Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALPPL2 Gene

Aliases for ALPPL2 Gene

  • Alkaline Phosphatase, Placental Like 2 2 3 5
  • Alkaline Phosphatase Nagao Isozyme 3 4
  • Germ Cell Alkaline Phosphatase 3 4
  • EC 4 56
  • ALP-1 3 4
  • ALPPL 3 4
  • GCAP 3 4
  • Testicular And Thymus Alkaline Phosphatase 3
  • Alkaline Phosphatase, Placental-Like 2 2
  • Alkaline Phosphatase, Placental-Like 3
  • Placental-Like Alkaline Phosphatase 3
  • Placental Alkaline Phosphatase-Like 4
  • Nagao Isozyme 3
  • PLAP-Like 4
  • ALPG 3

External Ids for ALPPL2 Gene

Previous GeneCards Identifiers for ALPPL2 Gene

  • GC02P231328
  • GC02P232001
  • GC02P233235
  • GC02P233474
  • GC02P233097
  • GC02P232979
  • GC02P233273
  • GC02P225122

Summaries for ALPPL2 Gene

Entrez Gene Summary for ALPPL2 Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALPPL2 Gene

ALPPL2 (Alkaline Phosphatase, Placental Like 2) is a Protein Coding gene. Diseases associated with ALPPL2 include Seminoma and Gonadoblastoma. Among its related pathways are Metabolism of proteins and Thiamine metabolism. Gene Ontology (GO) annotations related to this gene include phosphatase activity and alkaline phosphatase activity. An important paralog of this gene is ALPP.

Additional gene information for ALPPL2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPPL2 Gene

Genomics for ALPPL2 Gene

GeneHancer (GH) Regulatory Elements for ALPPL2 Gene

Promoters and enhancers for ALPPL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I232406 Promoter 0.6 EPDnew 550.8 0.0 -17 0.1 KLF1 ALPPL2 ECEL1P2
GH02I232418 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +13.3 13278 3.6 ELF3 CTCF ZBTB6 SIN3A ZNF335 CTBP1 SCRT2 ZNF143 ZNF444 EZH2 ECEL1P1 ENSG00000237087 ECEL1P2 ALPPL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ALPPL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALPPL2 gene promoter:

Genomic Locations for ALPPL2 Gene

Genomic Locations for ALPPL2 Gene
3,873 bases
Plus strand

Genomic View for ALPPL2 Gene

Genes around ALPPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPPL2 Gene

Proteins for ALPPL2 Gene

  • Protein details for ALPPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alkaline phosphatase, placental-like
    Protein Accession:
    Secondary Accessions:
    • A8KAF2
    • Q16727
    • Q53S81
    • Q96CM1

    Protein attributes for ALPPL2 Gene

    532 amino acids
    Molecular mass:
    57377 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
    • Sequence=CAA30232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ALPPL2 Gene

Selected DME Specific Peptides for ALPPL2 Gene


Post-translational modifications for ALPPL2 Gene

  • Glycosylation at Asn141 and posLast=268268
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALPPL2 Gene

Gene Families for ALPPL2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ALPPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPPL2: view

Function for ALPPL2 Gene

Molecular function for ALPPL2 Gene

GENATLAS Biochemistry:
phosphatase alkaline,placental-like 2
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPPL2 Gene

Gene Ontology (GO) - Molecular Function for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004035 alkaline phosphatase activity NAS 2162249
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALPPL2: view
genes like me logo Genes that share phenotypes with ALPPL2: view

Animal Models for ALPPL2 Gene

MGI Knock Outs for ALPPL2:

Animal Model Products

miRNA for ALPPL2 Gene

miRTarBase miRNAs that target ALPPL2

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPPL2 Gene

Localization for ALPPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPPL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALPPL2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPPL2: view

Pathways & Interactions for ALPPL2 Gene

genes like me logo Genes that share pathways with ALPPL2: view

Pathways by source for ALPPL2 Gene

Interacting Proteins for ALPPL2 Gene

Gene Ontology (GO) - Biological Process for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0008152 metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ALPPL2: view

No data available for SIGNOR curated interactions for ALPPL2 Gene

Drugs & Compounds for ALPPL2 Gene

(17) Drugs for ALPPL2 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Target, inducer 81
Levamisole Approved, Investigational, Vet_approved, Withdrawn Pharma Target, inhibitor 16
Zinc sulfate Approved, Investigational Pharma Enzyme, cofactor 75
Ethyol Approved December 8, 1995 Pharma 0
Isopropyl alcohol Approved, Investigational Pharma 0

(10) Additional Compounds for ALPPL2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with ALPPL2: view

Transcripts for ALPPL2 Gene

mRNA/cDNA for ALPPL2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALPPL2 Gene

Alkaline phosphatase, placental-like 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPPL2 Gene

No ASD Table

Relevant External Links for ALPPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALPPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPPL2 Gene

This gene is overexpressed in Colon - Transverse (x10.4), Lung (x9.7), Testis (x9.6), Fallopian Tube (x7.4), and Cervix - Endocervix (x5.3).

Protein differential expression in normal tissues from HIPED for ALPPL2 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALPPL2 Gene

Protein tissue co-expression partners for ALPPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALPPL2 Gene:


SOURCE GeneReport for Unigene cluster for ALPPL2 Gene:


mRNA Expression by UniProt/SwissProt for ALPPL2 Gene:

Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Evidence on tissue expression from TISSUES for ALPPL2 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ALPPL2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ALPPL2 Gene

Orthologs for ALPPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALPPL2 33 34
  • 99.06 (n)
(Mus musculus)
Mammalia Alppl2 33 16 34
  • 78.19 (n)
Alpi 34
  • 70 (a)
Akp3 34
  • 69 (a)
(Rattus norvegicus)
Mammalia Alpp 33
  • 77.51 (n)
(Bos Taurus)
Mammalia -- 34
  • 77 (a)
-- 34
  • 76 (a)
-- 34
  • 73 (a)
-- 34
  • 73 (a)
(Canis familiaris)
Mammalia -- 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
(Danio rerio)
Actinopterygii alpi.2 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3290 35 33 34
  • 52.65 (n)
Aph-4 35 34
  • 44 (a)
CG5656 35 34
  • 44 (a)
CG10827 35 34
  • 43 (a)
CG1809 35 34
  • 43 (a)
CG10592 35 34
  • 42 (a)
CG3264 35 34
  • 42 (a)
CG5150 35 34
  • 42 (a)
CG3292 35 34
  • 41 (a)
CG8105 35 34
  • 39 (a)
CG16771 35 34
  • 38 (a)
CG8147 34
  • 34 (a)
CG5361 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 34 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 38 (a)
CSA.180 34
  • 38 (a)
CSA.4362 34
  • 37 (a)
Species where no ortholog for ALPPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPPL2 Gene

Gene Tree for ALPPL2 (if available)
Gene Tree for ALPPL2 (if available)

Paralogs for ALPPL2 Gene

Paralogs for ALPPL2 Gene

(3) SIMAP similar genes for ALPPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALPPL2: view

Variants for ALPPL2 Gene

Sequence variations from dbSNP and Humsavar for ALPPL2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001565605 -- 232,409,079(+) G/A coding_sequence_variant, missense_variant
rs1002575086 -- 232,410,421(+) C/G 3_prime_UTR_variant
rs1002723586 -- 232,405,481(+) G/A upstream_transcript_variant
rs1003794478 -- 232,406,650(+) G/T upstream_transcript_variant
rs1003854496 -- 232,411,109(+) T/C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ALPPL2 Gene

Variant ID Type Subtype PubMed ID
dgv1218e212 CNV loss 25503493
dgv160n111 CNV duplication 26073780
dgv4182n100 CNV gain 25217958
dgv4183n100 CNV gain+loss 25217958
dgv4184n100 CNV loss 25217958
dgv4185n100 CNV gain 25217958
dgv4186n100 CNV loss 25217958
dgv4187n100 CNV loss 25217958
dgv493n27 CNV loss 19166990
dgv494n27 CNV gain 19166990
dgv632e201 CNV deletion 23290073
dgv7336n54 CNV gain 21841781
dgv7337n54 CNV loss 21841781
dgv7338n54 CNV gain 21841781
dgv765e214 CNV loss 21293372
esv2659833 CNV deletion 23128226
esv2759118 CNV gain 17122850
esv2760660 CNV loss 21179565
esv2763626 CNV gain+loss 21179565
esv34493 CNV gain 17911159
esv3561154 CNV deletion 23714750
esv3575339 CNV gain 25503493
esv3575340 CNV gain 25503493
esv3594646 CNV loss 21293372
esv3594649 CNV gain 21293372
esv3594651 CNV loss 21293372
esv3594652 CNV gain 21293372
esv3893570 CNV gain+loss 25118596
esv3893572 CNV loss 25118596
nsv1003690 CNV gain+loss 25217958
nsv1009043 CNV gain 25217958
nsv436293 CNV deletion 17901297
nsv472038 CNV novel sequence insertion 20440878
nsv482058 CNV gain 20164927
nsv518263 CNV loss 19592680
nsv521461 CNV loss 19592680
nsv522450 CNV loss 19592680
nsv584679 CNV gain 21841781
nsv584687 CNV gain+loss 21841781
nsv584692 CNV loss 21841781
nsv584693 CNV loss 21841781
nsv821918 CNV gain 20364138

Variation tolerance for ALPPL2 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALPPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPPL2 Gene

Disorders for ALPPL2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALPPL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • seminoma, pure
  • gby
  • chorioepithelioma
malignant germ cell tumor
  • germ cell cancer
complete androgen insensitivity syndrome
  • testicular feminization
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ALPPL2

genes like me logo Genes that share disorders with ALPPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPPL2 Gene

Publications for ALPPL2 Gene

  1. Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells. (PMID: 2297757) Gum JR … Kim YS (Cancer research 1990) 3 4 22 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer. (PMID: 10471145) Ben-Arie A … Dgani R (European journal of obstetrics, gynecology, and reproductive biology 1999) 3 22 58
  5. Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (PMID: 9823315) Shigenari A … Inoko H (Cancer research 1998) 3 22 58

Products for ALPPL2 Gene

Sources for ALPPL2 Gene

Loading form....