Aliases for ALOX15B Gene
Aliases for ALOX15B Gene
External Ids for ALOX15B Gene
- HGNC: 434
- Entrez Gene: 247
- Ensembl: ENSG00000179593
- OMIM: 603697
- UniProtKB: O15296
Previous GeneCards Identifiers for ALOX15B Gene
- GC17P008408
- GC17P008813
- GC17P007884
- GC17P008142
- GC17P007883
- GC17P007942
Summaries for ALOX15B Gene
-
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ALOX15B Gene
ALOX15B (Arachidonate 15-Lipoxygenase, Type B) is a Protein Coding gene. Diseases associated with ALOX15B include Prostate Cancer and Congenital Ichthyosiform Erythroderma. Among its related pathways are Metabolism and Eicosanoid Synthesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is ALOXE3.
UniProtKB/Swiss-Prot for ALOX15B Gene
-
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
Additional gene information for ALOX15B Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX15B Gene
Genomics for ALOX15B Gene
GeneHancer (GH) Regulatory Elements for ALOX15B Gene
Promoters and enhancers for ALOX15B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ALOX15B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ALOX15B gene promoter:
-
- SEF-1 (1)
- AhR
- GR-beta
- GR-alpha
- GR
- POU3F1
- CREB
- RORalpha2
- LCR-F1
- PPAR-gamma1
Regulatory Element Products
Genomic Locations for ALOX15B Gene
Genomic Locations for ALOX15B Gene
- chr17:8,039,017-8,049,134
- (GRCh38/hg38)
- Size:
- 10,118 bases
- Orientation:
- Plus strand
- chr17:7,942,335-7,952,452
- (GRCh37/hg19)
- Size:
- 10,118 bases
- Orientation:
- Plus strand
Genomic View for ALOX15B Gene
Genes around ALOX15B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
- 17p13.1 by Ensembl
ALOX15B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALOX15B Gene
Proteins for ALOX15B Gene
-
Protein details for ALOX15B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15296-LX15B_HUMAN
- Recommended name:
- Arachidonate 15-lipoxygenase B
- Protein Accession:
- O15296
- D3DTR2
- Q8IYQ2
- Q8TEV3
- Q8TEV4
- Q8TEV5
- Q8TEV6
- Q9UKM4
Protein attributes for ALOX15B Gene
- Size:
- 676 amino acids
- Molecular mass:
- 75857 Da
- Cofactor:
- Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD37786.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for ALOX15B Gene
Post-translational modifications for ALOX15B Gene
Other Protein References for ALOX15B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ALOX15B
-
Abcam antibodies for ALOX15B
- Invitrogen Antibodies for ALOX15B
- GeneTex ALOX15B Antibody for ALOX15B
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALOX15B
- Sino Biological Antibodies for ALOX15B
Protein Products
-
OriGene Purified Proteins for ALOX15B
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- Sino Biological Recombinant Proteins for ALOX15B
- Sino Biological Cell Lysates for ALOX15B
- antibodies-online: Search results for 8 available ALOX15B Proteins ranked by validation data
- Compare Top ALOX15B Proteins
-
Quality Products:
- Search GeneTex for Proteins for ALOX15B
-
Abcam proteins for ALOX15B
Assay Products
- Novus Biologicals ELISA Kits for ALOX15B
- antibodies-online: Search results for 9 available ALOX15B Elisa Kits ranked by validation data
- Compare Top ALOX15B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ALOX15B Gene
Domains & Families for ALOX15B Gene
Gene Families for ALOX15B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ALOX15B Gene
Suggested Antigen Peptide Sequences for ALOX15B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15296UniProtKB/Swiss-Prot:
LX15B_HUMAN :- The PLAT domain can bind calcium ions; this promotes association with membranes.
- Belongs to the lipoxygenase family.
- Domain:
-
- The PLAT domain can bind calcium ions; this promotes association with membranes.
- Family:
-
- Belongs to the lipoxygenase family.
Function for ALOX15B Gene
Molecular function for ALOX15B Gene
- UniProtKB/Swiss-Prot Function:
- Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Linoleate + O(2) = (9Z,11E)-13-hydroxyoctadeca-9,11-dienoate.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1100 uM for arachidonate (isoform D at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; KM=10 uM for linoleate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; KM=25 uM for arachidonate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; Vmax=4 umol/min/mg enzyme with arachidonate as substrate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; Vmax=2 umol/min/mg enzyme with arachidonate as substrate (isoform D at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; Vmax=4 umol/min/mg enzyme with linoleate as substrate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053};
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by UV-irradiation.
Enzyme Numbers (IUBMB) for ALOX15B Gene
Phenotypes From GWAS Catalog for ALOX15B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005506 | iron ion binding | IDA | 24497644 |
| GO:0005509 | calcium ion binding | IDA | 24497644 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0016165 | linoleate 13S-lipoxygenase activity | IDA | 10542053 |
Phenotypes for ALOX15B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
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OriGene CRISPR knockouts for ALOX15B
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-
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-
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miRNA for ALOX15B Gene
- miRTarBase miRNAs that target ALOX15B
miRNA Products
Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for ALOX15B
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- VectorBuilder custom plasmid, inducible vectors for ALOX15B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX15B
- genomics-online: cdna clones - Search results for available ALOX15B gene related products
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- Applied Biological Materials Clones for ALOX15B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ALOX15B
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALOX15B Gene
Localization for ALOX15B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALOX15B Gene
- Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.
- Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | 11839751 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA,IDA | 12704195 |
Pathways & Interactions for ALOX15B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Arachidonic acid metabolism | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Serotonergic synapse | ||
| 5 | HETE and HPETE biosynthesis and metabolism | ||
Pathways by source for ALOX15B Gene
2 BioSystems pathways for ALOX15B Gene
4 Reactome pathways for ALOX15B Gene
3 KEGG pathways for ALOX15B Gene
1 GeneGo (Thomson Reuters) pathway for ALOX15B Gene
UniProtKB/Swiss-Prot O15296-LX15B_HUMAN
- Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
Interacting Proteins for ALOX15B Gene
Selected Interacting proteins:
ENSP00000369530
O15296-LX15B_HUMAN
for ALOX15B Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for ALOX15B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | TAS | 11839751 |
| GO:0006915 | apoptotic process | TAS | 11839751 |
| GO:0008285 | negative regulation of cell proliferation | IMP | 12704195 |
| GO:0010744 | positive regulation of macrophage derived foam cell differentiation | IMP | 22912809 |
| GO:0019369 | arachidonic acid metabolic process | IDA | 9177185 |
No data available for SIGNOR curated interactions for ALOX15B Gene
Drugs & Compounds for ALOX15B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 13-L-Hydroperoxylinoleic acid |
|
33964-75-9 |
|
|||
| 15(S)-HPETE |
|
70981-96-3 |
|
|||
| 8(S)-HPETE |
|
|
||||
| Fe2+ |
|
15438-31-0 |
|
Transcripts for ALOX15B Gene
mRNA/cDNA for ALOX15B Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (63) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000380183 2739 bps (uc002gju.4)
- ENST00000572022 2396 bps (uc010vun.3)
- ENST00000571240 2944 bps (uc060axu.1)
- ENST00000573359 1809 bps (uc002gjw.4)
- ENST00000380173 2605 bps (uc002gjv.4)
Unigene Clusters for ALOX15B Gene
CRISPR Products
-
OriGene CRISPR knockouts for ALOX15B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX15B
- genomics-online: gRNA clones - Search results for available ALOX15B gene related products
- Applied Biological Materials CRISPR for ALOX15B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX15B
- GenScript: Design CRISPR guide RNA sequences for ALOX15B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX15B
- Browse OriGene Inhibitory RNA Products For ALOX15B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX15B
- genomics-online: shRNA clones - Search results for available ALOX15B gene related products
Clone Products
-
OriGene ORF clones in human for ALOX15B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ALOX15B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX15B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX15B
- genomics-online: cdna clones - Search results for available ALOX15B gene related products
- orf clones - Search results for available ALOX15B gene related products
- Applied Biological Materials Clones for ALOX15B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b |
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| SP1: | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for ALOX15B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for ALOX15B Gene
This gene is overexpressed in Prostate (x7.5), Esophagus - Mucosa (x6.7), Lung (x6.3), Vagina (x5.5), and Skin - Not Sun Exposed (Suprapubic) (x4.7).
This gene is overexpressed in Cervix (52.1) and Urine (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALOX15B Gene
NURSA nuclear receptor signaling pathways regulating expression of ALOX15B Gene:
ALOX15BSOURCE GeneReport for Unigene cluster for ALOX15B Gene:
Hs.111256mRNA Expression by UniProt/SwissProt for ALOX15B Gene:
O15296-LX15B_HUMAN
Tissue specificity:
Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
Evidence on tissue expression from TISSUES for ALOX15B Gene
- Skin(4.5)
Primer Products
-
OriGene qPCR primer pairs for ALOX15B
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Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX15B Gene
Orthologs for ALOX15B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ALOX15B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ALOX15B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ALOX15B 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Alox15b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Alox8 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ALOXE3 33 |
|
||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25238 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ALOXE3 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| CSA.6148 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ALOX15B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ALOX15B Gene
- ENSEMBL:
- Gene Tree for ALOX15B (if available)
- TreeFam:
- Gene Tree for ALOX15B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALOX15B: view image
Paralogs for ALOX15B Gene
Variants for ALOX15B Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000478509 | -- | 8,046,742(+) | GG/G | coding_sequence_variant, frameshift, intron_variant | |
| rs1001108602 | -- | 8,039,464(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1001268361 | -- | 8,042,574(+) | C/A | intron_variant | |
| rs1001547213 | -- | 8,041,602(+) | A/G | intron_variant | |
| rs1001561370 | -- | 8,039,217(+) | A/G | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.38;
88.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALOX15B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ALOX15B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX15B Gene
Disorders for ALOX15B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer |
|
|
| congenital ichthyosiform erythroderma |
|
|
| suppression of tumorigenicity 12 |
|
|
Search ALOX15B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALOX15B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ALOX15B Gene
Publications for ALOX15B Gene
- Discovery of a second 15S-lipoxygenase in humans. (PMID: 9177185) Brash AR … Chang MS (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
- 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. (PMID: 18067895) Danielsson KN … Hultén LM (Atherosclerosis 2008) 3 4 22 58
- Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. (PMID: 12704195) Bhatia B … Tang DG (The Journal of biological chemistry 2003) 3 4 22 58
- Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. (PMID: 11839751) Tang S … Tang DG (The Journal of biological chemistry 2002) 3 4 22 58
- A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PMID: 11350124) Krieg P … Fürstenberger G (Genomics 2001) 3 4 22 58
Products for ALOX15B Gene
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- Browse OriGene miRNA Products For ALOX15B
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- GenScript Custom Purified and Recombinant Proteins Services for ALOX15B
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- GenScript Custom overexpressing Cell Line Services for ALOX15B
- GenScript: Design CRISPR guide RNA sequences for ALOX15B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Recombinant Proteins for ALOX15B
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- Sino Biological Antibodies for ALOX15B
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ALOX15B
- Novus Biologicals proteins and lysates for ALOX15B
- Novus Biologicals ELISA Kits for ALOX15B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for ALOX15B
- Abcam proteins for ALOX15B
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ALOX15B
- VectorBuilder custom plasmid, inducible vectors for ALOX15B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX15B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 70 available ALOX15B Antibodies ranked by validation data
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- antibodies-online: Search results for 9 available ALOX15B Elisa Kits ranked by validation data
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- antibodies-online: Search results for 8 available ALOX15B Proteins ranked by validation data
- Compare Top ALOX15B Proteins
- Quality Products:
- GeneTex ALOX15B Antibody for ALOX15B
- Search GeneTex for Proteins for ALOX15B
- Santa Cruz Biotechnology (SCBT) Antibodies for ALOX15B
- Search Santa Cruz Biotechnology (SCBT) for ALOX15B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ALOX15B
- Horizon Cell Lines for ALOX15B
- genomics-online: cdna clones - Search results for available ALOX15B gene related products
- orf clones - Search results for available ALOX15B gene related products
- genomics-online: gRNA clones - Search results for available ALOX15B gene related products
- genomics-online: primer clones - Search results for available ALOX15B gene related products
- genomics-online: shRNA clones - Search results for available ALOX15B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX15B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX15B
- GeneCopoeia miRNA 3'UTR Target clone products for ALOX15B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX15B
Sources for ALOX15B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (125) NCBI Bookshelf
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt