Aliases for ANAPC4 Gene
External Ids for ANAPC4 Gene
Previous GeneCards Identifiers for ANAPC4 Gene
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ANAPC4 Gene
ANAPC4 (Anaphase Promoting Complex Subunit 4) is a Protein Coding gene. Diseases associated with ANAPC4 include Joubert Syndrome 31 and Brugada Syndrome 9. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and protein phosphatase binding.
UniProtKB/Swiss-Prot Summary for ANAPC4 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.