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Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
AMY1A (Amylase Alpha 1A) is a Protein Coding gene. Diseases associated with AMY1A include Major Depressive Disorder and Stereotypic Movement Disorder. Among its related pathways are Metabolism and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY1B.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J103656 | Promoter | 0.3 | EPDnew | 600.7 | +0.7 | 744 | 0.1 | AMY1A ENSG00000234441 AMY1B | ||
GH01J103655 | Promoter | 0.3 | EPDnew | 600.7 | +0.5 | 498 | 0.1 | AMY1A ENSG00000234441 AMY1B | ||
GH01J103617 | Promoter | 0.3 | EPDnew | 0.3 | -37.9 | -37882 | 0.1 | AMY2A piR-31225-001 AMY1A | ||
GH01J103616 | Promoter | 0.3 | EPDnew | 0.3 | -38.4 | -38444 | 0.1 | AMY2A piR-31225-001 AMY1A | ||
GH01J103696 | Promoter | 0.3 | EPDnew | 0.3 | +40.9 | 40940 | 0.1 | AMY1B ENSG00000234441 AMY1A |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004556 | alpha-amylase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 16203048 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 24248522 |
GO:0070062 | extracellular exosome | HDA | 19199708 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
|
|
2 | Carbohydrate digestion and absorption | ||
3 | Pancreatic secretion | ||
4 | Salivary secretion | ||
5 | Galactose metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0008152 | metabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Semaglutide | Approved, Investigational | Pharma | Enzyme, inhibitor | 0 | ||
Pidolic acid | Approved, Investigational | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
4,6-dideoxy-4-amino-alpha-D-glucose | Experimental | Pharma | Target | 0 | ||
5-Hydroxymethyl-Chonduritol | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Alpha-D-Glucose |
|
492-62-6 |
|
|||
Dextrin |
|
9004-53-9 |
|
|||
Glycogen |
|
9005-79-2 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AMY1A 30 |
|
||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | AMY2B 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Amy1 31 |
|
ManyToMany | |
Amy2a2 31 |
|
ManyToMany | |||
Amy2a4 31 |
|
ManyToMany | |||
Amy2a3 31 |
|
ManyToMany | |||
Amy2a5 31 |
|
ManyToMany | |||
Amy2a1 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | AMY2A 31 |
|
ManyToMany | |
AMY1A 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | amy2a 31 |
|
ManyToMany | |
zgc:92137 31 |
|
ManyToMany | |||
zgc:66313 31 |
|
ManyToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8384 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Amy-d 31 32 |
|
ManyToMany | |
Amy-p 31 32 |
|
ManyToMany | |||
Amyrel 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | C50B6.7 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
major depressive disorder |
|
|
stereotypic movement disorder |
|
|
panic disorder |
|
|
sick building syndrome |
|
|
chromophobe renal cell carcinoma |
|
|