There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by... See more...

Aliases for ALPG Gene

Aliases for ALPG Gene

  • Alkaline Phosphatase, Germ Cell 2 3 5
  • Germ Cell Alkaline Phosphatase 2 3 4
  • GCAP 2 3 4
  • Alkaline Phosphatase, Placental Like 2 2 3
  • Alkaline Phosphatase, Germ Cell Type 3 4
  • Alkaline Phosphatase, Placental-Like 3 4
  • Alkaline Phosphatase Nagao Isozyme 3 4
  • EC 3.1.3.1 4 51
  • ALPPL2 3 4
  • ALPPL 3 4
  • ALP-1 3 4
  • Testicular And Thymus Alkaline Phosphatase 3
  • Placental-Like Alkaline Phosphatase 3
  • Placental Alkaline Phosphatase-Like 4
  • Nagao Isozyme 3
  • PLAP-Like 4
  • ALPG 5

External Ids for ALPG Gene

Previous HGNC Symbols for ALPG Gene

  • ALPPL2

Summaries for ALPG Gene

Entrez Gene Summary for ALPG Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALPG Gene

ALPG (Alkaline Phosphatase, Germ Cell) is a Protein Coding gene. Diseases associated with ALPG include Gonadoblastoma and Seminoma. Among its related pathways are Metabolism of proteins and Thiamine metabolism. An important paralog of this gene is ALPP.

Additional gene information for ALPG Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALPG Gene

Genomics for ALPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALPG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J232406 Promoter 0.4 EPDnew 600.7 0.0 -19 0.1 KLF1 ALPG ECEL1P2 ALPP
GH02J232418 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 1.6 +12.2 12166 0.8 EZH2 NRF1 EGR1 GATA2 ECEL1P1 ALPG LOC107985999 ALPI
GH02J232369 Enhancer 0.2 Ensembl 5.2 -36.9 -36943 1 ENSG00000275157 ECEL1P2 ALPG INPP5D ALPP DIS3L2
GH02J232419 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +14.1 14094 1.9 EZH2 SCRT2 CTCF CTBP1 ZNF444 ZBTB26 CHD1 TFDP1 POLR2A ELF1 ECEL1P1 ENSG00000237087 ECEL1P2 ALPG ALPI
GH02J232385 Enhancer 0.8 Ensembl ENCODE 0.4 -19.9 -19927 3.2 CREB1 TEAD4 FOXA1 EZH2 CTBP1 YY1 GATA3 DPF2 ZNF513 ZNF366 ECEL1P2 lnc-ECEL1-3 ECEL1 ALPP ENSG00000224516 ALPG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALPG

Genomic Locations for ALPG Gene

Genomic Locations for ALPG Gene
chr2:232,406,844-232,410,714
(GRCh38/hg38)
Size:
3,871 bases
Orientation:
Plus strand
chr2:233,271,552-233,275,424
(GRCh37/hg19)
Size:
3,873 bases
Orientation:
Plus strand

Genomic View for ALPG Gene

Genes around ALPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPG Gene

Proteins for ALPG Gene

  • Protein details for ALPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10696-PPBN_HUMAN
    Recommended name:
    Alkaline phosphatase, germ cell type
    Protein Accession:
    P10696
    Secondary Accessions:
    • A8KAF2
    • Q16727
    • Q53S81
    • Q96CM1

    Protein attributes for ALPG Gene

    Size:
    532 amino acids
    Molecular mass:
    57377 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAA30232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • In most mammals there are four different isozymes: placental, germ cell, intestinal and tissue non-specific (liver/bone/kidney).

neXtProt entry for ALPG Gene

Selected DME Specific Peptides for ALPG Gene

P10696:
  • VTADHSHVF
  • GTPDPEYP
  • GVVTTTR
  • GGGRKYM
  • LMGLFEP
  • SAAARFNQCN
  • TATAYLCGVK
  • FARGPQAHL
  • GDGMGVSTVTA
  • TTRGNEV
  • VEGGRID
  • LAMDRFP
  • FLGDGMGV
  • GLFEPGD
  • RAKKAGKSVGV
  • NLVQEWL
  • LYGNGPGY

Post-translational modifications for ALPG Gene

  • Glycosylation at Asn141 and Asn268
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALPG Gene

Gene Families for ALPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ALPG Gene

InterPro:
Blocks:
  • Alkaline phosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for ALPG Gene

GenScript: Design optimal peptide antigens:
  • Placental alkaline phosphatase-like (PPBN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10696

UniProtKB/Swiss-Prot:

PPBN_HUMAN :
  • Belongs to the alkaline phosphatase family.
Family:
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPG: view

Function for ALPG Gene

Molecular function for ALPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10042};.

Enzyme Numbers (IUBMB) for ALPG Gene

Phenotypes From GWAS Catalog for ALPG Gene

Gene Ontology (GO) - Molecular Function for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004035 alkaline phosphatase activity IDA,NAS 2162249
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALPG: view
genes like me logo Genes that share phenotypes with ALPG: view

Animal Models for ALPG Gene

MGI Knock Outs for ALPG:

Animal Model Products

CRISPR Products

miRNA for ALPG Gene

miRTarBase miRNAs that target ALPG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALPG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPG Gene

Localization for ALPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPG Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALPG gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPG: view

Pathways & Interactions for ALPG Gene

genes like me logo Genes that share pathways with ALPG: view

Pathways by source for ALPG Gene

1 GeneGo (Thomson Reuters) pathway for ALPG Gene
  • NAD metabolism

Gene Ontology (GO) - Biological Process for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with ALPG: view

No data available for SIGNOR curated interactions for ALPG Gene

Drugs & Compounds for ALPG Gene

(18) Drugs for ALPG Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Target, inducer 82
Levamisole Approved, Investigational, Vet_approved, Withdrawn Pharma Target, inhibitor 22
Hydrogen peroxide Approved, Vet_approved Pharma Enzyme, inhibitor 115
Strontium chloride Sr-89 Approved, Investigational Pharma Enzyme, cofactor 0
Zinc sulfate Approved, Investigational Pharma Enzyme, cofactor 91

(10) Additional Compounds for ALPG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
71-41-0
dihydroneopterin triphosphate
  • 2-amino-4-Hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
  • 6-(L-erythro-1,2-Dihydroxy-3-triphosphooxypropyl)-7,8-dihydropterin
  • 6-(L-erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 2-amino-4-Hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphoric acid
20574-65-6
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl-1-propanol
  • 2-Methylpropanol
  • I-butanol
  • I-butyl alcohol
78-83-1
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with ALPG: view

Transcripts for ALPG Gene

mRNA/cDNA for ALPG Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALPG

Alternative Splicing Database (ASD) splice patterns (SP) for ALPG Gene

No ASD Table

Relevant External Links for ALPG Gene

GeneLoc Exon Structure for
ALPG

Expression for ALPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALPG

mRNA Expression by UniProt/SwissProt for ALPG Gene:

P10696-PPBN_HUMAN
Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Evidence on tissue expression from TISSUES for ALPG Gene

  • Intestine(4.5)
  • Liver(2.7)
  • Blood(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ALPG: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALPG Gene

Orthologs for ALPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ALPPL2 30 31
  • 99.06 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Alppl2 30 17 31
  • 78.19 (n)
ManyToMany
Alpi 31
  • 70 (a)
ManyToMany
Akp3 31
  • 69 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Alpp 30
  • 77.51 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 77 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
-- 31
  • 73 (a)
ManyToMany
-- 31
  • 73 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 72 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 72 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 64 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 60 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii alpi.2 31
  • 55 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG3290 30 31
  • 52.65 (n)
ManyToMany
CG5656 31
  • 37 (a)
ManyToMany
CG1809 31
  • 37 (a)
ManyToMany
CG5150 31
  • 36 (a)
ManyToMany
CG10827 31
  • 35 (a)
ManyToMany
CG8105 31
  • 35 (a)
ManyToMany
CG3264 31
  • 34 (a)
ManyToMany
CG8147 31
  • 34 (a)
ManyToMany
CG10592 31
  • 34 (a)
ManyToMany
CG3292 31
  • 33 (a)
ManyToMany
Aph-4 31
  • 32 (a)
ManyToMany
CG16771 31
  • 27 (a)
ManyToMany
CG5361 31
  • 22 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 31 33
  • 21 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
CSA.180 31
  • 38 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
CSA.4362 31
  • 37 (a)
ManyToMany
Species where no ortholog for ALPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ALPG Gene

ENSEMBL:
Gene Tree for ALPG (if available)
TreeFam:
Gene Tree for ALPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALPG: view image

Paralogs for ALPG Gene

Paralogs for ALPG Gene

genes like me logo Genes that share paralogs with ALPG: view

Variants for ALPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALPG Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
711874 Likely Benign: not provided 232,409,458(+) G/A INTRON_VARIANT
712452 Benign: not provided 232,407,142(+) C/T SYNONYMOUS_VARIANT
717615 Likely Benign: not provided 232,409,772(+) G/A MISSENSE_VARIANT
770697 Benign: not provided 232,408,301(+) C/G MISSENSE_VARIANT
770698 Benign: not provided 232,408,308(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ALPG Gene

Structural Variations from Database of Genomic Variants (DGV) for ALPG Gene

Variant ID Type Subtype PubMed ID
dgv1218e212 CNV loss 25503493
dgv160n111 CNV duplication 26073780
dgv4182n100 CNV gain 25217958
dgv4183n100 CNV gain+loss 25217958
dgv4184n100 CNV loss 25217958
dgv4185n100 CNV gain 25217958
dgv4186n100 CNV loss 25217958
dgv4187n100 CNV loss 25217958
dgv493n27 CNV loss 19166990
dgv494n27 CNV gain 19166990
dgv632e201 CNV deletion 23290073
dgv7336n54 CNV gain 21841781
dgv7337n54 CNV loss 21841781
dgv7338n54 CNV gain 21841781
dgv765e214 CNV loss 21293372
esv2659833 CNV deletion 23128226
esv2759118 CNV gain 17122850
esv2760660 CNV loss 21179565
esv2763626 CNV gain+loss 21179565
esv34493 CNV gain 17911159
esv3561154 CNV deletion 23714750
esv3575339 CNV gain 25503493
esv3575340 CNV gain 25503493
esv3594646 CNV loss 21293372
esv3594649 CNV gain 21293372
esv3594651 CNV loss 21293372
esv3594652 CNV gain 21293372
esv3893570 CNV gain+loss 25118596
esv3893572 CNV loss 25118596
nsv1003690 CNV gain+loss 25217958
nsv1009043 CNV gain 25217958
nsv436293 CNV deletion 17901297
nsv472038 CNV novel sequence insertion 20440878
nsv482058 CNV gain 20164927
nsv518263 CNV loss 19592680
nsv521461 CNV loss 19592680
nsv522450 CNV loss 19592680
nsv584679 CNV gain 21841781
nsv584687 CNV gain+loss 21841781
nsv584692 CNV loss 21841781
nsv584693 CNV loss 21841781
nsv821918 CNV gain 20364138

Variation tolerance for ALPG Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPG Gene

Disorders for ALPG Gene

MalaCards: The human disease database

(18) MalaCards diseases for ALPG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gonadoblastoma
  • gby
seminoma
  • seminoma, pure
germ cell cancer
  • germ cell neoplasm
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
choriocarcinoma
  • chorioepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search ALPG in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ALPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPG Gene

Publications for ALPG Gene

  1. Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells. (PMID: 2297757) Gum JR … Kim YS (Cancer research 1990) 3 4 23
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer. (PMID: 10471145) Ben-Arie A … Dgani R (European journal of obstetrics, gynecology, and reproductive biology 1999) 3 23
  5. Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (PMID: 9823315) Shigenari A … Inoko H (Cancer research 1998) 3 23

Products for ALPG Gene

  • Signalway ELISA kits for ALPG

Sources for ALPG Gene