Aliases for ALPP Gene
External Ids for ALPP Gene
Previous GeneCards Identifiers for ALPP Gene
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
GeneCards Summary for ALPP Gene
ALPP (Alkaline Phosphatase, Placental) is a Protein Coding gene. Diseases associated with ALPP include Obstructive Jaundice and Hypophosphatasia. Among its related pathways are Folate biosynthesis and Vitamin B6 metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and alkaline phosphatase activity. An important paralog of this gene is ALPG.