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Aliases for ALOX5AP Gene

Aliases for ALOX5AP Gene

  • Arachidonate 5-Lipoxygenase Activating Protein 2 3 5
  • MK-886-Binding Protein 2 3 4
  • Arachidonate 5-Lipoxygenase-Activating Protein 2 3
  • FLAP 3 4
  • Five-Lipoxygenase Activating Protein 2

External Ids for ALOX5AP Gene

Previous GeneCards Identifiers for ALOX5AP Gene

  • GC13P029289
  • GC13P025289
  • GC13P030239
  • GC13P029108
  • GC13P029109
  • GC13P030207
  • GC13P031309
  • GC13P012127

Summaries for ALOX5AP Gene

Entrez Gene Summary for ALOX5AP Gene

  • This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ALOX5AP Gene

ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) is a Protein Coding gene. Diseases associated with ALOX5AP include Stroke, Ischemic and Myocardial Infarction. Among its related pathways are Metabolism and Eicosanoid Synthesis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is MGST2.

UniProtKB/Swiss-Prot for ALOX5AP Gene

  • Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

Tocris Summary for ALOX5AP Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Gene Wiki entry for ALOX5AP Gene

Additional gene information for ALOX5AP Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX5AP Gene

Genomics for ALOX5AP Gene

GeneHancer (GH) Regulatory Elements for ALOX5AP Gene

Promoters and enhancers for ALOX5AP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J030734 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 707.7 +24.2 24173 7.1 HDGF PKNOX1 BMI1 BATF IRF4 EGR1 SCRT2 ATF7 FOS ETV6 ALOX5AP USPL1 LINC00398
GH13J030712 Enhancer 0.9 Ensembl ENCODE 650.7 -0.2 -208 1.5 CTCF PKNOX1 JUN MAX CEBPB EP300 NR2F2 GABPA POLR2A GABPB1 ALOX5AP ENSG00000275788
GH13J030714 Enhancer 0.5 FANTOM5 Ensembl 699.2 +1.5 1518 0.8 ALOX5AP USPL1 HMGB1 LINC00398
GH13J030742 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 38.9 +31.8 31843 6 PKNOX1 CLOCK NEUROD1 SIN3A IRF4 YY1 ZNF143 ATF7 FOS RUNX3 ALOX5AP HMGB1 USPL1 LINC00398
GH13J030689 Enhancer 1.1 FANTOM5 Ensembl ENCODE 17.8 -23.0 -22963 2 TFAP4 USF2 MAX SIN3A ZBTB5 GABPA SP1 CTBP1 POLR2A GLIS1 ALOX5AP MEDAG USPL1 ENSG00000275788
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALOX5AP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALOX5AP gene promoter:
  • STAT1
  • GR-alpha
  • GR
  • GATA-3
  • Nkx2-5
  • POU3F2 (N-Oct-5b)
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • AP-1
  • AML1a

Genomic Locations for ALOX5AP Gene

Genomic Locations for ALOX5AP Gene
50,951 bases
Plus strand
50,951 bases
Plus strand

Genomic View for ALOX5AP Gene

Genes around ALOX5AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALOX5AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALOX5AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX5AP Gene

Proteins for ALOX5AP Gene

  • Protein details for ALOX5AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arachidonate 5-lipoxygenase-activating protein
    Protein Accession:
    Secondary Accessions:
    • Q5VV04

    Protein attributes for ALOX5AP Gene

    161 amino acids
    Molecular mass:
    18157 Da
    Quaternary structure:
    • Homotrimer. Interacts with LTC4S and ALOX5.

    Three dimensional structures from OCA and Proteopedia for ALOX5AP Gene

neXtProt entry for ALOX5AP Gene

Post-translational modifications for ALOX5AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX5AP Gene

No data available for DME Specific Peptides for ALOX5AP Gene

Domains & Families for ALOX5AP Gene

Gene Families for ALOX5AP Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ALOX5AP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal part after residue 140 is mostly unstructured.
  • Belongs to the MAPEG family.
  • The C-terminal part after residue 140 is mostly unstructured.
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with ALOX5AP: view

Function for ALOX5AP Gene

Molecular function for ALOX5AP Gene

UniProtKB/Swiss-Prot Function:
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
GENATLAS Biochemistry:
arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily

Phenotypes From GWAS Catalog for ALOX5AP Gene

Gene Ontology (GO) - Molecular Function for ALOX5AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004051 arachidonate 5-lipoxygenase activity IEA --
GO:0004364 NOT glutathione transferase activity IBA --
GO:0004464 NOT leukotriene-C4 synthase activity IBA --
GO:0004602 NOT glutathione peroxidase activity IBA --
GO:0005515 protein binding IPI 19233132
genes like me logo Genes that share ontologies with ALOX5AP: view
genes like me logo Genes that share phenotypes with ALOX5AP: view

Animal Models for ALOX5AP Gene

MGI Knock Outs for ALOX5AP:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX5AP Gene

Localization for ALOX5AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX5AP Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALOX5AP gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 2
lysosome 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ALOX5AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS,IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 19233132
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with ALOX5AP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ALOX5AP Gene

Pathways & Interactions for ALOX5AP Gene

genes like me logo Genes that share pathways with ALOX5AP: view

Pathways by source for ALOX5AP Gene

Gene Ontology (GO) - Biological Process for ALOX5AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IEA --
GO:0006691 leukotriene metabolic process IEA,TAS --
GO:0019370 leukotriene biosynthetic process IEA,IDA 2300173
GO:0019372 lipoxygenase pathway IEA,TAS --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ALOX5AP: view

No data available for SIGNOR curated interactions for ALOX5AP Gene

Drugs & Compounds for ALOX5AP Gene

(31) Drugs for ALOX5AP Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zileuton Approved, Investigational, Withdrawn Pharma Inhibition, Inhibitor 5-lipoxygenase (5-LOX) inhibitor, orally active 20
DG031 Investigational Pharma inhibitor, Target 0
AM103 Investigational Pharma Target 0
Fiboflapon Investigational Pharma Target 0
MK 886 Pharma Inhibitor of 5-lipoxygenase-activating protein (FLAP) 0

(14) Additional Compounds for ALOX5AP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for ALOX5AP Gene

Compound Action Cas Number
2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor 132465-10-2
Baicalein 5- and 12-Lipoxygenase inhibitor 491-67-8
BAY-X 1005 Orally active 5-lipoxygenase activating protein (FLAP) inhibitor 128253-31-6
BW-B 70C 5-Lipoxygenase inhibitor 134470-38-5
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) 118414-82-7
genes like me logo Genes that share compounds with ALOX5AP: view

Transcripts for ALOX5AP Gene

mRNA/cDNA for ALOX5AP Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(167) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALOX5AP Gene

Arachidonate 5-lipoxygenase-activating protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - - - - -
SP4: -

Relevant External Links for ALOX5AP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALOX5AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALOX5AP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX5AP Gene

This gene is overexpressed in Whole Blood (x40.3).

Protein differential expression in normal tissues from HIPED for ALOX5AP Gene

This gene is overexpressed in Nasal epithelium (37.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALOX5AP Gene

Protein tissue co-expression partners for ALOX5AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ALOX5AP Gene:


SOURCE GeneReport for Unigene cluster for ALOX5AP Gene:


Evidence on tissue expression from TISSUES for ALOX5AP Gene

  • Blood(3.1)
  • Lung(2.6)
  • Bone marrow(2.2)
  • Spleen(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ALOX5AP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX5AP Gene

Orthologs for ALOX5AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX5AP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALOX5AP 34 33
  • 98.62 (n)
(Monodelphis domestica)
Mammalia ALOX5AP 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia ALOX5AP 34
  • 90 (a)
(Canis familiaris)
Mammalia ALOX5AP 34 33
  • 86.89 (n)
(Bos Taurus)
Mammalia ALOX5AP 34 33
  • 86.13 (n)
(Mus musculus)
Mammalia Alox5ap 16 34 33
  • 85.71 (n)
(Rattus norvegicus)
Mammalia Alox5ap 33
  • 85.09 (n)
(Gallus gallus)
Aves ALOX5AP 34 33
  • 76.19 (n)
(Anolis carolinensis)
Reptilia ALOX5AP 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alox5ap 33
  • 72.05 (n)
Str.11819 33
(Danio rerio)
Actinopterygii alox5ap 34 33
  • 62.82 (n)
wufj65d02 33
Species where no ortholog for ALOX5AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX5AP Gene

Gene Tree for ALOX5AP (if available)
Gene Tree for ALOX5AP (if available)
Evolutionary constrained regions (ECRs) for ALOX5AP: view image

Paralogs for ALOX5AP Gene

Paralogs for ALOX5AP Gene

(2) SIMAP similar genes for ALOX5AP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALOX5AP: view

Variants for ALOX5AP Gene

Sequence variations from dbSNP and Humsavar for ALOX5AP Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs281864911 not-provided, not provided 30,758,476(+) T/C intron_variant
rs1000006854 -- 30,729,860(+) G/C/T genic_upstream_transcript_variant, intron_variant
rs1000150654 -- 30,746,109(+) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000151151 -- 30,714,637(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000152628 -- 30,735,107(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ALOX5AP Gene

Variant ID Type Subtype PubMed ID
esv2747225 CNV deletion 23290073
esv3406702 CNV duplication 20981092
nsv1145656 CNV deletion 24896259
nsv474284 CNV novel sequence insertion 20440878
nsv561396 CNV loss 21841781
nsv561397 CNV loss 21841781
nsv832574 CNV gain 17160897
nsv984 CNV insertion 18451855

Variation tolerance for ALOX5AP Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALOX5AP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX5AP Gene

Disorders for ALOX5AP Gene

MalaCards: The human disease database

(4) MalaCards diseases for ALOX5AP Gene - From: HGMD, OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
stroke, ischemic
  • cerebrovascular accident
myocardial infarction
  • myocardial infarction, susceptibility to
macular holes
  • macular hole
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards


  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269 PubMed:14770184, ECO:0000269 PubMed:17304054}.

Additional Disease Information for ALOX5AP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ALOX5AP: view

No data available for Genatlas for ALOX5AP Gene

Publications for ALOX5AP Gene

  1. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PMID: 14770184) Helgadottir A … Stefansson K (Nature genetics 2004) 3 4 22 44 58
  2. Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP). (PMID: 1673682) Kennedy BP … Dixon RA (The Journal of biological chemistry 1991) 2 3 4 22 58
  3. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. (PMID: 20067482) Via M … Genetics of Asthma in Latino Americans (GALA) Study (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010) 3 22 44 58
  4. Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study. (PMID: 20357438) Domingues-Montanari S … Montaner J (Cerebrovascular diseases (Basel, Switzerland) 2010) 3 22 44 58
  5. [Association of the ALOX5AP gene SG13S114 A/T polymorphism with atherosclerosis]. (PMID: 20376802) He YL … Chen QY (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2010) 3 22 44 58

Products for ALOX5AP Gene

Sources for ALOX5AP Gene

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