Aliases for AMD1 Gene
External Ids for AMD1 Gene
Previous GeneCards Identifiers for AMD1 Gene
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
GeneCards Summary for AMD1 Gene
AMD1 (Adenosylmethionine Decarboxylase 1) is a Protein Coding gene. Diseases associated with AMD1 include Sleeping Sickness and Trypanosomiasis. Among its related pathways are Viral mRNA Translation and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include adenosylmethionine decarboxylase activity.
UniProtKB/Swiss-Prot Summary for AMD1 Gene
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.