Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANAPC10 Gene

Aliases for ANAPC10 Gene

  • Anaphase Promoting Complex Subunit 10 2 3 5
  • Cyclosome Subunit 10 3 4
  • APC10 3 4
  • Anaphase-Promoting Complex Subunit 10 3
  • DOC1 3

External Ids for ANAPC10 Gene

Previous GeneCards Identifiers for ANAPC10 Gene

  • GC04M146490
  • GC04M146273
  • GC04M146135
  • GC04M145916
  • GC04M141647
  • GC04M144967

Summaries for ANAPC10 Gene

Entrez Gene Summary for ANAPC10 Gene

  • ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

GeneCards Summary for ANAPC10 Gene

ANAPC10 (Anaphase Promoting Complex Subunit 10) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for ANAPC10 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC10 Gene

Additional gene information for ANAPC10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC10 Gene

Genomics for ANAPC10 Gene

GeneHancer (GH) Regulatory Elements for ANAPC10 Gene

Promoters and enhancers for ANAPC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J145096 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 144 4 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ANAPC10 ABCE1 ENSG00000248356 OTUD4
GH04J145175 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -81.0 -80973 7.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 OTUD4 LSM6 ANAPC10 ABCE1 MMAA GC04M145156
GH04J145130 Enhancer 0.7 Ensembl ENCODE 11.3 -32.5 -32455 1.6 JUND POLR2A HLF HNF4A SUPT5H ZNF205 OTUD4 ANAPC10 ABCE1 ENSG00000238713 GC04M145151
GH04J145132 Enhancer 0.7 ENCODE 11.3 -34.1 -34110 1.2 STAT5A EBF1 BATF IRF4 RELA POLR2B POLR2A NFATC1 EED RBM22 OTUD4 ABCE1 ANAPC10 ENSG00000238713 GC04M145151
GH04J145195 Enhancer 0.7 ENCODE 10.4 -97.2 -97213 1.1 BACH1 BMI1 BATF IRF4 RELA NFATC1 EED ATF7 BCLAF1 IKZF2 ABCE1 ANAPC10 GC04P145186 LOC105377465
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANAPC10 gene promoter:
  • Cart-1
  • AML1a
  • MRF-2
  • Pbx1a
  • E2F-1
  • LCR-F1
  • Spz1
  • E2F

Genomic Locations for ANAPC10 Gene

Genomic Locations for ANAPC10 Gene
chr4:144,831,908-145,098,541
(GRCh38/hg38)
Size:
266,634 bases
Orientation:
Minus strand
chr4:145,888,264-146,019,693
(GRCh37/hg19)
Size:
131,430 bases
Orientation:
Minus strand

Genomic View for ANAPC10 Gene

Genes around ANAPC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC10 Gene

Proteins for ANAPC10 Gene

  • Protein details for ANAPC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM13-APC10_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 10
    Protein Accession:
    Q9UM13
    Secondary Accessions:
    • D3DNZ7
    • Q2V500
    • Q9UG51
    • Q9Y5R0

    Protein attributes for ANAPC10 Gene

    Size:
    185 amino acids
    Molecular mass:
    21252 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa (PubMed:25043029). The C-terminus of APC10 binds to CDC27/APC3 (PubMed:11524682). Interacts with PIWIL1; interaction only takes place when PIWIL1 binds piRNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for ANAPC10 Gene

neXtProt entry for ANAPC10 Gene

Post-translational modifications for ANAPC10 Gene

  • Ubiquitination at posLast=169169 and posLast=1414
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANAPC10 Gene

Domains & Families for ANAPC10 Gene

Gene Families for ANAPC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANAPC10 Gene

Suggested Antigen Peptide Sequences for ANAPC10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UM13

UniProtKB/Swiss-Prot:

APC10_HUMAN :
  • Belongs to the APC10 family.
Family:
  • Belongs to the APC10 family.
genes like me logo Genes that share domains with ANAPC10: view

Function for ANAPC10 Gene

Molecular function for ANAPC10 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC10 Gene

Gene Ontology (GO) - Molecular Function for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ANAPC10: view
genes like me logo Genes that share phenotypes with ANAPC10: view

Animal Model Products

miRNA for ANAPC10 Gene

miRTarBase miRNAs that target ANAPC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC10 Gene

Localization for ANAPC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC10 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 10318877
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC10 Gene

Pathways & Interactions for ANAPC10 Gene

SuperPathways for ANAPC10 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC10: view

UniProtKB/Swiss-Prot Q9UM13-APC10_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process IBA,TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC10: view

No data available for SIGNOR curated interactions for ANAPC10 Gene

Drugs & Compounds for ANAPC10 Gene

No Compound Related Data Available

Transcripts for ANAPC10 Gene

Unigene Clusters for ANAPC10 Gene

Anaphase promoting complex subunit 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: - - - -

Relevant External Links for ANAPC10 Gene

GeneLoc Exon Structure for
ANAPC10
ECgene alternative splicing isoforms for
ANAPC10

Expression for ANAPC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC10 Gene

Protein differential expression in normal tissues from HIPED for ANAPC10 Gene

This gene is overexpressed in Breast (37.3) and Lung (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC10 Gene



Protein tissue co-expression partners for ANAPC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC10 Gene:

ANAPC10

SOURCE GeneReport for Unigene cluster for ANAPC10 Gene:

Hs.480876

Evidence on tissue expression from TISSUES for ANAPC10 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ANAPC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC10 Gene

Orthologs for ANAPC10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC10 34 33
  • 99.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC10 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC10 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC10 34 33
  • 96.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC10 34 33
  • 96.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc10 16 34 33
  • 92.61 (n)
rat
(Rattus norvegicus)
Mammalia Anapc10 33
  • 91.35 (n)
chicken
(Gallus gallus)
Aves ANAPC10 34 33
  • 88.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC10 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc10 33
  • 80.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10673 33
zebrafish
(Danio rerio)
Actinopterygii anapc10 34 33
  • 74.41 (n)
OneToOne
Dr.14526 33
fruit fly
(Drosophila melanogaster)
Insecta Apc10 34 33
  • 57.3 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011799 33
  • 57.25 (n)
worm
(Caenorhabditis elegans)
Secernentea Y48G1C.12 34 33
  • 50.97 (n)
OneToMany
apc-10 34
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOC1 36 34
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC10 33
  • 57.72 (n)
soybean
(Glycine max)
eudicotyledons Gma.10755 33
rice
(Oryza sativa)
Liliopsida Os05g0579800 33
  • 55.89 (n)
Os.2307 33
wheat
(Triticum aestivum)
Liliopsida Ta.9190 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToOne
Cin.7204 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7204 33
Species where no ortholog for ANAPC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ANAPC10 Gene

ENSEMBL:
Gene Tree for ANAPC10 (if available)
TreeFam:
Gene Tree for ANAPC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC10: view image

Paralogs for ANAPC10 Gene

(1) SIMAP similar genes for ANAPC10 Gene using alignment to 5 proteins:

  • APC10_HUMAN
  • D6R9Q5_HUMAN
  • D6RA92_HUMAN
  • D6RB36_HUMAN
  • D6RD74_HUMAN

Pseudogenes.org Pseudogenes for ANAPC10 Gene

genes like me logo Genes that share paralogs with ANAPC10: view

No data available for Paralogs for ANAPC10 Gene

Variants for ANAPC10 Gene

Sequence variations from dbSNP and Humsavar for ANAPC10 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000003245 -- 145,016,837(-) /AAA genic_downstream_transcript_variant, intron_variant
rs1000003944 -- 144,979,131(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000009618 -- 145,019,957(-) AAAAAAAAA/AAAAAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000062759 -- 145,022,206(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000070659 -- 145,066,262(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC10 Gene

Variant ID Type Subtype PubMed ID
dgv174n6 CNV deletion 16902084
esv22214 CNV gain 19812545
esv2653755 CNV deletion 19546169
esv2728486 CNV deletion 23290073
esv3602551 CNV loss 21293372
esv3602553 CNV gain 21293372

Variation tolerance for ANAPC10 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC10 Gene

Human Gene Mutation Database (HGMD)
ANAPC10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC10 Gene

Disorders for ANAPC10 Gene

Additional Disease Information for ANAPC10

No disorders were found for ANAPC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC10 Gene

Publications for ANAPC10 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. (PMID: 10318877) Grossberger R … Peters JM (The Journal of biological chemistry 1999) 2 3 4 58
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 58
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4 58

Products for ANAPC10 Gene

Sources for ANAPC10 Gene

Content
Loading form....