Aliases for ANAPC11 Gene
External Ids for ANAPC11 Gene
Previous GeneCards Identifiers for ANAPC11 Gene
GeneCards Summary for ANAPC11 Gene
ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Diseases associated with ANAPC11 include Milker's Nodule. Among its related pathways are Cellular Senescence (REACTOME) and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.
UniProtKB/Swiss-Prot Summary for ANAPC11 Gene
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.