Aliases for AMMECR1L Gene

Aliases for AMMECR1L Gene

  • AMMECR1 Like 2 3 5
  • AMME Chromosomal Region Gene 1-Like 2 3
  • AMMECR1-Like Protein 3 4
  • AMMECR1-Like 2
  • AMMECR1L 5
  • MGC4268 2

External Ids for AMMECR1L Gene

Previous GeneCards Identifiers for AMMECR1L Gene

  • GC02M128336
  • GC02M128619
  • GC02M120925

Summaries for AMMECR1L Gene

GeneCards Summary for AMMECR1L Gene

AMMECR1L (AMMECR1 Like) is a Protein Coding gene. An important paralog of this gene is AMMECR1.

Additional gene information for AMMECR1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AMMECR1L Gene

Genomics for AMMECR1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AMMECR1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMMECR1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AMMECR1L

Top Transcription factor binding sites by QIAGEN in the AMMECR1L gene promoter:
  • AML1a
  • Cart-1
  • E47
  • Egr-1
  • Egr-4
  • LUN-1
  • Pax-5
  • POU2F1a
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for AMMECR1L Gene

Genomic Locations for AMMECR1L Gene
chr2:127,861,630-127,887,575
(GRCh38/hg38)
Size:
25,946 bases
Orientation:
Minus strand
chr2:128,619,204-128,643,514
(GRCh37/hg19)
Size:
24,311 bases
Orientation:
Minus strand

Genomic View for AMMECR1L Gene

Genes around AMMECR1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMMECR1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMMECR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMMECR1L Gene

Proteins for AMMECR1L Gene

  • Protein details for AMMECR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DCA0-AMERL_HUMAN
    Recommended name:
    AMMECR1-like protein
    Protein Accession:
    Q6DCA0
    Secondary Accessions:
    • B4E276

    Protein attributes for AMMECR1L Gene

    Size:
    310 amino acids
    Molecular mass:
    34499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AMMECR1L Gene

Post-translational modifications for AMMECR1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMMECR1L Gene

Domains & Families for AMMECR1L Gene

Gene Families for AMMECR1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AMMECR1L Gene

Suggested Antigen Peptide Sequences for AMMECR1L Gene

GenScript: Design optimal peptide antigens:
  • AMMECR1-like protein (AMERL_HUMAN)
genes like me logo Genes that share domains with AMMECR1L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AMMECR1L Gene

Function for AMMECR1L Gene

Phenotypes From GWAS Catalog for AMMECR1L Gene

genes like me logo Genes that share phenotypes with AMMECR1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AMMECR1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMMECR1L Gene

Localization for AMMECR1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMMECR1L gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AMMECR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with AMMECR1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AMMECR1L Gene

Pathways & Interactions for AMMECR1L Gene

PathCards logo

SuperPathways for AMMECR1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMMECR1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AMMECR1L Gene

Drugs & Compounds for AMMECR1L Gene

No Compound Related Data Available

Transcripts for AMMECR1L Gene

mRNA/cDNA for AMMECR1L Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AMMECR1L

Alternative Splicing Database (ASD) splice patterns (SP) for AMMECR1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for AMMECR1L Gene

GeneLoc Exon Structure for
AMMECR1L

Expression for AMMECR1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMMECR1L Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMMECR1L Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AMMECR1L

SOURCE GeneReport for Unigene cluster for AMMECR1L Gene:

Hs.546449
genes like me logo Genes that share expression patterns with AMMECR1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMMECR1L Gene

Orthologs for AMMECR1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AMMECR1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AMMECR1L 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia AMMECR1L 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia AMMECR1L 30 31
  • 97.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AMMECR1L 30 31
  • 95.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ammecr1l 30
  • 94.95 (n)
Mouse
(Mus musculus)
Mammalia Ammecr1l 30 17 31
  • 94.3 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AMMECR1L 31
  • 91 (a)
OneToOne
Chicken
(Gallus gallus)
Aves AMMECR1L 30 31
  • 88.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AMMECR1L 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ammecr1l 30
  • 74.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii Dr.13202 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5902 31
  • 55 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea R166.3 31
  • 43 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 27 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9118 31
  • 45 (a)
OneToMany
Species where no ortholog for AMMECR1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AMMECR1L Gene

ENSEMBL:
Gene Tree for AMMECR1L (if available)
TreeFam:
Gene Tree for AMMECR1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AMMECR1L: view image

Paralogs for AMMECR1L Gene

Paralogs for AMMECR1L Gene

(1) SIMAP similar genes for AMMECR1L Gene using alignment to 1 proteins:

  • AMERL_HUMAN

Pseudogenes.org Pseudogenes for AMMECR1L Gene

genes like me logo Genes that share paralogs with AMMECR1L: view

Variants for AMMECR1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AMMECR1L Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
769573 Benign: not provided 127,873,991(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AMMECR1L Gene

Structural Variations from Database of Genomic Variants (DGV) for AMMECR1L Gene

Variant ID Type Subtype PubMed ID
esv3303901 CNV mobile element insertion 20981092
esv3308379 CNV mobile element insertion 20981092
esv3373656 CNV insertion 20981092
esv3393135 CNV duplication 20981092
esv3448130 CNV insertion 20981092
nsv1133485 CNV deletion 24896259
nsv834367 CNV loss 17160897

Variation tolerance for AMMECR1L Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMMECR1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMMECR1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMMECR1L Gene

Disorders for AMMECR1L Gene

Additional Disease Information for AMMECR1L

No disorders were found for AMMECR1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMMECR1L Gene

Publications for AMMECR1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for AMMECR1L Gene

Sources for AMMECR1L Gene