Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANAPC13 Gene

Aliases for ANAPC13 Gene

  • Anaphase Promoting Complex Subunit 13 2 3 5
  • Cyclosome Subunit 13 3 4
  • APC13 3 4
  • Anaphase-Promoting Complex Subunit 13 3
  • SWM1 3

External Ids for ANAPC13 Gene

Previous GeneCards Identifiers for ANAPC13 Gene

  • GC03M135518
  • GC03M135679
  • GC03M134196
  • GC03M131574

Summaries for ANAPC13 Gene

Entrez Gene Summary for ANAPC13 Gene

  • This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC13 Gene

ANAPC13 (Anaphase Promoting Complex Subunit 13) is a Protein Coding gene. Among its related pathways are Innate Immune System and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for ANAPC13 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Additional gene information for ANAPC13 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC13 Gene

Genomics for ANAPC13 Gene

GeneHancer (GH) Regulatory Elements for ANAPC13 Gene

Promoters and enhancers for ANAPC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I134482 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 624.4 +1.5 1482 6 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ANAPC13 CEP63 TOPBP1 RYK MIR4788
GH03I134460 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 68.7 +23.2 23190 6.8 RFX1 MAX MNT REST BMI1 NR2F2 SP1 JUND POLR2A FOS ANAPC13 AMOTL2 CEP63 MIR4788
GH03I134471 Enhancer 1.1 Ensembl ENCODE dbSUPER 67.1 +13.8 13775 3.4 CTCF MAX SIN3A RAD21 RFX5 TEAD3 GATA3 POLR2A ZNF143 SMC3 ANAPC13 RYK CEP63 MIR4788
GH03I134496 Enhancer 1.1 ENCODE dbSUPER 65.1 -9.9 -9863 0.8 PKNOX1 SMAD1 ATF1 ARNT TCF12 ZNF766 GATA2 RUNX3 CAVIN1 NCOA1 ANAPC13 RYK SLCO2A1 CEP63 LOC100421154
GH03I134492 Enhancer 0.8 Ensembl ENCODE 70.3 -5.9 -5885 0.4 CTCF ZNF654 TRIM22 RAD21 ATF2 SMC3 CREB1 ATF7 ANAPC13 CEP63 LOC100421154
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANAPC13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANAPC13 gene promoter:

Genomic Locations for ANAPC13 Gene

Genomic Locations for ANAPC13 Gene
chr3:134,477,704-134,486,716
(GRCh38/hg38)
Size:
9,013 bases
Orientation:
Minus strand
chr3:134,196,546-134,205,558
(GRCh37/hg19)

Genomic View for ANAPC13 Gene

Genes around ANAPC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC13 Gene

Proteins for ANAPC13 Gene

  • Protein details for ANAPC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS18-APC13_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 13
    Protein Accession:
    Q9BS18
    Secondary Accessions:
    • Q9Y3V0

    Protein attributes for ANAPC13 Gene

    Size:
    74 amino acids
    Molecular mass:
    8521 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=CAB43251.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC13 Gene

neXtProt entry for ANAPC13 Gene

Post-translational modifications for ANAPC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANAPC13 Gene

No data available for DME Specific Peptides for ANAPC13 Gene

Domains & Families for ANAPC13 Gene

Gene Families for ANAPC13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC13 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BS18

UniProtKB/Swiss-Prot:

APC13_HUMAN :
  • Belongs to the APC13 family.
Family:
  • Belongs to the APC13 family.
genes like me logo Genes that share domains with ANAPC13: view

Function for ANAPC13 Gene

Molecular function for ANAPC13 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC13 Gene

Gene Ontology (GO) - Molecular Function for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with ANAPC13: view
genes like me logo Genes that share phenotypes with ANAPC13: view

Animal Models for ANAPC13 Gene

MGI Knock Outs for ANAPC13:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC13 Gene

Localization for ANAPC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC13 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005680 anaphase-promoting complex IDA 16364912
genes like me logo Genes that share ontologies with ANAPC13: view

Pathways & Interactions for ANAPC13 Gene

genes like me logo Genes that share pathways with ANAPC13: view

UniProtKB/Swiss-Prot Q9BS18-APC13_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051301 cell division IEA --
GO:0070979 protein K11-linked ubiquitination IDA 18485873
genes like me logo Genes that share ontologies with ANAPC13: view

No data available for SIGNOR curated interactions for ANAPC13 Gene

Drugs & Compounds for ANAPC13 Gene

(1) Drugs for ANAPC13 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC13 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC13: view

Drug Products

Transcripts for ANAPC13 Gene

Unigene Clusters for ANAPC13 Gene

Anaphase promoting complex subunit 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for ANAPC13 Gene

GeneLoc Exon Structure for
ANAPC13
ECgene alternative splicing isoforms for
ANAPC13

Expression for ANAPC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC13 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANAPC13 Gene:

ANAPC13

SOURCE GeneReport for Unigene cluster for ANAPC13 Gene:

Hs.106909

Evidence on tissue expression from TISSUES for ANAPC13 Gene

  • Kidney(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ANAPC13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC13 Gene

Orthologs for ANAPC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANAPC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC13 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC13 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC13 33 34
  • 94.59 (n)
cow
(Bos Taurus)
Mammalia ANAPC13 33 34
  • 92.79 (n)
mouse
(Mus musculus)
Mammalia Anapc13 33 16 34
  • 86.94 (n)
rat
(Rattus norvegicus)
Mammalia Anapc13 33
  • 86.04 (n)
chicken
(Gallus gallus)
Aves ANAPC13 33
  • 78.83 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc13.1 33
  • 74.77 (n)
Str.10321 33
zebrafish
(Danio rerio)
Actinopterygii anapc13 33 34
  • 72.52 (n)
Dr.14480 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1080 33
fruit fly
(Drosophila melanogaster)
Insecta CG33981 34
  • 40 (a)
OneToOne
Species where no ortholog for ANAPC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC13 Gene

ENSEMBL:
Gene Tree for ANAPC13 (if available)
TreeFam:
Gene Tree for ANAPC13 (if available)

Paralogs for ANAPC13 Gene

Pseudogenes.org Pseudogenes for ANAPC13 Gene

genes like me logo Genes that share paralogs with ANAPC13: view

No data available for Paralogs for ANAPC13 Gene

Variants for ANAPC13 Gene

Sequence variations from dbSNP and Humsavar for ANAPC13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000813621 -- 134,483,450(-) G/ intron_variant
rs1000849571 -- 134,478,736(-) T/A intron_variant
rs1001369834 -- 134,485,301(-) A/G intron_variant
rs1002333677 -- 134,482,892(-) C/A coding_sequence_variant, missense_variant
rs1002660373 -- 134,485,998(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC13 Gene

Variant ID Type Subtype PubMed ID
esv33705 CNV loss 17666407
nsv829730 CNV loss 17160897

Variation tolerance for ANAPC13 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC13 Gene

Disorders for ANAPC13 Gene

Additional Disease Information for ANAPC13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANAPC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC13 Gene

Publications for ANAPC13 Gene

  1. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. (PMID: 15060174) Schwickart M … Zachariae W (Molecular and cellular biology 2004) 2 3 4 58
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  4. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee JJ … Hirschhorn J (Annals of human genetics 2010) 3 44 58
  5. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 58

Products for ANAPC13 Gene

Sources for ANAPC13 Gene

Content
Loading form....