Aliases for ALPP Gene
External Ids for ALPP Gene
Previous GeneCards Identifiers for ALPP Gene
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]
GeneCards Summary for ALPP Gene
ALPP (Alkaline Phosphatase, Placental) is a Protein Coding gene. Diseases associated with ALPP include Hypophosphatasia and Obstructive Jaundice. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Vitamin B6 metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and alkaline phosphatase activity. An important paralog of this gene is ALPG.