This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and spl... See more...

Aliases for ANAPC13 Gene

Aliases for ANAPC13 Gene

  • Anaphase Promoting Complex Subunit 13 2 3 5
  • APC13 2 3 4
  • Anaphase-Promoting Complex Subunit 13 3 4
  • Cyclosome Subunit 13 3 4
  • SWM1 2 3
  • DKFZP566D193 2
  • ANAPC13 5

External Ids for ANAPC13 Gene

Previous GeneCards Identifiers for ANAPC13 Gene

  • GC03M135518
  • GC03M135679
  • GC03M134196
  • GC03M131574

Summaries for ANAPC13 Gene

Entrez Gene Summary for ANAPC13 Gene

  • This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC13 Gene

ANAPC13 (Anaphase Promoting Complex Subunit 13) is a Protein Coding gene. Diseases associated with ANAPC13 include Omsk Hemorrhagic Fever and Cornea Cancer. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling.

UniProtKB/Swiss-Prot Summary for ANAPC13 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Additional gene information for ANAPC13 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANAPC13 Gene

Genomics for ANAPC13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANAPC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J134482 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 674.3 +1.5 1482 6 CEBPG SP1 CREB1 GATAD2A HNRNPL ATF7 ZNF629 PRDM10 REST TFE3 ANAPC13 CEP63 lnc-AMOTL2-4 MIR4788 AMOTL2
GH03J134460 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 68.7 +22.7 22660 7.9 RNF2 TEAD4 RFX1 SP1 POLR2A MNT JUND CEBPB BMI1 FOS ANAPC13 AMOTL2 CEP63 MIR4788
GH03J134471 Enhancer 1 Ensembl ENCODE dbSUPER 73 +11.3 11348 9.1 CTCF ZBTB33 TEAD4 ZHX2 FOXA1 PRDM1 RAD21 SP1 TRIM22 ARID3A ANAPC13 AMOTL2 RYK CEP63 lnc-AMOTL2-4 MIR4788
GH03J134496 Enhancer 1.1 ENCODE dbSUPER 65.1 -9.9 -9863 0.8 LEF1 MTA2 PKNOX1 MTA1 ZNF740 DPF2 HDAC1 SOX6 TCF12 EP300 ANAPC13 RYK SLCO2A1 CEP63 ENSG00000249691 lnc-ANAPC13-1 EPHB1
GH03J134597 Enhancer 1 FANTOM5 Ensembl ENCODE 51.7 -111.5 -111485 3.2 RFX1 ZIC2 CTBP1 FOXA2 CTCF SPI1 FOXA1 FOSL2 MAZ FOS lnc-EPHB1-1 ANAPC13 CEP63 RYK EPHB1 lnc-KY-3 KY
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANAPC13

Top Transcription factor binding sites by QIAGEN in the ANAPC13 gene promoter:
  • NF-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ANAPC13 Gene

Genomic Locations for ANAPC13 Gene
chr3:134,477,704-134,486,716
(GRCh38/hg38)
Size:
9,013 bases
Orientation:
Minus strand
chr3:134,196,546-134,205,558
(GRCh37/hg19)
Size:
9,013 bases
Orientation:
Minus strand

Genomic View for ANAPC13 Gene

Genes around ANAPC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC13 Gene

Proteins for ANAPC13 Gene

  • Protein details for ANAPC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS18-APC13_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 13
    Protein Accession:
    Q9BS18
    Secondary Accessions:
    • Q9Y3V0

    Protein attributes for ANAPC13 Gene

    Size:
    74 amino acids
    Molecular mass:
    8521 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
    SequenceCaution:
    • Sequence=CAB43251.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC13 Gene

neXtProt entry for ANAPC13 Gene

Post-translational modifications for ANAPC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANAPC13 Gene

No data available for DME Specific Peptides for ANAPC13 Gene

Domains & Families for ANAPC13 Gene

Gene Families for ANAPC13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC13 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76550, highly similar to Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), mRNA (A8K3Z6_HUMAN)
  • Cylosome subunit 13 (APC13_HUMAN)
  • Anaphase promoting complex subunit 13, isoform CRA_c (D3DND7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BS18

UniProtKB/Swiss-Prot:

APC13_HUMAN :
  • Belongs to the APC13 family.
Family:
  • Belongs to the APC13 family.
genes like me logo Genes that share domains with ANAPC13: view

Function for ANAPC13 Gene

Molecular function for ANAPC13 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC13 Gene

Gene Ontology (GO) - Molecular Function for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with ANAPC13: view
genes like me logo Genes that share phenotypes with ANAPC13: view

Animal Models for ANAPC13 Gene

MGI Knock Outs for ANAPC13:
  • Anapc13 Anapc13<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC13 Gene

Localization for ANAPC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC13 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005680 anaphase-promoting complex IBA,IDA 16364912
genes like me logo Genes that share ontologies with ANAPC13: view

Pathways & Interactions for ANAPC13 Gene

PathCards logo

SuperPathways for ANAPC13 Gene

genes like me logo Genes that share pathways with ANAPC13: view

Pathways by source for ANAPC13 Gene

7 GeneGo (Thomson Reuters) pathways for ANAPC13 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for ANAPC13 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases

UniProtKB/Swiss-Prot Q9BS18-APC13_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051301 cell division IEA --
GO:0070979 protein K11-linked ubiquitination IDA 18485873
genes like me logo Genes that share ontologies with ANAPC13: view

No data available for SIGNOR curated interactions for ANAPC13 Gene

Drugs & Compounds for ANAPC13 Gene

(1) Drugs for ANAPC13 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC13 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC13: view

Transcripts for ANAPC13 Gene

mRNA/cDNA for ANAPC13 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC13

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for ANAPC13 Gene

GeneLoc Exon Structure for
ANAPC13

Expression for ANAPC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANAPC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC13 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANAPC13

SOURCE GeneReport for Unigene cluster for ANAPC13 Gene:

Hs.106909

Evidence on tissue expression from TISSUES for ANAPC13 Gene

  • Kidney(4.4)
  • Nervous system(4.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ANAPC13: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC13 Gene

Orthologs for ANAPC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANAPC13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANAPC13 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANAPC13 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANAPC13 30 31
  • 94.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANAPC13 30 31
  • 92.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Anapc13 30 17 31
  • 86.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Anapc13 30
  • 86.04 (n)
Chicken
(Gallus gallus)
Aves ANAPC13 30
  • 78.83 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anapc13.1 30
  • 74.77 (n)
Str.10321 30
Zebrafish
(Danio rerio)
Actinopterygii anapc13 30 31
  • 72.52 (n)
OneToOne
Dr.14480 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1080 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG33981 31
  • 40 (a)
OneToOne
Species where no ortholog for ANAPC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ANAPC13 Gene

ENSEMBL:
Gene Tree for ANAPC13 (if available)
TreeFam:
Gene Tree for ANAPC13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC13: view image

Paralogs for ANAPC13 Gene

Pseudogenes.org Pseudogenes for ANAPC13 Gene

genes like me logo Genes that share paralogs with ANAPC13: view

No data available for Paralogs for ANAPC13 Gene

Variants for ANAPC13 Gene

Additional dbSNP identifiers (rs#s) for ANAPC13 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANAPC13 Gene

Variant ID Type Subtype PubMed ID
esv33705 CNV loss 17666407
nsv829730 CNV loss 17160897

Variation tolerance for ANAPC13 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANAPC13 Gene

Disorders for ANAPC13 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANAPC13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
omsk hemorrhagic fever
  • ohf
cornea cancer
  • corneal tumor
kyasanur forest disease
  • kfd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANAPC13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANAPC13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANAPC13 Gene

Publications for ANAPC13 Gene

  1. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. (PMID: 15060174) Schwickart M … Zachariae W (Molecular and cellular biology 2004) 2 3 4
  2. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 41
  5. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee JJ … Hirschhorn J (Annals of human genetics 2010) 3 41

Products for ANAPC13 Gene

  • Signalway Proteins for ANAPC13

Sources for ANAPC13 Gene