Aliases for ANAPC13 Gene
External Ids for ANAPC13 Gene
Previous GeneCards Identifiers for ANAPC13 Gene
This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
GeneCards Summary for ANAPC13 Gene
ANAPC13 (Anaphase Promoting Complex Subunit 13) is a Protein Coding gene. Diseases associated with ANAPC13 include Omsk Hemorrhagic Fever and Cornea Cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions.
UniProtKB/Swiss-Prot Summary for ANAPC13 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.