External Ids for AMOT Gene
Previous GeneCards Identifiers for AMOT Gene
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for AMOT Gene
AMOT (Angiomotin) is a Protein Coding gene. Diseases associated with AMOT include Papilloma and Myeloproliferative Syndrome, Transient. Among its related pathways are Signaling by GPCR and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include angiostatin binding. An important paralog of this gene is AMOTL1.
UniProtKB/Swiss-Prot Summary for AMOT Gene
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.