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This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
ALOX15B (Arachidonate 15-Lipoxygenase Type B) is a Protein Coding gene. Diseases associated with ALOX15B include Embryoma and Autosomal Recessive Congenital Ichthyosis. Among its related pathways are Folate Metabolism and Eicosanoid Synthesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is ALOXE3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005506 | iron ion binding | IDA | 24497644 |
GO:0005509 | calcium ion binding | IDA | 24497644 |
GO:0005515 | protein binding | IEA | -- |
GO:0008289 | lipid binding | IEA | -- |
GO:0016165 | linoleate 13S-lipoxygenase activity | IDA | 10542053 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA,IDA | 12704195 |
GO:0005886 | plasma membrane | IEA,IDA | 12704195 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
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2 | Arachidonic acid metabolism | ||
3 | Linoleic acid metabolism | ||
4 | Serotonergic synapse | ||
5 | HETE and HPETE biosynthesis and metabolism |
HETE and HPETE biosynthesis and metabolism
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | TAS | 11839751 |
GO:0006644 | phospholipid metabolic process | IDA | 27435673 |
GO:0006915 | apoptotic process | TAS | 11839751 |
GO:0008285 | negative regulation of cell proliferation | IMP | 12704195 |
GO:0010744 | positive regulation of macrophage derived foam cell differentiation | IMP | 22912809 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
Iron | Approved, Experimental | Pharma | 1560 | |||
Oxygen | Approved, Vet_approved | Pharma | 0 | |||
arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation | 40 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
13-L-Hydroperoxylinoleic acid |
|
33964-75-9 |
|
|||
15(S)-HPETE |
|
70981-96-3 |
|
|||
8(S)-HPETE |
|
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ALOX15B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ALOX15B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ALOX15B 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Alox15b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Alox8 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | ALOXE3 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.25238 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ALOXE3 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
CSA.6148 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711528 | Likely Benign: not provided | 8,042,407(+) | A/G | MISSENSE_VARIANT | |
731066 | Likely Benign: not provided | 8,045,375(+) | C/T | SYNONYMOUS_VARIANT | |
745180 | Benign: not provided | 8,045,477(+) | C/T | INTRON_VARIANT | |
777126 | Benign: not provided | 8,048,438(+) | G/A | MISSENSE_VARIANT | |
780167 | Likely Benign: not provided | 8,044,921(+) | C/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
embryoma |
|
|
autosomal recessive congenital ichthyosis |
|
|
ichthyosis |
|
|
prostate cancer |
|
|
squamous cell carcinoma, head and neck |
|