Aliases for AMIGO1 Gene

Aliases for AMIGO1 Gene

  • Adhesion Molecule With Ig Like Domain 1 2 3 5
  • AMIGO 2 3 4
  • Amphoterin-Induced Protein 1 3 4
  • Alivin-2 3 4
  • KIAA1163 2 4
  • AMIGO-1 3 4
  • ALI2 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 2
  • Amphoterin-Induced Gene And ORF 3
  • AMIGO1 5

External Ids for AMIGO1 Gene

Previous GeneCards Identifiers for AMIGO1 Gene

  • GC01M109763
  • GC01M109848
  • GC01M110046
  • GC01M107942

Summaries for AMIGO1 Gene

GeneCards Summary for AMIGO1 Gene

AMIGO1 (Adhesion Molecule With Ig Like Domain 1) is a Protein Coding gene. Diseases associated with AMIGO1 include Thymus Sarcomatoid Carcinoma. An important paralog of this gene is AMIGO2.

UniProtKB/Swiss-Prot Summary for AMIGO1 Gene

  • Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Additional gene information for AMIGO1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AMIGO1 Gene

Genomics for AMIGO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AMIGO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J109508 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 663.6 +0.2 241 1.8 PRDM10 BACH1 LARP7 ZSCAN4 POLR2A PATZ1 HDAC1 ZNF600 GTF2F1 ZNF341 AMIGO1 piR-33881 GSTM3 CYB561D1
GH01J109527 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 49.5 -21.0 -20985 5.7 HNRNPL CTCF PRDM10 IKZF1 KDM1A ZNF692 JUND PRDM1 ZNF143 ZIC2 AMIGO1 ENSG00000258634 STRIP1 RBM15 PRPF38B CELSR2 GPR61 LOC105378893
GH01J109305 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.8 +203.3 203282 4.5 HNRNPL LEF1 IKZF1 RCOR2 JUND MTA2 PHF21A ZIC2 HNRNPUL1 PKNOX1 MYBPHL lnc-SORT1-3 SYPL2 AMIGO1 ENSG00000258634 ENSG00000228665 PRPF38B ENSG00000244716 GNAI3 WDR47
GH01J109423 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 23.8 +84.1 84082 4.8 SP1 HNRNPL CREB1 ZBTB33 PRDM10 ZNF629 TFE3 RFX1 LEF1 IKZF1 PSMA5 lnc-SYPL2-2 SYPL2 AMIGO1 ENSG00000258634 STRIP1 ATXN7L2 lnc-SYPL2-1 SORT1
GH01J109465 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 28.7 +42.7 42658 3 ZNF512 ZNF692 ZIC2 PATZ1 EZH2 ZNF600 KLF9 ZBTB20 SP2 UBTF SYPL2 AMIGO1 UBL4B ATXN7L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AMIGO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AMIGO1

Top Transcription factor binding sites by QIAGEN in the AMIGO1 gene promoter:
  • AP-4
  • c-Myb
  • C/EBPalpha
  • CHOP-10
  • Chx10
  • E47
  • Egr-2
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a

Genomic Locations for AMIGO1 Gene

Genomic Locations for AMIGO1 Gene
chr1:109,504,178-109,509,742
(GRCh38/hg38)
Size:
5,565 bases
Orientation:
Minus strand
chr1:110,046,797-110,052,360
(GRCh37/hg19)
Size:
5,564 bases
Orientation:
Minus strand

Genomic View for AMIGO1 Gene

Genes around AMIGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO1 Gene

Proteins for AMIGO1 Gene

  • Protein details for AMIGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK6-AMGO1_HUMAN
    Recommended name:
    Amphoterin-induced protein 1
    Protein Accession:
    Q86WK6
    Secondary Accessions:
    • B4DIM3
    • Q8IW71
    • Q9ULQ7

    Protein attributes for AMIGO1 Gene

    Size:
    493 amino acids
    Molecular mass:
    55239 Da
    Quaternary structure:
    • Homodimer, and heterodimer with AMIGO2 and AMIGO3. Interacts with KCNB1.

neXtProt entry for AMIGO1 Gene

Post-translational modifications for AMIGO1 Gene

  • Glycosylation at Asn72, Asn264, Asn315, Asn349, and Asn360
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMIGO1 Gene

Domains & Families for AMIGO1 Gene

Gene Families for AMIGO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for AMIGO1 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for AMIGO1 Gene

GenScript: Design optimal peptide antigens:
  • Alivin-2 (AMGO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WK6

UniProtKB/Swiss-Prot:

AMGO1_HUMAN :
  • The LRR repeat region mediates homodimerization.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Domain:
  • The LRR repeat region mediates homodimerization.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
genes like me logo Genes that share domains with AMIGO1: view

Function for AMIGO1 Gene

Molecular function for AMIGO1 Gene

UniProtKB/Swiss-Prot Function:
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Phenotypes From GWAS Catalog for AMIGO1 Gene

Gene Ontology (GO) - Molecular Function for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0015459 potassium channel regulator activity ISS --
genes like me logo Genes that share ontologies with AMIGO1: view
genes like me logo Genes that share phenotypes with AMIGO1: view

Animal Models for AMIGO1 Gene

MGI Knock Outs for AMIGO1:
  • Amigo1 Amigo1<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for AMIGO1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AMIGO1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AMIGO1 Gene

Localization for AMIGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO1 Gene

Cell membrane. Single-pass type I membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells. {ECO:0000250 UniProtKB:Q80ZD7, ECO:0000250 UniProtKB:Q80ZD8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMIGO1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0008076 colocalizes_with voltage-gated potassium channel complex ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with AMIGO1: view

Pathways & Interactions for AMIGO1 Gene

PathCards logo

SuperPathways for AMIGO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with AMIGO1: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO1 Gene

Drugs & Compounds for AMIGO1 Gene

No Compound Related Data Available

Transcripts for AMIGO1 Gene

mRNA/cDNA for AMIGO1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AMIGO1

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO1 Gene

No ASD Table

Relevant External Links for AMIGO1 Gene

GeneLoc Exon Structure for
AMIGO1

Expression for AMIGO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMIGO1 Gene

Protein differential expression in normal tissues from HIPED for AMIGO1 Gene

This gene is overexpressed in Pancreatic juice (45.7) and Frontal cortex (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMIGO1 Gene



Protein tissue co-expression partners for AMIGO1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AMIGO1

SOURCE GeneReport for Unigene cluster for AMIGO1 Gene:

Hs.726479

Evidence on tissue expression from TISSUES for AMIGO1 Gene

  • Nervous system(4.6)
  • Muscle(2.5)
  • Skin(2.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with AMIGO1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO1 Gene

Orthologs for AMIGO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AMIGO1 30 31
  • 99.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AMIGO1 30 31
  • 92.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AMIGO1 30 31
  • 92.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Amigo1 30
  • 87.83 (n)
Mouse
(Mus musculus)
Mammalia Amigo1 30 17 31
  • 87.8 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia AMIGO1 31
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO1 31
  • 57 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AMIGO1 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia amigo1 30
  • 60.53 (n)
Zebrafish
(Danio rerio)
Actinopterygii amigo1 30 31
  • 59.7 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToMany
Species where no ortholog for AMIGO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AMIGO1 Gene

ENSEMBL:
Gene Tree for AMIGO1 (if available)
TreeFam:
Gene Tree for AMIGO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AMIGO1: view image

Paralogs for AMIGO1 Gene

Paralogs for AMIGO1 Gene

(3) SIMAP similar genes for AMIGO1 Gene using alignment to 1 proteins:

  • AMGO1_HUMAN
genes like me logo Genes that share paralogs with AMIGO1: view

Variants for AMIGO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AMIGO1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
718581 Benign: not provided 109,508,840(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AMIGO1 Gene

Variation tolerance for AMIGO1 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMIGO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMIGO1 Gene

Disorders for AMIGO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMIGO1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thymus sarcomatoid carcinoma
  • thymic carcinosarcoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with AMIGO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO1 Gene

Publications for AMIGO1 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J … Rauvala H (The Journal of cell biology 2003) 2 3 4 23
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for AMIGO1 Gene

  • Signalway ELISA kits for AMIGO1

Sources for AMIGO1 Gene