There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by... See more...

Aliases for ALPG Gene

Aliases for ALPG Gene

  • Alkaline Phosphatase, Germ Cell 2 3 5
  • Germ Cell Alkaline Phosphatase 2 3 4
  • GCAP 2 3 4
  • Alkaline Phosphatase, Placental Like 2 2 3
  • Alkaline Phosphatase, Germ Cell Type 3 4
  • Alkaline Phosphatase, Placental-Like 3 4
  • Alkaline Phosphatase Nagao Isozyme 3 4
  • EC 4 50
  • ALPPL2 3 4
  • ALPPL 3 4
  • ALP-1 3 4
  • Testicular And Thymus Alkaline Phosphatase 3
  • Placental-Like Alkaline Phosphatase 3
  • Placental Alkaline Phosphatase-Like 4
  • Nagao Isozyme 3
  • PLAP-Like 4
  • ALPG 5

External Ids for ALPG Gene

Previous HGNC Symbols for ALPG Gene

  • ALPPL2

Summaries for ALPG Gene

Entrez Gene Summary for ALPG Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALPG Gene

ALPG (Alkaline Phosphatase, Germ Cell) is a Protein Coding gene. Diseases associated with ALPG include Seminoma and Gonadoblastoma. Among its related pathways are Folate biosynthesis and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is ALPP.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALPG Gene

Genomics for ALPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALPG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J232406 Promoter 0.4 EPDnew 250.7 0.0 -19 0.1 KLF1 ALPG HSALNG0023031 HSALNG0023030 ALPP
GH02J232418 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +12.0 11968 1.2 NRF1 EGR1 GATA2 EZH2 ECEL1P1 ALPG LOC107985999 HSALNG0023030 ALPI
GH02J232369 Enhancer 0.2 Ensembl 5.2 -37.1 -37143 1 ENSG00000275157 HSALNG0023025 ECEL1P2 ALPG INPP5D ALPP DIS3L2
GH02J232419 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +14.1 14094 1.9 POLR2A SIN3A ELF1 CTBP1 GABPB1 CTCF MAZ TAF1 ELF3 ZNF687 ECEL1P1 ENSG00000237087 HSALNG0023032 ECEL1P2 ALPG HSALNG0023030 ALPI
GH02J232441 Promoter 0.9 Ensembl 0.3 +33.7 33657 0.2 MXD4 REST KLF11 TRIM22 ZNF341 THAP11 SMAD4 ZNF511 SMC3 MIER3 DIS3L2P1 ECEL1P2 ECEL1 ALPI piR-48049-045 ALPG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALPG

Genomic Locations for ALPG Gene

Latest Assembly
3,871 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,871 bases
Plus strand

(GRCh37/hg19 by Ensembl)
3,872 bases
Plus strand

Genomic View for ALPG Gene

Genes around ALPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPG Gene

Proteins for ALPG Gene

  • Protein details for ALPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alkaline phosphatase, germ cell type
    Protein Accession:
    Secondary Accessions:
    • A8KAF2
    • Q16727
    • Q53S81
    • Q96CM1

    Protein attributes for ALPG Gene

    532 amino acids
    Molecular mass:
    57377 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • Sequence=CAA30232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    • In most mammals there are four different isozymes: placental, germ cell, intestinal and tissue non-specific (liver/bone/kidney).

neXtProt entry for ALPG Gene

Selected DME Specific Peptides for ALPG Gene


Post-translational modifications for ALPG Gene

  • Glycosylation at Asn141 and Asn268
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALPG Gene

Gene Families for ALPG Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ALPG Gene

Suggested Antigen Peptide Sequences for ALPG Gene

GenScript: Design optimal peptide antigens:
  • Placental alkaline phosphatase-like (PPBN_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPG: view

Function for ALPG Gene

Molecular function for ALPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=; Evidence={ECO:0000255|PROSITE-ProRule:PRU10042};.

Enzyme Numbers (IUBMB) for ALPG Gene

Phenotypes From GWAS Catalog for ALPG Gene

Gene Ontology (GO) - Molecular Function for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004035 alkaline phosphatase activity IDA,NAS 2162249
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALPG: view
genes like me logo Genes that share phenotypes with ALPG: view

Animal Models for ALPG Gene

MGI Knock Outs for ALPG:

miRNA for ALPG Gene

miRTarBase miRNAs that target ALPG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALPG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPG Gene

Localization for ALPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPG Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALPG gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPG: view

Pathways & Interactions for ALPG Gene

genes like me logo Genes that share pathways with ALPG: view

Pathways by source for ALPG Gene

Gene Ontology (GO) - Biological Process for ALPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with ALPG: view

No data available for SIGNOR curated interactions for ALPG Gene

Drugs & Compounds for ALPG Gene

(18) Drugs for ALPG Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Target, inducer 82
Levamisole Approved, Investigational, Vet_approved, Withdrawn Pharma Target, inhibitor 23
Hydrogen peroxide Approved, Vet_approved Pharma Enzyme, inhibitor 140
Strontium chloride Sr-89 Approved, Investigational Pharma Enzyme, cofactor 0
Zinc sulfate Approved, Investigational Pharma Enzyme, cofactor 97

(9) Additional Compounds for ALPG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-dihydroxy-3-triphosphooxypropyl)-7,8-dihydropterin
  • 6-(L-Erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphoric acid
  • 1-Hydroxymethylpropane
  • 2-Methyl-1-propanol
  • 2-Methylpropanol
  • I-butanol
  • I-butyl alcohol
genes like me logo Genes that share compounds with ALPG: view

Transcripts for ALPG Gene

mRNA/cDNA for ALPG Gene

8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALPG

Alternative Splicing Database (ASD) splice patterns (SP) for ALPG Gene

No ASD Table

Relevant External Links for ALPG Gene

GeneLoc Exon Structure for

Expression for ALPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALPG

mRNA Expression by UniProt/SwissProt for ALPG Gene:

Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Evidence on tissue expression from TISSUES for ALPG Gene

  • Intestine(4.4)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with ALPG: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALPG Gene

Orthologs for ALPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALPPL2 29 30
  • 99.06 (n)
(Mus musculus)
Mammalia Alppl2 29 16 30
  • 78.19 (n)
Alpi 30
  • 70 (a)
Akp3 30
  • 69 (a)
(Rattus norvegicus)
Mammalia Alpp 29
  • 77.51 (n)
(Bos Taurus)
Mammalia -- 30
  • 77 (a)
-- 30
  • 76 (a)
-- 30
  • 73 (a)
-- 30
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 72 (a)
(Canis familiaris)
Mammalia -- 30
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
(Gallus gallus)
Aves -- 30
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 60 (a)
(Danio rerio)
Actinopterygii alpi.2 30
  • 55 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG3290 29 30
  • 52.65 (n)
CG5656 30
  • 37 (a)
CG1809 30
  • 37 (a)
CG5150 30
  • 36 (a)
CG10827 30
  • 35 (a)
CG8105 30
  • 35 (a)
CG3264 30
  • 34 (a)
CG8147 30
  • 34 (a)
CG10592 30
  • 34 (a)
CG3292 30
  • 33 (a)
Aph-4 30
  • 32 (a)
CG16771 30
  • 27 (a)
CG5361 30
  • 22 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 30 32
  • 21 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
-- 30
  • 39 (a)
CSA.180 30
  • 38 (a)
-- 30
  • 38 (a)
CSA.4362 30
  • 37 (a)
Species where no ortholog for ALPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ALPG Gene

Gene Tree for ALPG (if available)
Gene Tree for ALPG (if available)
Evolutionary constrained regions (ECRs) for ALPG: view image
Alliance of Genome Resources:
Additional Orthologs for ALPG

Paralogs for ALPG Gene

Paralogs for ALPG Gene

genes like me logo Genes that share paralogs with ALPG: view

Variants for ALPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALPG Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs112965314 Benign: not provided 232,407,385(+) A/T
NM_031313.3(ALPG):c.284A>T (p.Tyr95Phe)
rs113898433 Benign: not provided 232,407,885(+) T/C
NM_031313.3(ALPG):c.516T>C (p.His172=)
rs146482704 Benign: not provided 232,407,381(+) C/T
NM_031313.3(ALPG):c.280C>T (p.Pro94Ser)
rs147653632 Benign: not provided 232,407,743(+) C/T
NM_031313.3(ALPG):c.450C>T (p.Ser150=)
rs201615790 Likely Benign: not provided 232,409,772(+) G/A
NM_031313.3(ALPG):c.1499G>A (p.Gly500Asp)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ALPG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ALPG Gene

Variant ID Type Subtype PubMed ID
dgv1218e212 CNV loss 25503493
dgv160n111 CNV duplication 26073780
dgv4182n100 CNV gain 25217958
dgv4183n100 CNV gain+loss 25217958
dgv4184n100 CNV loss 25217958
dgv4185n100 CNV gain 25217958
dgv4186n100 CNV loss 25217958
dgv4187n100 CNV loss 25217958
dgv493n27 CNV loss 19166990
dgv494n27 CNV gain 19166990
dgv632e201 CNV deletion 23290073
dgv7336n54 CNV gain 21841781
dgv7337n54 CNV loss 21841781
dgv7338n54 CNV gain 21841781
dgv765e214 CNV loss 21293372
esv2659833 CNV deletion 23128226
esv2759118 CNV gain 17122850
esv2760660 CNV loss 21179565
esv2763626 CNV gain+loss 21179565
esv34493 CNV gain 17911159
esv3561154 CNV deletion 23714750
esv3575339 CNV gain 25503493
esv3575340 CNV gain 25503493
esv3594646 CNV loss 21293372
esv3594649 CNV gain 21293372
esv3594651 CNV loss 21293372
esv3594652 CNV gain 21293372
esv3893570 CNV gain+loss 25118596
esv3893572 CNV loss 25118596
nsv1003690 CNV gain+loss 25217958
nsv1009043 CNV gain 25217958
nsv436293 CNV deletion 17901297
nsv472038 CNV novel sequence insertion 20440878
nsv482058 CNV gain 20164927
nsv518263 CNV loss 19592680
nsv521461 CNV loss 19592680
nsv522450 CNV loss 19592680
nsv584679 CNV gain 21841781
nsv584687 CNV gain+loss 21841781
nsv584692 CNV loss 21841781
nsv584693 CNV loss 21841781
nsv821918 CNV gain 20364138

Variation tolerance for ALPG Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPG Gene

Disorders for ALPG Gene

MalaCards: The human disease database

(14) MalaCards diseases for ALPG Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • seminoma, pure
  • gby
germ cell cancer
  • germ cell neoplasm
mixed type thymoma
  • thymoma, mixed type
endodermal sinus tumor
  • endodermal sinus tumour
- elite association - COSMIC cancer census association via MalaCards
Search ALPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ALPG

genes like me logo Genes that share disorders with ALPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPG Gene

Publications for ALPG Gene

  1. Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells. (PMID: 2297757) Gum JR … Kim YS (Cancer research 1990) 3 4 22
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer. (PMID: 10471145) Ben-Arie A … Dgani R (European journal of obstetrics, gynecology, and reproductive biology 1999) 3 22
  5. Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (PMID: 9823315) Shigenari A … Inoko H (Cancer research 1998) 3 22

Products for ALPG Gene

Sources for ALPG Gene