Aliases for AMIGO2 Gene

Aliases for AMIGO2 Gene

  • Adhesion Molecule With Ig Like Domain 2 2 3 5
  • Differentially Expressed In Gastric Adenocarcinomas 3 4
  • Amphoterin-Induced Protein 2 3 4
  • AMIGO-2 3 4
  • ALI1 3 4
  • DEGA 3 4
  • Differentially Expressed In Gastric Adenocarcinoma 3
  • Amphoterin-Induced Gene And Open Reading Frame 2 2
  • Transmembrane Protein AMIGO2 3
  • Amphoterin Induced Gene 2 3
  • Alivin 1 3
  • Alivin-1 4

External Ids for AMIGO2 Gene

Previous GeneCards Identifiers for AMIGO2 Gene

  • GC12M047186
  • GC12M045756
  • GC12M045755
  • GC12M047469
  • GC12M044500

Summaries for AMIGO2 Gene

GeneCards Summary for AMIGO2 Gene

AMIGO2 (Adhesion Molecule With Ig Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include Gastric Adenocarcinoma and Emphysematous Cholecystitis. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot Summary for AMIGO2 Gene

  • Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Additional gene information for AMIGO2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AMIGO2 Gene

Genomics for AMIGO2 Gene

GeneHancer (GH) Regulatory Elements for AMIGO2 Gene

Promoters and enhancers for AMIGO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J047076 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.5 -1541 13.9 ZNF217 CTCF ZSCAN5C TCF12 NRF1 JUND FOS ZNF639 ZBTB5 ZIC2 AMIGO2 PCED1B ENSG00000258181 IFITM3P6
GH12J047211 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.8 -137.3 -137256 14.6 EP300 ZBTB40 ZNF217 TCF12 NCOR1 GTF2E2 ZBTB5 TCF7 FOXA1 AFF1 PCED1B PCED1B-AS1 AMIGO2 CCDC184 ENSG00000258181 ENSG00000199566 lnc-PCED1B-6
GH12J047204 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 17.1 -126.9 -126855 6.2 TCF12 PHB2 ZBTB5 ZBTB11 REST DNMT1 MYC TOE1 CTBP1 HINFP AMIGO2 PCED1B-AS1 PCED1B MIR4698
GH12J047188 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.3 -113.2 -113175 14 ZNF217 TCF12 FOS TEAD4 ZIC2 AFF1 REST MYC EP300 GATAD2B AMIGO2 CCDC184 ENSG00000199566 ENSG00000258181 PCED1B-AS1 PCED1B MIR4698
GH12J047376 Promoter/Enhancer 1.3 Ensembl ENCODE 10.7 -297.5 -297461 2.7 TCF12 JUND FOS ZIC2 ZBTB10 AFF1 TRIM28 TARDBP HES1 MYC LINC02156 ENSG00000199566 AMIGO2 LINC02416 PCED1B lnc-RPAP3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMIGO2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AMIGO2

Top Transcription factor binding sites by QIAGEN in the AMIGO2 gene promoter:
  • aMEF-2
  • AML1a
  • AP-4
  • Cart-1
  • GATA-3
  • Lhx3a
  • LHX3b
  • Lmo2
  • MEF-2A
  • RelA

Genomic Locations for AMIGO2 Gene

Genomic Locations for AMIGO2 Gene
chr12:47,075,707-47,080,826
(GRCh38/hg38)
Size:
5,120 bases
Orientation:
Minus strand
chr12:47,469,490-47,473,734
(GRCh37/hg19)
Size:
4,245 bases
Orientation:
Minus strand

Genomic View for AMIGO2 Gene

Genes around AMIGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO2 Gene

Proteins for AMIGO2 Gene

  • Protein details for AMIGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SJ2-AMGO2_HUMAN
    Recommended name:
    Amphoterin-induced protein 2
    Protein Accession:
    Q86SJ2
    Secondary Accessions:
    • Q4VBP6
    • Q7Z4A0
    • Q96CN8

    Protein attributes for AMIGO2 Gene

    Size:
    522 amino acids
    Molecular mass:
    57934 Da
    Quaternary structure:
    • Binds itself as well as AMIGO1 and AMIGO3.

neXtProt entry for AMIGO2 Gene

Post-translational modifications for AMIGO2 Gene

  • Glycosylation at Asn58, Asn104, Asn281, Asn288, Asn345, Asn373, Asn381, and Asn384
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • AMGO2_HUMAN (1007)

Other Protein References for AMIGO2 Gene

No data available for DME Specific Peptides for AMIGO2 Gene

Domains & Families for AMIGO2 Gene

Gene Families for AMIGO2 Gene

Protein Domains for AMIGO2 Gene

Suggested Antigen Peptide Sequences for AMIGO2 Gene

GenScript: Design optimal peptide antigens:
  • Differentially expressed in gastric adenocarcinomas (AMGO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86SJ2

UniProtKB/Swiss-Prot:

AMGO2_HUMAN :
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
genes like me logo Genes that share domains with AMIGO2: view

Function for AMIGO2 Gene

Molecular function for AMIGO2 Gene

UniProtKB/Swiss-Prot Function:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Phenotypes From GWAS Catalog for AMIGO2 Gene

Gene Ontology (GO) - Molecular Function for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with AMIGO2: view
genes like me logo Genes that share phenotypes with AMIGO2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AMIGO2

CRISPR Products

miRNA for AMIGO2 Gene

miRTarBase miRNAs that target AMIGO2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO2 Gene

Localization for AMIGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMIGO2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
extracellular 2
mitochondrion 2
golgi apparatus 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with AMIGO2: view

Pathways & Interactions for AMIGO2 Gene

PathCards logo

SuperPathways for AMIGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007420 brain development IBA 21873635
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with AMIGO2: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO2 Gene

Drugs & Compounds for AMIGO2 Gene

No Compound Related Data Available

Transcripts for AMIGO2 Gene

mRNA/cDNA for AMIGO2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1:
SP2:
SP3: -

Relevant External Links for AMIGO2 Gene

GeneLoc Exon Structure for
AMIGO2

Expression for AMIGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMIGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMIGO2 Gene

This gene is overexpressed in Artery - Tibial (x6.5).

Protein differential expression in normal tissues from HIPED for AMIGO2 Gene

This gene is overexpressed in Amniocyte (60.2) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMIGO2 Gene



Protein tissue co-expression partners for AMIGO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AMIGO2

SOURCE GeneReport for Unigene cluster for AMIGO2 Gene:

Hs.121520

mRNA Expression by UniProt/SwissProt for AMIGO2 Gene:

Q86SJ2-AMGO2_HUMAN
Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

Evidence on tissue expression from TISSUES for AMIGO2 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with AMIGO2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO2 Gene

Orthologs for AMIGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO2 31 30
  • 99.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AMIGO2 31 30
  • 89.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO2 31 30
  • 87.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Amigo2 17 31 30
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Amigo2 30
  • 83.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO2 31
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO2 31 30
  • 68.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMIGO2 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo2 30
  • 65.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToMany
Species where no ortholog for AMIGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMIGO2 Gene

ENSEMBL:
Gene Tree for AMIGO2 (if available)
TreeFam:
Gene Tree for AMIGO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AMIGO2: view image

Paralogs for AMIGO2 Gene

Paralogs for AMIGO2 Gene

(2) SIMAP similar genes for AMIGO2 Gene using alignment to 1 proteins:

  • AMGO2_HUMAN
genes like me logo Genes that share paralogs with AMIGO2: view

Variants for AMIGO2 Gene

Additional dbSNP identifiers (rs#s) for AMIGO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for AMIGO2 Gene

Variant ID Type Subtype PubMed ID
nsv558784 CNV gain 21841781
nsv694 CNV deletion 18451855

Variation tolerance for AMIGO2 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMIGO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AMIGO2 Gene

Disorders for AMIGO2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AMIGO2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
emphysematous cholecystitis
  • gaseous pericholecystitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AMIGO2

genes like me logo Genes that share disorders with AMIGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO2 Gene

Publications for AMIGO2 Gene

  1. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PMID: 15107827) Rabenau KE … Pereira DS (Oncogene 2004) 2 3 4 23 54
  2. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PMID: 12843293) Ono T … Kawashima S (The Journal of neuroscience : the official journal of the Society for Neuroscience 2003) 2 3 4 23 54
  3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J … Rauvala H (The Journal of cell biology 2003) 2 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 54

Products for AMIGO2 Gene

Sources for AMIGO2 Gene