Aliases for AMZ1 Gene

Aliases for AMZ1 Gene

  • Archaelysin Family Metallopeptidase 1 2 3 5
  • Archaemetzincin-1 2 3 4
  • Archeobacterial Metalloproteinase-Like Protein 1 3 4
  • Metalloproteinase-Like Protein 3
  • EC 3.4.-.- 4
  • KIAA1950 4

External Ids for AMZ1 Gene

Previous GeneCards Identifiers for AMZ1 Gene

  • GC07P002493
  • GC07P002685
  • GC07P002719

Summaries for AMZ1 Gene

GeneCards Summary for AMZ1 Gene

AMZ1 (Archaelysin Family Metallopeptidase 1) is a Protein Coding gene. Diseases associated with AMZ1 include Congenital Toxoplasmosis. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity. An important paralog of this gene is AMZ2.

UniProtKB/Swiss-Prot Summary for AMZ1 Gene

  • Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.

Additional gene information for AMZ1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AMZ1 Gene

Genomics for AMZ1 Gene

GeneHancer (GH) Regulatory Elements for AMZ1 Gene

Promoters and enhancers for AMZ1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J002701 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 513.8 +22.5 22508 0.9 RXRA HNF4A SP1 AMZ1 HSALNG0055746 TTYH3 lnc-TTYH3-2
GH07J002680 Enhancer 0.9 ENCODE dbSUPER 500.7 +1.6 1550 0.2 CTCF GABPA REST RAD21 ZBTB26 ZKSCAN8 SMC3 SAP130 YY1 IKZF1 AMZ1 BRAT1 piR-32287-086
GH07J002681 Promoter 0.5 Ensembl 500.7 +0.7 678 0.4 ZIC2 CTCF AMZ1 piR-32287-086
GH07J002658 Promoter 0.4 EPDnew 500.4 -20.6 -20590 0.1 ZIC2 AMZ1 piR-43602 piR-32287-085 TTYH3
GH07J002693 Enhancer 0.8 FANTOM5 50.5 +14.6 14579 0.4 POLR2G TOE1 CTBP1 FOXA2 NFRKB CEBPG SAP130 CEBPB ZNF592 GABPB1 AMZ1 LFNG GNA12 SNX8 lnc-GNA12-3 HSALNG0055746
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMZ1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AMZ1

Top Transcription factor binding sites by QIAGEN in the AMZ1 gene promoter:
  • AML1a
  • COUP
  • COUP-TF
  • COUP-TF1
  • CP2
  • GATA-3
  • POU2F1
  • POU2F1a

Genomic Locations for AMZ1 Gene

Genomic Locations for AMZ1 Gene
chr7:2,679,522-2,775,500
(GRCh38/hg38)
Size:
95,979 bases
Orientation:
Plus strand
chr7:2,719,156-2,815,134
(GRCh37/hg19)
Size:
95,979 bases
Orientation:
Plus strand

Genomic View for AMZ1 Gene

Genes around AMZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMZ1 Gene

Proteins for AMZ1 Gene

  • Protein details for AMZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q400G9-AMZ1_HUMAN
    Recommended name:
    Archaemetzincin-1
    Protein Accession:
    Q400G9
    Secondary Accessions:
    • B3KRS0
    • Q8TF51

    Protein attributes for AMZ1 Gene

    Size:
    498 amino acids
    Molecular mass:
    54924 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85536.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AMZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMZ1 Gene

Post-translational modifications for AMZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMZ1 Gene

Domains & Families for AMZ1 Gene

Gene Families for AMZ1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for AMZ1 Gene

Suggested Antigen Peptide Sequences for AMZ1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76739, highly similar to Homo sapiens archaemetzincin-1 (AMZ1), mRNA (A4D202_HUMAN)
  • Archeobacterial metalloproteinase-like protein 1 (AMZ1_HUMAN)
  • cDNA FLJ34788 fis, clone NT2NE2004787, highly similar to Archaemetzincin-1 (EC 3.-.-.-) (B3KRS0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q400G9

UniProtKB/Swiss-Prot:

AMZ1_HUMAN :
  • Belongs to the peptidase M54 family.
Family:
  • Belongs to the peptidase M54 family.
genes like me logo Genes that share domains with AMZ1: view

Function for AMZ1 Gene

Molecular function for AMZ1 Gene

UniProtKB/Swiss-Prot Function:
Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:15972818};

Enzyme Numbers (IUBMB) for AMZ1 Gene

Phenotypes From GWAS Catalog for AMZ1 Gene

Gene Ontology (GO) - Molecular Function for AMZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMZ1: view
genes like me logo Genes that share phenotypes with AMZ1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMZ1 Gene

Localization for AMZ1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMZ1 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for AMZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with AMZ1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AMZ1 Gene

Pathways & Interactions for AMZ1 Gene

PathCards logo

SuperPathways for AMZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with AMZ1: view

No data available for Pathways by source and SIGNOR curated interactions for AMZ1 Gene

Drugs & Compounds for AMZ1 Gene

No Compound Related Data Available

Transcripts for AMZ1 Gene

mRNA/cDNA for AMZ1 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMZ1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - -
SP3: -

Relevant External Links for AMZ1 Gene

GeneLoc Exon Structure for
AMZ1

Expression for AMZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMZ1 Gene