Aliases for AMOTL2 Gene
External Ids for AMOTL2 Gene
Previous GeneCards Identifiers for AMOTL2 Gene
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for AMOTL2 Gene
AMOTL2 (Angiomotin Like 2) is a Protein Coding gene. Diseases associated with AMOTL2 include Meningioma, Familial and Wilson-Turner X-Linked Mental Retardation Syndrome. Among its related pathways are Signaling by GPCR and Signaling by Hippo. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is AMOT.
UniProtKB/Swiss-Prot Summary for AMOTL2 Gene
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.