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Aliases for AMY2B Gene

Aliases for AMY2B Gene

  • Amylase, Alpha 2B (Pancreatic) 2 3 5
  • 1,4-Alpha-D-Glucan Glucanohydrolase 2B 3 4
  • Carcinoid Alpha-Amylase 3 4
  • Amylase, Alpha 2B; Pancreatic 2
  • Alpha-Amylase 2B 3
  • Glycogenase 3
  • EC 4
  • AMY3 3
  • AMY2 3
  • HXA 3

External Ids for AMY2B Gene

Previous HGNC Symbols for AMY2B Gene

  • AMY2

Previous GeneCards Identifiers for AMY2B Gene

  • GC01P104761
  • GC01P103104
  • GC01P103251
  • GC01P103424
  • GC01P103426
  • GC01P103781
  • GC01P103809
  • GC01P103897
  • GC01P104096
  • GC01P102153

Summaries for AMY2B Gene

Entrez Gene Summary for AMY2B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

GeneCards Summary for AMY2B Gene

AMY2B (Amylase, Alpha 2B (Pancreatic)) is a Protein Coding gene. Among its related pathways are Metabolism and Digestion of dietary carbohydrate. Gene Ontology (GO) annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY2A.

Gene Wiki entry for AMY2B Gene

Additional gene information for AMY2B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2B Gene

Genomics for AMY2B Gene

GeneHancer (GH) Regulatory Elements for AMY2B Gene

Promoters and enhancers for AMY2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J103554 Promoter 0.5 EPDnew 650.7 +1.2 1183 0.1 AMY2B ACTG1P4 RNPC3
GH01J103555 Promoter 0.5 EPDnew 650.7 +0.6 649 0.1 AMY2B ACTG1P4 RNPC3
GH01J103556 Promoter 0.5 EPDnew 650.7 +0.9 879 0.1 AMY2B ACTG1P4 RNPC3
GH01J103570 Promoter 0.5 EPDnew 650.4 +16.8 16812 0.1 ACTG1P4 AMY2B GC01P103577
GH01J103571 Promoter 0.5 EPDnew 650.4 +17.3 17270 0.1 ACTG1P4 AMY2B GC01P103577
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMY2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AMY2B gene promoter:
  • IRF-7A
  • FOXF2
  • FOXD1
  • Evi-1
  • c-Rel
  • Nkx2-2
  • RelA
  • FOXO4
  • FOXC1
  • FAC1

Genomic Locations for AMY2B Gene

Genomic Locations for AMY2B Gene
25,720 bases
Plus strand
25,720 bases
Plus strand

Genomic View for AMY2B Gene

Genes around AMY2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMY2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2B Gene

Proteins for AMY2B Gene

  • Protein details for AMY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-amylase 2B
    Protein Accession:
    Secondary Accessions:
    • B3KTI1
    • B3KXB7
    • D3DT76
    • Q9UBH3

    Protein attributes for AMY2B Gene

    511 amino acids
    Molecular mass:
    57710 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=chloride; Xref=ChEBI:CHEBI:17996;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for AMY2B Gene


neXtProt entry for AMY2B Gene

Post-translational modifications for AMY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMY2B Gene

No data available for DME Specific Peptides for AMY2B Gene

Domains & Families for AMY2B Gene

Gene Families for AMY2B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for AMY2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2B: view

Function for AMY2B Gene

Molecular function for AMY2B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
GENATLAS Biochemistry:
amylase,alpha-2B,liver,pancreas,see AMY@

Enzyme Numbers (IUBMB) for AMY2B Gene

Gene Ontology (GO) - Molecular Function for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004556 alpha-amylase activity ISS 2401405
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0043169 cation binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY2B: view
genes like me logo Genes that share phenotypes with AMY2B: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2B Gene

Localization for AMY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMY2B gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with AMY2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AMY2B Gene

Pathways & Interactions for AMY2B Gene

genes like me logo Genes that share pathways with AMY2B: view

Pathways by source for AMY2B Gene

Gene Ontology (GO) - Biological Process for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AMY2B: view

No data available for SIGNOR curated interactions for AMY2B Gene

Drugs & Compounds for AMY2B Gene

(13) Drugs for AMY2B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pidolic Acid Approved, Investigational Pharma Target 0
calcium Approved Nutra 0
Water Approved Pharma 0
maltose Experimental, Investigational Pharma Target 0
1,4-dithio-alpha-D-glucopyranose Experimental Pharma Target 0

(6) Additional Compounds for AMY2B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Chloride(1-)
  • Chlorine anion
  • CL(-)
  • Bertholite
  • Chloor
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
  • Amylotriose
  • 4-O-(4-O-Hexopyranosylhexopyranosyl)hexose
  • D-(+)-Maltotriose
  • delta-(+)-Maltotriose
  • O-alpha-D-Glucopyranosyl-(1beta94)-O-alpha-D-glucopyranosyl-(1beta94)-O-alpha-D-glucose
genes like me logo Genes that share compounds with AMY2B: view

Transcripts for AMY2B Gene

mRNA/cDNA for AMY2B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(222) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMY2B Gene

Amylase, alpha 2B (pancreatic):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2B Gene

No ASD Table

Relevant External Links for AMY2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMY2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2B Gene

This gene is overexpressed in Pancreas (x37.3).

Protein differential expression in normal tissues from HIPED for AMY2B Gene

This gene is overexpressed in Saliva (29.0), Pancreatic juice (27.7), and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AMY2B Gene

Protein tissue co-expression partners for AMY2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AMY2B Gene:


SOURCE GeneReport for Unigene cluster for AMY2B Gene:


Evidence on tissue expression from TISSUES for AMY2B Gene

  • Pancreas(4.8)
  • Nervous system(4.4)
  • Kidney(4.3)
  • Urine(4.2)
genes like me logo Genes that share expression patterns with AMY2B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMY2B Gene

Orthologs for AMY2B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMY2B 34 33
  • 99.61 (n)
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
-- 34
  • 91 (a)
-- 34
  • 91 (a)
-- 34
  • 90 (a)
-- 34
  • 89 (a)
-- 34
  • 88 (a)
(Bos Taurus)
Mammalia -- 34
  • 86 (a)
AMY2B 34
  • 86 (a)
(Mus musculus)
Mammalia Amy2a3 34
  • 85 (a)
Amy2a2 34
  • 85 (a)
Amy2a4 34
  • 85 (a)
Amy1 34
  • 85 (a)
Amy2a5 16 34 33
  • 84.51 (n)
Amy2a1 34
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
(Rattus norvegicus)
Mammalia LOC100911494 33
  • 84.25 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 84 (a)
(Gallus gallus)
Aves AMY2A 34
  • 82 (a)
AMY1A 34
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2a 33
  • 73.59 (n)
Str.5812 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64337 33
(Danio rerio)
Actinopterygii amy2a 34 33
  • 69.21 (n)
zgc:92137 34
  • 69 (a)
zgc:66313 34
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-p 34 35 33
  • 55.81 (n)
Amy-d 34 35
  • 54 (a)
Amyrel 34 35
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002318 33
  • 52.22 (n)
(Caenorhabditis elegans)
Secernentea CELE_C50B6.7 33
  • 55.33 (n)
C50B6.7 34 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
Species where no ortholog for AMY2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2B Gene

Gene Tree for AMY2B (if available)
Gene Tree for AMY2B (if available)
Evolutionary constrained regions (ECRs) for AMY2B: view image

Paralogs for AMY2B Gene

Paralogs for AMY2B Gene

(4) SIMAP similar genes for AMY2B Gene using alignment to 4 proteins:

  • C9J2Z5_HUMAN
genes like me logo Genes that share paralogs with AMY2B: view

Variants for AMY2B Gene

Sequence variations from dbSNP and Humsavar for AMY2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000077186 -- 103,575,014(+) GTGTGTGTGTGT/GTGTGTGTGT intron_variant
rs1000260855 -- 103,569,589(+) G/C intron_variant
rs1000381755 -- 103,557,418(+) A/G/T intron_variant
rs1000515817 -- 103,564,242(+) A/C intron_variant
rs1000549551 -- 103,574,810(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2B Gene

Variant ID Type Subtype PubMed ID
dgv14n21 CNV gain 19592680
dgv213n100 CNV gain 25217958
dgv214n100 CNV gain 25217958
dgv215n100 CNV gain 25217958
dgv216n100 CNV gain 25217958
dgv217n100 CNV gain 25217958
dgv218n100 CNV gain 25217958
dgv2e203 CNV gain+loss 21179565
dgv35e214 CNV gain 21293372
dgv392n54 CNV gain 21841781
dgv393n54 CNV gain 21841781
dgv394n54 CNV gain 21841781
dgv395n54 CNV gain 21841781
dgv396n54 CNV gain 21841781
dgv397n54 CNV loss 21841781
dgv398n54 CNV gain 21841781
dgv399n54 CNV gain 21841781
dgv3n64 CNV gain 17921354
dgv68e212 CNV gain 25503493
dgv69e212 CNV gain 25503493
esv1004547 CNV gain 20482838
esv23292 CNV gain+loss 19812545
esv2758954 CNV gain+loss 17122850
esv33927 CNV gain 17666407
esv3583026 CNV gain 25503493
esv3893856 CNV gain+loss 25118596
nsv1012949 CNV gain 25217958
nsv10428 CNV gain+loss 18304495
nsv1152675 CNV duplication 26484159
nsv1161038 CNV duplication 26073780
nsv428157 CNV gain+loss 18775914
nsv442937 CNV gain 18776908
nsv511132 CNV gain 21212237
nsv514909 CNV gain 21397061
nsv517215 CNV gain+loss 19592680
nsv523177 CNV gain 19592680
nsv526367 CNV gain 19592680
nsv546955 CNV loss 21841781
nsv546976 CNV gain 21841781
nsv546979 CNV gain 21841781
nsv823686 CNV gain 20364138
nsv830904 CNV loss 17160897
nsv830915 CNV gain+loss 17160897
nsv946105 CNV duplication 23825009
nsv946106 CNV duplication 23825009

Variation tolerance for AMY2B Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMY2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY2B Gene

Disorders for AMY2B Gene

Additional Disease Information for AMY2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AMY2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMY2B Gene

Publications for AMY2B Gene

  1. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PMID: 8268204) Omichi K … Hase S (Biochimica et biophysica acta 1993) 2 3 4 58
  2. Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PMID: 2401405) Yokouchi H … Matsubara K (Gene 1990) 3 4 22 58
  3. On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PMID: 16152770) Baltova SD (Folia medica 2005) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for AMY2B Gene

Sources for AMY2B Gene

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