Aliases for AMN1 Gene

Aliases for AMN1 Gene

  • Antagonist Of Mitotic Exit Network 1 Homolog 2 3 5
  • Protein AMN1 Homolog 3 4
  • Antagonist Of Mitotic Exit Network 1 Homolog (S. Cerevisiae) 2

External Ids for AMN1 Gene

Previous GeneCards Identifiers for AMN1 Gene

  • GC12M031716
  • GC12M031824
  • GC12M031576

Summaries for AMN1 Gene

GeneCards Summary for AMN1 Gene

AMN1 (Antagonist Of Mitotic Exit Network 1 Homolog) is a Protein Coding gene. Diseases associated with AMN1 include Astigmatism and Coccidioidomycosis.

Additional gene information for AMN1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AMN1 Gene

Genomics for AMN1 Gene

GeneHancer (GH) Regulatory Elements for AMN1 Gene

Promoters and enhancers for AMN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMN1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AMN1

Top Transcription factor binding sites by QIAGEN in the AMN1 gene promoter:
  • Arnt
  • Elk-1
  • Evi-1
  • GATA-1
  • GATA-2
  • GATA-3
  • GR
  • GR-alpha
  • Lmo2
  • Nkx5-1

Genomic Locations for AMN1 Gene

Genomic Locations for AMN1 Gene
chr12:31,671,137-31,730,392
(GRCh38/hg38)
Size:
59,256 bases
Orientation:
Minus strand
chr12:31,824,071-31,882,108
(GRCh37/hg19)
Size:
58,038 bases
Orientation:
Minus strand

Genomic View for AMN1 Gene

Genes around AMN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMN1 Gene

Proteins for AMN1 Gene

  • Protein details for AMN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY45-AMN1_HUMAN
    Recommended name:
    Protein AMN1 homolog
    Protein Accession:
    Q8IY45
    Secondary Accessions:
    • B7Z7J3
    • Q6NVU4
    • Q86X98

    Protein attributes for AMN1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37897.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH45831.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67906.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AMN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMN1 Gene

Post-translational modifications for AMN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMN1 Gene

Domains & Families for AMN1 Gene

Gene Families for AMN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AMN1 Gene

Suggested Antigen Peptide Sequences for AMN1 Gene

GenScript: Design optimal peptide antigens:
  • Protein AMN1 homolog (AMN1_HUMAN)
  • cDNA FLJ52028 (B7Z7J3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IY45

UniProtKB/Swiss-Prot:

AMN1_HUMAN :
  • Belongs to the AMN1 family.
Family:
  • Belongs to the AMN1 family.
genes like me logo Genes that share domains with AMN1: view

Function for AMN1 Gene

Phenotypes From GWAS Catalog for AMN1 Gene

Gene Ontology (GO) - Molecular Function for AMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with AMN1: view
genes like me logo Genes that share phenotypes with AMN1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMN1 Gene

Localization for AMN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMN1 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
cytosol 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IBA 21873635
genes like me logo Genes that share ontologies with AMN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AMN1 Gene

Pathways & Interactions for AMN1 Gene

PathCards logo

SuperPathways for AMN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0016567 protein ubiquitination IEA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with AMN1: view

No data available for Pathways by source and SIGNOR curated interactions for AMN1 Gene

Drugs & Compounds for AMN1 Gene

No Compound Related Data Available

Transcripts for AMN1 Gene

mRNA/cDNA for AMN1 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - -

Relevant External Links for AMN1 Gene

GeneLoc Exon Structure for
AMN1

Expression for AMN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMN1 Gene

Protein differential expression in normal tissues from HIPED for AMN1 Gene

This gene is overexpressed in Testis (36.3) and Ovary (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMN1 Gene



Protein tissue co-expression partners for AMN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AMN1

SOURCE GeneReport for Unigene cluster for AMN1 Gene:

Hs.585084

Evidence on tissue expression from TISSUES for AMN1 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with AMN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMN1 Gene

Orthologs for AMN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AMN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMN1 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AMN1 31 30
  • 91.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AMN1 31 30
  • 90.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amn1 30
  • 83.2 (n)
mouse
(Mus musculus)
Mammalia Amn1 17 31 30
  • 82.17 (n)
oppossum
(Monodelphis domestica)
Mammalia AMN1 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMN1 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMN1 31 30
  • 70.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMN1 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485350 30
  • 59.67 (n)
zebrafish
(Danio rerio)
Actinopterygii amn1 31 30
  • 55.56 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMN1 33
Species where no ortholog for AMN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMN1 Gene

ENSEMBL:
Gene Tree for AMN1 (if available)
TreeFam:
Gene Tree for AMN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AMN1: view image

Paralogs for AMN1 Gene

(9) SIMAP similar genes for AMN1 Gene using alignment to 8 proteins:

  • AMN1_HUMAN
  • B7Z7J3_HUMAN
  • E9PHB0_HUMAN
  • F5GWF7_HUMAN
  • F5H1R2_HUMAN
  • F5H286_HUMAN
  • F5H3D1_HUMAN
  • F5H7U5_HUMAN
genes like me logo Genes that share paralogs with AMN1: view

No data available for Paralogs for AMN1 Gene

Variants for AMN1 Gene

Additional dbSNP identifiers (rs#s) for AMN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AMN1 Gene

Variant ID Type Subtype PubMed ID
esv2422415 CNV duplication 17116639
esv2667845 CNV deletion 23128226
esv2760267 CNV gain+loss 21179565
esv3629053 CNV loss 21293372
nsv1050448 CNV gain 25217958
nsv473227 CNV novel sequence insertion 20440878
nsv558100 CNV gain 21841781
nsv558101 CNV gain 21841781
nsv662 CNV insertion 18451855

Variation tolerance for AMN1 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AMN1 Gene

Disorders for AMN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AMN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
astigmatism
coccidioidomycosis
  • primary extrapulmonary coccidioidomycosis
- elite association - COSMIC cancer census association via MalaCards
Search AMN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AMN1

genes like me logo Genes that share disorders with AMN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMN1 Gene

Publications for AMN1 Gene

  1. Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae. (PMID: 30273335) Fang O … Luo Z (PLoS genetics 2018) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. (PMID: 23761726) Yazar S … Hewitt AW (Molecular vision 2013) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 54

Products for AMN1 Gene

Sources for AMN1 Gene