Aliases for ANAPC11 Gene

Aliases for ANAPC11 Gene

  • Anaphase Promoting Complex Subunit 11 2 3 5
  • Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog) 2 3
  • Hepatocellular Carcinoma-Associated RING Finger Protein 3 4
  • Anaphase-Promoting Complex Subunit 11 3 4
  • Cyclosome Subunit 11 3 4
  • APC11 3 4
  • APC11 Anaphase Promoting Complex Subunit 11 Homolog 3
  • HSPC214 3
  • Apc11p 3

External Ids for ANAPC11 Gene

Previous GeneCards Identifiers for ANAPC11 Gene

  • GC17P079341
  • GC17P9I0152
  • GC17P080384
  • GC17P077442
  • GC17P079849
  • GC17P075220

Summaries for ANAPC11 Gene

GeneCards Summary for ANAPC11 Gene

ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.

UniProtKB/Swiss-Prot Summary for ANAPC11 Gene

  • Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Wiki entry for ANAPC11 Gene

Additional gene information for ANAPC11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANAPC11 Gene

Genomics for ANAPC11 Gene

GeneHancer (GH) Regulatory Elements for ANAPC11 Gene

Promoters and enhancers for ANAPC11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANAPC11 gene promoter:
  • CUTL1

Genomic Locations for ANAPC11 Gene

Genomic Locations for ANAPC11 Gene
chr17:81,890,790-81,900,991
(GRCh38/hg38)
Size:
10,202 bases
Orientation:
Plus strand
chr17:79,848,666-79,858,867
(GRCh37/hg19)
Size:
10,202 bases
Orientation:
Plus strand

Genomic View for ANAPC11 Gene

Genes around ANAPC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC11 Gene

Proteins for ANAPC11 Gene

  • Protein details for ANAPC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG5-APC11_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 11
    Protein Accession:
    Q9NYG5
    Secondary Accessions:
    • A8MTT2
    • B7ZW64
    • Q502X9
    • Q9BW64
    • Q9P0R2

    Protein attributes for ANAPC11 Gene

    Size:
    84 amino acids
    Molecular mass:
    9841 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:10922056, PubMed:25043029). Interacts with the cullin domain of ANAPC2 (PubMed:11739784). Interacts with UBE2D2 (PubMed:11739784).
    SequenceCaution:
    • Sequence=AAF36134.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC11 Gene

    Alternative splice isoforms for ANAPC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC11 Gene

Post-translational modifications for ANAPC11 Gene

No data available for DME Specific Peptides for ANAPC11 Gene

Domains & Families for ANAPC11 Gene

Gene Families for ANAPC11 Gene

Protein Domains for ANAPC11 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC11 Gene

GenScript: Design optimal peptide antigens:
  • Hepatocellular carcinoma-associated RING finger protein (APC11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYG5

UniProtKB/Swiss-Prot:

APC11_HUMAN :
  • The RING-type zinc finger domain coordinates an additional third zinc ion.
  • Belongs to the RING-box family.
Domain:
  • The RING-type zinc finger domain coordinates an additional third zinc ion.
Family:
  • Belongs to the RING-box family.
genes like me logo Genes that share domains with ANAPC11: view

Function for ANAPC11 Gene

Molecular function for ANAPC11 Gene

UniProtKB/Swiss-Prot Function:
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Phenotypes From GWAS Catalog for ANAPC11 Gene

Gene Ontology (GO) - Molecular Function for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA,IEA 11739784
GO:0034450 ubiquitin-ubiquitin ligase activity IDA 10230407
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 10230407
GO:0097602 cullin family protein binding IDA 10230407
genes like me logo Genes that share ontologies with ANAPC11: view
genes like me logo Genes that share phenotypes with ANAPC11: view

Animal Model Products

CRISPR Products

miRNA for ANAPC11 Gene

miRTarBase miRNAs that target ANAPC11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC11 Gene

Localization for ANAPC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC11 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA,IEA 11739784
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ANAPC11: view

Pathways & Interactions for ANAPC11 Gene

PathCards logo

SuperPathways for ANAPC11 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC11: view

UniProtKB/Swiss-Prot Q9NYG5-APC11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 11739784
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IDA,IEA 11739784
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC11: view

No data available for SIGNOR curated interactions for ANAPC11 Gene

Drugs & Compounds for ANAPC11 Gene

(1) Drugs for ANAPC11 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC11 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC11: view

Transcripts for ANAPC11 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC11 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - -
SP16: - - - - - -
SP17: - - -

Relevant External Links for ANAPC11 Gene

GeneLoc Exon Structure for
ANAPC11
ECgene alternative splicing isoforms for
ANAPC11

Expression for ANAPC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC11 Gene

This gene is overexpressed in Bone (56.3) and Lung (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANAPC11 Gene



Protein tissue co-expression partners for ANAPC11 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC11 Gene:

ANAPC11

SOURCE GeneReport for Unigene cluster for ANAPC11 Gene:

Hs.534456

mRNA Expression by UniProt/SwissProt for ANAPC11 Gene:

Q9NYG5-APC11_HUMAN
Tissue specificity: Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.

Evidence on tissue expression from TISSUES for ANAPC11 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Skin(4.3)
  • Lung(2.7)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with ANAPC11: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC11 Gene

Orthologs for ANAPC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC11 33 32
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC11 33 32
  • 93.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC11 33 32
  • 92.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc11 17 33 32
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Anapc11 32
  • 89.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC11 33
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc11 32
  • 82.14 (n)
zebrafish
(Danio rerio)
Actinopterygii anapc11 33 32
  • 79.37 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lmgA 32
  • 74.7 (n)
lmg 33 34
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008196 32
  • 72.69 (n)
worm
(Caenorhabditis elegans)
Secernentea apc-11 33
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER016C 32
  • 59.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC11 35 33 32
  • 54.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17711g 32
  • 49.21 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC11 32
  • 61.79 (n)
rice
(Oryza sativa)
Liliopsida Os07g0411101 32
  • 69.88 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11300 32
  • 64.91 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apc11 32
  • 54.58 (n)
Species where no ortholog for ANAPC11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC11 Gene

ENSEMBL:
Gene Tree for ANAPC11 (if available)
TreeFam:
Gene Tree for ANAPC11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC11: view image

Paralogs for ANAPC11 Gene

(12) SIMAP similar genes for ANAPC11 Gene using alignment to 4 proteins:

  • APC11_HUMAN
  • J3KSK3_HUMAN
  • J3QL35_HUMAN
  • J3QS46_HUMAN
genes like me logo Genes that share paralogs with ANAPC11: view

No data available for Paralogs for ANAPC11 Gene

Variants for ANAPC11 Gene

Sequence variations from dbSNP and Humsavar for ANAPC11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000030905 -- 81,895,528(+) G/A intron_variant
rs1000144064 -- 81,892,449(+) A/G intron_variant
rs1000204782 -- 81,898,743(+) GTTTTAATTTAAAAAAATG/G intron_variant
rs1000262493 -- 81,893,374(+) G/C intron_variant
rs1000372449 -- 81,898,394(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC11 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
esv33475 CNV gain+loss 17666407
nsv1070854 CNV deletion 25765185
nsv1118775 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for ANAPC11 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC11 Gene

Disorders for ANAPC11 Gene

Additional Disease Information for ANAPC11

No disorders were found for ANAPC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC11 Gene

Publications for ANAPC11 Gene

  1. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. (PMID: 11573242) Chan AH … Tsui SK (Journal of cellular biochemistry 2001) 3 4 23 56
  2. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M … Peters JM (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 56
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4 56
  4. RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. (PMID: 25825779) Brown NG … Schulman BA (Proceedings of the National Academy of Sciences of the United States of America 2015) 2 3 56
  5. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 56

Products for ANAPC11 Gene

Sources for ANAPC11 Gene