Aliases for AMIGO3 Gene

Aliases for AMIGO3 Gene

  • Adhesion Molecule With Ig Like Domain 3 2 3 5
  • Amphoterin-Induced Protein 3 3 4
  • Alivin-3 3 4
  • AMIGO-3 3 4
  • ALI3 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 3 2
  • Amphoterin-Induced Gene And ORF 3 3
  • KIAA1851 4

External Ids for AMIGO3 Gene

Previous GeneCards Identifiers for AMIGO3 Gene

  • GC03U900475
  • GC03M049713
  • GC03M049729
  • GC03M049755

Summaries for AMIGO3 Gene

GeneCards Summary for AMIGO3 Gene

AMIGO3 (Adhesion Molecule With Ig Like Domain 3) is a Protein Coding gene. Diseases associated with AMIGO3 include Urofacial Syndrome 1. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot Summary for AMIGO3 Gene

  • May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

Additional gene information for AMIGO3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AMIGO3 Gene

Genomics for AMIGO3 Gene

GeneHancer (GH) Regulatory Elements for AMIGO3 Gene

Promoters and enhancers for AMIGO3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049718 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 500.7 +0.5 546 2.1 ZNF217 SP1 CTCF POLR2A TRIM22 NFYB MXI1 ZNF341 SIN3A SMC3 AMIGO3 INKA1 GMPPB MST1 RNF123 RF00017-3998
GH03J050316 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -600.8 -600805 9.1 FOXK2 ZBTB40 ZNF217 EP300 CTCF MYC NRF1 USF1 POLR2G SP1 HYAL2 RBM6 AMT RBM5 HYAL3 RHOA-IT1 TMEM115 SEMA3F-AS1 HEMK1 GMPPB
GH03J049685 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +31.3 31327 5.4 FOXK2 ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G SP1 PHF8 ZFX MST1 RNF123 lnc-MST1-1 piR-46140 AMT RBM6 QRICH1 CDHR4 AMIGO3 GMPPB
GH03J049016 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +699.5 699544 6.8 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A MYC NRF1 POLR2G SP1 DALRD3 MIR191 MIR425 NDUFAF3 WDR6 AMT ENSG00000235236 ENSG00000223343 P4HTM RBM6
GH03J050297 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 -581.1 -581068 6.5 ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G NCOR1 PHF8 ZIC2 ZBTB10 HYAL3 HYAL1 NAA80 lnc-HYAL3-1 RBM6 AMT RHOA-IT1 TMEM115 SEMA3F-AS1 HEMK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMIGO3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AMIGO3

Top Transcription factor binding sites by QIAGEN in the AMIGO3 gene promoter:
  • MIF-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for AMIGO3 Gene

Genomic Locations for AMIGO3 Gene
2,977 bases
Minus strand
7,083 bases
Minus strand

Genomic View for AMIGO3 Gene

Genes around AMIGO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO3 Gene

Proteins for AMIGO3 Gene

  • Protein details for AMIGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amphoterin-induced protein 3
    Protein Accession:
    Secondary Accessions:
    • Q494V6
    • Q96JH6

    Protein attributes for AMIGO3 Gene

    504 amino acids
    Molecular mass:
    55250 Da
    Quaternary structure:
    • Binds AMIGO1 or AMIGO2.
    • Sequence=BAB47480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AMIGO3 Gene

Post-translational modifications for AMIGO3 Gene

  • Glycosylation at Asn107, Asn272, Asn301, Asn362, and Asn368
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMIGO3 Gene

Domains & Families for AMIGO3 Gene

Gene Families for AMIGO3 Gene

Protein Domains for AMIGO3 Gene

  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, N-terminal

Suggested Antigen Peptide Sequences for AMIGO3 Gene

GenScript: Design optimal peptide antigens:
  • Alivin-3 (AMGO3_HUMAN)
  • Adhesion molecule with Ig-like domain 3 (Q494V5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
genes like me logo Genes that share domains with AMIGO3: view

Function for AMIGO3 Gene

Molecular function for AMIGO3 Gene

UniProtKB/Swiss-Prot Function:
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

Phenotypes From GWAS Catalog for AMIGO3 Gene

genes like me logo Genes that share phenotypes with AMIGO3: view

Animal Models for AMIGO3 Gene

MGI Knock Outs for AMIGO3:
  • Amigo3 Amigo3<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for AMIGO3

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AMIGO3 Gene

Localization for AMIGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMIGO3 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 2
extracellular 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AMIGO3 Gene

Pathways & Interactions for AMIGO3 Gene

PathCards logo

SuperPathways for AMIGO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007420 brain development IBA 21873635
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO3 Gene

Drugs & Compounds for AMIGO3 Gene

No Compound Related Data Available

Transcripts for AMIGO3 Gene

mRNA/cDNA for AMIGO3 Gene

7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO3 Gene

No ASD Table

Relevant External Links for AMIGO3 Gene

GeneLoc Exon Structure for

Expression for AMIGO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMIGO3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AMIGO3

SOURCE GeneReport for Unigene cluster for AMIGO3 Gene:

genes like me logo Genes that share expression patterns with AMIGO3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO3 Gene

Orthologs for AMIGO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMIGO3 31
  • 99 (a)
(Canis familiaris)
Mammalia AMIGO3 31 30
  • 83.4 (n)
(Bos Taurus)
Mammalia AMIGO3 31 30
  • 82.34 (n)
(Rattus norvegicus)
Mammalia Amigo3 30
  • 78.84 (n)
(Mus musculus)
Mammalia Amigo3 17 31 30
  • 78 (n)
(Monodelphis domestica)
Mammalia AMIGO3 31
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia AMIGO3 31
  • 51 (a)
(Gallus gallus)
Aves AMIGO3 31 30
  • 63.31 (n)
(Anolis carolinensis)
Reptilia AMIGO3 31
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo3 30
  • 51.83 (n)
(Danio rerio)
Actinopterygii amigo3 31 30
  • 51.21 (n)
CR385022.1 31
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
Species where no ortholog for AMIGO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO3 Gene

Gene Tree for AMIGO3 (if available)
Gene Tree for AMIGO3 (if available)
Evolutionary constrained regions (ECRs) for AMIGO3: view image

Paralogs for AMIGO3 Gene

Paralogs for AMIGO3 Gene

(4) SIMAP similar genes for AMIGO3 Gene using alignment to 2 proteins:

  • Q494V5_HUMAN
genes like me logo Genes that share paralogs with AMIGO3: view

Variants for AMIGO3 Gene

Additional dbSNP identifiers (rs#s) for AMIGO3 Gene

Structural Variations from Database of Genomic Variants (DGV) for AMIGO3 Gene

Variant ID Type Subtype PubMed ID
nsv482082 CNV gain 20164927
nsv508217 CNV deletion 20534489

Variation tolerance for AMIGO3 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMIGO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AMIGO3 Gene

Disorders for AMIGO3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMIGO3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
urofacial syndrome 1
  • ufs1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AMIGO3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AMIGO3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO3 Gene

Publications for AMIGO3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  2. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J … Rauvala H (The Journal of cell biology 2003) 2 3 4 54
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan AR … Ferguson LR (Human immunology 2010) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 54

Products for AMIGO3 Gene

Sources for AMIGO3 Gene