Aliases for AMN Gene
External Ids for AMN Gene
Previous GeneCards Identifiers for AMN Gene
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
GeneCards Summary for AMN Gene
AMN (Amnion Associated Transmembrane Protein) is a Protein Coding gene. Diseases associated with AMN include Imerslund-Grasbeck Syndrome 2 and Megaloblastic Anemia. Among its related pathways are Lipoprotein metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.
UniProtKB/Swiss-Prot Summary for AMN Gene
Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:14576052, PubMed:30523278, PubMed:29402915). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:14576052, PubMed:29402915). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052, PubMed:26040326). Required for normal CUBN-mediated protein transport in the kidney (Probable).