Aliases for ANAPC10 Gene
External Ids for ANAPC10 Gene
Previous GeneCards Identifiers for ANAPC10 Gene
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
GeneCards Summary for ANAPC10 Gene
ANAPC10 (Anaphase Promoting Complex Subunit 10) is a Protein Coding gene. Diseases associated with ANAPC10 include Opitz-Gbbb Syndrome. Among its related pathways are Cellular Senescence (REACTOME) and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ENSG00000285713.
UniProtKB/Swiss-Prot Summary for ANAPC10 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.