Aliases for AMH Gene
External Ids for AMH Gene
Previous GeneCards Identifiers for AMH Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
GeneCards Summary for AMH Gene
AMH (Anti-Mullerian Hormone) is a Protein Coding gene. Diseases associated with AMH include Persistent Mullerian Duct Syndrome, Types I And Ii and Persistent Mullerian Duct Syndrome. Among its related pathways are ALK2 signaling events and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity.
UniProtKB/Swiss-Prot Summary for AMH Gene
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.