ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit o... See more...

Aliases for ANAPC10 Gene

Aliases for ANAPC10 Gene

  • Anaphase Promoting Complex Subunit 10 2 3 5
  • APC10 2 3 4
  • Anaphase-Promoting Complex Subunit 10 3 4
  • Cyclosome Subunit 10 3 4
  • DOC1 2 3
  • DKFZP564L0562 2
  • ANAPC10 5

External Ids for ANAPC10 Gene

Previous GeneCards Identifiers for ANAPC10 Gene

  • GC04M146490
  • GC04M146273
  • GC04M146135
  • GC04M145916
  • GC04M141647
  • GC04M144967

Summaries for ANAPC10 Gene

Entrez Gene Summary for ANAPC10 Gene

  • ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

GeneCards Summary for ANAPC10 Gene

ANAPC10 (Anaphase Promoting Complex Subunit 10) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signal transduction_PKA signaling. An important paralog of this gene is ENSG00000285713.

UniProtKB/Swiss-Prot Summary for ANAPC10 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Wiki entry for ANAPC10 Gene

Additional gene information for ANAPC10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANAPC10 Gene

Genomics for ANAPC10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANAPC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J145096 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.0 47 4.2 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 SIX5 NFKBIZ ANAPC10 ABCE1 ENSG00000285713 lnc-OTUD4-5 ENSG00000248356 OTUD4
GH04J145175 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.2 -80.9 -80860 8 SP1 HNRNPL PRDM10 RFX1 SIX5 NFKBIZ POLR2A BACH1 LARP7 PRDM1 OTUD4 lnc-ANAPC10-4 ANAPC10 ABCE1 MMAA HE856056
GH04J145878 Enhancer 1 Ensembl ENCODE 10.7 -783.4 -783360 7 ZNF629 ZNF692 PRDM1 ZNF776 PATZ1 ZNF501 ZNF311 ZNF148 ZNF561 ZBTB44 ZNF827 ABCE1 ANAPC10 SLC10A7 lnc-SLC10A7-5 lnc-SLC10A7-6 lnc-SLC10A7-7 C4orf51
GH04J145130 Enhancer 0.9 Ensembl ENCODE 11.3 -33.5 -33455 3.6 POLR2A STAT3 PRDM1 RELA IKZF2 EED ARID3A DPF2 RELB RUNX3 MN297119-002 OTUD4 ABCE1 ANAPC10
GH04J145195 Enhancer 0.9 Ensembl ENCODE 10.4 -97.0 -97009 1.5 BACH1 RELA TCF12 IKZF2 TRIM22 EED DPF2 RELB RUNX3 BCLAF1 ABCE1 ANAPC10 lnc-ABCE1-2 lnc-OTUD4-1 OTUD4 SMAD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANAPC10

Top Transcription factor binding sites by QIAGEN in the ANAPC10 gene promoter:
  • AML1a
  • Cart-1
  • E2F
  • E2F-1
  • LCR-F1
  • MRF-2
  • Pbx1a
  • Spz1

Genomic Locations for ANAPC10 Gene

Genomic Locations for ANAPC10 Gene
chr4:144,831,908-145,098,541
(GRCh38/hg38)
Size:
266,634 bases
Orientation:
Minus strand
chr4:145,888,264-146,019,693
(GRCh37/hg19)
Size:
131,430 bases
Orientation:
Minus strand

Genomic View for ANAPC10 Gene

Genes around ANAPC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC10 Gene

Proteins for ANAPC10 Gene

  • Protein details for ANAPC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM13-APC10_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 10
    Protein Accession:
    Q9UM13
    Secondary Accessions:
    • D3DNZ7
    • Q2V500
    • Q9UG51
    • Q9Y5R0

    Protein attributes for ANAPC10 Gene

    Size:
    185 amino acids
    Molecular mass:
    21252 Da
    Quaternary structure:
    • The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). The C-terminus of APC10 binds to CDC27/APC3 (PubMed:11524682). Interacts with PIWIL1; interaction only takes place when PIWIL1 binds piRNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for ANAPC10 Gene

neXtProt entry for ANAPC10 Gene

Post-translational modifications for ANAPC10 Gene

  • Ubiquitination at Lys6, Lys14, and Lys169
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANAPC10 Gene

Domains & Families for ANAPC10 Gene

Gene Families for ANAPC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC10 Gene

Suggested Antigen Peptide Sequences for ANAPC10 Gene

GenScript: Design optimal peptide antigens:
  • Cyclosome subunit 10 (APC10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UM13

UniProtKB/Swiss-Prot:

APC10_HUMAN :
  • Belongs to the APC10 family.
Family:
  • Belongs to the APC10 family.
genes like me logo Genes that share domains with ANAPC10: view

Function for ANAPC10 Gene

Molecular function for ANAPC10 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC10 Gene

genes like me logo Genes that share phenotypes with ANAPC10: view

Animal Model Products

CRISPR Products

miRNA for ANAPC10 Gene

miRTarBase miRNAs that target ANAPC10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC10 Gene

Localization for ANAPC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC10 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IBA,IDA 10318877
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC10 Gene

Pathways & Interactions for ANAPC10 Gene

PathCards logo

SuperPathways for ANAPC10 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC10: view

Pathways by source for ANAPC10 Gene

7 GeneGo (Thomson Reuters) pathways for ANAPC10 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
6 Qiagen pathways for ANAPC10 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Mitotic Roles of Polo Like Kinases
1 Cell Signaling Technology pathway for ANAPC10 Gene

UniProtKB/Swiss-Prot Q9UM13-APC10_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC10: view

No data available for SIGNOR curated interactions for ANAPC10 Gene

Drugs & Compounds for ANAPC10 Gene

No Compound Related Data Available

Transcripts for ANAPC10 Gene

mRNA/cDNA for ANAPC10 Gene

9 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: - - - -

Relevant External Links for ANAPC10 Gene

GeneLoc Exon Structure for
ANAPC10

Expression for ANAPC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANAPC10 Gene

Protein differential expression in normal tissues from HIPED for ANAPC10 Gene

This gene is overexpressed in Breast (37.3) and Lung (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC10 Gene



Protein tissue co-expression partners for ANAPC10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANAPC10

SOURCE GeneReport for Unigene cluster for ANAPC10 Gene:

Hs.480876

Evidence on tissue expression from TISSUES for ANAPC10 Gene

  • Nervous system(4.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with ANAPC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC10 Gene

Orthologs for ANAPC10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANAPC10 30 31
  • 99.83 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ANAPC10 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC10 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ANAPC10 30 31
  • 96.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ANAPC10 30 31
  • 96.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Anapc10 30 17 31
  • 92.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Anapc10 30
  • 91.35 (n)
Chicken
(Gallus gallus)
Aves ANAPC10 30 31
  • 88.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ANAPC10 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia anapc10 30
  • 80.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10673 30
Zebrafish
(Danio rerio)
Actinopterygii anapc10 30 31
  • 74.41 (n)
OneToOne
Dr.14526 30
Fruit Fly
(Drosophila melanogaster)
Insecta Apc10 30 31
  • 57.3 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011799 30
  • 57.25 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y48G1C.12 30 31
  • 50.97 (n)
OneToMany
apc-10 31
  • 24 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOC1 31 33
  • 21 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons APC10 30
  • 57.72 (n)
Soybean
(Glycine max)
eudicotyledons Gma.10755 30
Rice
(Oryza sativa)
Liliopsida Os05g0579800 30
  • 55.89 (n)
Os.2307 30
Wheat
(Triticum aestivum)
Liliopsida Ta.9190 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 56 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7204 30
Species where no ortholog for ANAPC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ANAPC10 Gene

ENSEMBL:
Gene Tree for ANAPC10 (if available)
TreeFam:
Gene Tree for ANAPC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC10: view image

Paralogs for ANAPC10 Gene

Paralogs for ANAPC10 Gene

(1) SIMAP similar genes for ANAPC10 Gene using alignment to 5 proteins:

  • APC10_HUMAN
  • D6R9Q5_HUMAN
  • D6RA92_HUMAN
  • D6RB36_HUMAN
  • D6RD74_HUMAN

Pseudogenes.org Pseudogenes for ANAPC10 Gene

genes like me logo Genes that share paralogs with ANAPC10: view

Variants for ANAPC10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANAPC10 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs35257136 - p.Arg46Gln

Additional dbSNP identifiers (rs#s) for ANAPC10 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANAPC10 Gene

Variant ID Type Subtype PubMed ID
dgv174n6 CNV deletion 16902084
esv22214 CNV gain 19812545
esv2653755 CNV deletion 19546169
esv2728486 CNV deletion 23290073
esv3602551 CNV loss 21293372
esv3602553 CNV gain 21293372

Variation tolerance for ANAPC10 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC10 Gene

Human Gene Mutation Database (HGMD)
ANAPC10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC10 Gene

Disorders for ANAPC10 Gene

No disorders were found for ANAPC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC10 Gene

Publications for ANAPC10 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. (PMID: 10318877) Grossberger R … Peters JM (The Journal of biological chemistry 1999) 2 3 4
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L … Barford D (Nature 2015) 3 4
  4. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4
  5. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4

Products for ANAPC10 Gene

Sources for ANAPC10 Gene