.46 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ANAPC5 33
  • 83 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia anapc5 32
  • 75.64 (n)
Str.11772 32
zebrafish
(Danio rerio)
 Actinopterygii anapc5 33 32
  • 65.65 (n)
 OneToOne
wufb75a09 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4568 32
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005578 32
  • 44.2 (n)
fruit fly
(Drosophila melanogaster)
 Insecta ida 33 32
  • 40.67 (n)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G06590 32
  • 42.53 (n)
Species where no ortholog for ANAPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC5 Gene

ENSEMBL:
Gene Tree for ANAPC5 (if available)
TreeFam:
Gene Tree for ANAPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC5: view image

Paralogs for ANAPC5 Gene

No data available for Paralogs for ANAPC5 Gene

Variants for ANAPC5 Gene

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Sequence variations from dbSNP and Humsavar for ANAPC5 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_035793 A breast cancer sample p.Gln617His
rs1000019377 -- 121,317,517(-) G/A intron_variant
rs1000152768 -- 121,333,128(-) C/T intron_variant
rs1000231546 -- 121,314,286(-) C/A intron_variant
rs1000353813 -- 121,308,173(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC5 Gene

Variant ID Type Subtype PubMed ID
esv3630946 CNV loss 21293372
nsv1048801 CNV gain 25217958
nsv1054878 CNV gain 25217958
nsv521928 CNV gain 19592680
nsv560455 CNV gain 21841781

Variation tolerance for ANAPC5 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC5 Gene

Human Gene Mutation Database (HGMD)
ANAPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC5 Gene

Disorders for ANAPC5 Gene

Additional Disease Information for ANAPC5

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANAPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC5 Gene

Publications for ANAPC5 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H … Kirschner MW (Science (New York, N.Y.) 1998) 2 3 4 23 56
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4 56
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 56
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 56
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4 56

ExternalLinks

View latest publications for ANAPC5 gene in Mastermind

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