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AMN1 Gene(Protein Coding)

Antagonist Of Mitotic Exit Network 1 Homolog

GCID:
GC12M031671
GIFtS:
38
Genes Participants
UDN Logo

Aliases for AMN1 Gene

Aliases for AMN1 Gene

  • Antagonist Of Mitotic Exit Network 1 Homolog 2 3 5
  • Antagonist Of Mitotic Exit Network 1 Homolog (S. Cerevisiae) 2

External Ids for AMN1 Gene

Previous GeneCards Identifiers for AMN1 Gene

  • GC12M031716
  • GC12M031824
  • GC12M031576

Summaries for AMN1 Gene

GeneCards Summary for AMN1 Gene

AMN1 (Antagonist Of Mitotic Exit Network 1 Homolog) is a Protein Coding gene.

Additional gene information for AMN1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMN1 Gene

Genomics for AMN1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for AMN1 Gene

Promoters and enhancers for AMN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I031726 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.9 1915 3.9 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 AMN1 ENSG00000276900 GC12P031730 CAPRIN2 DDX11 DDX11-AS1 BICD1 SINHCAF LOC100420981 FLJ13224
GH12I031714 Promoter/Enhancer 2.1 VISTA EPDnew Ensembl ENCODE dbSUPER 550.4 +14.7 14691 3 HDGF PKNOX1 SMAD1 FOXA2 ARNT IRF4 YY1 POLR2B ZNF766 E2F8 STMN1P1 AMN1 H3F3C DDX11 FLJ13224 KIAA1551 SINHCAF GC12P031714
GH12I031755 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -26.7 -26653 2.1 HDAC1 ZBTB40 TCF12 SCRT2 SIRT6 ATF7 SMARCC1 USF2 ZEB2 SMARCA4 LOC105369724 AMN1 ENSG00000252204 H3F3C DSPA2D
GH12I031745 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -18.9 -18939 6.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000256843 GC12M031774 LOC100420981 DDX11 DDX11-AS1 H3F3C KIAA1551 CAPRIN2 BICD1 SINHCAF
GH12I031905 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 9.1 -176.2 -176177 2.1 SOX13 EBF1 CEBPG KLF5 ZNF280A CBX5 POLR2A ZNF143 TRIM24 IKZF2 KIAA1551 AMN1 LINC02422 H3F3C RPLP2P4 GC12M031929
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AMN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AMN1 gene promoter:

Genomic Locations for AMN1 Gene

Genomic Locations for AMN1 Gene
chr12:31,671,137-31,730,392
(GRCh38/hg38)
Size:
59,256 bases
Orientation:
Minus strand
chr12:31,824,071-31,882,108
(GRCh37/hg19)

Genomic View for AMN1 Gene

Genes around AMN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AMN1 Gene

Proteins for AMN1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AMN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY45-AMN1_HUMAN
    Recommended name:
    Protein AMN1 homolog
    Protein Accession:
    Q8IY45
    Secondary Accessions:
    • B7Z7J3
    • Q6NVU4
    • Q86X98

    Protein attributes for AMN1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37897.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH45831.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67906.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AMN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMN1 Gene

Protein Expression for AMN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AMN1 Gene

No Post-translational modifications

Other Protein References for AMN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMN1 Gene

Domains & Families for AMN1 Gene

Gene Families for AMN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AMN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AMN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY45

UniProtKB/Swiss-Prot:

AMN1_HUMAN :
  • Belongs to the AMN1 family.
Family:
  • Belongs to the AMN1 family.
genes like me logo Genes that share domains with AMN1: view

Function for AMN1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for AMN1 Gene

genes like me logo Genes that share phenotypes with AMN1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMN1 Gene

Localization for AMN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMN1 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMN1 Gene

Pathways & Interactions for AMN1 Gene

SuperPathways for AMN1 Gene

PathCards logo More details on SuperPathways for AMN1
No Data Available

Interacting Proteins for AMN1 Gene

Selected Interacting proteins: Q8IY45-AMN1_HUMAN for AMN1 Gene via IID

Symbol External ID(s) Details
UBR2

Gene Ontology (GO) - Biological Process for AMN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AMN1 Gene

Drugs & Compounds for AMN1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for AMN1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for AMN1 Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(122) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMN1 Gene

Antagonist of mitotic exit network 1 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - -

Relevant External Links for AMN1 Gene

GeneLoc Exon Structure for
AMN1
ECgene alternative splicing isoforms for
AMN1

Expression for AMN1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMN1 Gene

mRNA expression in normal human tissues for AMN1 Gene
mRNA expression by GTEx for AMN1 GenemRNA expression by BioGPS for AMN1 Gene

Protein differential expression in normal tissues from HIPED for AMN1 Gene

This gene is overexpressed in Testis (36.3) and Ovary (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMN1 Gene



Protein tissue co-expression partners for AMN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AMN1 Gene:

AMN1

SOURCE GeneReport for Unigene cluster for AMN1 Gene:

Hs.585084

Evidence on tissue expression from TISSUES for AMN1 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with AMN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMN1 Gene

Orthologs for AMN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AMN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia AMN1 33 34
  • 99.61 (n)
dog
(Canis familiaris)
 Mammalia AMN1 33 34
  • 91.09 (n)
cow
(Bos Taurus)
 Mammalia AMN1 33 34
  • 90.96 (n)
rat
(Rattus norvegicus)
 Mammalia Amn1 33
  • 83.2 (n)
mouse
(Mus musculus)
 Mammalia Amn1 33 16 34
  • 82.17 (n)
oppossum
(Monodelphis domestica)
 Mammalia AMN1 34
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia AMN1 34
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves AMN1 33 34
  • 70.37 (n)
lizard
(Anolis carolinensis)
 Reptilia AMN1 34
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485350 33
  • 59.67 (n)
zebrafish
(Danio rerio)
 Actinopterygii amn1 33 34
  • 55.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes AMN1 36
Species where no ortholog for AMN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMN1 Gene

ENSEMBL:
Gene Tree for AMN1 (if available)
TreeFam:
Gene Tree for AMN1 (if available)

Paralogs for AMN1 Gene

(9) SIMAP similar genes for AMN1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with AMN1: view

No data available for Paralogs for AMN1 Gene

Variants for AMN1 Gene

Sequence variations from dbSNP and Humsavar for AMN1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000050426 -- 31,701,475(-) T/G intron_variant
rs1000106667 -- 31,682,737(-) C/A intron_variant
rs1000161298 -- 31,689,503(-) C/G intron_variant
rs1000201362 -- 31,696,167(-) A/G intron_variant
rs1000209549 -- 31,682,528(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AMN1 Gene

Variant ID Type Subtype PubMed ID
esv2422415 CNV duplication 17116639
esv2667845 CNV deletion 23128226
esv2760267 CNV gain+loss 21179565
esv3629053 CNV loss 21293372
nsv1050448 CNV gain 25217958
nsv473227 CNV novel sequence insertion 20440878
nsv558100 CNV gain 21841781
nsv558101 CNV gain 21841781
nsv662 CNV insertion 18451855

Variation tolerance for AMN1 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMN1 Gene

Disorders for AMN1 Gene

Additional Disease Information for AMN1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AMN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMN1 Gene

Publications for AMN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. (PMID: 23761726) Yazar S … Hewitt AW (Molecular vision 2013) 3 58
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for AMN1 Gene

Sources for AMN1 Gene

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