This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination ... See more...

Aliases for ANAPC5 Gene

Aliases for ANAPC5 Gene

  • Anaphase Promoting Complex Subunit 5 2 3 5
  • APC5 2 3 4
  • Anaphase-Promoting Complex Subunit 5 3 4
  • Cyclosome Subunit 5 3 4
  • ANAPC5 5

External Ids for ANAPC5 Gene

Previous GeneCards Identifiers for ANAPC5 Gene

  • GC12M120611
  • GC12M121326
  • GC12M121529
  • GC12M120158
  • GC12M120208
  • GC12M121746
  • GC12M118756

Summaries for ANAPC5 Gene

Entrez Gene Summary for ANAPC5 Gene

  • This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC5 Gene

ANAPC5 (Anaphase Promoting Complex Subunit 5) is a Protein Coding gene. Diseases associated with ANAPC5 include Breast Cancer and Brain Cancer. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot Summary for ANAPC5 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for ANAPC5 Gene

Additional gene information for ANAPC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANAPC5 Gene

Genomics for ANAPC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANAPC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANAPC5

Top Transcription factor binding sites by QIAGEN in the ANAPC5 gene promoter:
  • HOXA9
  • MIF-1
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ANAPC5 Gene

Genomic Locations for ANAPC5 Gene
chr12:121,308,245-121,399,896
(GRCh38/hg38)
Size:
91,652 bases
Orientation:
Minus strand
chr12:121,746,048-121,837,699
(GRCh37/hg19)
Size:
91,652 bases
Orientation:
Minus strand

Genomic View for ANAPC5 Gene

Genes around ANAPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC5 Gene

Proteins for ANAPC5 Gene

  • Protein details for ANAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX4-APC5_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 5
    Protein Accession:
    Q9UJX4
    Secondary Accessions:
    • E9PFB2
    • Q8N4H7
    • Q9BQD4

    Protein attributes for ANAPC5 Gene

    Size:
    755 amino acids
    Molecular mass:
    85077 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

    Three dimensional structures from OCA and Proteopedia for ANAPC5 Gene

    Alternative splice isoforms for ANAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC5 Gene

Post-translational modifications for ANAPC5 Gene

  • Ubiquitination at Lys224, Lys229, Lys238, Lys289, Lys403, and Lys669
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANAPC5 Gene

Domains & Families for ANAPC5 Gene

Gene Families for ANAPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC5 Gene

Suggested Antigen Peptide Sequences for ANAPC5 Gene

GenScript: Design optimal peptide antigens:
  • Cyclosome subunit 5 (APC5_HUMAN)
  • cDNA FLJ55537, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5) (B4DFK4_HUMAN)
  • cDNA FLJ30217 fis, clone BRACE2001709, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5) (Q49A41_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJX4

UniProtKB/Swiss-Prot:

APC5_HUMAN :
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
  • Belongs to the APC5 family.
Domain:
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
Family:
  • Belongs to the APC5 family.
genes like me logo Genes that share domains with ANAPC5: view

Function for ANAPC5 Gene

Molecular function for ANAPC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC5 Gene

Gene Ontology (GO) - Molecular Function for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019903 protein phosphatase binding IPI 21241890
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ANAPC5: view
genes like me logo Genes that share phenotypes with ANAPC5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC5 Gene

Localization for ANAPC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC5 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IEA,IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC5 Gene

Pathways & Interactions for ANAPC5 Gene

PathCards logo

SuperPathways for ANAPC5 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC5: view

Pathways by source for ANAPC5 Gene

7 GeneGo (Thomson Reuters) pathways for ANAPC5 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for ANAPC5 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases

UniProtKB/Swiss-Prot Q9UJX4-APC5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process IBA,TAS --
GO:0045842 positive regulation of mitotic metaphase/anaphase transition IBA 21873635
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for SIGNOR curated interactions for ANAPC5 Gene

Drugs & Compounds for ANAPC5 Gene

(1) Drugs for ANAPC5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC5 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC5: view

Drug Products

Transcripts for ANAPC5 Gene

mRNA/cDNA for ANAPC5 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13: - - - - - - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ANAPC5 Gene

GeneLoc Exon Structure for
ANAPC5

Expression for ANAPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANAPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC5 Gene

This gene is overexpressed in Breast (17.2), Plasma (14.0), Bone (8.3), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC5 Gene



Protein tissue co-expression partners for ANAPC5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANAPC5

SOURCE GeneReport for Unigene cluster for ANAPC5 Gene:

Hs.7101

Evidence on tissue expression from TISSUES for ANAPC5 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Skin(3.5)
  • Intestine(3.3)
  • Eye(3.2)
  • Kidney(2.3)
  • Bone marrow(2.2)
  • Lymph node(2.2)
  • Liver(2.1)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Muscle(2)
  • Blood(2)
genes like me logo Genes that share expression patterns with ANAPC5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC5 Gene

Orthologs for ANAPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANAPC5 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ANAPC5 30 31
  • 92.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANAPC5 30 31
  • 92.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Anapc5 30 17 31
  • 90.05 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANAPC5 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Anapc5 30
  • 89.04 (n)
Chicken
(Gallus gallus)
Aves ANAPC5 30 31
  • 78.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANAPC5 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anapc5 30
  • 75.64 (n)
Str.11772 30
Zebrafish
(Danio rerio)
Actinopterygii anapc5 30 31
  • 65.65 (n)
OneToOne
wufb75a09 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4568 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005578 30
  • 44.2 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta ida 30 31
  • 40.67 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G06590 30
  • 42.53 (n)
Species where no ortholog for ANAPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANAPC5 Gene

ENSEMBL:
Gene Tree for ANAPC5 (if available)
TreeFam:
Gene Tree for ANAPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC5: view image

Paralogs for ANAPC5 Gene

No data available for Paralogs for ANAPC5 Gene

Variants for ANAPC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANAPC5 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_035793 A breast cancer sample p.Gln617His

Additional dbSNP identifiers (rs#s) for ANAPC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANAPC5 Gene

Variant ID Type Subtype PubMed ID
esv3630946 CNV loss 21293372
nsv1048801 CNV gain 25217958
nsv1054878 CNV gain 25217958
nsv521928 CNV gain 19592680
nsv560455 CNV gain 21841781

Variation tolerance for ANAPC5 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC5 Gene

Human Gene Mutation Database (HGMD)
ANAPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC5 Gene

Disorders for ANAPC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ANAPC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ANAPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANAPC5 Gene

Publications for ANAPC5 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H … Kirschner MW (Science (New York, N.Y.) 1998) 2 3 4 23
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4

Products for ANAPC5 Gene