Aliases for ANAPC5 Gene
External Ids for ANAPC5 Gene
Previous GeneCards Identifiers for ANAPC5 Gene
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
GeneCards Summary for ANAPC5 Gene
ANAPC5 (Anaphase Promoting Complex Subunit 5) is a Protein Coding gene. Diseases associated with ANAPC5 include Breast Cancer and Hemolytic Uremic Syndrome, Atypical 1. Among its related pathways are Cellular Senescence (REACTOME) and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding.
UniProtKB/Swiss-Prot Summary for ANAPC5 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.