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This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene t... See more...
Aliases for ALOX15B Gene
Aliases for ALOX15B Gene
External Ids for ALOX15B Gene
- HGNC: 434
- Entrez Gene: 247
- Ensembl: ENSG00000179593
- OMIM: 603697
- UniProtKB: O15296
Previous GeneCards Identifiers for ALOX15B Gene
- GC17P008408
- GC17P008813
- GC17P007884
- GC17P008142
- GC17P007883
- GC17P007942
Summaries for ALOX15B Gene
-
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ALOX15B Gene
ALOX15B (Arachidonate 15-Lipoxygenase Type B) is a Protein Coding gene. Diseases associated with ALOX15B include Embryoma and Autosomal Recessive Congenital Ichthyosis. Among its related pathways are Folate Metabolism and Eicosanoid Synthesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is ALOXE3.
UniProtKB/Swiss-Prot Summary for ALOX15B Gene
-
[Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644) (Probable). Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoic acid glyceryl ester (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). In addition to metabolize free PUFAs hydrolyzed from phospholipids, directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809).
-
[Isoform B]: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE.
Additional gene information for ALOX15B Gene
- HGNC(434)
- Entrez Gene(247)
- Ensembl(ENSG00000179593)
- OMIM(603697)
- UniProtKB(O15296)
- Open Targets Platform(ENSG00000179593)
- Search for ALOX15B at DataMed
- Search for ALOX15B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALOX15B Gene
Genomics for ALOX15B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ALOX15B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALOX15B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALOX15B
- Top Transcription factor binding sites by QIAGEN in the ALOX15B gene promoter:
-
- AhR
- CREB
- GR
- GR-alpha
- GR-beta
- LCR-F1
- POU3F1
- PPAR-gamma1
- RORalpha2
- SEF-1 (1)
Genomic Locations for ALOX15B Gene
Genomic Locations for ALOX15B Gene
- chr17:8,039,034-8,049,134
- (GRCh38/hg38)
- Size:
- 10,101 bases
- Orientation:
- Plus strand
- chr17:7,942,335-7,952,452
- (GRCh37/hg19)
- Size:
- 10,118 bases
- Orientation:
- Plus strand
Genomic View for ALOX15B Gene
Genes around ALOX15B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by HGNC
- 17p13.1 by Entrez Gene
- 17p13.1 by Ensembl
ALOX15B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALOX15B Gene
Proteins for ALOX15B Gene
-
Protein details for ALOX15B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15296-LX15B_HUMAN
- Recommended name:
- Polyunsaturated fatty acid lipoxygenase ALOX15B
- Protein Accession:
- O15296
- D3DTR2
- Q8IYQ2
- Q8TEV3
- Q8TEV4
- Q8TEV5
- Q8TEV6
- Q9UKM4
Protein attributes for ALOX15B Gene
- Size:
- 676 amino acids
- Molecular mass:
- 75857 Da
- Cofactor:
- Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD37786.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for ALOX15B Gene
Selected DME Specific Peptides for ALOX15B Gene
- O15296:
-
- NPVLIRRC
- TCSAKHAAV
- YPDEHFTE
Post-translational modifications for ALOX15B Gene
Other Protein References for ALOX15B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ALOX15B
- Invitrogen Antibodies for ALOX15B (AFLGC-ALOX15B)
-
Boster Bio Antibodies for ALOX15B
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALOX15B
- Sino Biological Antibodies for ALOX15B
Protein Products
-
OriGene Purified Proteins for ALOX15B
- Search Origene for MassSpec and Protein Over-expression Lysates for ALOX15B
- Origene Custom Protein Services for ALOX15B
- Sino Biological Cell Lysates for ALOX15B
- Sino Biological Recombinant Proteins for ALOX15B
- antibodies-online: Show 8 available ALOX15B Proteins ranked by validation data
- Compare Top ALOX15B Proteins
-
Quality Products:
-
Abcam proteins for ALOX15B
Assay Products
- Novus Biologicals ELISA Kits for ALOX15B
- antibodies-online: Show 14 available ALOX15B Elisa Kits ranked by validation data
- Compare Top ALOX15B Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for ALOX15B
Domains & Families for ALOX15B Gene
Gene Families for ALOX15B Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ALOX15B Gene
- InterPro:
- Blocks:
-
- Lipoxygenase, LH2 domain
- Lipoxygenase
- Mammalian lipoxygenase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for ALOX15B Gene
- GenScript: Design optimal peptide antigens:
-
- Arachidonate 15-lipoxygenase type II (LX15B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15296UniProtKB/Swiss-Prot:
LX15B_HUMAN :- The PLAT domain can bind calcium ions; this promotes association with membranes.
- Belongs to the lipoxygenase family.
- Domain:
-
- The PLAT domain can bind calcium ions; this promotes association with membranes.
- Family:
-
- Belongs to the lipoxygenase family.
Function for ALOX15B Gene
Molecular function for ALOX15B Gene
- UniProtKB/Swiss-Prot Function:
- [Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644) (Probable). Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoic acid glyceryl ester (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). In addition to metabolize free PUFAs hydrolyzed from phospholipids, directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809).
- UniProtKB/Swiss-Prot Function:
- [Isoform B]: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:16869, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57446; EC=1.13.11.33; Evidence={ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11956198, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:17493578, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24497644, ECO:0000269|PubMed:9177185, ECO:0000305|PubMed:10542053, ECO:0000305|PubMed:27145229, ECO:0000305|PubMed:27435673};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate; Xref=Rhea:RHEA:48848, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:90823; Evidence={ECO:0000269|PubMed:27435673, ECO:0000305|PubMed:10542053};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:53660, ChEBI:CHEBI:15379, ChEBI:CHEBI:90632, ChEBI:CHEBI:137546; Evidence={ECO:0000269|PubMed:27145229};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:48844, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:90822; Evidence={ECO:0000269|PubMed:10542053};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:53656, ChEBI:CHEBI:15379, ChEBI:CHEBI:137542, ChEBI:CHEBI:137547; Evidence={ECO:0000269|PubMed:27145229};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:53652, ChEBI:CHEBI:15379, ChEBI:CHEBI:57450, ChEBI:CHEBI:137543; Evidence={ECO:0000269|PubMed:27145229};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol; Xref=Rhea:RHEA:53332, ChEBI:CHEBI:15379, ChEBI:CHEBI:52392, ChEBI:CHEBI:137187; Evidence={ECO:0000269|PubMed:11956198};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:50932, ChEBI:CHEBI:15379, ChEBI:CHEBI:75322, ChEBI:CHEBI:133899; Evidence={ECO:0000305|PubMed:16112079};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50184, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132077; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate; Xref=Rhea:RHEA:50180, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132078; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50188, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132076; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50156, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132062; Evidence={ECO:0000269|PubMed:18311922};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol; Xref=Rhea:RHEA:63224, ChEBI:CHEBI:15379, ChEBI:CHEBI:52392, ChEBI:CHEBI:146254; Evidence={ECO:0000269|PubMed:11956198};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:63264, ChEBI:CHEBI:15379, ChEBI:CHEBI:74965, ChEBI:CHEBI:146283; Evidence={ECO:0000269|PubMed:27435673};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol); Xref=Rhea:RHEA:63276, ChEBI:CHEBI:15379, ChEBI:CHEBI:75243, ChEBI:CHEBI:146285; Evidence={ECO:0000269|PubMed:27435673};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol); Xref=Rhea:RHEA:63280, ChEBI:CHEBI:15379, ChEBI:CHEBI:146286, ChEBI:CHEBI:146287; Evidence={ECO:0000269|PubMed:27435673};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:63268, ChEBI:CHEBI:15379, ChEBI:CHEBI:78268, ChEBI:CHEBI:146282; Evidence={ECO:0000269|PubMed:27435673};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol); Xref=Rhea:RHEA:63272, ChEBI:CHEBI:15379, ChEBI:CHEBI:133606, ChEBI:CHEBI:146284; Evidence={ECO:0000269|PubMed:27435673};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate; Xref=Rhea:RHEA:63312, ChEBI:CHEBI:15379, ChEBI:CHEBI:71589, ChEBI:CHEBI:146292; Evidence={ECO:0000269|PubMed:27435673};.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by UV-irradiation.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1100 uM for arachidonate (isoform D at pH 7.4 and 20 degrees Celsius) {ECO:0000269|PubMed:10542053}; KM=10 uM for linoleate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269|PubMed:10542053}; KM=25 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269|PubMed:10542053}; KM=23 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate (Sf9-expressed enzyme) {ECO:0000269|PubMed:11956198}; KM=15 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate (E. Coli-expressed enzyme) {ECO:0000269|PubMed:11956198}; KM=9 uM for 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol (Sf9-expressed enzyme) {ECO:0000269|PubMed:11956198}; KM=8 uM for 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol (E. Coli-expressed enzyme) {ECO:0000269|PubMed:11956198}; KM=14 uM for anandamide (Sf9-expressed enzyme) {ECO:0000269|PubMed:11956198}; KM=11 uM for anandamide (E. Coli-expressed enzyme) {ECO:0000269|PubMed:11956198}; KM=8 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:17493578}; KM=11 uM for N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine {ECO:0000269|PubMed:17493578}; KM=6 uM for N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine {ECO:0000269|PubMed:17493578}; KM=8 uM for N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate {ECO:0000269|PubMed:17493578}; KM=1.2 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:24282679}; KM=4 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:27145229}; KM=3.3 uM for (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:27145229}; KM=19 uM for (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:27145229}; KM=1.74 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:27435673}; KM=3.46 uM for (8Z,11Z,14Z)-eicosatrienoate {ECO:0000269|PubMed:27435673}; Vmax=4 umol/min/mg enzyme with arachidonate as substrate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269|PubMed:10542053}; Vmax=2 umol/min/mg enzyme with arachidonate as substrate (isoform D at pH 7.4 and 20 degrees Celsius) {ECO:0000269|PubMed:10542053}; Vmax=4 umol/min/mg enzyme with linoleate as substrate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269|PubMed:10542053}; Vmax=0.82 nmol/sec/mg enzyme with (5Z,8Z,11Z,14Z)-eicosatetraenoate (Sf9-expressed enzyme) {ECO:0000269|PubMed:11956198}; Vmax=4.3 nmol/sec/mg enzyme with (5Z,8Z,11Z,14Z)-eicosatetraenoate (E. Coli-expressed enzyme) {ECO:0000269|PubMed:11956198}; Vmax=9 nmol/sec/mg enzyme with 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol (Sf9-expressed enzyme) {ECO:0000269|PubMed:11956198}; Vmax=8 nmol/sec/mg enzyme with 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol (E. Coli-expressed enzyme) {ECO:0000269|PubMed:11956198}; Vmax=14 nmol/sec/mg enzyme with anandamide (Sf9-expressed enzyme) {ECO:0000269|PubMed:11956198}; Vmax=11 nmol/sec/mg enzyme with anandamide (E. Coli-expressed enzyme) {ECO:0000269|PubMed:11956198}; Note=kcat is 2 sec(-1) for (5Z,8Z,11Z,14Z)-eicosatetraenoate. kcat is 2.1 sec(-1) for N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine. kcat is 2 sec(-1) for N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine. kcat is 2 sec(-1) for N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate (PubMed:17493578). kcat is 0.18 sec(-1) for (5Z,8Z,11Z,14Z)-eicosatetraenoate (PubMed:24282679). kcat is 1 sec(-1) for (5Z,8Z,11Z,14Z)-eicosatetraenoate. kcat is 2.1 sec(-1) for (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate. kcat is 1.5 sec(-1) for (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate (PubMed:27145229). kcat is 0.46 sec(-1) for (5Z,8Z,11Z,14Z)-eicosatetraenoate. kcat is 0.31 sec(-1) for (8Z,11Z,14Z)-eicosatrienoate (PubMed:27435673). {ECO:0000269|PubMed:17493578, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:27145229, ECO:0000269|PubMed:27435673};
Enzyme Numbers (IUBMB) for ALOX15B Gene
Phenotypes From GWAS Catalog for ALOX15B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005506 | iron ion binding | IDA | 24497644 |
| GO:0005509 | calcium ion binding | IDA | 24497644 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0016165 | linoleate 13S-lipoxygenase activity | IDA | 10542053 |
Phenotypes for ALOX15B Gene
- MGI mutant phenotypes for ALOX15B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALOX15B:
Animal Models for ALOX15B Gene
- MGI Knock Outs for ALOX15B:
-
- Alox8 Alox8<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
OriGene CRISPR knockouts for ALOX15B
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX15B
miRNA for ALOX15B Gene
- miRTarBase miRNAs that target ALOX15B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX15B
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Clone Products
- Applied Biological Materials (abm): Clones for ALOX15B - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for ALOX15B
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Cell Line Products
-
Horizon Cell Lines for ALOX15B
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX15B Gene
Localization for ALOX15B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALOX15B Gene
- [Isoform A]: Nucleus. Note=Other isoforms are excluded from the nucleus. {ECO:0000269 PubMed:12704195}.
- Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane. Peripheral membrane protein. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. {ECO:0000269 PubMed:10542053, ECO:0000269 PubMed:12704195, ECO:0000269 PubMed:24497644, ECO:0000269 PubMed:27435673}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| peroxisome | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA,IDA | 12704195 |
| GO:0005886 | plasma membrane | IEA,IDA | 12704195 |
Pathways & Interactions for ALOX15B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Arachidonic acid metabolism | ||
| 3 | Linoleic acid metabolism | ||
| 4 | Serotonergic synapse | ||
| 5 | HETE and HPETE biosynthesis and metabolism |
HETE and HPETE biosynthesis and metabolism
-
|
|
Pathways by source for ALOX15B Gene
2 BioSystems pathways for ALOX15B Gene
4 Reactome pathways for ALOX15B Gene
3 KEGG pathways for ALOX15B Gene
1 GeneGo (Thomson Reuters) pathway for ALOX15B Gene
- HETE and HPETE biosynthesis and metabolism
UniProtKB/Swiss-Prot O15296-LX15B_HUMAN
- Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
Interacting Proteins for ALOX15B Gene
Selected Interacting proteins:
O15296-LX15B_HUMAN
ENSP00000369530
for ALOX15B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ALOX15B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | TAS | 11839751 |
| GO:0006644 | phospholipid metabolic process | IDA | 27435673 |
| GO:0006915 | apoptotic process | TAS | 11839751 |
| GO:0008285 | negative regulation of cell proliferation | IMP | 12704195 |
| GO:0010744 | positive regulation of macrophage derived foam cell differentiation | IMP | 22912809 |
No data available for SIGNOR curated interactions for ALOX15B Gene
Drugs & Compounds for ALOX15B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
| Iron | Approved, Experimental | Pharma | 1560 | |||
| Oxygen | Approved, Vet_approved | Pharma | 0 | |||
| arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation | 40 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 13-L-Hydroperoxylinoleic acid |
|
33964-75-9 |
|
|||
| 15(S)-HPETE |
|
70981-96-3 |
|
|||
| 8(S)-HPETE |
|
|
Transcripts for ALOX15B Gene
mRNA/cDNA for ALOX15B Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380183 2697 nts (view in UCSC)
- ENST00000572022 2396 nts (view in UCSC)
- ENST00000571240 2944 nts (view in UCSC)
- ENST00000573359 1809 nts (view in UCSC)
- ENST00000380173 2605 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALOX15B - Select products 50% OFF >
- * ALOX15B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ALOX15B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX15B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX15B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX15B
- Browse OriGene Inhibitory RNA Products For ALOX15B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX15B
Clone Products
- Applied Biological Materials (abm): Clones for ALOX15B - Select products 50% OFF >
- * ALOX15B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for ALOX15B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX15B
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for ALOX15B Gene
- GeneLoc Exon Structure for
- ALOX15B
Expression for ALOX15B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for ALOX15B Gene
This gene is overexpressed in Prostate (x7.5), Esophagus - Mucosa (x6.7), Lung (x6.3), Vagina (x5.5), and Skin - Not Sun Exposed (Suprapubic) (x4.7).
This gene is overexpressed in Cervix (52.1) and Urine (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALOX15B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALOX15B
SOURCE GeneReport for Unigene cluster for ALOX15B Gene:
Hs.111256mRNA Expression by UniProt/SwissProt for ALOX15B Gene:
O15296-LX15B_HUMAN
Tissue specificity:
Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
Evidence on tissue expression from TISSUES for ALOX15B Gene
- Skin(4.5)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for ALOX15B
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX15B Gene
Orthologs for ALOX15B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ALOX15B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ALOX15B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ALOX15B 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Alox15b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Alox8 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | ALOXE3 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25238 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ALOXE3 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.6148 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for ALOX15B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ALOX15B Gene
- ENSEMBL:
- Gene Tree for ALOX15B (if available)
- TreeFam:
- Gene Tree for ALOX15B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALOX15B: view image
Paralogs for ALOX15B Gene
Variants for ALOX15B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALOX15B Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711528 | Likely Benign: not provided | 8,042,407(+) | A/G | MISSENSE_VARIANT | |
| 731066 | Likely Benign: not provided | 8,045,375(+) | C/T | SYNONYMOUS_VARIANT | |
| 745180 | Benign: not provided | 8,045,477(+) | C/T | INTRON_VARIANT | |
| 777126 | Benign: not provided | 8,048,438(+) | G/A | MISSENSE_VARIANT | |
| 780167 | Likely Benign: not provided | 8,044,921(+) | C/T | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.38;
88.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALOX15B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ALOX15B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX15B Gene
Disorders for ALOX15B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| embryoma |
|
|
| autosomal recessive congenital ichthyosis |
|
|
| ichthyosis |
|
|
| prostate cancer |
|
|
| squamous cell carcinoma, head and neck |
|
Search ALOX15B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALOX15B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ALOX15B Gene
Publications for ALOX15B Gene
- Discovery of a second 15S-lipoxygenase in humans. (PMID: 9177185) Brash AR … Chang MS (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23
- 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. (PMID: 18067895) Danielsson KN … Hultén LM (Atherosclerosis 2008) 3 4 23
- Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. (PMID: 12704195) Bhatia B … Tang DG (The Journal of biological chemistry 2003) 3 4 23
- Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. (PMID: 11839751) Tang S … Tang DG (The Journal of biological chemistry 2002) 3 4 23
- A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PMID: 11350124) Krieg P … Fürstenberger G (Genomics 2001) 3 4 23
ExternalLinks
Products for ALOX15B Gene
- Custom Antibody Services
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- OriGene qPCR primer pairs for ALOX15B
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- Sino Biological Human cDNA Clone for ALOX15B
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- Sino Biological Recombinant Proteins for ALOX15B
- Sino Biological Antibodies for ALOX15B
- Browse Sino Biological Assays
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- Novus Biologicals Antibodies for ALOX15B
- Novus Biologicals proteins and lysates for ALOX15B
- Novus Biologicals ELISA Kits for ALOX15B
- Browse Antibodies
- Browse Peptides and Proteins
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- Invitrogen Antibodies for ALOX15B (AFLGC-ALOX15B)
- VectorBuilder Custom and pre-made DNA vectors for ALOX15B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ALOX15B (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for ALOX15B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ALOX15B
- antibodies-online: Show 34 available ALOX15B Antibodies ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ALOX15B
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX15B
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- Boster Bio Antibodies for ALOX15B
- Browse Boster Bio ELISA Kits
Sources for ALOX15B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
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- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
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- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB