Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANAPC1 Gene

Aliases for ANAPC1 Gene

  • Anaphase Promoting Complex Subunit 1 2 3 5
  • Testis-Specific Gene 24 Protein 3 4
  • Mitotic Checkpoint Regulator 3 4
  • Cyclosome Subunit 1 3 4
  • TSG24 3 4
  • APC1 3 4
  • Anaphase-Promoting Complex 1 (Meiotic Checkpoint Regulator) 3
  • Anaphase-Promoting Complex Subunit 1 3
  • MCPR 3

External Ids for ANAPC1 Gene

Previous GeneCards Identifiers for ANAPC1 Gene

  • GC02M110445
  • GC02M112430
  • GC02M112621
  • GC02M112242
  • GC02M087019
  • GC02M112523
  • GC02M111768

Summaries for ANAPC1 Gene

Entrez Gene Summary for ANAPC1 Gene

  • This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

GeneCards Summary for ANAPC1 Gene

ANAPC1 (Anaphase Promoting Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for ANAPC1 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC1 Gene

Additional gene information for ANAPC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC1 Gene

Genomics for ANAPC1 Gene

GeneHancer (GH) Regulatory Elements for ANAPC1 Gene

Promoters and enhancers for ANAPC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J111882 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656.4 +0.7 693 2.3 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ANAPC1 TMEM87B RPS20P11 ENSG00000230958
GH02J111120 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.3 +762.7 762694 4.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 BCL2L11 PIR45517 ANAPC1 GC02M111153 ACOXL MIR4435-2HG
GH02J112762 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.8 -879.5 -879452 3.3 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CKAP2L ANAPC1 POLR1B RGPD8 ENSG00000227359 PSD4 IL1A NT5DC4 FLJ42351 GC02P113902
GH02J112642 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 23.6 -761.4 -761370 6.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 FLJ42351 PIR36945 SLC20A1 ANAPC1 WASH2P ZC3H6 TMEM87B RPS20P11 ENSG00000243389 CHCHD5
GH02J112541 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 -657.9 -657889 2.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B POLR1B LOC105373562 CHCHD5 ANAPC1 RPS20P11 RGPD8 TMEM87B ENSG00000207383 ENSG00000243389 ZC3H8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANAPC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANAPC1 gene promoter:
  • ZIC2
  • AREB6
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • GR
  • GR-alpha

Genomic Locations for ANAPC1 Gene

Genomic Locations for ANAPC1 Gene
chr2:111,611,639-111,884,690
(GRCh38/hg38)
Size:
273,052 bases
Orientation:
Minus strand
chr2:112,523,848-112,642,267
(GRCh37/hg19)
Size:
118,420 bases
Orientation:
Minus strand

Genomic View for ANAPC1 Gene

Genes around ANAPC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC1 Gene

Proteins for ANAPC1 Gene

  • Protein details for ANAPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1A4-APC1_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 1
    Protein Accession:
    Q9H1A4
    Secondary Accessions:
    • Q2M3H8
    • Q9BSE6
    • Q9H8D0

    Protein attributes for ANAPC1 Gene

    Size:
    1944 amino acids
    Molecular mass:
    216500 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for ANAPC1 Gene

neXtProt entry for ANAPC1 Gene

Post-translational modifications for ANAPC1 Gene

  • Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
  • Ubiquitination at Lys1066, Lys985, Lys905, Lys695, and Lys310
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANAPC1 Gene

Domains & Families for ANAPC1 Gene

Gene Families for ANAPC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ANAPC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1A4

UniProtKB/Swiss-Prot:

APC1_HUMAN :
  • Belongs to the APC1 family.
Family:
  • Belongs to the APC1 family.
genes like me logo Genes that share domains with ANAPC1: view

Function for ANAPC1 Gene

Molecular function for ANAPC1 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC1 Gene

Gene Ontology (GO) - Molecular Function for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061630 CONTRIBUTES_TO ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ANAPC1: view
genes like me logo Genes that share phenotypes with ANAPC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC1 Gene

Localization for ANAPC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IEA,IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC1 Gene

Pathways & Interactions for ANAPC1 Gene

SuperPathways for ANAPC1 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC1: view

UniProtKB/Swiss-Prot Q9H1A4-APC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IBA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC1: view

Drugs & Compounds for ANAPC1 Gene

No Compound Related Data Available

Transcripts for ANAPC1 Gene

Unigene Clusters for ANAPC1 Gene

Anaphase promoting complex subunit 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANAPC1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC1 Gene

No ASD Table

Relevant External Links for ANAPC1 Gene

GeneLoc Exon Structure for
ANAPC1
ECgene alternative splicing isoforms for
ANAPC1

Expression for ANAPC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC1 Gene

Protein differential expression in normal tissues from HIPED for ANAPC1 Gene

This gene is overexpressed in Breast (24.6), Lung (15.2), and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANAPC1 Gene



Protein tissue co-expression partners for ANAPC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANAPC1 Gene:

ANAPC1

SOURCE GeneReport for Unigene cluster for ANAPC1 Gene:

Hs.436527

Evidence on tissue expression from TISSUES for ANAPC1 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with ANAPC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC1 Gene

Orthologs for ANAPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC1 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANAPC1 34 33
  • 93.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC1 34 33
  • 90.05 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC1 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc1 33
  • 87.96 (n)
mouse
(Mus musculus)
Mammalia Anapc1 16 34 33
  • 87.93 (n)
chicken
(Gallus gallus)
Aves ANAPC1 34 33
  • 76.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc1 33
  • 73.59 (n)
Str.16338 33
zebrafish
(Danio rerio)
Actinopterygii anapc1 34 33
  • 65.73 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shtd 34 33
  • 46.97 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000374 33
  • 43.77 (n)
worm
(Caenorhabditis elegans)
Secernentea mat-2 34
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC1 36 34
  • 19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2771 33
  • 45.78 (n)
rice
(Oryza sativa)
Liliopsida Os05g0354300 33
  • 49.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for ANAPC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC1 Gene

ENSEMBL:
Gene Tree for ANAPC1 (if available)
TreeFam:
Gene Tree for ANAPC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANAPC1: view image

Paralogs for ANAPC1 Gene

No data available for Paralogs for ANAPC1 Gene

Variants for ANAPC1 Gene

Sequence variations from dbSNP and Humsavar for ANAPC1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs72936240 benign, not specified 111,856,852(-) G/A coding_sequence_variant, stop_gained
rs1000016869 -- 111,767,127(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000092760 -- 111,883,376(-) G/A intron_variant
rs1000137181 -- 111,825,559(-) T/C intron_variant
rs1000195887 -- 111,874,352(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC1 Gene

Variant ID Type Subtype PubMed ID
dgv4047n100 CNV loss 25217958
esv26491 CNV gain 19812545
esv27292 CNV gain+loss 19812545
esv2759083 CNV gain+loss 17122850
nsv10127 CNV gain 18304495
nsv1148179 CNV duplication 26484159
nsv1149522 OTHER inversion 26484159
nsv215083 CNV deletion 16902084
nsv428402 CNV loss 18775914
nsv514974 CNV loss 21397061
nsv521956 CNV loss 19592680
nsv582699 CNV loss 21841781
nsv834333 CNV gain 17160897
nsv961487 CNV duplication 23825009
nsv961488 CNV duplication 23825009
nsv961995 CNV duplication 23825009
nsv961996 CNV duplication 23825009
nsv963701 CNV duplication 23825009
nsv963702 CNV duplication 23825009
nsv979098 CNV duplication 23825009
nsv979099 CNV duplication 23825009

Variation tolerance for ANAPC1 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANAPC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC1 Gene

Disorders for ANAPC1 Gene

Additional Disease Information for ANAPC1

No disorders were found for ANAPC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC1 Gene

Publications for ANAPC1 Gene

  1. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. (PMID: 11179667) Jörgensen PM … Höög C (Gene 2001) 2 3 4 22 58
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
  3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 58
  4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ANAPC1 Gene

Sources for ANAPC1 Gene

Content
Loading form....