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Aliases for AMIGO2 Gene

Aliases for AMIGO2 Gene

  • Adhesion Molecule With Ig Like Domain 2 2 3 5
  • Differentially Expressed In Gastric Adenocarcinomas 3 4
  • AMIGO-2 3 4
  • ALI1 3 4
  • DEGA 3 4
  • Differentially Expressed In Gastric Adenocarcinoma 3
  • Amphoterin-Induced Gene And Open Reading Frame 2 2
  • Amphoterin-Induced Protein 2 3
  • Transmembrane Protein AMIGO2 3
  • Amphoterin Induced Gene 2 3
  • Alivin 1 3
  • Alivin-1 4

External Ids for AMIGO2 Gene

Previous GeneCards Identifiers for AMIGO2 Gene

  • GC12M047186
  • GC12M045756
  • GC12M045755
  • GC12M047469
  • GC12M044500

Summaries for AMIGO2 Gene

GeneCards Summary for AMIGO2 Gene

AMIGO2 (Adhesion Molecule With Ig Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include Gastric Adenocarcinoma. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot for AMIGO2 Gene

  • Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Additional gene information for AMIGO2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO2 Gene

Genomics for AMIGO2 Gene

GeneHancer (GH) Regulatory Elements for AMIGO2 Gene

Promoters and enhancers for AMIGO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J047077 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -2.4 -2378 12.3 PKNOX1 SMAD1 FOXA2 ARNT SIN3A FEZF1 ZNF2 E2F8 FOS KLF13 AMIGO2 PCED1B HDAC7 LOC643058 GC12M047038
GH12J047211 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.8 -134.6 -134592 8.7 HDGF PKNOX1 ARNT SIN3A POLR2B ZNF766 E2F8 ZNF207 REST ZNF592 PCED1B PCED1B-AS1 GC12M047038 SENP1 AMIGO2 LOC102723757 ENSG00000258181 RPAP3
GH12J047204 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -126.9 -126855 6.2 HDGF PKNOX1 ARNT TCF12 ZNF766 ATF7 RUNX3 CAVIN1 JUNB NCOA1 AMIGO2 PCED1B-AS1 PCED1B GC12M047038 GC12P047188
GH12J047188 Enhancer 1.3 Ensembl ENCODE dbSUPER 16 -110.9 -110920 6.3 HDGF FOXA2 PKNOX1 FEZF1 BRCA1 YY1 ZNF766 ATF7 FOS RXRA AMIGO2 ENSG00000199566 ENSG00000258181 PCED1B-AS1 GC12P047188 GC12M047038 PCED1B
GH12J047392 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -312.8 -312809 1.7 HDAC1 PKNOX1 ARNT FEZF1 ZNF121 ZNF398 ZEB2 NFIC ZNF184 SMARCA4 ENSG00000199566 AMIGO2 LINC02156 MIR4494
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AMIGO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AMIGO2 gene promoter:

Genomic Locations for AMIGO2 Gene

Genomic Locations for AMIGO2 Gene
chr12:47,075,707-47,080,826
(GRCh38/hg38)
Size:
5,120 bases
Orientation:
Minus strand
chr12:47,469,490-47,473,734
(GRCh37/hg19)

Genomic View for AMIGO2 Gene

Genes around AMIGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO2 Gene

Proteins for AMIGO2 Gene

  • Protein details for AMIGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SJ2-AMGO2_HUMAN
    Recommended name:
    Amphoterin-induced protein 2
    Protein Accession:
    Q86SJ2
    Secondary Accessions:
    • Q4VBP6
    • Q7Z4A0
    • Q96CN8

    Protein attributes for AMIGO2 Gene

    Size:
    522 amino acids
    Molecular mass:
    57934 Da
    Quaternary structure:
    • Binds itself as well as AMIGO1 and AMIGO3.

neXtProt entry for AMIGO2 Gene

Post-translational modifications for AMIGO2 Gene

  • Glycosylation at posLast=384384, Asn381, posLast=373373, posLast=345345, posLast=288288, posLast=281281, Asn104, and posLast=5858
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO2 Gene

No data available for DME Specific Peptides for AMIGO2 Gene

Domains & Families for AMIGO2 Gene

Gene Families for AMIGO2 Gene

Suggested Antigen Peptide Sequences for AMIGO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SJ2

UniProtKB/Swiss-Prot:

AMGO2_HUMAN :
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
genes like me logo Genes that share domains with AMIGO2: view

Function for AMIGO2 Gene

Molecular function for AMIGO2 Gene

UniProtKB/Swiss-Prot Function:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Phenotypes From GWAS Catalog for AMIGO2 Gene

Gene Ontology (GO) - Molecular Function for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with AMIGO2: view
genes like me logo Genes that share phenotypes with AMIGO2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AMIGO2

miRNA for AMIGO2 Gene

miRTarBase miRNAs that target AMIGO2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO2 Gene

Localization for AMIGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMIGO2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AMIGO2: view

Pathways & Interactions for AMIGO2 Gene

SuperPathways for AMIGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007420 brain development IBA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with AMIGO2: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO2 Gene

Drugs & Compounds for AMIGO2 Gene

No Compound Related Data Available

Transcripts for AMIGO2 Gene

mRNA/cDNA for AMIGO2 Gene

Unigene Clusters for AMIGO2 Gene

Adhesion molecule with Ig-like domain 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1:
SP2:
SP3: -

Relevant External Links for AMIGO2 Gene

GeneLoc Exon Structure for
AMIGO2
ECgene alternative splicing isoforms for
AMIGO2

Expression for AMIGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMIGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMIGO2 Gene

This gene is overexpressed in Artery - Tibial (x6.5).

Protein differential expression in normal tissues from HIPED for AMIGO2 Gene

This gene is overexpressed in Amniocyte (60.2) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMIGO2 Gene



Protein tissue co-expression partners for AMIGO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AMIGO2 Gene:

AMIGO2

SOURCE GeneReport for Unigene cluster for AMIGO2 Gene:

Hs.121520

mRNA Expression by UniProt/SwissProt for AMIGO2 Gene:

Q86SJ2-AMGO2_HUMAN
Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

Evidence on tissue expression from TISSUES for AMIGO2 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with AMIGO2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO2 Gene

Orthologs for AMIGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO2 34 33
  • 99.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AMIGO2 34 33
  • 89.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO2 34 33
  • 87.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Amigo2 16 34 33
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Amigo2 33
  • 83.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO2 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO2 34 33
  • 68.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMIGO2 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo2 33
  • 65.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for AMIGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMIGO2 Gene

ENSEMBL:
Gene Tree for AMIGO2 (if available)
TreeFam:
Gene Tree for AMIGO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AMIGO2: view image

Paralogs for AMIGO2 Gene

Paralogs for AMIGO2 Gene

(2) SIMAP similar genes for AMIGO2 Gene using alignment to 1 proteins:

  • AMGO2_HUMAN
genes like me logo Genes that share paralogs with AMIGO2: view

Variants for AMIGO2 Gene

Sequence variations from dbSNP and Humsavar for AMIGO2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000071932 -- 47,079,799(-) G/A/T 5_prime_UTR_variant
rs1000339042 -- 47,081,253(-) T/A upstream_transcript_variant
rs1000368638 -- 47,081,006(-) T/C upstream_transcript_variant
rs1001005665 -- 47,078,549(-) G/T coding_sequence_variant, missense_variant
rs1001479528 -- 47,077,895(-) G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for AMIGO2 Gene

Variant ID Type Subtype PubMed ID
nsv558784 CNV gain 21841781
nsv694 CNV deletion 18451855

Variation tolerance for AMIGO2 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMIGO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO2 Gene

Disorders for AMIGO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMIGO2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AMIGO2

genes like me logo Genes that share disorders with AMIGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO2 Gene

Publications for AMIGO2 Gene

  1. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PMID: 15107827) Rabenau KE … Pereira DS (Oncogene 2004) 2 3 4 22 58
  2. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PMID: 12843293) Ono T … Kawashima S (The Journal of neuroscience : the official journal of the Society for Neuroscience 2003) 2 3 4 22 58
  3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J … Rauvala H (The Journal of cell biology 2003) 2 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. (PMID: 29149598) Fontanals-Cirera B … Bernstein E (Molecular cell 2017) 3 58

Products for AMIGO2 Gene

Sources for AMIGO2 Gene

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