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Aliases for ANAPC2 Gene

Aliases for ANAPC2 Gene

  • Anaphase Promoting Complex Subunit 2 2 3 5
  • Cyclosome Subunit 2 3 4
  • APC2 3 4
  • Anaphase-Promoting Complex Subunit 2 3
  • KIAA1406 4

External Ids for ANAPC2 Gene

Previous GeneCards Identifiers for ANAPC2 Gene

  • GC09M131759
  • GC09M133510
  • GC09M135426
  • GC09M137345
  • GC09M139189
  • GC09M140069
  • GC09M109530

Summaries for ANAPC2 Gene

Entrez Gene Summary for ANAPC2 Gene

  • A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANAPC2 Gene

ANAPC2 (Anaphase Promoting Complex Subunit 2) is a Protein Coding gene. Among its related pathways are PAK Pathway and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for ANAPC2 Gene

  • Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Gene Wiki entry for ANAPC2 Gene

Additional gene information for ANAPC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC2 Gene

Genomics for ANAPC2 Gene

GeneHancer (GH) Regulatory Elements for ANAPC2 Gene

Promoters and enhancers for ANAPC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I137187 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.3 -1.0 -1026 4.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ANAPC2 SSNA1 PIR44674 LOC651337 DPH7 EHMT1 TPRN PIR49240
GH09I137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 51 -49.7 -49701 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 SDCCAG3 ANAPC2 NDOR1 DPH7 INPP5E LOC651337 MAN1B1 SNHG7
GH09I137610 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 33.7 -427.0 -426959 10.5 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 POLR2B EHMT1 ANAPC2 DPH7 SNHG7 LOC651337 EXD3 MAN1B1 ZMYND19 ARRDC1-AS1 ARRDC1
GH09I136563 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 40 +620.1 620063 10.7 HDGF CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A YBX1 ZBTB7B IRF4 EXD3 INPP5E ANAPC2 QSOX2 SNHG7 SNAPC4 SDCCAG3 MAN1B1 SEC16A NOTCH1
GH09I136725 Promoter/Enhancer 1.6 Ensembl ENCODE 36.7 +461.2 461157 4.1 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 SNHG7 GC09M136753 GC09M136755 GC09M136756 SNORA17B SNORA17A ENSG00000281808 DPH7 EHMT1 ANAPC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANAPC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANAPC2 gene promoter:

Genomic Locations for ANAPC2 Gene

Genomic Locations for ANAPC2 Gene
chr9:137,174,784-137,188,605
(GRCh38/hg38)
Size:
13,822 bases
Orientation:
Minus strand
chr9:140,069,236-140,083,057
(GRCh37/hg19)

Genomic View for ANAPC2 Gene

Genes around ANAPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC2 Gene

Proteins for ANAPC2 Gene

  • Protein details for ANAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX6-ANC2_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 2
    Protein Accession:
    Q9UJX6
    Secondary Accessions:
    • Q5VSG1
    • Q96DG5
    • Q96GG4
    • Q9P2E1

    Protein attributes for ANAPC2 Gene

    Size:
    822 amino acids
    Molecular mass:
    93828 Da
    Quaternary structure:
    • Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa (PubMed:25043029). In the context of the APC/C complex, directly interacts with UBE2C and UBE2S (PubMed:27259151). Interacts (via cullin domain) with ANAPC11 and with UBCH10 (PubMed:11739784). Interacts with NEUROD2 (By similarity).
    SequenceCaution:
    • Sequence=AAH09487.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC2 Gene

    Alternative splice isoforms for ANAPC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC2 Gene

Post-translational modifications for ANAPC2 Gene

  • Ubiquitination at posLast=134134, posLast=190190, and posLast=228228

Other Protein References for ANAPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC2 Gene

Domains & Families for ANAPC2 Gene

Gene Families for ANAPC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ANAPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX6

UniProtKB/Swiss-Prot:

ANC2_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with ANAPC2: view

Function for ANAPC2 Gene

Molecular function for ANAPC2 Gene

UniProtKB/Swiss-Prot Function:
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Phenotypes From GWAS Catalog for ANAPC2 Gene

Gene Ontology (GO) - Molecular Function for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23708001
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ANAPC2: view
genes like me logo Genes that share phenotypes with ANAPC2: view

Animal Models for ANAPC2 Gene

MGI Knock Outs for ANAPC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC2 Gene

Localization for ANAPC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC2 Gene

Pathways & Interactions for ANAPC2 Gene

SuperPathways for ANAPC2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC2: view

UniProtKB/Swiss-Prot Q9UJX6-ANC2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0007399 nervous system development IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANAPC2: view

Drugs & Compounds for ANAPC2 Gene

No Compound Related Data Available

Transcripts for ANAPC2 Gene

Unigene Clusters for ANAPC2 Gene

Anaphase promoting complex subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
SP1: - -
SP2: - -
SP3:
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ANAPC2 Gene

GeneLoc Exon Structure for
ANAPC2
ECgene alternative splicing isoforms for
ANAPC2

Expression for ANAPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC2 Gene

This gene is overexpressed in Bone (50.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANAPC2 Gene:

ANAPC2

SOURCE GeneReport for Unigene cluster for ANAPC2 Gene:

Hs.533262

Evidence on tissue expression from TISSUES for ANAPC2 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with ANAPC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC2 Gene

Orthologs for ANAPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC2 33 34
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANAPC2 33
  • 89.45 (n)
rat
(Rattus norvegicus)
Mammalia Anapc2 33
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Anapc2 33 16 34
  • 85.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC2 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC2 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC2 33 34
  • 75.93 (n)
lizard
(Anolis carolinensis)
Reptilia ANAPC2 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc2 33
  • 69.08 (n)
Str.15442 33
zebrafish
(Danio rerio)
Actinopterygii anapc2 33 34
  • 61.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta mr 33 34
  • 50.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005048 33
  • 50.69 (n)
worm
(Caenorhabditis elegans)
Secernentea apc-2 34
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC2 34 36
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons APC2 33
  • 48.19 (n)
rice
(Oryza sativa)
Liliopsida Os04g0484800 33
  • 48.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToOne
Species where no ortholog for ANAPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC2 Gene

ENSEMBL:
Gene Tree for ANAPC2 (if available)
TreeFam:
Gene Tree for ANAPC2 (if available)

Paralogs for ANAPC2 Gene

No data available for Paralogs for ANAPC2 Gene

Variants for ANAPC2 Gene

Sequence variations from dbSNP and Humsavar for ANAPC2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000143800 -- 137,182,079(-) C/T intron_variant
rs1000219495 -- 137,185,489(-) C/T intron_variant
rs1000250402 -- 137,185,697(-) T/C intron_variant
rs1000254588 -- 137,175,320(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000352600 -- 137,183,401(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC2 Gene

Variant ID Type Subtype PubMed ID
nsv951207 CNV deletion 24416366
nsv616007 CNV loss 21841781
nsv524322 CNV loss 19592680
nsv1161918 CNV duplication 26073780
esv2761561 CNV gain 21179565
esv2422220 CNV deletion 17116639
dgv13009n54 CNV loss 21841781

Variation tolerance for ANAPC2 Gene

Residual Variation Intolerance Score: 6.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC2 Gene

Disorders for ANAPC2 Gene

Additional Disease Information for ANAPC2

No disorders were found for ANAPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC2 Gene

Publications for ANAPC2 Gene

  1. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PMID: 11739784) Tang Z … Yu H (Molecular biology of the cell 2001) 2 3 4 58
  2. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H … Kirschner MW (Science (New York, N.Y.) 1998) 3 4 22 58
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 58
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58

Products for ANAPC2 Gene

Sources for ANAPC2 Gene

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