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Aliases for ANAPC16 Gene

Aliases for ANAPC16 Gene

  • Anaphase Promoting Complex Subunit 16 2 3 5
  • Anaphase-Promoting Complex Subunit 16 3 4
  • Centromere Protein 27 2 3
  • Cyclosome Subunit 16 3 4
  • C10orf104 3 4
  • CENP-27 3 4
  • APC16 3 4
  • Metabolic Syndrome-Associated Protein 3
  • Chromosome 10 Open Reading Frame 104 2
  • BA570G20.3 3
  • MSAG 3

External Ids for ANAPC16 Gene

Previous HGNC Symbols for ANAPC16 Gene

  • C10orf104

Previous GeneCards Identifiers for ANAPC16 Gene

  • GC10P073975
  • GC10P067970
  • GC10P072217
  • GC10P072222
  • GC10P072218

Summaries for ANAPC16 Gene

GeneCards Summary for ANAPC16 Gene

ANAPC16 (Anaphase Promoting Complex Subunit 16) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and APC-Cdc20 mediated degradation of Nek2A.

UniProtKB/Swiss-Prot for ANAPC16 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Additional gene information for ANAPC16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC16 Gene

Genomics for ANAPC16 Gene

GeneHancer (GH) Regulatory Elements for ANAPC16 Gene

Promoters and enhancers for ANAPC16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J072212 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 609.7 +0.5 516 7.1 HDGF SP1 CC2D1A ZFX ELF3 ZKSCAN8 MNT ZNF148 POLR2A MLLT1 ANAPC16 ASCC1 DNAJB12 ECD ENSG00000272630 RPL15P14 NUDT13 FAM149B1
GH10J072221 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.4 +7.4 7401 2.4 ZNF384 CTCF ZBTB7A SP1 RAD21 IKZF1 PKNOX1 RXRA REST TRIM22 ANAPC16 ENSG00000200294 DNAJB12 ASCC1 NUDT13 FAM149B1 ENSG00000200170 GC10M072248
GH10J072270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.4 +58.8 58767 8.5 MTA3 SP1 CC2D1A ZFX CTCF ELF3 ZKSCAN8 MNT NKRF POLR2A DDIT4 DDIT4-AS1 ECD DNAJB12 ENSG00000227540 FAM149B1 DNAJC9 RPL17P50 ENSG00000272630 ASCC1
GH10J072352 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +138.3 138274 3.1 CC2D1A SP1 ZFX ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF POLR2A DNAJB12 ECD ENSG00000227540 DNAJC9 ENSG00000272599 CHST3 ANAPC16 EIF4A2P2 RPL17P50 P4HA1
GH10J073166 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +952.1 952101 2.6 SP1 CC2D1A ZFX ELF3 MNT SIX5 NKRF POLR2A MLLT1 ZNF121 ECD FAM149B1 NUDT13 VCL PLAU ANAPC16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ANAPC16 Gene

Genomic Locations for ANAPC16 Gene
chr10:72,216,000-72,235,860
(GRCh38/hg38)
Size:
19,861 bases
Orientation:
Plus strand
chr10:73,975,758-73,995,618
(GRCh37/hg19)
Size:
19,861 bases
Orientation:
Plus strand

Genomic View for ANAPC16 Gene

Genes around ANAPC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC16 Gene

Proteins for ANAPC16 Gene

  • Protein details for ANAPC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DE5-APC16_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 16
    Protein Accession:
    Q96DE5

    Protein attributes for ANAPC16 Gene

    Size:
    110 amino acids
    Molecular mass:
    11667 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11.

    Three dimensional structures from OCA and Proteopedia for ANAPC16 Gene

neXtProt entry for ANAPC16 Gene

Post-translational modifications for ANAPC16 Gene

  • Ubiquitination at posLast=6868
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC16 Gene

No data available for DME Specific Peptides for ANAPC16 Gene

Domains & Families for ANAPC16 Gene

Gene Families for ANAPC16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC16 Gene

GenScript: Design optimal peptide antigens:
  • Cyclosome subunit 16 (APC16_HUMAN)
  • Metabolic syndrome-associated protein (C5H3H2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96DE5

UniProtKB/Swiss-Prot:

APC16_HUMAN :
  • Belongs to the APC16 family.
Family:
  • Belongs to the APC16 family.
genes like me logo Genes that share domains with ANAPC16: view

Function for ANAPC16 Gene

Molecular function for ANAPC16 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC16 Gene

genes like me logo Genes that share phenotypes with ANAPC16: view

Animal Model Products

CRISPR Products

miRNA for ANAPC16 Gene

miRTarBase miRNAs that target ANAPC16

Clone Products

  • Applied Biological Materials (abm): Clones for ANAPC16 - Now 50% OFF >
  • * ANAPC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ANAPC16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC16 Gene

Localization for ANAPC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC16 Gene

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC16 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANAPC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA,IEA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 20360068
genes like me logo Genes that share ontologies with ANAPC16: view

Pathways & Interactions for ANAPC16 Gene

PathCards logo

SuperPathways for ANAPC16 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cell Cycle, Mitotic
.60
4 Cellular Senescence (REACTOME)
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC16: view

UniProtKB/Swiss-Prot Q96DE5-APC16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IDA,IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC16: view

No data available for SIGNOR curated interactions for ANAPC16 Gene

Drugs & Compounds for ANAPC16 Gene

(1) Drugs for ANAPC16 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC16 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC16: view

Drug Products

Transcripts for ANAPC16 Gene

Unigene Clusters for ANAPC16 Gene

Anaphase promoting complex subunit 16:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ANAPC16 - Now 50% OFF >
  • * ANAPC16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ANAPC16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - -
SP10:
SP11: - - - -

Relevant External Links for ANAPC16 Gene

GeneLoc Exon Structure for
ANAPC16
ECgene alternative splicing isoforms for
ANAPC16

Expression for ANAPC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.0), Pancreas (18.2), and Breast (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC16 Gene



Protein tissue co-expression partners for ANAPC16 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC16 Gene:

ANAPC16

SOURCE GeneReport for Unigene cluster for ANAPC16 Gene:

Hs.426296

Evidence on tissue expression from TISSUES for ANAPC16 Gene

  • Lung(4.6)
  • Nervous system(3.3)
  • Heart(2)
  • Liver(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ANAPC16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC16 Gene

Orthologs for ANAPC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANAPC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC16 35 34
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC16 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC16 35 34
  • 96.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC16 35 34
  • 94.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc16 34
  • 91.21 (n)
mouse
(Mus musculus)
Mammalia Anapc16 17 35 34
  • 90 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC16 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC16 35 34
  • 82.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC16 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc16 34
  • 80.8 (n)
Str.1888 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7541 34
zebrafish
(Danio rerio)
Actinopterygii anapc16 35 34
  • 75.56 (n)
OneToOne
Dr.13949 34
Species where no ortholog for ANAPC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC16 Gene

ENSEMBL:
Gene Tree for ANAPC16 (if available)
TreeFam:
Gene Tree for ANAPC16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC16: view image

Paralogs for ANAPC16 Gene

(1) SIMAP similar genes for ANAPC16 Gene using alignment to 1 proteins:

  • APC16_HUMAN
genes like me logo Genes that share paralogs with ANAPC16: view

No data available for Paralogs for ANAPC16 Gene

Variants for ANAPC16 Gene

Sequence variations from dbSNP and Humsavar for ANAPC16 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000040012 -- 72,214,339(+) T/C upstream_transcript_variant
rs1000266167 -- 72,220,050(+) C/A/T intron_variant
rs1000437428 -- 72,225,755(+) A/C intron_variant
rs1000556282 -- 72,225,474(+) T/G intron_variant
rs1000652744 -- 72,231,961(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC16 Gene

Variant ID Type Subtype PubMed ID
esv3342969 CNV insertion 20981092
nsv1134027 CNV deletion 24896259
nsv1144501 CNV deletion 24896259
nsv508592 CNV deletion 20534489

Variation tolerance for ANAPC16 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC16 Gene

Disorders for ANAPC16 Gene

Additional Disease Information for ANAPC16

No disorders were found for ANAPC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC16 Gene

Publications for ANAPC16 Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins JR … Peters JM (Science (New York, N.Y.) 2010) 2 3 4 58
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4 58
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 58

Products for ANAPC16 Gene

Sources for ANAPC16 Gene

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