Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANAPC15 Gene

Aliases for ANAPC15 Gene

  • Anaphase Promoting Complex Subunit 15 2 3 5
  • C11orf51 3 4
  • APC15 3 4
  • Anaphase-Promoting Complex Subunit 15 3
  • Chromosome 11 Open Reading Frame 51 2
  • HSPC020 3

External Ids for ANAPC15 Gene

Previous HGNC Symbols for ANAPC15 Gene

  • C11orf51

Previous GeneCards Identifiers for ANAPC15 Gene

  • GC11M071817

Summaries for ANAPC15 Gene

GeneCards Summary for ANAPC15 Gene

ANAPC15 (Anaphase Promoting Complex Subunit 15) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for ANAPC15 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.

Additional gene information for ANAPC15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC15 Gene

Genomics for ANAPC15 Gene

GeneHancer (GH) Regulatory Elements for ANAPC15 Gene

Promoters and enhancers for ANAPC15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I072110 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -245 4.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 FOLR3 ANAPC15 NUMA1 IL18BP NADSYN1 LOC100128494 FAM86C1 LRTOMT OR7E128P
GH11I072037 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11 +71.9 71931 6.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 LRTOMT NUMA1 FAM86C1 LOC100128494 LAMTOR1 ANAPC15 FOLR3 IL18BP RNF121 PHOX2A
GH11I071995 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.2 +114.3 114270 5.1 PKNOX1 ARNT TCF12 ATF7 NCOA1 REST ZNF592 MBD2 SMARCA4 ZNF184 IL18BP LRTOMT LOC100133315 RNF121 LAMTOR1 ANAPC15 FAM86C1 GC11P072002
GH11I072143 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -31.9 -31928 2.8 RB1 BATF RAD21 RFX5 SCRT2 ZNF143 FOS ATF7 RUNX3 CREM FOLR3 NUMA1 LOC100128494 IL18BP ZNF705E ANAPC15 LAMTOR1 LRTOMT PHOX2A RNF121
GH11I071962 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.1 +149.8 149836 1.6 BMI1 BATF IRF4 ATF7 IKZF2 RUNX3 CEBPB JUNB ZNF217 SP1 LOC100133315 RNF121 LOC100128494 NUMA1 LRTOMT ANAPC15 LAMTOR1 PHOX2A FAM86C1 PIR62264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANAPC15 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ANAPC15 Gene

Genomic Locations for ANAPC15 Gene
chr11:72,106,378-72,112,780
(GRCh38/hg38)
Size:
6,403 bases
Orientation:
Minus strand
chr11:71,817,424-71,823,826
(GRCh37/hg19)

Genomic View for ANAPC15 Gene

Genes around ANAPC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC15 Gene

Proteins for ANAPC15 Gene

  • Protein details for ANAPC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60006-APC15_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 15
    Protein Accession:
    P60006
    Secondary Accessions:
    • G3V1Q3
    • Q9CXK2
    • Q9Y269

    Protein attributes for ANAPC15 Gene

    Size:
    121 amino acids
    Molecular mass:
    14281 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=EAW74842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC15 Gene

    Alternative splice isoforms for ANAPC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC15 Gene

Post-translational modifications for ANAPC15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ANAPC15 Gene

Domains & Families for ANAPC15 Gene

Gene Families for ANAPC15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P60006

UniProtKB/Swiss-Prot:

APC15_HUMAN :
  • Belongs to the APC15 family.
Family:
  • Belongs to the APC15 family.
genes like me logo Genes that share domains with ANAPC15: view

No data available for Suggested Antigen Peptide Sequences for ANAPC15 Gene

Function for ANAPC15 Gene

Molecular function for ANAPC15 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
genes like me logo Genes that share phenotypes with ANAPC15: view

Animal Model Products

CRISPR Products

miRNA for ANAPC15 Gene

miRTarBase miRNAs that target ANAPC15

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC15 Gene

Localization for ANAPC15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC15 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IEA,IDA 21926987
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC15 Gene

Pathways & Interactions for ANAPC15 Gene

SuperPathways for ANAPC15 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cell Cycle, Mitotic
.60
4 Cellular Senescence (REACTOME)
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC15: view

Gene Ontology (GO) - Biological Process for ANAPC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC15: view

No data available for SIGNOR curated interactions for ANAPC15 Gene

Drugs & Compounds for ANAPC15 Gene

(1) Drugs for ANAPC15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC15 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC15: view

Drug Products

Transcripts for ANAPC15 Gene

Unigene Clusters for ANAPC15 Gene

Anaphase promoting complex subunit 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for ANAPC15 Gene

GeneLoc Exon Structure for
ANAPC15
ECgene alternative splicing isoforms for
ANAPC15

Expression for ANAPC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC15 Gene

Protein differential expression in normal tissues from HIPED for ANAPC15 Gene

This gene is overexpressed in Pancreas (46.0) and Fetal ovary (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC15 Gene



Protein tissue co-expression partners for ANAPC15 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC15 Gene:

ANAPC15

SOURCE GeneReport for Unigene cluster for ANAPC15 Gene:

Hs.38044

Evidence on tissue expression from TISSUES for ANAPC15 Gene

  • Kidney(4.3)
  • Muscle(4.3)
  • Nervous system(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with ANAPC15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC15 Gene

Orthologs for ANAPC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANAPC15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC15 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC15 33 34
  • 93.87 (n)
mouse
(Mus musculus)
Mammalia Anapc15 34
  • 92 (a)
OneToMany
Anapc15-ps 34
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ANAPC15 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC15 34
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC15 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6387 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6427 33
zebrafish
(Danio rerio)
Actinopterygii anapc15 34
  • 83 (a)
OneToOne
Dr.13292 33
Species where no ortholog for ANAPC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC15 Gene

ENSEMBL:
Gene Tree for ANAPC15 (if available)
TreeFam:
Gene Tree for ANAPC15 (if available)

Paralogs for ANAPC15 Gene

Pseudogenes.org Pseudogenes for ANAPC15 Gene

genes like me logo Genes that share paralogs with ANAPC15: view

No data available for Paralogs for ANAPC15 Gene

Variants for ANAPC15 Gene

Sequence variations from dbSNP and Humsavar for ANAPC15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1025935979 uncertain-significance, Nonsyndromic Hearing Loss, Recessive 72,108,829(-) T/G genic_downstream_transcript_variant, intron_variant
rs113912971 uncertain-significance, Nonsyndromic Hearing Loss, Recessive 72,109,802(-) T/C 3_prime_UTR_variant, intron_variant
rs116397624 uncertain-significance, Nonsyndromic Hearing Loss, Recessive 72,109,526(-) A/C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs137853185 pathogenic, Deafness, autosomal recessive 63 72,106,094(-) G/A downstream_transcript_variant
rs137853186 pathogenic, Deafness, autosomal recessive 63 72,106,165(-) T/C downstream_transcript_variant

Variation tolerance for ANAPC15 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANAPC15 Gene

Disorders for ANAPC15 Gene

Additional Disease Information for ANAPC15

No disorders were found for ANAPC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC15 Gene

Publications for ANAPC15 Gene

  1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PMID: 21926987) Mansfeld J … Pines J (Nature cell biology 2011) 2 3 4 58
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for ANAPC15 Gene

Sources for ANAPC15 Gene

Content
Loading form....