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Aliases for AMMECR1L Gene

Aliases for AMMECR1L Gene

  • AMMECR1 Like 2 3 5
  • AMME Chromosomal Region Gene 1-Like 2
  • AMMECR1-Like 2

External Ids for AMMECR1L Gene

Previous GeneCards Identifiers for AMMECR1L Gene

  • GC02M128336
  • GC02M128619
  • GC02M120925

Summaries for AMMECR1L Gene

GeneCards Summary for AMMECR1L Gene

AMMECR1L (AMMECR1 Like) is a Protein Coding gene. An important paralog of this gene is AMMECR1.

Additional gene information for AMMECR1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMMECR1L Gene

Genomics for AMMECR1L Gene

GeneHancer (GH) Regulatory Elements for AMMECR1L Gene

Promoters and enhancers for AMMECR1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I127883 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 578.7 +2.4 2390 4.5 HDGF ATF1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 AMMECR1L PIR57738 ENSG00000272667 GC02P127896 WDR33 SAP130 MAP3K2 ERCC3 CYP27C1 GC02P127874
GH02I128090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.3 -202.8 -202831 2.4 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 UGGT1 AMMECR1L WDR33 SAP130 ERCC3 MAP3K2 GC02P128122 GC02P127983
GH02I127770 Enhancer 1 Ensembl ENCODE 78 +116.9 116889 2 ZFP64 ZNF213 ZNF354C ZNF138 KLF7 FOS ZNF202 ZNF654 ZBTB11 ZC3H11A AMMECR1L WDR33 ERCC3 ENSG00000231731 MAP3K2 UGGT1 ENSG00000260634 SAP130 POLR2D PIR38298
GH02I127525 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.5 +361.4 361440 4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IWS1 MAP3K2 AMMECR1L WDR33 ENSG00000236682 UGGT1 ENSG00000272789 ENSG00000231731 SFT2D3 GC02P127529
GH02I127385 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +500.1 500143 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000236682 MAP3K2 ERCC3 AMMECR1L GPR17 WDR33 ENSG00000231731 SFT2D3 GC02P127390 GC02P127379
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AMMECR1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AMMECR1L gene promoter:

Genomic Locations for AMMECR1L Gene

Genomic Locations for AMMECR1L Gene
chr2:127,861,630-127,888,570
(GRCh38/hg38)
Size:
26,941 bases
Orientation:
Minus strand
chr2:128,619,204-128,643,514
(GRCh37/hg19)

Genomic View for AMMECR1L Gene

Genes around AMMECR1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMMECR1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMMECR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMMECR1L Gene

Proteins for AMMECR1L Gene

  • Protein details for AMMECR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DCA0-AMERL_HUMAN
    Recommended name:
    AMMECR1-like protein
    Protein Accession:
    Q6DCA0
    Secondary Accessions:
    • B4E276

    Protein attributes for AMMECR1L Gene

    Size:
    310 amino acids
    Molecular mass:
    34499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AMMECR1L Gene

Post-translational modifications for AMMECR1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMMECR1L Gene

Domains & Families for AMMECR1L Gene

Gene Families for AMMECR1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AMMECR1L Gene

Suggested Antigen Peptide Sequences for AMMECR1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AMMECR1L: view

No data available for UniProtKB/Swiss-Prot for AMMECR1L Gene

Function for AMMECR1L Gene

Phenotypes From GWAS Catalog for AMMECR1L Gene

genes like me logo Genes that share phenotypes with AMMECR1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMMECR1L Gene

Localization for AMMECR1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMMECR1L gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMMECR1L Gene

Pathways & Interactions for AMMECR1L Gene

SuperPathways for AMMECR1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMMECR1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AMMECR1L Gene

Drugs & Compounds for AMMECR1L Gene

No Compound Related Data Available

Transcripts for AMMECR1L Gene

Unigene Clusters for AMMECR1L Gene

AMMECR1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMMECR1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for AMMECR1L Gene

GeneLoc Exon Structure for
AMMECR1L
ECgene alternative splicing isoforms for
AMMECR1L

Expression for AMMECR1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMMECR1L Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMMECR1L Gene



NURSA nuclear receptor signaling pathways regulating expression of AMMECR1L Gene:

AMMECR1L

SOURCE GeneReport for Unigene cluster for AMMECR1L Gene:

Hs.546449
genes like me logo Genes that share expression patterns with AMMECR1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMMECR1L Gene

Orthologs for AMMECR1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AMMECR1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMMECR1L 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia AMMECR1L 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMMECR1L 33 34
  • 97.53 (n)
cow
(Bos Taurus)
Mammalia AMMECR1L 33 34
  • 95.59 (n)
rat
(Rattus norvegicus)
Mammalia Ammecr1l 33
  • 94.95 (n)
mouse
(Mus musculus)
Mammalia Ammecr1l 33 16 34
  • 94.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AMMECR1L 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMMECR1L 33 34
  • 88.39 (n)
lizard
(Anolis carolinensis)
Reptilia AMMECR1L 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ammecr1l 33
  • 74.34 (n)
zebrafish
(Danio rerio)
Actinopterygii Dr.13202 33
fruit fly
(Drosophila melanogaster)
Insecta CG5902 34
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R166.3 34
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9118 34
  • 45 (a)
OneToMany
Species where no ortholog for AMMECR1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMMECR1L Gene

ENSEMBL:
Gene Tree for AMMECR1L (if available)
TreeFam:
Gene Tree for AMMECR1L (if available)

Paralogs for AMMECR1L Gene

Paralogs for AMMECR1L Gene

(1) SIMAP similar genes for AMMECR1L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for AMMECR1L Gene

genes like me logo Genes that share paralogs with AMMECR1L: view

Variants for AMMECR1L Gene

Sequence variations from dbSNP and Humsavar for AMMECR1L Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000280971 -- 127,861,841(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000442092 -- 127,862,101(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000691840 -- 127,867,714(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000697803 -- 127,879,140(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000769841 -- 127,879,351(-) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AMMECR1L Gene

Variant ID Type Subtype PubMed ID
esv3303901 CNV mobile element insertion 20981092
esv3308379 CNV mobile element insertion 20981092
esv3373656 CNV insertion 20981092
esv3393135 CNV duplication 20981092
esv3448130 CNV insertion 20981092
nsv1133485 CNV deletion 24896259
nsv834367 CNV loss 17160897

Variation tolerance for AMMECR1L Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMMECR1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMMECR1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMMECR1L Gene

Disorders for AMMECR1L Gene

Additional Disease Information for AMMECR1L

No disorders were found for AMMECR1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMMECR1L Gene

Publications for AMMECR1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for AMMECR1L Gene

Sources for AMMECR1L Gene

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