Aliases for ANAPC1 Gene
External Ids for ANAPC1 Gene
Previous GeneCards Identifiers for ANAPC1 Gene
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]
GeneCards Summary for ANAPC1 Gene
ANAPC1 (Anaphase Promoting Complex Subunit 1) is a Protein Coding gene. Diseases associated with ANAPC1 include Rothmund-Thomson Syndrome, Type 1 and Retinitis Pigmentosa 38. Among its related pathways are Cellular Senescence (REACTOME) and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot Summary for ANAPC1 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.