Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMIGO3 Gene

Aliases for AMIGO3 Gene

  • Adhesion Molecule With Ig Like Domain 3 2 3 5
  • Alivin-3 3 4
  • AMIGO-3 3 4
  • ALI3 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 3 2
  • Amphoterin-Induced Gene And ORF 3 3
  • Amphoterin-Induced Protein 3 3
  • KIAA1851 4

External Ids for AMIGO3 Gene

Previous GeneCards Identifiers for AMIGO3 Gene

  • GC03U900475
  • GC03M049713
  • GC03M049729
  • GC03M049755

Summaries for AMIGO3 Gene

GeneCards Summary for AMIGO3 Gene

AMIGO3 (Adhesion Molecule With Ig Like Domain 3) is a Protein Coding gene. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot for AMIGO3 Gene

  • May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

Additional gene information for AMIGO3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO3 Gene

Genomics for AMIGO3 Gene

GeneHancer (GH) Regulatory Elements for AMIGO3 Gene

Promoters and enhancers for AMIGO3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I049719 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 271 1.6 HDGF CTCF MXI1 ZNF133 MAX BACH1 SIN3A EBF1 RAD21 CCNT2 AMIGO3 FAM212A GMPPB MST1 RNF123 GC03P049421
GH03I049718 Enhancer 0.4 ENCODE 550.8 +1.2 1229 0.1 ZNF133 ZBTB33 AMIGO3 GMPPB MST1 RNF123 GC03P049421
GH03I049686 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.6 +31.5 31457 4.2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MST1 PIR39139 RNF123 AMT RBM6 QRICH1 CDHR4 AMIGO3 GMPPB IMPDH2
GH03I050257 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 -547.7 -547696 19.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SEMA3B SEMA3B-AS1 HYAL3 CYB561D2 IFRD2 GNAI2 AMT HYAL1 AMIGO3 DOCK3
GH03I049747 Enhancer 0.7 ENCODE 12.2 -28.6 -28593 1.9 SOX5 GATAD2A SAP130 TEAD1 JUN HLF CEBPG HMG20A ZNF644 ZKSCAN1 FAM212A PHF5EP IP6K1 GMPPB AMIGO3 RNF123 BSN-AS1 BSN BSN-AS2 COX6CP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AMIGO3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AMIGO3 gene promoter:

Genomic Locations for AMIGO3 Gene

Genomic Locations for AMIGO3 Gene
chr3:49,716,834-49,719,805
(GRCh38/hg38)
Size:
2,972 bases
Orientation:
Minus strand
chr3:49,754,267-49,761,349
(GRCh37/hg19)

Genomic View for AMIGO3 Gene

Genes around AMIGO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO3 Gene

Proteins for AMIGO3 Gene

  • Protein details for AMIGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK7-AMGO3_HUMAN
    Recommended name:
    Amphoterin-induced protein 3
    Protein Accession:
    Q86WK7
    Secondary Accessions:
    • Q494V6
    • Q96JH6

    Protein attributes for AMIGO3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55250 Da
    Quaternary structure:
    • Binds AMIGO1 or AMIGO2.
    SequenceCaution:
    • Sequence=BAB47480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AMIGO3 Gene

Post-translational modifications for AMIGO3 Gene

  • Glycosylation at posLast=107107, Asn272, Asn301, posLast=362362, and Asn368

Other Protein References for AMIGO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMIGO3 Gene

Domains & Families for AMIGO3 Gene

Gene Families for AMIGO3 Gene

Suggested Antigen Peptide Sequences for AMIGO3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK7

UniProtKB/Swiss-Prot:

AMGO3_HUMAN :
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
genes like me logo Genes that share domains with AMIGO3: view

Function for AMIGO3 Gene

Molecular function for AMIGO3 Gene

UniProtKB/Swiss-Prot Function:
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).
genes like me logo Genes that share phenotypes with AMIGO3: view

Animal Models for AMIGO3 Gene

MGI Knock Outs for AMIGO3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AMIGO3 Gene

Localization for AMIGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMIGO3 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AMIGO3 Gene

Pathways & Interactions for AMIGO3 Gene

SuperPathways for AMIGO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO3 Gene

Drugs & Compounds for AMIGO3 Gene

No Compound Related Data Available

Transcripts for AMIGO3 Gene

mRNA/cDNA for AMIGO3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMIGO3 Gene

Adhesion molecule with Ig-like domain 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO3 Gene

No ASD Table

Relevant External Links for AMIGO3 Gene

GeneLoc Exon Structure for
AMIGO3
ECgene alternative splicing isoforms for
AMIGO3

Expression for AMIGO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMIGO3 Gene

NURSA nuclear receptor signaling pathways regulating expression of AMIGO3 Gene:

AMIGO3

SOURCE GeneReport for Unigene cluster for AMIGO3 Gene:

Hs.567903
genes like me logo Genes that share expression patterns with AMIGO3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO3 Gene

Orthologs for AMIGO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO3 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO3 33 34
  • 83.4 (n)
cow
(Bos Taurus)
Mammalia AMIGO3 33 34
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Amigo3 33
  • 78.84 (n)
mouse
(Mus musculus)
Mammalia Amigo3 33 16 34
  • 78 (n)
oppossum
(Monodelphis domestica)
Mammalia AMIGO3 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO3 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO3 33 34
  • 63.31 (n)
lizard
(Anolis carolinensis)
Reptilia AMIGO3 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo3 33
  • 51.83 (n)
zebrafish
(Danio rerio)
Actinopterygii amigo3 33 34
  • 51.21 (n)
CR385022.1 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for AMIGO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO3 Gene

ENSEMBL:
Gene Tree for AMIGO3 (if available)
TreeFam:
Gene Tree for AMIGO3 (if available)

Paralogs for AMIGO3 Gene

Paralogs for AMIGO3 Gene

(4) SIMAP similar genes for AMIGO3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AMIGO3: view

Variants for AMIGO3 Gene

Sequence variations from dbSNP and Humsavar for AMIGO3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs184127567 uncertain-significance, likely-benign, not specified, Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 14, Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type b, 14, Muscular dystrophy-dystroglycanopathy (limb-girdle), type c, 14 49,721,787(-) C/T upstream_transcript_variant
rs1000783242 -- 49,720,182(-) G/A upstream_transcript_variant
rs1000848134 -- 49,721,336(-) C/T upstream_transcript_variant
rs1001399602 -- 49,721,226(-) T/G upstream_transcript_variant
rs1002239690 -- 49,719,828(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AMIGO3 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV deletion 20534489
nsv482082 CNV gain 20164927

Variation tolerance for AMIGO3 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMIGO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO3 Gene

Disorders for AMIGO3 Gene

Additional Disease Information for AMIGO3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AMIGO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMIGO3 Gene

Publications for AMIGO3 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J … Rauvala H (The Journal of cell biology 2003) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan AR … Ferguson LR (Human immunology 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58

Products for AMIGO3 Gene

Sources for AMIGO3 Gene

Content
Loading form....